Article
Biochemistry & Molecular Biology
Daniel Wegener, Daniel M. Aebersold, Marc-Oliver Grimm, Peter Hammerer, Michael Froehner, Markus Graefen, Dirk Boehmer, Daniel Zips, Thomas Wiegel
Summary: The results of three randomized clinical trials comparing adjuvant radiotherapy (ART) and early salvage radiotherapy (eSRT) for prostate carcinoma were recently published. The findings suggest that early eSRT is as effective and potentially less toxic than ART. Therefore, eSRT should be considered the standard of care. However, ART remains a valid treatment option for patients with high-risk features.
Article
Health Care Sciences & Services
Feten Fekih-Romdhane, Nihed Riahi, Leila Achouri, Haitham Jahrami, Majda Cheour
Summary: This study examines posttraumatic growth (PTG) and its relationship with psychosocial, sociodemographic, and cancer-related factors in Tunisian women operated on for breast cancer. The findings suggest that anxiety and social support are significantly associated with PTG, while no significant relationship has been found for spiritual well-being.
Review
Multidisciplinary Sciences
Solveigh P. Lingens, Holger Schulz, Christiane Bleich
Summary: This scoping review aimed to provide an overview of current literature evaluating out-patient psychosocial support services. The included studies showed some improvements in well-being for patients with cancer, but the low number and lack of high-quality research indicate that caution should be taken when interpreting these findings. High-quality research on the effectiveness of psychosocial support services is needed to determine their efficacy.
Article
Oncology
Kristen J. Wells, Julia H. Drizin, Amy E. Ustjanauskas, Coralia Vazquez-Otero, Tonya M. Pan-Weisz, Danielle Ung, Claudia Carrizosa, Christine Laronga, Richard G. Roetzheim, Kenneth Johnson, Marilyn Norton, Rosa Cobian Aguilar, Gwendolyn P. Quinn
Summary: The study found that breast cancer survivors face many psychosocial difficulties post-treatment, and healthcare and support providers' perceptions of their needs may differ from survivors' actual needs. Providers and survivors agreed on post-treatment mood changes and familial stress, but differed on preferred sources of support and effects of cancer treatment on body image.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Kelly A. Metcalfe, Andrea Eisen, Frances Wright, Aletta Poll, Alexandra Candib, David McCready, Tulin Cil, Susan Armel, Yael Silberman, Sarah Brennenstuhl, Steven A. Narod
Summary: For women receiving RGT for BRCA1 and BRCA2 at the time of breast cancer diagnosis, the study found that identifying a BRCA1 or BRCA2 mutation does not impair psychosocial functioning in the short or long term. Women with a BRCA1 or BRCA2 mutation had significantly lower depression scores compared to those with a negative result at one year post-testing.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Emily Lam, Gina Wong, Liying Zhang, Leah Drost, Irene Karam, Caitlin Yee, Emma McCurdy-Franks, Yasmeen Razvi, Krista Ariello, Bo Angela Wan, Amy Nolen, Katie Wang, Carlo DeAngelis, Edward Chow
Summary: This study investigated the trends and risk factors in patient-reported pain associated with breast irradiation. The results showed that acute pain increased significantly after radiotherapy, particularly in younger patients and those who had received previous chemotherapy. Close monitoring of acute pain in younger breast cancer patients undergoing radiotherapy is recommended based on these findings.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Zhenkun Fu, Zhoujun Lin, Mao Yang, Chenggang Li
Summary: Breast cancer is a common type of cancer, with surgery being the preferred treatment method. Various adjuvant therapies such as radiotherapy, chemotherapy, endocrine therapy, and targeted drug therapy can also be used.
FRONTIERS IN ONCOLOGY
(2022)
Article
Psychology, Multidisciplinary
Letizia Iannopollo, Grazia Cristaldi, Caterina Borgese, Samuela Sommacal, Giulia Silvestri, Samantha Serpentini
Summary: This article presents a case report of a breast cancer patient, highlighting the use of mindfulness-based interventions to improve her psychological well-being and quality of life. Through a combination of individual and group therapies, the patient received peer support and tools to manage her psychoemotional reactions.
