Article
Radiology, Nuclear Medicine & Medical Imaging
Audrey Asuncion, Paul Michael Walker, Aurelie Bertaut, Julie Blanc, Maxime Labarre, Etienne Martin, Florian Bardet, Jeremy Cassin, Luc Cormier, Gilles Crehange, Romaric Loffroy, Alexandre Cochet
Summary: This study aims to assess the prognostic factors of biochemical relapse in localized prostate cancer patients treated by external radiotherapy or brachytherapy using pre-therapeutic multiparametric magnetic resonance imaging (mpMRI) combined with three-dimensional magnetic resonance spectroscopy (3D MRS).
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Review
Oncology
Petra J. van Houdt, Yingli Yang, Uulke A. van der Heide
Summary: MRI-guided radiotherapy systems combine adaptive radiotherapy and biological targeting, updating treatment plans regularly to accommodate observed treatment responses. Quantitative imaging biomarkers are necessary for predicting treatment outcomes early in the process. This review provides an overview of the current evidence on the potential of quantitative MRI measurements as imaging biomarkers in MRI-guided radiotherapy systems.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Panpan Hu, Xiaoyang Li, Wei Liu, Bing Yan, Xudong Xue, Fei Yang, John Chetley Ford, Lorraine Portelance, Yidong Yang
Summary: The gating latency in cine MRI guided radiotherapy for pancreatic cancer can affect dose delivery, with potential impact on PTV coverage and nearby critical structures. Additional beam-on control techniques or faster cine MRI sequences may help mitigate these dosimetry effects.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Helge Herthum, Hugo Carrillo, Axel Osses, Sergio Uribe, Ingolf Sack, Cristobal Bertoglio
Summary: This article proposes an optimal multiple motion encoding method (OMME) to address the issue of phase wraps in high-efficiency motion encoding in MRI, aiming to improve the fidelity of motion images. The study demonstrates that OMME, applied in MRE data, successfully combines multiple phase images with different motion encoding gradients, outperforming dual encoding strategies in terms of motion-to-noise ratio (MNR) or the number of successfully reconstructed voxels. The proposed method enables the generation of wrap-free phase images with high MNR, particularly beneficial for obtaining high-resolution images in MRE.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chang Liu, Yu Shi, Gongyu Lan, Youli Xu, Fei Yang
Summary: This study evaluated pancreatic stiffness, size, and fibrosis levels using magnetic resonance imaging techniques, and the results showed that a combination of MRE and T1 mapping can better diagnose pancreatic fibrosis, especially at an early stage.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
M. R. Tomaszewski, K. Latifi, E. Boyer, R. F. Palm, I. El Naqa, E. G. Moros, S. E. Hoffe, S. A. Rosenberg, J. M. Frakes, R. J. Gillies
Summary: This study demonstrates the potential of using quantitative image analysis in MRgRT for predicting treatment response in PDAC patients. The change in histogram skewness during treatment was found to be significantly associated with progression free survival, suggesting it could serve as a predictive biomarker for RT response. Additionally, stability analysis revealed a wide distribution of feature sensitivities to region of interest delineation, highlighting the importance of robust feature selection in radiomic studies for MRgRT.
RADIATION ONCOLOGY
(2021)
Review
Medicine, General & Internal
Elit Quingalahua, Mahmoud M. Al-Hawary, Jorge D. Machicado
Summary: Pancreatic cystic lesions (PCLs) are commonly found incidental findings on cross-sectional imaging. Magnetic resonance imaging (MRI) has become the preferred non-invasive method for predicting cyst type, stratifying risk of neoplasia, and monitoring changes in PCLs. In some cases, additional diagnostic approaches such as endoscopic ultrasound (EUS) and molecular analysis may be necessary for treatment decisions. The use of radiomics and artificial intelligence in MRI could enhance the stratification of PCLs and improve treatment guidance.
