Review
Chemistry, Medicinal
Shuo Li, Jia-shu Chen, Xiangqian Li, Xiaoyi Bai, Dayong Shi
Summary: Overexpression of eIF4E is common in various solid tumors and hematologic cancers, making it a potential anti-cancer target. This review provides a detailed classification and description of the anti-cancer activities of promising compounds, concluding that MNK1/2 and eIF4E/eIF4G interaction inhibitors are superior to mTOR inhibitors for targeted therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Sheikh Tahir Majeed, Asiya Batool, Rabiya Majeed, Nadiem Nazir Bhat, Muhammad Afzal Zargar, Khurshid Iqbal Andrabi
Summary: Phosphorylated S209-eIF4E interacts with the TOS motif of S6K1, releasing it from auto-inhibition and priming it for activation in an mTORC1-independent manner. The role of mTORC1 is limited to engaging eIF4E with the S6K1-TOS motif to influence S6K1's state of activation.
Review
Biochemistry & Molecular Biology
Stacey L. Lehman, Evan D. Wilson, Kevin Camphausen, Philip J. Tofilon
Summary: Research suggests that targeting proteins involved in the translational machinery can increase the sensitivity of tumor cells to radiotherapy, thereby improving efficacy. Inhibiting key proteins in the translation initiation machinery can reduce protein expression and potentially impact DNA repair, making tumor cells more susceptible to the effects of radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dorota Gil, Piotr Laidler, Marta Zarzycka, Joanna Dulinska-Litewka
Summary: The study highlights the dual role of autophagy in cancer and the potential therapeutic implications. Knockdown of ILK was found to promote autophagy through AMPK activation, leading to suppression of melanoma cell growth and induction of apoptosis. Combining CQ and siILK showed stronger antitumor effects, possibly through synergistic inhibition of protein synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Dorota Gil, Marta Zarzycka, Joanna Pabijan, Ma lgorzata Lekka, Joanna Duli Dulinska-Litewka
Summary: Melanoma is resistant to chemotherapy and lacks fully effective targeted therapies. The mutations in melanoma lead to the hyperactivation of the MAPK and PI3K/AKT/mTOR pathways, which are responsible for abnormal protein synthesis. In this study, we investigated the effects of a specific PI3K/mTOR inhibitor, dactolisib, and Mnk inhibitor -CGP57380, alone and in combination on human melanoma cell lines. Both drugs showed inhibition of cell proliferation and migration when used individually, but their combination had additional antitumor effects. Simultaneous inhibition of both pathways may help overcome drug resistance.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Zhibao Wang, Bo Cao, Peng Ji, Fan Yao
Summary: Propofol inhibits tubular structure formation and various biological functions of tumor-associated endothelial cells, including migration, adhesion, proliferation, and survival, by suppressing the expression and secretion of multiple pro-angiogenic factors and specific signaling pathways. These findings provide preclinical evidence for the anti-cancer properties of propofol and its potential mechanisms in inhibiting tumor growth and metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Jessika Poliana Teixeira, Teodorico Castro Ramalho
Summary: Autism Spectrum Disorder (ASD) is a disorder characterized by changes in social and cognitive skills, but the etiology is complex and therapeutic progress is limited. Dysfunctions in synaptic protein synthesis observed in patients with ASD may be targeted through research on the mTOR pathway for potential new treatments.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Jie Liu, Xiaochun Hu, Lei Feng, Yun Lin, Shujing Liang, Zhounan Zhu, Shuo Shi, Chunyan Dong
Summary: In this study, a novel drug delivery nanoplatform was designed to mitigate hypoxia adaptation and improve breast cancer treatment. The nanoplatform effectively suppressed the PI3K/mTOR signal and HIF-1 alpha-dependent tumor hypoxia adaptation, and reduced tumor growth and metastasis by altering the microenvironment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Oncology
Trang Uyen Nguyen, Harrison Hector, Eric Nels Pederson, Jianan Lin, Zhengqing Ouyang, Hans-Guido Wendel, Kamini Singh
Summary: Pancreatic cancer is a aggressive cancer with a low survival rate. In this study, we explored the effect of inhibiting protein synthesis and its role in inducing feedback mechanisms that may impact the therapeutic response. We found that rapamycin treatment inhibited the synthesis of proteins required for cancer cell growth, but also induced the synthesis of proteins that limited the anti-tumor effect of rapamycin. However, the combination of rapamycin with the small molecule inhibitor CR-1-31-B increased the efficacy of rapamycin.
