Article
Chemistry, Multidisciplinary
Merav Antman-Passig, Jonathan Giron, Moshe Karni, Menachem Motiei, Hadas Schori, Orit Shefi
Summary: Nerve growth conduits play a crucial role in supporting and promoting axon regeneration following nerve injuries. A biomimetic regenerative gel enriched with magnetic nanoparticles coated with nerve growth factor has been developed, showing promising effects on enhancing nerve regeneration in in vivo rat models. The magnet-based therapeutic conduits demonstrate oriented and directed axonal growth, providing a novel therapeutic approach to overcoming current medical obstacles for nerve injuries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Qi Dong, Xindi Yang, Xiao Liang, Jing Liu, Binyi Wang, Yanteng Zhao, Celine Huselstein, Xiaolin Feng, Zan Tong, Yun Chen
Summary: Peripheral nerve regeneration and functional recovery remain challenging in clinical practice. The utilization of nerve guidance conduits (NGCs) and platelet-rich plasma (PRP) can regulate the regenerative microenvironment and promote peripheral nerve repair. A composite nerve conduit, GelMA/SA-3/PRP-20 NGCs, incorporating PRP into a gelatin methacrylate (GelMA) and sodium alginate (SA) hydrogel, showed optimal mechanical properties and sustained release of growth factors (VEGF-A, PDGF-BB) from PRP, promoting axonal regeneration and functional recovery in peripheral nerves.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Enxing Yu, Zhiwu Chen, Yuye Huang, Yibing Wu, Zonghuan Wang, Fangfang Wang, Miaoben Wu, Kailei Xu, Wei Peng
Summary: Peripheral nerve injury (PNI) is a common and severe clinical disease with poor prognosis. Autologous nerve grafting is limited in availability and size, leading to the development of artificial nerve conduits. In this study, a novel composite neural conduit containing decellularized tissues and a grooved PLGA conduit was found to significantly promote nerve regeneration. This artificial nerve conduit could potentially be used in clinical practice.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Binghui Jin, Yiling Yu, Chenghao Lou, Xiaodi Zhang, Bowen Gong, Jinghao Chen, Xiangxiang Chen, Zihan Zhou, Liqun Zhang, Jian Xiao, Jiajia Xue
Summary: A multi-functional nerve guidance conduit (NGC) is constructed to promote nerve regeneration by integrating ordered topological structure, density gradient of biomacromolecular nanoparticles, and controlled delivery of biological effectors. The NGC promotes the proliferation of Schwann cells and directional extension of neurites, achieving both anatomical and functional regeneration of the nerve. It provides a favorable microenvironment for peripheral nerve regeneration and holds great promise for nerve repair.
Article
Engineering, Environmental
Ying Ma, Hao Wang, Qiqi Wang, Xiaodong Cao, Huichang Gao
Summary: This study developed a multi-channel nerve guidance conduit (NGC) with dual electrical activity of piezoelectricity and conductivity to enhance peripheral nerve regeneration. In vitro and in vivo experiments demonstrated that the electroactive NGC promoted cell proliferation, differentiation, axonal regeneration, and functional recovery of peripheral nerves, indicating its great potential in repairing peripheral nerve injuries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Neurosciences
Yi-jun Liu, Xiao-feng Chen, Li-ping Zhou, Feng Rao, Dian-ying Zhang, Yan-hua Wang
Summary: This study aimed to analyze the effect and mechanism of Wnt5a-loaded fibrin hydrogel on a 10-mm rat sciatic nerve defect. Results showed that Wnt5a could promote Schwann cell proliferation and the expression of various neurotrophic factors, and the Wnt5a/Fn group outperformed the control groups in terms of nerve regeneration and functional recovery 12 weeks after the operation. The Wnt5a/Fn nerve conduit may promote peripheral nerve defect regeneration by facilitating multiple neurotrophin secretion, combining vascularization and neurotrophic growth cues.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Chaoying Zhang, Jiaxing Gong, Jingyu Zhang, Ziyu Zhu, Ying Qian, Kejie Lu, Siyi Zhou, Tianyi Gu, Huiming Wang, Yong He, Mengfei Yu
