Article
Biochemistry & Molecular Biology
Olawale R. Ajuwon, Jeanine L. Marnewick, Oluwafemi O. Oguntibeju, Lester M. Davids
Summary: This study demonstrates the protective effect of red palm oil against LPS-induced hepatic injury by improving hepatic histological function, lowering liver function markers and inflammatory factors. Red palm oil also exerts its effects by regulating antioxidant enzyme activity, improving oxidative stress status, as well as modulating signaling pathways such as Nrf2/GCL/HO-1 and NF kappa beta.
Article
Biochemistry & Molecular Biology
Rong He, Mengting Liu, Zhipeng Zou, Mingjie Wang, Zhigao Wang, Xingrong Ju, Guangfei Hao
Summary: This study investigated the anti-inflammatory effect of millet bran peptides and found that they can reduce the levels of inflammatory factors and regulate the signaling pathways involved in inflammation.
Review
Biochemistry & Molecular Biology
Yu Jin Ahn, Hyeyoung Kim
Summary: Lutein, obtained from foods like dark green leafy vegetables and egg yolk, has antioxidant properties and can inhibit inflammatory mediators and signaling pathways, thus preventing the development of inflammatory diseases. This review discusses the anti-inflammatory function of lutein in various organs against diseases such as neurodegenerative disorders, eye diseases, diabetes, osteoporosis, cardiovascular diseases, skin diseases, liver injury, obesity, and colon diseases.
Article
Pharmacology & Pharmacy
Xiyuan Pang, Zhiqiang Miao, Yuanyang Dong, Huiyu Cheng, Xiangqi Xin, Yuan Wu, Miaomiao Han, Yuan Su, Jianmin Yuan, Yuxin Shao, Lei Yan, Jianhui Li
Summary: This study investigated the effects of dietary methionine restriction (MR) on antioxidant function and inflammatory responses in LPS-challenged broilers reared at high stocking density. The results showed that MR can improve antioxidant capacity, immunological stress, and liver health in LPS-challenged broilers.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Sarit Uzzan, Abed N. Azab
Summary: Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology and treatment of mood disorders. This study found that chronic combined treatment attenuated LPS-induced hypothermia and reduced cytokine levels, suggesting a potential approach for treating inflammation-related mental illness. The treatment also showed antidepressant-like effects.
Article
Agriculture, Dairy & Animal Science
Mei-Yan Wang, Yao Zhang, Yu-Xin Tong, Ping-Ting Guo, Jing Zhang, Chang-Kang Wang, Yu-Yun Gao
Summary: This study aimed to investigate the effects of lutein on jejunal mucosal barrier function and inflammatory responses of yellow-feather broilers challenged with lipopolysaccharide (LPS). The results showed that lutein supplementation improved growth performance, enhanced intestinal barrier function, and alleviated inflammation in broilers.
Article
Chemistry, Medicinal
Ling Guo, Bei Jiang, Dengren Li, Xiaoyan Xiao
Summary: Adropinin exhibited significant nephroprotective effects in STZ-induced diabetic nephropathy rats, primarily through anti-inflammatory and antioxidant pathways.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Genetics & Heredity
Feiyang Ji, Menghao Zhou, Huihui Zhu, Zhengyi Jiang, Qirui Li, Xiaoxi Ouyang, Yiming Lv, Sainan Zhang, Tian Wu, Lanjuan Li
Summary: Posttranslational modifications (PTMs), including acetylation, phosphorylation, and ubiquitination, are crucial for the host innate immune response. The dynamic changes and crosstalk among these PTMs are complex. By integrating proteomic data from human and mouse macrophages, we identified PTM crosstalk within and across proteins involved in the inflammatory response, and revealed the effects of lipopolysaccharide stimulation on ubiquitination.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Review
Nutrition & Dietetics
Kabelo Mokgalaboni, Wendy Nokhwezi Phoswa
Summary: This article investigates the efficacy of the plant-based remedy Corchorus olitorius in combating obesity and type 2 diabetes. The study found that C. olitorius significantly reduces blood glucose, body weight, total cholesterol, triglycerides, and low-density lipoprotein, while increasing high-density lipoprotein-cholesterol. It also reduces oxidative stress and inflammation, making it highly effective in improving symptoms of obesity and diabetes.
