Article
Oncology
Jocelyn E. Ray, Marie D. Ralff, Aakash Jhaveri, Lanlan Zhou, David T. Dicker, Eric A. Ross, Wafik S. El-Deiry
Summary: ONC201 demonstrated promising activity in patients with advanced endometrial cancer by upregulating DR5 and sensitizing tumors to TRAIL. The combination of ONC201 and TRAIL promoted cell death in endometrial cancer models in vitro and in vivo, suggesting a novel cancer therapeutic strategy.
CANCER BIOLOGY & THERAPY
(2021)
Review
Oncology
Daniel Westaby, Juan M. Jimenez-Vacas, Ana Padilha, Andreas Varkaris, Steven P. Balk, Johann S. de Bono, Adam Sharp
Summary: This article discusses the treatment of prostate cancer and the need for new options. Triggering apoptosis in cancer cells is an attractive strategy, and BH3 mimetics have been designed for this purpose. The article provides an overview of cell death and apoptosis, focusing on the intrinsic pathway, and discusses the potential use of BH3 mimetics in treating prostate cancer.
Review
Physiology
Laurel A. Grisanti
Summary: Cardiovascular disease is a leading cause of death globally. Cardiomyocyte death, which occurs in heart damage and stress, contributes to cardiac dysfunction and further damages the heart. Apoptosis, a regulated form of cell death, can occur through intrinsic or extrinsic pathways. The poorly characterized TNF-related ligand TRAIL and its receptors have been found to play a role in cardiac pathology. This article aims to provide an overview of the current understanding of TRAIL and its receptors in normal and pathological conditions in the heart.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Sebastian Weisse, Nicolai Maass, Anna Trauzold
Summary: Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well documented. TRAIL also binds to TRAIL-R3 and TRAIL-R4, which have regulatory functions in apoptotic and non-apoptotic signaling pathways. Knockdown of TRAIL-R4 affects the activation of apoptotic and non-apoptotic pathways in cancer cells, showing opposing effects on cell death and clonogenic survival. TRAIL-R4 also regulates the expression of anti-apoptotic proteins and affects the activity of AKT, ERK, p38 and NF-kappa B. This study provides evidence for the important role of endogenous TRAIL-R4 in cancer cells and improves the understanding of the complex TRAIL/TRAIL-R system in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Min Huang, Cheng Yi, Xian-Zhou Huang, Juan Yan, Li-Jia Wei, Wei-Ju Tang, Shou-Chun Chen, Ying Huang
Summary: TRAIL-Mu3 exhibits stronger antitumor effects on pancreatic cancer cells compared with TRAIL by enhancing the apoptotic signaling pathway.
Article
Biochemistry & Molecular Biology
Liya Qin, Jian Zou, Alexandra Barnett, Ryan P. Vetreno, Fulton T. Crews, Leon G. Coleman
Summary: The study reports the role of TLR7-mediated apoptotic neuronal death in alcohol use disorder. It suggests that TRAIL may act as a mediator of neuronal apoptosis downstream of TLR7 activation and represent a potential therapeutic target for slowing neurodegeneration in multiple diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Manjari Kundu, Yoshimi Endo Greer, Jennifer L. Dine, Stanley Lipkowitz
Summary: This review discusses the signaling components and mechanisms of the TRAIL pathway, as well as the challenges and potential solutions for TRAIL/DR targeted therapy in TNBC clinical trials. The article also explores the pharmacokinetic and pharmacodynamic properties of DR agonists, patient selection through predictive biomarkers, and potential combination therapies. Additionally, recent findings on the impact of TRAIL treatment on the immune response and novel strategies to address these challenges are discussed.
Review
Biochemistry & Molecular Biology
Longfei Deng, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: TRAIL holds therapeutic potential in cancer treatment, but many cancers, including GBM, exhibit resistance. Recent studies have identified new mechanisms in regulating TRAIL-induced apoptosis in GBM and effective combinatorial strategies. The TRAIL/TRAIL death receptor axis may have future clinical applications for GBM treatment.