Summary: The replacement of autograft with a nerve guidance conduit (NGC) in peripheral nerve injury is challenging due to the limited conductivity and biocompatibility of current NGCs in vivo. In this review, the authors explore the superior factors for nerve conduction, the construction of a more conductive regenerative scaffold, and the next steps in nerve regeneration for NGCs. The analysis of NGC-related references suggests that conductive materials, manufacturing technologies of neural scaffolds, and electrical stimulation (ES) play essential roles in accelerating nerve conduction.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Hui Zhang, Han Zhang, Huan Wang, Yuanjin Zhao, Renjie Chai
Summary: A novel silk fibroin-derived nerve guidance conduit (NGC) with internal-facing inverse opal structures is developed for local neurotrophic factor delivery and effective nerve regeneration. The NGC demonstrates excellent biocompatibility, suitable biodegradability, and spatial control over the distribution of loading factors, leading to enhanced therapeutic efficacy.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Zhi Yao, Weihao Yuan, Jiankun Xu, Wenxue Tong, Jie Mi, Pak-Cheong Ho, Dick Ho Kiu Chow, Ye Li, Hao Yao, Xu Li, Shunxiang Xu, Jiaxin Guo, Qingtang Zhu, Liming Bian, Ling Qin
Summary: In this study, an injectable hydrogel based on bisphosphonate was developed to sustainably release magnesium ions for peripheral nerve regeneration. The experimental results showed that magnesium ions promoted neurite outgrowth in a concentration-dependent manner by activating the PI3K/Akt signaling pathway and Sema5b. In a rat nerve defect model, filling the polycaprolactone conduit with magnesium-releasing hydrogel significantly enhanced axon regeneration and remyelination, leading to improved functional recovery.
Article
Chemistry, Multidisciplinary
Yongcong Fang, Chengjin Wang, Zibo Liu, Jeonghoon Ko, Li Chen, Ting Zhang, Zhuo Xiong, Lei Zhang, Wei Sun
Summary: In this study, a conductive multiscale filled NGC (MF-NGC) is developed, which significantly enhances peripheral nerve regeneration. The printed MF-NGCs possess good permeability, mechanical stability, and electrical conductivity, promoting the elongation and growth of Schwann cells and neurite outgrowth. Animal studies demonstrate that the MF-NGCs promote neovascularization and M2 transition, leading to improved peripheral nerve regeneration. This study demonstrates the feasibility of using 3D-printed conductive MF-NGCs with hierarchically oriented fibers as functional conduits.
Article
Neurosciences
Feixiang Chen, Weihuang Liu, Qiang Zhang, Ping Wu, Ao Xiao, Yanan Zhao, Ying Zhou, Qiaona Wang, Yun Chen, Zan Tong
Summary: The study demonstrated that modulating the immune microenvironment by IL-17F could enhance peripheral nerve repair mediated by chitosan conduits. IL-17F knockout mice showed improved functional recovery and axonal regeneration, along with enhanced anti-inflammatory macrophages in the NGC repairing microenvironment. These findings suggest a promising approach to improve peripheral nerve regeneration.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Yaowei Xuan, Lin Li, Xuelai Yin, Dongming He, Siyao Li, Chenping Zhang, Yuan Yin, Wanlin Xu, Zhen Zhang
Summary: This study developed a nerve guidance conduit (NGC) based on bredigite (BRT) bioceramic, which could promote the repair of peripheral nerve injury. BRT bioceramic showed good biocompatibility and sustained release of beneficial ions for nerve repair. The experiments demonstrated that BRT-incorporating NGC could promote cell proliferation, myelination, and vascular formation, as well as improve electrophysiological performance and muscle atrophy in a rat sciatic nerve defect model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Health Care Sciences & Services
Arne Boecker, Martin Aman, Ulrich Kneser, Leila Harhaus, Frank Siemers, Felix Stang
Summary: The efficacy of chitosan-based nerve conduits in regenerating sensory nerves in the hand was evaluated in this study. The results showed that this type of nerve conduit had similar functional outcomes and patient satisfaction to autologous nerve grafts in treating small nerve defects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Materials Science, Biomaterials
