期刊
REGENERATIVE MEDICINE
卷 7, 期 6, 页码 833-850出版社
FUTURE MEDICINE LTD
DOI: 10.2217/RME.12.82
关键词
endothelial progenitor cell; hematopoietic stem cell; mesenchymal stem cell; stem cell recruitment; tissue regeneration; very small embryonic-like cell
资金
- Institute of Diabetes, Digestive Disease Kidney Disease [2 RO1 DK074095-07]
- National Institute on Aging [2 RO1 AG025016]
- National Institute of Biomedical Imaging and Bioengineering [5 RO1 EB005718-02]
Tissue repair and regeneration are thought to involve resident cell proliferation as well as the selective recruitment of circulating stem and progenitor cell populations through complex signaling cascades. Many of these recruited cells originate from the bone marrow, and specific subpopulations of bone marrow cells have been isolated and used to augment adult tissue regeneration in preclinical models. Clinical studies of cell-based therapies have reported mixed results, however, and a variety of approaches to enhance the regenerative capacity of stem cell therapies are being developed based on emerging insights into the mechanisms of progenitor cell biology and recruitment following injury. This article discusses the function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells.
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