期刊
RADIOTHERAPY AND ONCOLOGY
卷 99, 期 3, 页码 262-270出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2011.05.078
关键词
Radiotherapy; Oncolytic viruses; DNA damage
资金
- Institut National du Cancer
- Societe Nationale Francaise de Gastro-Enterologie
- NHS
- The Institute of Cancer Research
- Cancer Research UK Section of Radiotherapy [CRUK] [C46/A10588]
- NIHR Biomedical Research Centre
- institut national de la sante et de la recherche medicale (INSERM)
- Cancer Research UK [10588] Funding Source: researchfish
Oncolytic viruses are investigational cancer treatments. They are currently being assessed as single agents or in combination with standard therapies such as external beam radiotherapy - a DNA damaging agent that is a standard of care for many tumour types. Preclinical data indicate that combinations of oncolytic viruses and radiation therapy are promising, showing additional or synergistic antitumour effects in in vitro and in vivo studies. This interaction has the potential to be multifaceted: viruses may act as radiosensitizing agents, but radiation may also enhance viral oncolysis by increasing viral uptake, replication, gene expression and cell death (apoptosis, autophagy or necrosis) in irradiated cells. Phase I and II clinical trials investigating combinations of viruses and radiation therapy have been completed, paving the way for ongoing phase III studies. The aim of this review is to focus on the therapeutic potential of these combinations and to highlight their mechanistic bases, with particular emphasis on the role of the DNA damage response. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 99 (2011) 262-270
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