Article
Biochemistry & Molecular Biology
Faisal Bin Rashed, Wisdom Deebeke Kate, Mesfin Fanta, Leonard Irving Wiebe, Piyush Kumar, Michael Weinfeld
Summary: Cellular adaptations to hypoxia enhance resistance to ionizing radiation (IR), which poses a challenge for head and neck cancer (HNC) treatment. Nitroimidazoles (NIs) like iodoazomycin arabinofuranoside (IAZA) and fluoroazomycin arabinofuranoside (FAZA) can selectively accumulate in hypoxic tumors. This study demonstrates that both IAZA and FAZA sensitize hypoxic HNC cells to IR, with IAZA being a better radiosensitizer. Moreover, IAZA and FAZA impair cellular adaptation to reoxygenation, suggesting their potential therapeutic use in targeting hypoxic HNC cells.
Article
Microbiology
Matthew Chung, Ricky S. Adkins, John S. A. Mattick, Katie R. Bradwell, Amol C. Shetty, Lisa Sadzewicz, Luke J. Tallon, Claire M. Fraser, David A. Rasko, Anup Mahurkar, Julie C. Dunning Hotopp
Summary: The manuscript introduces a quantification tool FADU specifically designed for prokaryotic RNA-Seq analyses, which can accurately quantify operonic genes by deriving proportional counts for multigene fragments within operons.
Article
Endocrinology & Metabolism
Shuqiong Wang, Youwen Wei, Caiyan Hu, Fang Liu
Summary: Chronic hypoxia exposure exacerbates low testosterone production in obese male mice by influencing key proteins involved in steroid hormone biosynthesis, cholesterol biosynthesis, oxidative stress responses, and retinol metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sirsendu Jana, Michael R. R. Heaven, Charles B. B. Stauft, Tony T. T. Wang, Matthew C. C. Williams, Felice D'Agnillo, Abdu I. I. Alayash
Summary: We found that SARS-CoV-2 infection in Syrian hamsters leads to the activation of the hypoxia-inducible factor (HIF-1 alpha) transcriptional pathway, possibly due to hypoxia or accumulation of mitochondrial reactive oxygen species (ROS) in the lungs. This activation results in increased expression of HIF-1 alpha target proteins and a rise in glycolysis, while mitochondrial respiration decreases. Proteomic analysis also revealed specific deficits in mitochondrial ATP synthase and ATP/ADP translocase. Activation of HIF-1 alpha in inflammatory macrophages may drive inflammation, proinflammatory cytokine production, complement activation, and oxidative stress in infected lungs. These findings suggest a central role for HIF-1 alpha in the metabolic reprogramming, inflammation, and bioenergetic dysfunction associated with SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jan Schmitz, Lydia J. Kolaparambil Varghese, Felix Liebold, Moritz Meyer, Lukas Nerlich, Clement Starck, Seamus Thierry, Stefanie Jansen, Jochen Hinkelbein
Summary: The present study aims to investigate the time-dependent changes in protein expression due to hypobaric hypoxia. The results show that protein expression differs based on the duration of exposure, with significant differences in proteins associated with hemostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
J. J. David Ho, Jeffrey H. S. Man, Jonathan H. Schatz, Philip A. Marsden
Summary: Translation plays a crucial role in generating the proteome that regulates phenotype, and recent discoveries have highlighted the importance of system-wide adaptive translational reprogramming in cellular adaptation. Stress-activated RBP networks and ncRNAs have been identified as key players in increasing translation efficiency of transcripts encoding proteins involved in common cellular processes, showcasing a new paradigm in cellular stress adaptation.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2021)
Article
Multidisciplinary Sciences
Lan Zhang, Yiyang Zhang, Juan Zhou, Yifan Yao, Rui Li, Manlin Zhou, Shuwu Chen, Zilin Qiao, Kun Yang
Summary: This study used transcriptomic and proteomic analyses to reveal the differential gene and protein expression in yak PASMCs under hypoxic conditions, and identified key genes and proteins related to hypoxia-adaptive pathways.
Article
Oncology
Alicja Gluszko, Miroslaw J. Szczepanski, Theresa L. Whiteside, Torsten E. Reichert, Jacek Siewiera, Nils Ludwig
Summary: Tissue hypoxia is a common feature in HNSCC, leading to alterations in tumor cells. The study found that sEVs released by HNSCC cells under hypoxic conditions have a unique protein composition, which can potentially serve as biomarkers for different degrees of tissue hypoxia and as a resource for anti-angiogenic therapies.