Article
Oncology
Regis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Benedicte Brounais-Le Royer, Franck Verrecchia, Francoise Redini, Romain Guiho
Summary: Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors in children. Triggering the TRAIL pro-apoptotic pathway shows promise in treating these tumors, but resistance mechanisms have limited its effectiveness. This study used human cell lines and xenograft models to investigate the differences in signaling pathways between TRAIL-sensitive and TRAIL-resistant cells, and proposed two strategies to overcome resistance.
Article
Cell Biology
Rosario Yerbes, Rocio Mora-Molina, F. Javier Fernandez-Farran, Laura Hiraldo, Abelardo Lopez-Rivas, Carmen Palacios
Summary: This study reveals a previously unknown cell death mechanism triggered in glutamine-addicted tumor cells in response to glutamine metabolism limitation. The mechanism is regulated by GCN2 activation induced by glutamine starvation and involves the activation of the extrinsic apoptotic pathway mediated by TRAIL-R2.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Dong-Wook Kim, Hyun Young Kim, Seung Hyun Kim, Ki Sung Kang
Summary: This study evaluated the anticancer activities of Centipeda minima (CMX) extracts and brevilin A against human gastric cancer cells and identified key anticancer genes targeted by brevilin A. The findings suggest that CMX and brevilin A may be novel sources of herbal medicine effective for the treatment of gastric cancer.
Article
Food Science & Technology
Chih-Chuan Teng, Shui-Yi Tung, Ko-Chao Lee, Kam-Fai Lee, Wen-Shih Huang, Chien-Heng Shen, Meng-Chiao Hsieh, Cheng-Yi Huang, Jiunn-Ming Sheen, Hsing-Chun Kuo
Summary: The study revealed that CIL-102 significantly induces apoptosis in gastric cancer cells, along with increased production of ROS and intracellular levels of Ca2+. CIL-102 induces G2/M phase arrest in gastric cancer cells through the inactivation of CDK1/cyclin B1, involving various signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pia Loren, Yuliannis Lugones, Nicolas Saavedra, Kathleen Saavedra, Isis Paez, Nelia Rodriguez, Patricia Moriel, Luis A. Salazar
Summary: Cisplatin is widely used as an antineoplastic agent in the treatment of solid tumors, but its main side effect is nephrotoxicity. Research has shown that epigenetic processes, particularly noncoding RNAs, are involved in cisplatin-induced nephrotoxicity. Studying the regulation of different microRNAs in cell death pathways can provide new strategies for diagnosing and treating this unwanted side effect.
Review
Pharmacology & Pharmacy
Anne V. Yagolovich, Marine E. Gasparian, Dmitry A. Dolgikh
Summary: The TRAIL apoptotic pathway is widely studied in targeted antitumor therapy. Researchers focus on the design of novel nanodelivery systems to enhance apoptotic signaling and achieve a synergistic effect by encapsulating multiple therapeutic molecules. This review summarizes recent innovative developments in the design of nanodelivery systems modified with TRAIL pathway-targeting ligands.
Article
Oncology
Korie A. Grayson, Jacob M. Hope, Wenjun Wang, Cynthia A. Reinhart-King, Michael R. King
Summary: Docetaxel and cabazitaxel alone do not significantly reduce cell viability in prostate cancer cells, indicating resistance to TRAIL and taxanes individually. However, the combination of taxanes and TRAIL synergistically enhances apoptosis, with taxanes sensitizing prostate cancer cells to TRAIL-induced apoptosis. Activation of JNK by ER stress upregulates death receptor expression and plays a role in sensitizing prostate cancer cells to TRAIL-induced apoptosis.