BEHAVIORAL SCIENCES
(2022)
Review
Oncology
Francesca Malandrone, Federica Bevilacqua, Mariagrazia Merola, Niccolo Gallio, Luca Ostacoli, Sara Carletto, Chiara Benedetto
Summary: The diagnostic and therapeutic pathway of vulvar cancer has a severe impact on the psychosocial and psychosexual equilibrium of affected women. Women diagnosed and treated for vulvar cancer are at higher risk of psychological distress, sexual dysfunction, and dissatisfaction with partner relationships. This article aims to review the psychological, relational, and sexual issues experienced by women with vulvar cancer, highlighting the importance of this issue and improving the quality of care offered to these patients. Implementing an integrated care model can help identify unmet needs and improve the quality of life of these women.
Article
Oncology
Zhijun Yuan, Yongjie Shui, Lihong Liu, Yinglu Guo, Qichun Wei
Summary: This study investigates the recurrent patterns of postoperative gallbladder cancer and confirms the high rates of recurrence and metastasis. It highlights the importance of adjuvant therapy, including radiotherapy, in improving local-regional control.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Alexander Fabian, Alexander Ruehle, Justus Domschikowski, Maike Trommer, Simone Wegen, Jan-Niklas Becker, Georg Wurschi, Simon Boeke, Mathias A. Sonnhoff, Christoph Fink, Lukas Kaesmann, Melanie Schneider, Elodie Bockelmann, Martin Treppner, Anja Mehnert-Theuerkauf, David H. Krug, Nils Nicolay
Summary: This study investigated the prevalence and risk factors for distress among cancer patients undergoing radiotherapy. The results showed that 63% of the patients reported clinically significant distress, which was associated with lower education level, higher income loss, lower global quality of life, and longer duration of radiotherapy. It emphasizes the importance of raising awareness, screening, and interventions in clinical practice.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Flavia Vicinanza, Edy Ippolito, Antonella Sisto, Bianca Santo, Michele Fiore, Luca Eolo Trodella, Sonia Silipigni, Livia Quintiliani, Sara Ramella
Summary: This study evaluated the psychological impact of the COVID-19 pandemic on cancer patients undergoing radiotherapy. The results showed that 37% of patients experienced significant distress, 22.4% reported depressive symptoms, and 99% of the sample had clinically significant anxiety symptoms. In addition, all patients experienced worsened anxiety during the COVID-19 pandemic, and patients on active treatment had higher levels of distress and anxiety. Lung cancer patients appeared to be more afraid of COVID-19 than other patients.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Eden R. Brauer, Stephanie Lazaro, Charlene L. Williams, David A. Rapkin, Amy B. Madnick, Roger Dafter, Guo Cheng, Ashleigh Porter, Elliot Abemayor, Wanxing Chai-Ho, Elizabeth Morasso, Andrew Erman, Dinesh Chhetri, Maie St John, Deborah J. Wong
Summary: Psychosocial distress is common among head and neck cancer patients, with 57% reporting clinical distress in this study. Factors such as pain, fatigue, anxiety, and depression were significantly associated with clinical distress. A high percentage of distressed patients received same-day psychosocial evaluation, suggesting the feasibility of implementing a brief screening protocol in routine oncology care.
Article
Oncology
Fan-Ko Sun, Chao-Ming Hung, YuChun Yao, Chi-Feng Fu, Pei-Jung Tsai, Chun-Ying Chiang
Summary: The study found that logotherapy is effective in reducing depression and demoralization in breast cancer and gynecological cancer patients, especially showing significant effectiveness in the Patient Health Questionnaire and the Demoralization Scale Mandarin Version assessments.
Article
Oncology
Muemtaz Koeksal, Clara Hoppe, Anna-Katharina Schroeder, Davide Scafa, David Koch, Gustavo R. Sarria, Christina Leitzen, Alina Abramian, Christina Kaiser, Andree Faridi, Christoph Henkenberens, Leonard C. Schmeel, Frank A. Giordano
Summary: This study evaluates decision regret and physical and psychological well-being among breast cancer patients who underwent adjuvant radiotherapy and explores their associations with patient, tumor, treatment, and symptom characteristics. The findings suggest that most patients have little or no decision regret, but several characteristics such as radiation therapy and psychological well-being are associated with higher levels of regret.
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)