Article
Medicine, General & Internal
Austin J. Iovoli, Lauren Turecki, Michelle L. Qiu, Michael Khan, Kelsey Smith, Han Yu, Sung Jun Ma, Mark K. Farrugia, Anurag K. Singh
Summary: Oral mucositis is a common adverse effect in head and neck cancer patients receiving radiation therapy. This study aimed to investigate the associations between the severity of oral mucositis and clinical outcomes and quality of life. The results showed that severe oral mucositis was associated with feeding tube placement, hospitalization, opiate use, and weight loss.
Article
Oncology
Kristian Hastoft Jensen, Ivan Vogelius, Claus Ernst Moser, Elo Andersen, Jesper Grau Eriksen, Jorgen Johansen, Mohammad Farhadi, Maria Andersen, Jens Overgaard, Jeppe Friborg
Summary: This study found that the risk of bloodstream infections (BSIs) in patients with head and neck squamous cell carcinoma undergoing radiotherapy or chemoradiation is associated with age, cancer stage, and performance status, with Staphylococcus aureus being a common pathogen. The 30-day post-BSI mortality rate was 26%, and BSIs contributed to 10% of early non-cancer deaths. Empiric antibiotic treatment should prioritize coverage for S. aureus in this population.
BRITISH JOURNAL OF CANCER
(2021)
Review
Health Care Sciences & Services
Martin Dolezel, Marek Slavik, Tomas Blazek, Tomas Kazda, Pavel Koranda, Lucia Veverkova, Petr Burkon, Jakub Cvek
Summary: Concurrent chemoradiotherapy is commonly used in the curative treatment of head and neck cancer patients, with locoregional failure being the main recurrence pattern. Tumor hypoxia is a major cause of treatment failure, and positron emission tomography (PET) has been extensively studied as a feasible method for detecting tumor hypoxia. Escalating the dose to hypoxic tumors has shown potential to improve outcomes. The optimization of radiotherapeutic plans has been well-documented, and there are two main approaches for defining the hypoxic tumor volume based on PET images.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Multidisciplinary Sciences
William Trung Le, Eugene Vorontsov, Francisco Perdigon Romero, Lotfi Seddik, Mohamed Mortada Elsharief, Phuc Felix Nguyen-Tan, David Roberge, Houda Bahig, Samuel Kadoury
Summary: In radiation oncology, predicting patient risk stratification using deep learning is important for improving patient outcomes. This study proposes a new deep learning model for predicting distant metastasis, locoregional recurrence, and overall survival probabilities in head and neck cancer patients. The model achieves high accuracy and can be applied to multi-center data.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Heleen Bollen, Julie van der Veen, Annouschka Laenen, Sandra Nuyts
Summary: IMRT and VMAT have become standard of care in treating head and neck cancer. By analyzing treatment failure patterns, this study indirectly investigated the quality of target volume delineation and treatment delivery, which were performed accurately with few recurrences outside high-dose regions and no marginal failures observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Prateek Bhardwaj, Vikram Gota, Komal Vishwakarma, Venkatesh Pai, Pradip Chaudhari, Bhabani Mohanty, Rahul Thorat, Subhash Yadav, Murari Gurjar, Jayant Sastri Goda, Rinti Banerjee
Summary: This study developed a dual nanocarrier hydrogel for site-specific delivery of radio sensitizers in the treatment of locally advanced unresectable head and neck squamous cell carcinoma (HNSCC). The hydrogel improved drug accumulation in the tumor and reduced systemic absorption, leading to enhanced therapeutic efficacy and safety compared to commercial formulations. The nanoparticles in the hydrogel also facilitated intracellular uptake of radiosensitizers and enhanced radiation-induced DNA damage and cell apoptosis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Kelly Saesen, Julie van der Veen, Bertien Buyse, Sandra Nuyts
Summary: The study aimed to confirm the prevalence of obstructive sleep apnea (OSA) after radiotherapy for head and neck cancer, as well as investigate the risk factors for developing OSA in this population. The results showed that patients treated for head and neck cancer are at a higher risk of developing OSA, with referral to a sleep clinic recommended for those experiencing fatigue and sleeping problems. Further research is needed to identify potential risk factors and develop prevention and treatment strategies.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Mischa de Ridder, Cornelis P. J. Raaijmakers, Frank A. Pameijer, Remco de Bree, Floris C. J. Reinders, Patricia A. H. Doornaert, Chris H. J. Terhaard, Marielle E. P. Philippens
Summary: MRI-guided radiotherapy has become more routine in the treatment of head and neck cancer. It provides superior anatomical imaging and functional information, while reducing radiation dose to organs at risk.
