Article
Oncology
Jana Mekis, Primoz Strojan, Dusan Mekis, Irena Hocevar Boltezar
Summary: The study aimed to track the changes in voice quality for two years after radiotherapy (RT) for early glottic cancer. The results showed that only a minority of patients had a normal voice two years post-RT, mainly due to post-RT changes in the larynx, such as fibrosis and scarring of the vocal folds.
Article
Otorhinolaryngology
Maarten C. Dorr, Aniel Sewnaik, Elrozy Andrinopoulou, Diako Berzenji, Emilie A. C. Dronkers, Simone E. Bernard, Arta Hoesseini, Lisa Tans, Dimitris Rizopoulos, Robert J. Baatenburg de Jong, Marinella P. J. Offerman
Summary: This study aimed to investigate the longitudinal trajectories for patient-reported voice quality after treatment for early-stage glottic cancer and identify associated risk factors. The results showed that different treatment modalities resulted in varying degrees of improvement in voice quality, but no significant differences were found in long-term outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Taner Yilmaz
Summary: T-1a glottic cancer can be treated with TLM or RT. Dysphonia is a major drawback of TLM, while voice preservation is considered a key advantage of RT. Studies on the voice outcomes of both treatment options have conflicting results but suggest a tendency towards better voice outcomes after TLM compared to the past.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Pihla Pakkanen, Heikki Irjala, Taru Ilmarinen, Elina Halme, Paula Lindholm, Antti Makitie, Tuija Wigren, Leena-Maija Aaltonen
Summary: This study compared the outcomes of transoral laser surgery (TLS) and radiation therapy (RT) in patients with glottic T1a laryngeal squamous cell carcinoma (LSCC). The study found that the oncological outcomes of both treatment modalities were similar.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Otorhinolaryngology
Maarten C. C. Dorr, Eleni-Rosalina Andrinopoulou, Aniel Sewnaik, Diako Berzenji, Kira S. S. van Hof, Emilie A. C. Dronkers, Simone E. E. Bernard, Arta Hoesseini, Dimitirs Rizopoulos, Robert J. Baatenburg J. de Jong, Marinella P. J. Offerman
Summary: This study aims to develop an individualized dynamic prediction model for patient-reported voice quality. The study found that the model can provide individualized predictions at every time point and can be used throughout the follow-up period. Increasing the number of measurements during prediction improves predictive performance, while adding more clinical and demographic variables does not provide better predictions.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Lucia Stanikova, Karol Zelenik, Martin Formanek, Jana Seko, Radana Walderova, Peter Kantor, Pavel Kominek
Summary: Voice quality evolution post-TLC depends on the extent of surgery, with no significant improvement at 6 weeks post-surgery. Improvements in less extensive cordectomies occur between 6 weeks and 6 months post-surgery. Understanding the progression of voice quality over time is crucial for counseling patients considering phonosurgical procedures.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Review
Oncology
Amit Gupta, Kee Howe Wong, Kate Newbold, Shreerang Bhide, Chris Nutting, Kevin Joseph Harrington
Summary: Early-stage squamous cell cancer of the glottis has a good prognosis, but radiotherapy may lead to late toxicities. Current research focuses on the radiation dose received by carotid arteries and the risk of cerebrovascular events. Motion has limited the reduction of radiation treatment volume.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Chin-Hsuan Liu, Pei-Ju Chien, Li-Ting Hung, Li-Mei Wang, Ya-Chuan Kao, Yueh-Ju Tsai, Pen-Yuan Chu
Summary: The modified type III cordectomy has been proven to be an oncologically safe method with satisfactory voice outcomes after long-term follow-up in selected cases of early glottic cancer.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Audiology & Speech-Language Pathology
Berat Demir, Adem Binnetoglu, Ece Gurol, Cagatay Oysu
Summary: The quality of life for patients with early glottic carcinoma varies depending on the treatment modality used, with ECRM showing the worst outcome in terms of voice quality. Differences were noted between the RT group and other groups in terms of percentage jitter, percentage shimmer, and fundamental frequency. No significant differences were found between the laser and RT groups in terms of voice quality.
