期刊
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
卷 8, 期 3, 页码 216-227出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/15748928113089990002
关键词
Glioblastoma; glioblastoma stem cells; molecular target; therapy
资金
- Miguel Servet Program from the Carlos III Health Institute [CP10/00539]
- Basque Foundation for Science (IKER-BASQUE)
- Diputacion Foral Gipuzkoa [DFG12/004]
- Industry Department of Basque Government [SAIO11-PC11BN002, SAIO12-PE12BNO13]
- Marie Curie CIG grant [2012/712404]
Glioblastoma is the most common, aggressive and lethal brain tumor in adults. However, current therapeutic protocols have low success rates and average overall survival is less than 15 months. The resistance to therapy is largely a result of the remarkable cellular and phenotypical heterogeneity that characterizes this type of tumor. The discovery of a subpopulation of cells exhibiting stem cell properties within the tumor bulk has profound implications for therapy as increasing evidence indicates that these cells, glioblastoma stem cells (GSCs), are responsible for the origin, maintenance and recurrence of the glioblastomas. These findings highlight the need to characterize GSCs in order to find novel treatments directly targeted specifically against them. In this review, we summarize the current knowledge regarding this issue, including some recent and relevant patents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据