Article
Plant Sciences
Jiantao Liu, Chunping Liu, Huiqi Chen, Huan Cen, Hailong Yang, Peijian Liu, Fang Liu, Liuling Ma, Quanfu Chen, Lei Wang
Summary: Tongguan capsule (TGC) shows potential as a therapeutic option for myocardial ischemia-reperfusion injury (MIRI) by up regulating autophagy-related proteins through the mTOR pathway.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Oncology
Peng Xu, Kang Hu, Ping Zhang, Zhi-Gang Sun, Nan Zhang
Summary: The study reveals that hypoxia-mediated YTHDF2 overexpression promotes cell proliferation and invasion in lung squamous cell carcinoma through activation of the mTOR/AKT signaling pathway, and YTHDF2 is closely associated with pN and pTNM stage, leading to poor prognosis for LUSC patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Paolo Uva, Maria Carla Bosco, Alessandra Eva, Massimo Conte, Alberto Garaventa, Loredana Amoroso, Davide Cangelosi
Summary: The study identified PI3K/Akt/mTOR inhibitors as novel candidate compounds to treat neuroblastoma patients with hypoxic tumors and poor prognosis. The compounds showed anti-hypoxia effects on gene expression profiles in cell lines, suggesting potential for future adjuvant therapy in clinical trials.
Article
Biochemistry & Molecular Biology
Ines Moniz, Joao Ramalho-Santos, Ana F. Branco
Summary: This study demonstrates that different oxygen tensions have distinct effects on umbilical cord-mesenchymal stem cells (UC-MSCs), including changes in proliferation and metabolism. The use of CoCl2 as a substitute for hypoxic chambers yields different metabolic effects compared to gas-based strategies. Severe hypoxia modulates survival-related mechanisms through different mTOR complexes. This research provides valuable insights into the establishment of a hypoxia model for UC-MSCs and how different strategies for modulating hypoxia may impact experimental outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Patrick Senechal, Francis Robert, Regina Cencic, Akiko Yanagiya, Jennifer Chu, Nahum Sonenberg, Marilene Paquet, Jerry Pelletier
Summary: The translation initiation factor eIF4F is crucial for cap-dependent protein synthesis initiation. Different subunits of eIF4F have varying roles in development and tumorigenesis, with some being essential for viability and tumor onset, while others have non-essential functions. This study highlights the complex roles of different eIF4F subunits in gene expression regulation during embryogenesis and tumor development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Patrick D. Fischer, Evangelos Papadopoulos, Jon M. Dempersmier, Zi-Fu Wang, Radoslaw P. Nowak, Katherine A. Donovan, Joann Kalabathula, Christoph Gorgulla, Pierre P. M. Junghanns, Eihab Kabha, Nikolaos Dimitrakakis, Ognyan Petrov, Constantine Mitsiades, Christian Ducho, Vladimir Gelev, Eric S. Fischer, Gerhard Wagner, Haribabu Arthanari
Summary: The translation initiation factor eIF4E is a key regulator of cap-dependent protein synthesis, with overexpression implicated in diseases like cancer. A novel inhibitor, i4EG-BiP, has been shown to displace eIF4G and inhibit cancer cell proliferation. Efforts to design PROTACs targeting eIF4E for proteasomal degradation have faced challenges, such as competitive effects from 4E-BP1 binding.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Tom G. Keulers, Alexander Koch, Marike W. van Gisbergen, Lydie M. O. Barbeau, Marijke Zonneveld, Monique C. de Jong, Kim G. M. Savelkouls, Roel G. Wanders, Johan Bussink, Veerle Melotte, Kasper M. A. Rouschop
Summary: Tumor hypoxia is associated with tumor progression, resistance to therapy, and metastasis. ATG12 loss in head and neck squamous cell carcinoma is linked to absence of hypoxia, improved prognosis after therapy, and decreased hypoxia tolerance.