Article
Oncology
Chen-Chi Wang, Wen-Jiun Lin, Jing-Jie Wang, Chien-Chih Chen, Kai-Li Liang, Yen-Jung Huang
Summary: Transoral robotic surgery (TORS) has shown promising results in the treatment of glottic cancer involving the anterior commissure (AC). It provides better exposure and can be used as a minimally invasive approach in patients with radiation failure to preserve the organ.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Dursun Mehmet Mehel, Abdulkadir Ozgur, Nilgun Sahin, Asli Aybuke Vural, Tugba Yemis, Mehmet Celebi, Samet Aydemir, Dogukan Ozdemir, Gokhan Akgul
Summary: In early-stage glottic carcinoma patients, there was no significant difference in voice quality between radiotherapy and microsurgical cordectomy, with emotional and physiological scores significantly higher in the MC group and no significant difference found in functional scores.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Article
Medicine, Research & Experimental
Rohith S. Voora, Bharat Panuganti, Mitchell Flagg, Abhishek Kumar, Alexander S. Qian, Nikhil V. Kotha, Edmund M. Qiao, Philip A. Weissbrod, Brent Rose, Ryan K. Orosco
Summary: Transoral laser microsurgery (TLM) is commonly used for early glottic cancer, and most patients do not require additional salvage therapy after TLM. For those who do require salvage therapy, there is no decrease in overall survival or cancer-specific survival.
Article
Biochemistry & Molecular Biology
Daniel Wegener, Daniel M. Aebersold, Marc-Oliver Grimm, Peter Hammerer, Michael Froehner, Markus Graefen, Dirk Boehmer, Daniel Zips, Thomas Wiegel
Summary: The results of three randomized clinical trials comparing adjuvant radiotherapy (ART) and early salvage radiotherapy (eSRT) for prostate carcinoma were recently published. The findings suggest that early eSRT is as effective and potentially less toxic than ART. Therefore, eSRT should be considered the standard of care. However, ART remains a valid treatment option for patients with high-risk features.
Article
Oncology
Avni Kachhwaha, Shankar Lal Jakhar, Tanya Syiem, Neeti Sharma, Harvinder Singh Kumar, Ajay Sharma
Summary: The study indicates that hypofractionated radiotherapy may offer better local control and symptomatic relief for glottic cancer patients, with the added benefit of shorter treatment time and improved patient compliance, particularly suitable for busy clinical settings.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Giuseppe Licci, Luca Giovanni Locatello, Giandomenico Maggiore, Flavia Cozzolino, Saverio Caini, Oreste Gallo
Summary: Compared with other head and neck cancer types, the prognosis of recurrent early glottic cancer (rEGC) may be less dependent on the presence of regional (N) and/or distant metastases (M). Thus, a new staging system (SUD) based on the comparison between the T stages of the recurrence and the primary tumor was developed and found to efficiently predict survival in rEGC patients, outperforming other existing staging systems.
Article
Otorhinolaryngology
Sarbani Ghosh Laskar, Prathamesh Pai, Shwetabh Sinha, Ashwini Budrukkar, Deepa Nair, Monali Swain, Naveen Mummudi, Tejpal Gupta, Vedang Murthy, Jai Prakash Agarwal, Neelesh Tiwari, Shiva Thiagrajan, Devendra Chaukar, Pankaj Chaturvedi, Gouri Pantvaidya, Anuja Deshmukh, Sudhir Nair, Kumar Prabhash, Amit Joshi, Vanita Noronha, Vijay Patil, Nandini Menon, Asawari Patil, Munita Bal, Neha Mittal, Swapnil Rane
Summary: A retrospective analysis showed that intensity-modulated radiation therapy (IMRT) is effective for tumors of the nasal cavity and paranasal sinus (PNS) region, across all histologies and treatment settings. However, patients treated with nonsurgical modalities, higher T classification, and undifferentiated/poorly differentiated histology had inferior 5-year local control, event-free survival, and overall survival rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Ravikumar Shah, Vikrant Gosavi, Abhishek Mahajan, Sushil Sonawane, Priya Hira, Vineeth Kurki, Munita Bal, Pragati Sathe, Prathamesh Pai, Anil D'Cruz, Shinya Uchino, Mahadeo Namdeo Garale, Virendra Patil, Anurag Lila, Nalini Shah, Tushar Bandgar
Summary: Differentiating between parathyroid carcinoma and benign parathyroid lesions in an Indian primary hyperparathyroidism cohort can be challenging based on clinical and biochemical parameters, but parameters derived from CECT imaging can aid in diagnosis.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Anil K. D'Cruz, Harsh Dhar, Richa Vaish, Rohini Hawaldar, Sudeep Gupta, Gouri Pantvaidya, Devendra Chaukar, Pankaj Chaturvedi, Prathamesh Pai, Anuja Deshmukh, Shubhada Kane, Deepa Nair, Sudhir Vasudevan Nair, Sarbani Ghosh-Laskar, Jaiprakash Agarwal
Summary: This study investigates the prognosis of early oral cancer patients under different neck treatment regimens and finds that depth of invasion is associated with neck metastasis and adverse tumor factors. Elective neck dissection negates the impact of depth of invasion on the prognosis of early oral cancers, but T3 tumors with a DOI greater than 10mm still have a higher association with other adverse risk factors, leading to poorer outcomes.