Yizhou Xu, Jianing Liu, Peng Zhang, Xiang Ao, Yunlun Li, Ye Tian, Xiaozhong Qiu, Jiasong Guo, Xiaofang Hu
Summary: In this study, a zwitterionic hydrogel was developed to mimic the continuous ion-based signal transmission in biological systems for efficient peripheral nerve regeneration. The hydrogel exhibited excellent mechanical stability, suitable electrical conductivity, and good cytocompatibility, which promoted cell proliferation and neurite growth.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Arvind Rengarajan, Aurelio Mauro, Matte Ghisa, Nicola De Bortoli, Michele Cicala, Mentore Ribolsi, Roberto Penagini, Edoardo Savarino, C. Prakash P. Gyawali
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Arvind Rengarajan, Ijlal A. Ali, Stephen L. Hasak, Vivek Hansalia, C. Prakash Gyawali
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Gastroenterology & Hepatology
Arvind Rengarajan, Julieta Arguero, Etsuro Yazaki, S. Sritharan Kadirkamanthan, H. P. Priyantha Siriwardana, L. Michael Brunt, Daniel Sifrim, C. Prakash Gyawali
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Gastroenterology & Hepatology
Mate Gergely, Michael D. Mello, Arvind Rengarajan, C. Prakash Gyawali
Summary: Pseudoachalasia is characterized by a shorter history, greater weight loss, and incomplete high-resolution manometry patterns compared to achalasia.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Arvind Rengarajan, Mentore Ribolsi, Matteo Ghisa, Farhan Quader, Roberto Penagini, Nicola de Bortoli, Aurelio Mauro, Michele Cicala, Edoardo Savarino, C. Prakash Gyawali
Summary: This multicenter study found that the PSPW index correlates with esophageal hypomotility and reflux burden, and is more relevant to esophageal reflux clearance. Only a minority of patients had intact esophageal contraction vigor, with the majority showing hypomotility.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Arvind Rengarajan, Luiz Abrahao, Shobna Bhatia, Serhat Bor, Dustin A. Carlson, Daniel Cisternas, Sutep Gonlachanvit, Albis Hani, Jamal Hayat, Osamu Kawamura, Yeung Yeh Lee, Ana Maria Leguizamo, Ans Pauwels, Julio Perez de la Serna, Rosa I. Ramos, Jose Maria Remes-Troche, Sabine Roman, Edoardo Savarino, Jordi Serra, Daniel Sifrim, Salvatore Tolone, Zhiqin Wong, Frank Zerbib, John Pandolfino, C. Prakash Gyawali
Summary: This study conducted internationally found that in healthy adults, esophagogastric junction morphology is mainly type 1, with EGJ-CI values varying widely in health and significantly influenced by gender, but consistent within each HRM system. Manufacturer-specific normative values should be utilized for clinical HRM interpretation.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Arvind Rengarajan, Margaux Pomarat, Frank Zerbib, C. Prakash Gyawali
Summary: Conventional and overlap FH and RH have similar clinical, psychological, and functional profiles, thereby proving ROME IV hypotheses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Letter
Hematology
Sunil K. Joshi, Setareh Sharzehi, Janet Pittsenbarger, Daniel Bottomly, Cristina E. Tognon, Shannon K. McWeeney, Brian J. Druker, Elie Traer
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Oncology
Sunil K. Joshi, Tamilla Nechiporuk, Daniel Bottomly, Paul D. Piehowski, Julie A. Reisz, Janet Pittsenbarger, Andy Kaempf, Sara J. C. Gosline, Yi-Ting Wang, Joshua R. Hansen, Marina A. Gritsenko, Chelsea Hutchinson, Karl K. Weitz, Jamie Moon, Francesca Cendali, Thomas L. Fillmore, Chia-Feng Tsai, Athena A. Schepmoes, Tujin Shi, Osama A. Arshad, Jason E. McDermott, Ozgun Babur, Kevin Watanabe-Smith, Emek Demir, Angelo D'Alessandro, Tao Liu, Cristina E. Tognon, Jeffrey W. Tyner, Shannon K. McWeeney, Karin D. Rodland, Brian J. Druker, Elie Traer
Summary: The study reveals that the bone marrow microenvironment protects residual AML cells and AML cells develop resistance mechanisms over time. By integrating multiple methods, early resistant cells were found to undergo metabolic reprogramming and depend on AURKB, while late resistant cells are characterized by expansion of pre-existing NRAS mutant subclones and metabolic reprogramming.