Article
Chemistry, Physical
Yingli Chen, Bo Yin, Zhuang Liu, Han Wang, Zi Fu, Xiuru Ji, Wei Tang, Dalong Ni, Weijun Peng
Summary: In this study, an organic sonodynamic therapy system was designed and fabricated, integrating MRI and fluorescence imaging for guidance of tumor sonodynamic therapy. Excellent therapeutic efficacy and biocompatibility of the system were verified in vitro and in vivo.
Article
Medicine, General & Internal
Davide Cusumano, Luca Boldrini, Poonam Yadav, Calogero Casa, Sangjune Laurence Lee, Angela Romano, Antonio Piras, Giuditta Chiloiro, Lorenzo Placidi, Francesco Catucci, Claudio Votta, Gian Carlo Mattiucci, Luca Indovina, Maria Antonietta Gambacorta, Michael Bassetti, Vincenzo Valentini
Summary: This study investigated the role of Delta Radiomics analysis in predicting one-year local control in patients with locally advanced pancreatic cancer treated with MRgRT. The most significant feature in predicting 1yLC was the variation of cluster shade calculated at BED = 40 Gy. Further studies with external validation datasets and larger patient cohorts are recommended to confirm the validity of these findings.
Article
Oncology
Isak Wahlstedt, Nicolaus Andratschke, Claus P. Behrens, Stefanie Ehrbar, Hubert S. Gabrys, Helena Garcia Schuler, Matthias Guckenberger, Abraham George Smith, Stephanie Tanadini-Lang, Jose D. Tascon-Vidarte, Ivan R. Vogelius, Janita E. van Timmeren
Summary: This study suggests that beam-gating has negligible dosimetric impact in online-adaptive MR-guided radiotherapy (MRgRT) for prostate cancer, and the prostate-to-PTV margin used in clinical practice could potentially be reduced from 5 mm to 3 mm.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Fasco Van Ommen, Gaelle A. T. le Quellenec, Mirjam E. Willemsen-Bosman, Max M. van Noesel, Marry M. van den Heuvel-eibrink, Enrica Seravalli, Petra S. Kroon, Geert O. Janssens
Summary: In this study, the inter- and intrafraction motion of the pancreatic tail/spleen was analyzed to evaluate the potential benefits of online MRI-guided radiotherapy (MRgRT).
RADIATION ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Tai Ermongkonchai, Richard Khor, Vijayaragavan Muralidharan, Niall Tebbutt, Kelvin Lim, Numan Kutaiba, Sweet Ping Ng
Summary: Stereotactic body radiotherapy (SBRT) may lead to improved survival outcomes and safer toxicity profiles compared to conventional techniques, while the introduction of magnetic resonance-guided techniques potentially improves imaging quality and adaptability of treatment plans.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Stefanie Ehrbar, Sarah Braga Kaeser, Madalyne Chamberlain, Jerome Krayenbuehl, Lotte Wilke, Michael Mayinger, Helena Garcia Schueler, Matthias Guckenberger, Nicolaus Andratschke, Stephanie Tanadini-Lang
Summary: This study investigates the efficiency and geometric as well as dosimetric benefits of magnetic-resonance guided beam gating for stereotactic treatments in moving organs. The results show that the applied gating protocol effectively reduces target offset and improves dose coverage, demonstrating the robust delivery of planned radiation doses.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
William G. Breen, Bradley J. Stish, William S. Harmsen, Adam T. Froemming, Lance A. Mynderse, C. Richard Choo, Brian J. Davis, Thomas M. Pisansky
Summary: Pelvic MRI prior to salvage radiation therapy (SRT) for biochemically recurrent prostate cancer following radical prostatectomy showed a sensitivity of 61% and specificity of 58.7% for detecting local recurrence. Positive or indeterminate MRI findings were associated with improved biochemical control post-SRT.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Gorkem Turkkan, Nazli Bilici, Huseyin Sertel, Yavuz Keskus, Sercan Alkaya, Busra Tavli, Muge Ozkirim, Merdan Fayda