Article
Oncology
John A. Vargo, Vitali Moiseenko, Jimm Grimm, Jimmy Caudell, David A. Clump, Ellen Yorke, Jinyu Xue, Yevgeniy Vinogradskiy, Eduardo G. Moros, Panayiotis Mavroidis, Sheena Jain, Issam El Naqa, Lawrence B. Marks, Dwight E. Heron
Summary: This study systematically reviewed the available literature on tumor control probability with SBRT in head and neck cancer patients, finding a dose-response relationship suggesting better local control and possibly improved overall survival with doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. It is suggested that SBRT doses equivalent to 5-fraction doses of 40 to 50 Gy are used for retreatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Oncology
Ling Zhou, Jia Chen, Chang-Juan Tao, Ming Chen, Zhong-Hua Yu, Yuan-Yuan Chen
Summary: Hypothyroidism after radiotherapy in head and neck cancer patients is influenced by factors such as radiation dose, treatment technique, thyroid volume, gender, and age. Incidence increases over time and a prospective large sample study is recommended for modeling complications related to radiation-induced hypothyroidism.
Article
Medicine, General & Internal
Ameeta Lubina Nayak, Arthur Travis Pickett, Megan Delisle, Brittany Dingley, Ranjeeta Mallick, Trevor Hamilton, Heather Stuart, Martha Talbot, Gregory Mckinnon, Evan Jost, Eva Thiboutot, Valerie Francescutti, Sal Samman, Alexandra Easson, Angela Schellenberg, Shaila Merchant, Julie La, Kaitlin Vanderbeck, Frances Wright, David Berger-Richardson, Pamela Hebbard, Olivia Hershorn, Rami Younan, Erica Patocskai, Samuel Rodriguez-Qizilbash, Ari Meguerditichian, Vanina Tchuente, Suzanne Kazandjian, Alex Mathieson, Farisa Hossain, Jessika Hetu, Martin Corsten, Angelina Tohme, Carolyn Nessim, Stephanie Johnson-Obaseki
Summary: This study, the largest Canadian evaluation of survival outcomes for head and neck MCC, found that disease staging and treatment modalities are associated with survival. Multimodal treatment is associated with higher survival rates across all stages of the disease.
Article
Oncology
Sachin R. Jhawar, Marcelo Bonomi, Paul M. Harari
Summary: The Oncology Grand Rounds series aims to help readers apply the results of key studies in clinical practice, using case presentations, literature reviews, and treatment recommendations to enhance understanding of the latest developments in oncology.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Mariangela Massaccesi, Nicola Dinapoli, Valentina Fuga, Cosimo Rupe, Marco Panfili, Rosalinda Calandrelli, Stefano Settimi, Michela Olivieri, Francesco Beghella Bartoli, Ciro Mazzarella, Silvia Longo, Carlo Lajolo, Luca Boldrini, Maria Antonietta Gambacorta, Vincenzo Valentini, Francesco Micciche
Summary: This study developed a prediction model for trismus based on a multivariable analysis of dosimetric and clinical factors. By measuring the maximum interincisal opening and dosimetry of masticatory structures, it is possible to accurately predict whether patients will develop trismus after radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Jacob Gadwa, Thomas E. Bickett, Laurel B. Darragh, Michael William Knitz, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Emily K. Kleczko, Raphael A. Nemenoff, Sana D. Karam
Summary: Inhibition of complement C3a and C5a signaling in HNSCC accelerates tumor growth and increases regulatory T cell populations. Local C3a and C5a signaling is important for CD4 T cell homeostasis and development into effector phenotypes. Depletion of Tregs reverses tumor growth and combining Treg depletion with C3a and C5a receptor inhibition reduces tumor growth further.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Otorhinolaryngology
Margot Baudelet, Frederic Duprez, Leen Van den Steen, Sandra Nuyts, Daan Nevens, Ann Goeleven, Caroline Vandenbruaene, Hanne Massonet, Alice Vergauwen, Heleen Bollen, Sarah Deschuymer, Kristien Wouters, Marc Peeters, Carl Van Laer, Steven Marien, Michiel Van den Brekel, Lisette van der Molen, Tom Vauterin, Joost van Dinther, Hilde Verstraete, Isabel Hutsebaut, Sabine Meersschout, Olivier Vanderveken, Marc De Bodt, Gwen Van Nuffelen
Summary: This multicenter RCT investigated the effect of three different service-delivery modes on patients' adherence to prophylactic swallowing exercises during radiotherapy. The study found that adherence decreased over time in all groups, but the therapist-supported group achieved the highest adherence rates. Increasing face-to-face contact with a speech-language therapist can overcome the problem of low adherence in this population.