Article
Gastroenterology & Hepatology
Arvind Rengarajan, Benjamin D. Rogers, Zhiqin Wong, Salvatore Tolone, Daniel Sifrim, Jordi Serra, Edoardo Savarino, Sabine Roman, Jose M. Remes-Troche, Rosa Ramos, Julio Perez de la Serna, Ans Pauwels, Ana Maria Leguizamo, Yeong Yeh Lee, Osamu Kawamura, Jamal Hayat, Albis Hani, Sutep Gonlachanvit, Daniel Cisternas, Dustin Carlson, Serhat Bor, Shobna Bhatia, Luiz Abrahao, John Pandolfino, C. Prakash Gyawali
Summary: The study aimed to investigate the prevalence of abnormal esophageal motor patterns in healthy individuals. Results showed that motor abnormalities are infrequent in healthy individuals and consist mainly of ineffective esophageal motility (IEM), with lower proportions when using stringent criteria in the supine position. Thresholds for HRM metrics varied across HRM systems and study positions.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Daniel Bottomly, Nicola Long, Anna Reister Schultz, Stephen E. Kurtz, Cristina E. Tognon, Kara Johnson, Melissa Abel, Anupriya Agarwal, Sammantha Avaylon, Erik Benton, Aurora Blucher, Uma Borate, Theodore P. Braun, Jordana Brown, Jade Bryant, Russell Burke, Amy Carlos, Bill H. Chang, Hyun Jun Cho, Stephen Christy, Cody Coblentz, Aaron M. Cohen, Amanda d'Almeida, Rachel Cook, Alexey Danilov, Kim-Hien T. Dao, Michie Degnin, James Dibb, Christopher A. Eide, Isabel English, Stuart Hagler, Heath Harrelson, Rachel Henson, Hibery Ho, Sunil K. Joshi, Brian Junio, Andy Kaempf, Yoko Kosaka, Ted Laderas, Matt Lawhead, Hyunjung Lee, Jessica T. Leonard, Chenwei Lin, Evan F. Lind, Selina Qiuying Liu, Pierrette Lo, Marc M. Loriaux, Samuel Luty, Julia E. Maxson, Tara Macey, Jacqueline Martinez, Jessica Minnier, Andrea Monteblanco, Motomi Mori, Quinlan Morrow, Dylan Nelson, Justin Ramsdill, Angela Rofelty, Alexandra Rogers, Kyle A. Romine, Peter Ryabinin, Jennifer N. Saultz, David A. Sampson, Samantha L. Savage, Robert Schuff, Robert Searles, Rebecca L. Smith, Stephen E. Spurgeon, Tyler Sweeney, Ronan T. Swords, Aashis Thapa, Karina Thiel-Klare, Elie Traer, Jake Wagner, Beth Wilmot, Joelle Wolf, Guanming Wu, Amy Yates, Haijiao Zhang, Christopher R. Cogle, Robert H. Collins, Michael W. Deininger, Christopher S. Hourigan, Craig T. Jordan, Tara L. Lin, Micaela E. Martinez, Rachel R. Pallapati, Daniel A. Pollyea, Anthony D. Pomicter, Justin M. Watts, Scott J. Weir, Brian J. Druker, Shannon K. McWeeney, Jeffrey W. Tyner
Summary: This report presents findings from a large cohort of AML patients, combining genomic, transcriptomic, and clinical data to uncover associations between drug sensitivity, cell differentiation state, and patient survival prediction.
Article
Biochemical Research Methods
Sara J. C. Gosline, Cristina Tognon, Michael Nestor, Sunil Joshi, Rucha Modak, Alisa Damnernsawad, Camilo Posso, Jamie Moon, Joshua R. Hansen, Chelsea Hutchinson-Bunch, James C. Pino, Marina A. Gritsenko, Karl K. Weitz, Elie Traer, Jeffrey Tyner, Brian Druker, Anupriya Agarwal, Paul Piehowski, Jason E. McDermott, Karin Rodland
Summary: This study describes a systematic, multi-omic approach to evaluate proteomic signatures of drug response in AML. The study demonstrates strong promise for proteomics-based patient stratification to assess drug sensitivity in AML.
CLINICAL PROTEOMICS
(2022)
Editorial Material
Biochemical Research Methods
Sunil K. Joshi, Cristina E. Tognon, Brian J. Druker, Karin D. Rodland
EXPERT REVIEW OF PROTEOMICS
(2022)
Letter
Hematology
Sunil K. Joshi, Janet Pittsenbarger, Vanessa E. Kennedy, Cheryl A. C. Peretz, Alexander E. Perl, Catherine C. Smith, Jeffrey W. Tyner, Brian J. Druker, Elie Traer
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Cell Biology
Sunaina Rengarajan, Kathryn A. Knoop, Arvind Rengarajan, Jiani N. Chai, Jose G. Grajales-Reyes, Vijay K. Samineni, Emilie Russler-Germain, Prabha Ranganathan, Alessio Fasano, Gregory S. Sayuk, Robert W. Gereau, Andrew L. Kau, Dan Knights, Purna C. Kashyap, Matthew A. Ciorba, Rodney D. Newberry, Chyi-Song Hsieh
CELL REPORTS MEDICINE
(2020)