Article
Otorhinolaryngology
Prathamesh Pai, Vidisha Tuljapurkar, Arun Balaji, Aseem Mishra, Prashant Chopda, Swapnil Agarwal, Gurmeet Kaur Bachher
Summary: The study suggests that following resection in early tongue cancers, secondary intention healing can lead to better speech and tongue mobility with minimal complications.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Anuja Deshmukh, Anand Ebin Thomas, Harsh Dhar, Parthiban Velayutham, Gouri Pantvaidya, Prathamesh Pai, Devendra Chaukar
Summary: The main 'functional' goals of thyroid surgery are to ensure the integrity of the RLN, EBSLN, and preservation of normal voice. Intraoperative nerve monitoring aids in nerve identification and early detection of functional impairment, but its utility and cost-effectiveness remain a topic of clinical equipoise despite numerous studies.
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Devendra Chaukar, Kumar Prabash, Pawan Rane, Vijay Maruti Patil, Shivakumar Thiagarajan, Sarbani Ghosh-Laskar, Shilpi Sharma, Prathamesh S. Pai, Pankaj Chaturvedi, Gouri Pantvaidya, Anuja Deshmukh, Deepa Nair, Sudhir Nair, Richa Vaish, Vanita Noronha, Asawari Patil, Supreeta Arya, Anil D'Cruz
Summary: This study examined the potential role and safety of neoadjuvant chemotherapy (NACT) in preserving the mandible in oral cancers. The results showed that NACT can achieve mandibular preservation with similar survival rates compared to standard surgical treatment. However, chemotherapy-induced toxicity was observed in the majority of patients in the NACT group.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Ginimol Mathew, Riaz Agha
Summary: The STROCSS 2021 guidelines were developed and approved by a Delphi consensus exercise with 89% participation rate, receiving high scores of 7 to 9, to ensure ongoing good reporting quality among observational studies in surgery.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Orthopedics
Ginimol Mathew, Riaz Agha
Summary: The updated STROCSS 2021 guidelines were developed through a Delphi consensus exercise and expert evaluation, receiving high scores and consensus. The new guidelines aim to improve the reporting quality of observational studies in surgery.
INTERNATIONAL JOURNAL OF SURGERY OPEN
(2021)
Article
Oncology
Vijay Patil, Vanita Noronha, Amit Joshi, Nandini Menon, Vijayalakshmi Mathrudev, Atanu Bhattacharjee, Arun Chandrasekharan, Dilip Vallathol, Hollis Dsouza, Sujay Srinivas, Tanmay Mandal, Pankaj Chaturvedi, Devendra Chaukar, Prathamesh Pai, Sudhir Nair, Shiva Thiagrajan, Sarbani Laskar, Kavita Nawale, Sachin Babanrao Dhumal, Rupali Tambe, Shripad Banavali, Kumar Prabhash
Summary: The study showed that a 6-month metronomic adjuvant chemotherapy was unable to improve outcomes in patients with recurrent head and neck cancer post salvage surgery who are ineligible for re-radiation.