Article
Medicine, Research & Experimental
Sanne A. M. van Lith, Fokko J. Huizing, Gerben M. Franssen, Bianca A. W. Hoeben, Jasper Lok, Sofia Doulkeridou, Otto C. Boerman, Martin Gotthardt, Paul M. P. van Bergen en Henegouwen, Johan Bussink, Sandra Heskamp
Summary: This study compared variants of CAIX-binding VHH B9 with different affinities (low and high) for SPECT imaging of CAIX expression. The results showed that B9 variants with ABD demonstrated better tumor uptake, but some uptake was CAIX-independent, limiting their use in hypoxia assessment.
MOLECULAR PHARMACEUTICS
(2022)
Review
Oncology
Evelien A. J. van Genugten, Jetty A. M. Weijers, Sandra Heskamp, Manfred Kneilling, Michel M. van den Heuvel, Berber Piet, Johan Bussink, Lizza E. L. Hendriks, Erik H. J. G. Aarntzen
Summary: Metabolic reprogramming is a key feature of cancer, and alterations in metabolic characteristics in the tumor microenvironment can impact the interactions between cancer cells and T cells as well as the efficacy of immune therapy. PET imaging tracers targeting metabolic pathways have the potential to improve immune therapeutic strategies, but their use in this context is currently limited. This review provides an overview of available PET tracers for clinical studies and discusses their potential roles in optimizing immune therapy for lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rahul Rana, Ravi N. Vellanki, Bradly G. Wouters, Mark Nitz
Summary: This study demonstrates a method to track a molecule in vivo by appending tellurophene to teniposide. Mass cytometry revealed significant nonspecific binding of the molecule to cells. In vivo experiments confirmed the expected DNA damage caused by tellurium-bearing teniposide, although the distribution of this analogue in tissue was close to the detection limit.
Article
Cardiac & Cardiovascular Systems
Lei Huang, Olivia Hough, Ravi N. Vellanki, Mamoru Takahashi, Zhiyuan Zhu, Yun-Yan Xiang, Manyin Chen, Hemant Gokhale, Hongchao Shan, Sahar Soltanieh, Lei Jing, Xinliang Gao, Bradly G. Wouters, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu
Summary: This study found that adding L-alanyl-L-glutamine during ex vivo lung perfusion (EVLP) can improve lung tissue function, provide antioxidant and cytoprotective effects, and provide additional energy support for lung transplantation. The study also developed a method to further optimize perfusates and improve EVLP outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Adriana C. H. van Engen-van Grunsven, Johan Bussink, Cathelijne Frielink, Lioe-Fee de Geus-Oei, Benno Kusters, Hans Peters, Wim J. G. Oyen, Dennis Vriens
Summary: This study explored the association between [F-18]FDG uptake and the quantitative expression of immunohistochemical markers related to glucose metabolism, hypoxia, and cell proliferation in benign and malignant thyroid nodules of indeterminate cytology. The results showed that the expression of GLUT1, HK2, and MCT4 increased in [F-18]FDG-positive benign nodules and thyroid carcinomas as compared to [F-18]FDG-negative benign nodules, and VEGF expression was higher in thyroid carcinomas.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Jose L. Cadavid, Simon Latour, Ferris Nowlan, Ileana L. Co, Natalie Landon-Brace, Bradly G. Wouters, Barbara T. Grunwald, Mark Nitz, Hartland Warren Jackson, Alison P. McGuigan
Summary: The spatial configuration of cells in the tumor microenvironment affects cancer and fibroblast cell phenotypes, leading to the clinical challenges of tumor heterogeneity and therapeutic resistance. In this study, a versatile system using pancreatic ductal adenocarcinoma as a model is described to investigate the impact of tissue architecture on cell phenotype. High dimensional characterization using CyTOF reveals distinct hypoxia and proliferation gradients in tissue architecture, and phenotypic markers for both cell types are also graded in a way that cannot be explained by hypoxia or coculture alone.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Oncology
Joel E. J. Beaumont, Nicky A. Beelen, Lotte Wieten, Kasper M. A. Rouschop
Summary: Hypoxia, a characteristic of many cancer types, can suppress the antitumor functions of the adaptive and innate immune system. Tumor-cell-derived extracellular vesicles (EVs), which participate in the communication between tumor cells and immune cells, are also affected by hypoxia and may contribute to immunosuppression. This review summarizes the current understanding of hypoxic cancer-cell-derived EVs in immunosuppression and provides an overview of the factors (miRNA and proteins) enriched in hypoxic tumor-derived EVs and their role in immunomodulation.