Summary: The initial experience of using a 1.5 T magnetic resonance imaging (MRI) linear accelerator (LINAC) for prostate cancer radiotherapy in a radiation oncology clinic was reported. The study evaluated various treatment parameters and toxicities. The results suggested that MRI-guided prostate radiotherapy is safe and feasible, but further studies with larger sample sizes and long-term results are needed for better evaluation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anneloes de Boer, Tim Leiner, Eva E. Vink, Peter J. Blankestijn, Cornelis A. T. van den Berg
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Andreychenko, B. Denis de Senneville, R. J. M. Navest, R. H. N. Tijssen, J. J. W. Lagendijk, C. A. T. van den Berg
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefano Mandija, Alessandro Sbrizzi, Ulrich Katscher, Peter R. Luijten, Cornelis A. T. van den Berg
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
J. P. Tokaya, A. J. E. Raaijmakers, P. R. Luijten, J. F. Bakker, C. A. T. van den Berg
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yulia Shcherbakova, Cornelis A. T. van den Berg, Chrit T. W. Moonen, Lambertus W. Bartels
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bart R. Steensma, Ingmar J. Voogt, Tim Leiner, Peter R. Luijten, Jesse Habets, Dennis W. J. Klomp, Cornelis A. T. van den Berg, Alexander J. E. Raaijmakers
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2018)
Review
Biophysics
Ulrich Katscher, Cornelius A. T. van den Berg
NMR IN BIOMEDICINE
(2017)
Article
Biophysics
Bjorn Stemkens, Thomas Benkert, Hersh Chandarana, Mark E. Bittman, Cornelis A. T. Van den Berg, Jan J. W. Lagendijk, Daniel K. Sodickson, Rob H. N. Tijssen, Kai Tobias Block
NMR IN BIOMEDICINE
(2017)
Article
Engineering, Biomedical
Matteo Maspero, Peter R. Seevinck, Gerald Schubert, Michaela A. U. Hoesl, Bram van Asselen, Max A. Viergever, Jan J. W. Lagendijk, Gert J. Meijer, Cornelis A. T. van den Berg
PHYSICS IN MEDICINE AND BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Petar I. Petrov, Stefano Mandija, Iris E. C. Sommer, Cornelis A. T. van den Berg, Sebastiaan F. W. Neggers
Article
Oncology
Anna Andreychenko, Petra S. Kroon, Matteo Maspero, Ina Jurgenliemk-Schulz, Astrid A. C. De Leeuw, Marnix G. E. H. Lam, Jan J. W. Lagendijk, Cornelis A. T. van den Berg
RADIOTHERAPY AND ONCOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alessandro Sbrizzi, Oscar van der Heide, Martijn Cloos, Annette van der Toorn, Hans Hoogduin, Peter R. Luijten, Cornelis A. T. van den Berg
MAGNETIC RESONANCE IMAGING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alena V. Shchelokova, Cornelis A. T. van den Berg, Dmitry A. Dobrykh, Stanislav B. Glybovski, Mikhail A. Zubkov, Ekaterina A. Brui, Dmitry S. Dmitriev, Alexander V. Kozachenko, Alexander Y. Efimtcev, Andrey V. Sokolov, Vladimir A. Fokin, Irina V. Melchakova, Pavel A. Belov
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Engineering, Biomedical
Matteo Maspero, Cornelis A. T. van den Berg, Guillaume Landry, Claus Belka, Katia Parodi, Peter R. Seevinck, Bas W. Raaymakers, Christopher Kurz
PHYSICS IN MEDICINE AND BIOLOGY
(2017)
Article
Oncology
H. D. Heerkens, W. A. Hall, X. A. Li, P. Knechtges, E. Dalah, E. S. Paulson, C. A. T. van den Berg, G. J. Meijer, E. J. Koay, C. H. Crane, K. Aitken, M. van Vulpen, B. A. Erickson
PRACTICAL RADIATION ONCOLOGY
(2017)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)