FRONTIERS IN NUTRITION
(2023)
Article
Immunology
Rogerio Marchete, Sarah Oliveira, Leonardo Bagne, Jennyffer Ione de Souza Silva, Ana Paula Valverde, Andrea Aparecida de Aro, Mariana Moreira Figueira, Marcio Fronza, Thaina Mikaela Bressam, Vivian Fernandes Furletti de Goes, Fernanda Oliveira de Gaspari de Gaspi, Glaucia Maria Tech dos Santos, Thiago Antonio Moretti Andrade
Summary: The extract of Alternanthera brasiliana exhibits important anti-inflammatory and antioxidant activities, promoting angiogenesis and tissue formation, accelerating wound healing process.
INFLAMMOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Elsa Easter Justine, Seo-Woo Jang, Sanghyun Lee, Hyo-Jun Lee, Rong-Bo Wang, Yeon-Ju Kim
Summary: This study reveals the differences between newly developed strawberry cultivars and Seolhyang in mitigating LPS-induced inflammation. The new cultivars exhibit better anti-inflammatory effects, and the enhanced phytochemical content may contribute to their improved effectiveness.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Pharmacology & Pharmacy
Xin Shi, Shaopin Zhu, Huiyi Jin, Junwei Fang, Xindan Xing, Yihan Wang, Hanying Wang, Chingyi Wang, Tian Niu, Kun Liu
Summary: The study revealed that KS23 had therapeutic effects on endotoxin-induced uveitis in rats, reduced infiltration of inflammatory cells, and levels of inflammatory cytokines. It also showed inhibitory effects on LPS-stimulated RAW 264.7 cells, suggesting KS23 as a promising therapeutic candidate for ocular inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Min Gao, Zhen Zou, Yu Qiu, Golamaully Sumayyah, Xuejun Jiang, Junhao Su, Xinhao Duan, Chengzhi Chen, Jingfu Qiu
Summary: In this study, it was found that pretreatment with HX can prevent inflammation induced by LPS, but it does not improve dysbiosis or intestinal local immunity. Furthermore, pretreatment with HX prevents the alterations in the expression levels of proteins related to the NF-Kappa B pathway induced by LPS.
Article
Nutrition & Dietetics
Yebing Zhang, Haoyue Ding, Lei Xu, Suli Zhao, Shouna Hu, Aiguo Ma, Yan Ma
Summary: This study found that lutein supplementation can protect against male reproductive damage caused by excessive alcohol intake through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
Article
Medicine, Research & Experimental
Delcio E. Paula, Fabiana C. Vilela, Alexandre Giusti-Paiva
Summary: The study found that a ghrelin receptor antagonist can alleviate sickness syndrome induced by LPS, including social withdrawal, anhedonia, depressive-like behavior, and anorexia, but has no effect on LPS-induced fever.
Article
Nutrition & Dietetics
Gurunathan Sharavana, G. S. Joseph, Vallikannan Baskaran
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Food Science & Technology
Gurunathan Sharavana, Vallikannan Baskaran
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Biochemistry & Molecular Biology
Sowmya Shree Gopal, Magisetty Jhansi Lakshmi, Gurunathan Sharavana, Gunaseelan Sathaiah, Yadahally N. Sreerama, Vallikannan Baskaran
Article
Genetics & Heredity
Sharavana Gurunathan, Jessica Sebastian, Jennifer Baker, Hoda Z. Abdel-Hamid, Shawn C. West, Brian Feingold, Vivek Peche, Miguel Reyes-Mugica, Suneeta Madan-Khetarpal, Jeffrey Field
Summary: This case report presents a patient with Nemaline Myopathy associated with a pathogenic variant in the CAP2 gene, leading to severe heart and muscle abnormalities including nemaline rods identified in heart tissue.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.