MOLECULAR CANCER THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Stella Bernardi, Annalisa Marcuzzi, Elisa Piscianz, Alberto Tommasini, Bruno Fabris
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Education & Educational Research
Stella Bernardi, Fabiola Giudici, Maria Fontana Leone, Giulia Zuolo, Stefano Furlotti, Renzo Carretta, Bruno Fabris
BMC MEDICAL EDUCATION
(2019)
Article
Endocrinology & Metabolism
M. Pastoricchio, A. Cubisino, A. Lanzaro, M. Troian, F. Zanconati, S. Bernardi, B. Fabris, N. de Manzini, C. Dobrinja
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Stella Bernardi, Barbara Toffoli, Federica Tonon, Morena Francica, Elena Campagnolo, Tommaso Ferretti, Sarah Comar, Fabiola Giudici, Elisabetta Stenner, Bruno Fabris
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Barbara Toffoli, Federica Tonon, Veronica Tisato, Andrea Michelli, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi
Article
Endocrinology & Metabolism
Stella Bernardi, Fabiola Giudici, Vincenzo Barbato, Lorenzo Zanatta, Andrea Grillo, Bruno Fabris
Summary: Current data on cardiovascular manifestations in patients with mild primary hyperparathyroidism (pHPT) show conflicting results. This study found that aortic stiffness is increased in patients with mild pHPT, but parathyroidectomy (PTX) significantly reduced arterial stiffness in these patients. Further research is needed to fully understand the impact of PTX on cardiovascular outcomes in mild pHPT.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Roberto Cesareo, Gaia Tabacco, Anda Mihaela Naciu, Anna Crescenzi, Stella Bernardi, Francesco Romanelli, Maurilio Deandrea, Pierpaolo Trimboli, Andrea Palermo, Marco Castellana
Summary: This study systematically reviewed the long-term efficacy and safety of PEI in treating benign cystic thyroid nodules, showing significant reduction in nodule volume, improvement in compressive symptoms and cosmetic concerns, with no permanent complications observed.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Federica Tonon, Riccardo Candido, Barbara Toffoli, Elisabetta Tommasi, Thomas Cortello, Bruno Fabris, Stella Bernardi
Summary: The study found that patients with type 1 diabetes have higher expression of ACE and AngII, and lower expression of ACE2, which may contribute to increased cardiovascular risk and sensitivity to tissue damage caused by SARS-CoV2. Gender has an impact on ACE2 expression, with higher levels in female patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Letter
Endocrinology & Metabolism
V. Calabro, S. Lovriha, L. Zandona, F. Sirianni, B. Fabris, S. Bernardi
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Medicine, General & Internal
Stella Bernardi, Veronica Calabro, Marco Cavallaro, Sara Lovriha, Rita Eramo, Bruno Fabris, Nicolo de Manzini, Chiara Dobrinja
Summary: Adrenal incidentalomas are common, with most being benign and not requiring surgery. However, some are functionally active, including hormone-secreting adenomas and malignant nodules. All patients should undergo screening and confirmatory tests to exclude the presence of a functionally active mass. Multidisciplinary meetings are advocated to improve perioperative management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Stella Bernardi, Silvia Taccogna, Martina D'Angelo, Fabiola Giudici, Giovanni Mauri, Bruno Raggiunti, Doris Tina, Fabrizio Zanconati, Enrico Papini, Roberto Negro
Summary: The purpose of this study was to evaluate the immunocytochemistry profile of thyroid nodules with poor response to thermal ablation (TA) in order to identify potential predictors of treatment response. The absence of CK-19 was associated with resistance to TA, while the presence of CK-19 was predictive of response to TA. Therefore, the expression of CK-19 could provide rapid and low-cost information about the potential outcome of TA on thyroid nodules.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2023)
Letter
Endocrinology & Metabolism
S. Bernardi, F. Zorat, V. Calabro, M. Faustini Fustini, B. Fabris
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Riccardo Candido, Sara Gaiotti, Fabiola Giudici, Barbara Toffoli, Federica De Luca, Valerio Velardi, Alessandra Petrucco, Chiara Gottardi, Elena Manca, Iris Buda, Bruno Fabris, Stella Bernardi
Summary: This study demonstrates the effectiveness and safety of oral semaglutide as a switch or add-on therapy for patients with type 2 diabetes mellitus in a real-world setting, showing significant reductions in HbA1c and BMI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Stella Bernardi, Andrea Grillo, Roberta Maria Antonello, Marco Fabio Cola, Chiara Dobrinja, Bruno Fabris, Fabiola Giudici
Summary: This study found that both subclinical and overt hypothyroidism, as well as thyrotoxicosis, were associated with an increase in aortic stiffness. The impact of treatment on aortic stiffness should be evaluated in clinical trials.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Letter
Oncology
Stella Bernardi, Fabiola Giudici, Giacomo Colombin, Marco Cavallaro, Fulvio Stacul, Bruno Fabris
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)