Article
Oncology
Philipp Heumann, Miguel E. Aguado-Barrera, Barbara Avuzzi, David Azria, Erik Briers, Renee Bultijnck, Ananya Choudhury, Dirk De Ruysscher, Marie-Pierre Farcy-Jacquet, Valerie Fonteyne, Antonio Gomez Caamano, Irmgard Helmbold, Kerstie Johnson, Sarah L. Kerns, Maarten Lambrecht, Zoe Lingard, Tiziana Rancati, Barry S. Rosenstein, Elena Sperk, R. Paul Symonds, Christopher Talbot, Riccardo Valdagni, Ana Vega, Liv Veldeman, Tim Ward, Adam Webb, Catharine M. West, Jenny Chang-Claude, Petra Seibold
Summary: Previous studies have shown low to moderate agreement between healthcare professionals and patients in assessing treatment-related symptoms. This study aimed to determine the levels of agreement in a large cohort of prostate cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Antti A. A. Maekitie, Rasheed Omobolaji Alabi, Sweet Ping Ng, Robert P. P. Takes, K. Thomas Robbins, Ohad Ronen, Ashok R. R. Shaha, Patrick J. J. Bradley, Nabil F. F. Saba, Sandra Nuyts, Asterios Triantafyllou, Cesare Piazza, Alessandra Rinaldo, Alfio Ferlito
Summary: This article provides an analysis of systematic reviews on the current status and limitations of the application of artificial intelligence (AI) and machine learning (ML) as decision-making tools in head and neck cancer (HNC) management. The reviews reveal that AI/ML can be used for detecting cancerous lesions, predicting histopathological nature, prognosticating, extracting pathological findings from imaging, and various applications in radiation oncology. However, the lack of standardized guidelines, performance reporting, external validation procedures, and regulatory frameworks limit their adoption in clinical practice.
ADVANCES IN THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Marilyn Wegge, Rueveyda Dok, Ludwig J. J. Dubois, Sandra Nuyts
Summary: In this study, the use of 3D spheroid models as a preclinical tool for radiobiological research was investigated by comparing the RT response of HPV-positive and HPV-negative HNC spheroid models to their corresponding 2D and in vivo models. Results showed that HPV-positive spheroids maintained higher intrinsic radiosensitivity compared to HPV-negative spheroids. Additionally, 3D spheroids captured the heterogeneity of RT responses within both HPV-positive and HPV-negative models. Overall, 3D spheroids are a promising model for assessing the RT response in HNC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Heleen Bollen, Siri Willems, Marilyn Wegge, Frederik Maes, Sandra Nuyts
Summary: An automated gross tumor volume (GTV) delineation approach based on a 3D convolutional neural network (CNN) was developed for head and neck cancer (HNC) radiation therapy planning. The multi-modality CNNs showed better performance compared to the single-modality CNN, and were proven to be more efficient and consistent than manual delineation in a clinical setting, leading to increased efficiency and reduced interobserver variability.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Charlotte Kerstens, Hans P. M. W. Wildiers, Gwen Schroyen, Mercedes Almela, Ruth E. Mark, Maarten Lambrecht, Sabine Deprez, Charlotte Sleurs
Summary: As more cancer patients survive into older age, the focus has shifted to the potential cognitive effects, which may result from accelerated brain aging. A systematic review was conducted to examine the risks of cognitive decline, neurotoxicity as shown by neuroimaging, and neurodegenerative disease development in older cancer survivors. The evidence suggests both structural and functional brain changes, with cognitive decline mainly affecting memory function. Various factors contribute to the risk, including cancer type, treatment methods, genetic predisposition, age, comorbidities, and psychological and social factors. Further research is needed to gain a more comprehensive understanding of accelerated neurocognitive aging in specific older subpopulations and to develop targeted interventions.