Article
Oncology
Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Borger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Gruetzmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Leonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe Masucci, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Benedicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon Van Lent-van Vliet, Nikki Knijn, Ana-Maria Muaina, Dragos-Viorel Scripcariu, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pages, Yutaka Kawakami, Jerome Galon
Summary: This study evaluated the prognostic value of Immunoscore in Asian patients with stage I-III colon cancer. The findings demonstrated a significant association between high Immunoscore and prolonged survival in this population.
Article
Oncology
Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Borger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grutzmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Leonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe Masucci, Emilia K. Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Benedicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon Van Lent-van Vliet, Nikki Knijn, Ana-Maria Musing, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Prabhu Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pages, Jerome Galon
Summary: This study found that the immune system status is a better predictor of prognosis in early-stage colon cancer patients than tumor cell-related parameters. The consensus Immunoscore accurately identifies early-stage colon cancer patients with different clinical outcomes, regardless of treatment bias.
Article
Cell Biology
Ioannis G. Lempesis, Nicole Hoebers, Yvonne Essers, Johan W. E. Jocken, Kasper M. A. Rouschop, Ellen E. Blaak, Konstantinos N. Manolopoulos, Gijs H. Goossens
Summary: The study found that low physiological oxygen partial pressure can increase leptin expression and secretion in adipocytes, while reducing the expression and secretion of some inflammatory factors in abdominal and femoral adipocytes of obese individuals.
Article
Medicine, Research & Experimental
Daan F. Boreel, Paul N. Span, Annemarie Kip, Milou Boswinkel, Johannes P. W. Peters, Gosse J. Adema, Johan Bussink, Sandra Heskamp
Summary: Limited oxygen diffusion and increased oxygen consumption in solid malignancies lead to chronic hypoxia, which induces radioresistance and an immunosuppressive microenvironment. This study aimed to develop a radiolabeled antibody to visualize chronic hypoxia and study immune cell populations in these hypoxic areas. The results showed that the radiotracer binds to CAIX-expressing cells in vitro and accumulates in CAIX+ areas in vivo. The technique can quantitatively distinguish between tumor models with varying CAIX+ fractions and identified less infiltration of immune cells in the CAIX+ areas.
MOLECULAR PHARMACEUTICS
(2023)
Correction
Medicine, Research & Experimental
Peter Tsai, Maria K. Kondratyev, Pratha Budhani, Arthur Liu, Neil N. Senzer, E. Gabriela Chiorean, Shadia I. Jalal, John J. Nemunaitis, Dennis Kee, Avik Shome, Way W. Wong, Dan Li, Nooriyah Poonawala-Lohani, Purvi M. Kakadia, Nicholas S. Knowlton, Courtney R. H. Lynch, Cho R. Hong, Tet Woo Lee, Reidar A. Grenman, Laura Caporiccio, Trevor D. McKee, Mark Zaidi, Sehrish Butt, Andrew M. J. Macann, Nicholas P. McIvor, John M. Chaplin, Kevin O. Hicks, Stefan K. Bohlander, Bradly G. Wouters, Charles P. Hart, Cristin G. Print, William R. Wilson, Michael A. Curran, Francis W. Hunter
Article
Biochemistry & Molecular Biology
Lei Huang, Ravi N. Vellanki, Zhiyuan Zhu, Bradly G. Wouters, Shaf Keshavjee, Mingyao Liu
Summary: Ex vivo lung perfusion (EVLP) has improved lung transplant success by evaluating marginal lungs before transplantation. To develop EVLP as a platform for donor lung reconditioning, a prolonged EVLP and new perfusates providing sufficient nutritional support are necessary. A combination of DMEM and a current EVLP perfusate (Steen solution) enhanced cell function and reduced apoptosis. A new EVLP perfusate, D05D7A solution, based on DMEM was designed and tested, showing improved cell function and higher levels of GSH and HSP70 compared to Steen solution. DMEM-based nutrient-rich perfusate could prolong EVLP and improve donor lung quality for transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
Maria Kondratyev, Aleksandra Pesic, Anna Dvorkin-Sheva, Marianne Koritzinsky, Bradly G. Wouters
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
