Fe3O4@SiO2-NH2 core-shell nanocomposite as an efficient and green catalyst for the multi-component synthesis of highly substituted chromeno[2,3-b]pyridines in aqueous ethanol media

An efficient and green approach for synthesizing chromeno[2,3-b]pyridine derivatives through one-pot three-component reactions of salicylaldehydes, thiols, and malononitrile has been developed by Fe3O4@SiO2-NH2 nanocatalyst in aqueous ethanol media under reFLux conditions. The present procedure provides several advantages such as environmentally benign, straightforward, excellent yields, short reaction times, cost-effective, good recyclability, little catalyst loading, and facile catalyst separation for the preparation of chromeno[2,3-b]pyridines as important privileged medicinal scaffold. In addition, aminopropyl-coated Fe3O4@SiO2 nanoparticles were fully characterized by scanning electron microscopy, X-ray diffraction, energy dispersive analysis of X-ray, vibrating sample magnetometer, and FT-IR analysis.