Article
Oncology
Sarbani Ghosh Laskar, Shwetabh Sinha, Prathamesh Pai, Deepa Nair, Ashwini Budrukkar, Monali Swain, Anuj Kumar, Aliasgar Moiyadi, Prakash Shetty, Vedanta Ray, Carlton Johnny, Vedang Murthy, Tejpal Gupta, Nandini Menon, Vijay Patil, Vanita Noronha, Amit Joshi, Kumar Prabhash, Jai Prakash Agarwal
Summary: Surgery followed by adjuvant therapy remains the mainstay of treatment for EAC and TB SCC, with better outcomes observed with adjuvant radiotherapy compared to definitive radiotherapy. IMRT is preferred due to lower late morbidity. Elective nodal irradiation is routinely not warranted in the adjuvant setting for EAC and TB squamous cell carcinomas.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Abhishek Mahajan, Navnath Dhone, Richa Vaish, Ankita Singhania, Akshat Malik, Kumar Prabhash, Ankita Ahuja, Nilesh Sable, Pankaj Chaturvedi, Vanita Noronha, Sarbani Gosh Laskar, Ujjwal Agarwal, Shreya Shukla, Gouri Pantvaidya, Prathamesh Pai, Atanu Bhattacharjee, Vijay Patil, Asawari Patil, Munita Bal, Swapnil Rane, Shivakumar Thiagarajan, Anil D' Cruz
Summary: This study analyzed the pattern of mandibular involvement in GBC-SCC patients and proposed a new staging system called MMC. The MMC system was found to be better for predicting survival outcomes compared to the AJCC8 staging.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Marco Ferrari, Davide Mattavelli, Michele Tomasoni, Elena Raffetti, Paolo Bossi, Alberto Schreiber, Ester Orlandi, Stefano Taboni, Vittorio Rampinelli, Tommaso Gualtieri, Mario Turri-Zanoni, Paolo Battaglia, Alberto D. Arosio, Maurizio Bignami, Tiziana Tartaro, Marinella Molteni, Giacomo Bertazzoni, Domitille Fiaux-Camous, Clement Jourdaine, Benjamin Verillaud, Donovan Eu, Deepa Nair, Aliasgar Moiyadi, Prakash Shetty, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Stefano M. Magrini, Sophie Guillerm, Sandrine Faivre, Cesare Piazza, Ralph W. Gilbert, Jonathan C. Irish, John R. de Almeida, Prathamesh Pai, Philippe Herman, Paolo Castelnuovo, Piero Nicolai
Summary: Transnasal endoscopic surgery (TES) has become the most commonly used surgical technique for treating sinonasal malignancies. This study evaluated the prognosis of sinonasal cancers treated with TES and provided benchmark data for different histological types.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Karthik Nagaraja Rao, Prathamesh S. Pai, Prajwal Dange, Luiz P. Kowalski, Primoz Strojan, Antti A. Makitie, Orlando Guntinas-Lichius, K. Thomas Robbins, Juan P. Rodrigo, Avraham Eisbruch, Robert P. Takes, Remco de Bree, Andres Coca-Pelaz, Cesare Piazza, Carlos Chiesa-Estomba, Fernando Lopez, Nabil F. Saba, Alessandra Rinaldo, Alfio Ferlito
Summary: The management of cT3 laryngeal cancers remains controversial, and there is a lack of studies showing which treatment has better survival outcomes. This study compared total laryngectomy, concurrent chemoradiation, and radiation therapy alone in T3 laryngeal cancers and found that TL and CRT had similar overall survival outcomes, which were better than RT alone.
Article
Pharmacology & Pharmacy
Sumitra G. Bakshi, Akash Tambule, Amit R. Panigrahi, Prathamesh Pai
Summary: The study evaluated the use of patient information leaflet (PIL) prior to general anesthesia for day care procedures, and found that introducing PIL significantly reduced the rescheduling rate and improved patient satisfaction levels.
JOURNAL OF ANAESTHESIOLOGY CLINICAL PHARMACOLOGY
(2021)
Article
Surgery
P. Lakshminarasimman, Prathamesh S. Pai, Shaesta Mehta, Prachi Patil
Summary: Direct laryngoscopy (DL) is the standard method for evaluating suspicious lesions in the larynx and hypopharynx, but it requires general anesthesia and a dedicated operating room. Transnasal endoscopy (TNE) under topical anesthesia is a simple, safe, and efficient office-based diagnostic procedure that can adequately map disease extent and provide adequate biopsy material. TNE has the potential to become the new standard of care, potentially replacing DL.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2021)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