Article
Otorhinolaryngology
Margot Baudelet, Leen van den Steen, Frederic Duprez, Ann Goeleven, Sandra Nuyts, Daan Nevens, Caroline Vandenbruaene, Hanne Massonet, Alice Vergauwen, Tom Vauterin, Hilde Verstraete, Kristien Wouters, Olivier Vanderveken, Marc De Bodt, Gwen Van Nuffelen, Belgian PRESTO Grp
Summary: Prophylactic swallowing exercises during (chemo)radiotherapy have a positive effect on swallowing function and muscle strength in head-and-neck cancer patients. However, adherence rates to these exercises are low. This study investigated the impact of service-delivery mode on swallowing function and muscle strength, and found that it had no significant effect. On the other hand, overall adherence level had a significant impact on these outcomes, and a high level of exercise repetitions is essential for benefiting from the exercises.
Editorial Material
Oncology
Sandra Nuyts
Review
Oncology
Karthik Nagaraja Rao, Ripudaman Arora, Prajwal Dange, Nitin Nagarkar, Antti A. Makitie, Luiz P. Kowalski, Avraham Eisbruch, Marc Hamoir, Francisco J. Civantos, Vincent Vander Poorten, Sweet Ping Ng, Sandra Nuyts, Mark Zafereo, Ameya A. Asarkar, Pawel Golusinski, Ohad Ronen, Alfio Ferlito
Summary: The overall surgical outcomes of infranotch T4b oral cancers were examined and compared with T4a oral cancers. The meta-analysis results suggest that IN-T4b oral cancers have similar outcomes to T4a oral cancers, supporting the down-staging of IN-T4b cancers to T4a cancers.
ONCOLOGY AND THERAPY
(2023)
Article
Oncology
Elnaz Naderi, Miguel E. Aguado-Barrera, Line M. H. Schack, Leila Dorling, Tim Rattay, Laura Fachal, Holly Summersgill, Laura Martinez-Calvo, Ceilidh Welsh, Tom Dudding, Yasmin Odding, Ana Varela-Pazos, Rajesh Jena, David J. Thomson, Roel J. H. M. Steenbakkers, Joe Dennis, Ramon Lobato-Busto, Jan Alsner, Andy Ness, Chris Nutting, Antonio Gomez-Caamano, Jesper G. Eriksen, Steve J. Thomas, Amy M. Bates, Adam J. Webb, Ananya Choudhury, Barry S. Rosenstein, Begona Taboada-Valladares, Carsten Herskind, David Azria, David P. Dearnaley, Dirk de Ruysscher, Elena Sperk, Emma Hall, Hilary Stobart, Jenny Chang-Claude, Kim De Ruyck, Liv Veldeman, Manuel Altabas, Maria Carmen De Santis, Marie-Pierre Farcy-Jacquet, Marlon R. Veldwijk, Matthew R. Sydes, Matthew Parliament, Nawaid Usmani, Neil G. Burnet, Petra Seibold, R. Paul Symonds, Rebecca M. Elliott, Renee Bultijnck, Sara Gutierrez-Enriquez, Meritxell Molla, Sarah L. Gulliford, Sheryl Green, Tiziana Rancati, Victoria Reyes, Ana Carballo, Paula Peleteiro, Paloma Sosa-Fajardo, Chris Parker, Valerie Fonteyne, Kerstie Johnson, Maarten Lambrecht, Ben Vanneste, Riccardo Valdagni, Alexandra Giraldo, Monica Ramos, Brenda Diergaarde, Geoffrey Liu, Suzanne M. Leal, Melvin L. K. Chua, Miranda Pring, Jens Overgaard, Luis M. Cascallar-Caneda, Frederic Duprez, Christopher J. Talbot, Gillian C. Barnett, Alison M. Dunning, Ana Vega, Christian Nicolaj Andreassen, Johannes A. Langendijk, Catharine M. L. West, Behrooz Z. Alizadeh, Sarah L. Kerns
Summary: This study identified shared genetic susceptibility for acute radiation-induced toxicity across different cancer types, with a shared SNV-based heritability estimated at around 10%. Higher heritability rates were found for prostate, head and neck, and breast cancers. Additionally, several potentially associated SNVs and gene sets related to acute toxicity were discovered.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Celie Cokelaere, Ruveyda Dok, Emanuela E. Cortesi, Peihua Zhao, Anna Sablina, Sandra Nuyts, Rita Derua, Veerle Janssens
Summary: Our study revealed that increased expression of TIPRL1 in tumor tissues is associated with poor locoregional control and decreased survival in RT-treated HNSCC patients. Deletion of TIPRL1 in HNSCC cells resulted in increased sensitivity to RT, prolonged cell cycle arrest, increased micronuclei formation, and altered proteome-wide DNA Damage Response. Additionally, we found that ATM-dependent phosphorylation of TIPRL1 plays a crucial role in radiotherapy resistance by modulating DDR, suggesting TIPRL1 as a potential predictive marker and therapeutic target in HNSCC.
Review
Oncology
Heleen Bollen, Akos Gulyban, Sandra Nuyts
Summary: The aim of this study was to evaluate the impact of international expert consensus guidelines (CG) on the delineation quality and consistency of clinical target volume of the primary tumor (CTVp). The results showed that the implementation of CG significantly improved delineation uniformity in Belgian radiation therapy centers. However, there is a need for clarification of the existing guidelines, especially for oropharyngeal and hypopharyngeal carcinoma.
RADIOTHERAPY AND ONCOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Ester Aguado-Flor, Petra Seibold, Miguel E. Aguado-Barrera, Manuel Altabas, Ananya Choudhury, Orland Diez, Noelia Docampo Azuaga, Sandrine Ducornet, David Gibon, Alexandra Giraldo, Renan Gomes, Antonio Gomez-Caamano, Maarten Lambrecht, Sarah Libert, Susana Magrina, Giovanna Muggiolu, Tiziana Rancati, Tim Rattay, Victoria Reyes, Sylvie Sauvaigo, Paloma Sosa-Fajardo, Christopher Talbot, Ana Vega, Liv Veldeman, Paolo Zunino, Jordi Giralt, Jenny Chang-Claude, Sara Gutierrez-Enriquez
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Oncology
Ursula Nestle, Sonja Adebahr, Coen Hurkmans, Merina Ahmed, Shahreen Ahmad, Matthias Guckenberger, Xavier Geets, Yolande Lievens, Maarten Lambrecht, Nicolas Pourel, Victor Lewitzki, Krzysztof Konopa, Kevin Franks, Rafal Dziadziuszko, Fiona Mcdonald, Enrico Clementel, Beatrice Fournier, Catherine Fortpied, Kin Jip Cheung, Eleni Gkika, Tanja Schimeck-Jasch, Christian Fink, Oliver Riesterer, Heike Peulen, Corinne Faivre-Finn, Anca-Ligia Grosu, Cecile Le Pechoux
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Harkeran K. Jandu, Colin D. Veal, Laura Fachal, Craig Luccarini, Miguel E. Aguado-Barrera, Manuel Altabas, David Azria, Adinda Baten, Celine Bourgier, Renee Bultijnck, Riccardo R. Colciago, Marie-Pierre Farcy-Jacquet, Jenny Chang-Claude, Ananya Choudhury, Alison Dunning, Rebecca M. Elliott, Sheryl Green, Sara Gutierrez-Enriquez, Carsten Herskind, Maarten Lambrecht, Christel Monten, Tiziana Rancati, Victoria Reyes, Barry S. Rosenstein, Dirk De Ruysscher, Maria Carmen De Santis, Petra Seibold, Elena Sperk, Marlon Veldwijk, R. Paul Symonds, Hilary Stobart, Begona Taboada-Valladares, Ana Vega, Liv Veldeman, Adam J. Webb, Caroline Weltens, Catharine M. West, Tim Rattay, Christopher J. Talbot
Summary: This study aimed to identify common single nucleotide polymorphisms (SNPs) associated with long-term toxicity following whole breast radiotherapy in breast cancer patients. A genome-wide association study was performed, and multiple SNPs were found to have significant associations with distinct toxicity endpoints. This study provides further evidence for tailoring treatment plans based on individual genetic profiles.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