Article
Astronomy & Astrophysics
Meng-Jie Zhao, Zhen-Yang Wang, Chao Wang, Xin-Heng Guo
Summary: The study shows that only the isoscalar D (D) over bar*=B (B) over bar* and DD (D) over bar*= B (B) over bar* systems can exist as bound states, while other systems do not meet this criterion.
Article
Medicine, Research & Experimental
Anamika Gangwar, Subhojit Paul, Aditya Arya, Yasmin Ahmad, Kalpana Bhargava
Summary: This study investigated redox post-translational modifications (PTMs), nitrosylation and carbonylation, in the context of extended environmental hypoxia exposure. The findings revealed the interplay between nitrosylation and carbonylation in coagulation and inflammation networks, and their role in hypoxia signaling and tolerance.
Article
Neurosciences
Manju Babu, Nikhil Singh, Arnab Datta
Summary: This systematic review summarizes proteomics studies on different OGD models, discusses cell-type-specific responses to oxygen and glucose deprivation, and explores the translational potential of this approach for therapeutic target and biomarker discovery.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Faisal Bin Rashed, Alexandru Cezar Stoica, Dawn MacDonald, Hassan El-Saidi, Carolynne Ricardo, Bhumi Bhatt, Jack Moore, Diana Diaz-Dussan, Nirilanto Ramamonjisoa, Yvonne Mowery, Sambasivarao Damaraju, Richard Fahlman, Piyush Kumar, Michael Weinfeld
Summary: Tumour hypoxia negatively impacts therapy outcomes and remains a major clinical challenge. Nitroimidazoles are hypoxia selective compounds with potential as hypoxia-directed therapeutics. A novel 2-nitroimidazole, N-3-AZA, has been shown to reduce enzymatic activities of critical proteins in cancer cells, indicating its potential as a target for nitroimidazole-based cancer therapeutics.
Article
Neurosciences
Shuhui Dai, Yuan Feng, Chuanhao Lu, Hongchen Zhang, Wenke Ma, Wenyu Xie, Xiuquan Wu, Peng Luo, Lei Zhang, Fei Fei, Zhou Fei, Xia Li
Summary: Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness. Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia remains unknown. This study demonstrates that acute exposure to hypobaric hypoxia impairs autophagic activity in the mouse brain, leading to oxidative stress, neuronal loss, and brain damage. This research also suggests that the protein dynamin2 potentially regulates autophagic flux, and enhancing autophagic activity can attenuate the negative effects of hypobaric hypoxia.
NEUROSCIENCE BULLETIN
(2023)
Article
Physiology
Rens L. J. Van Meijel, Ping Wang, Freek Bouwman, Ellen E. Blaak, Edwin C. M. Mariman, Gijs H. Goossens
Summary: This study demonstrates for the first time that MIH exposure affects the human adipose tissue proteome, particularly in pathways related to redox systems, cell adhesion, cytoskeleton organization, and energy metabolism.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Limnology
Peipei Zhao, Qinghua Wu, Xuekui Xia, Shiyi Guo, Sizhong Shen, Yujue Wang, Aiyou Huang
Summary: Diatoms, such as Phaeodactylum tricornutum, play a crucial role in global net primary productivity and biogeochemical cycles. This study investigated the responses of P. tricornutum to low oxygen conditions and found that it can reset its metabolism pathways and activate stress resistance mechanisms to adapt to hypoxic environments.
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2022)
Article
Genetics & Heredity
Pernille A. Gregersen, Mikkel Funding, Jan Alsner, Maja H. Olsen, Jens Overgaard, Steen F. Urbak, Sandra E. Staffieri, Stina Lou
Summary: Survivors of heritable retinoblastoma face complex and difficult reproductive decision-making, with a strong desire to avoid passing on the disease to their children. They consider various medical, practical, emotional, and moral issues in their family planning process, and express feelings of guilt. Healthcare professionals should provide necessary information and tools to support their unique decision-making process.
JOURNAL OF GENETIC COUNSELING
(2023)
Article
Public, Environmental & Occupational Health
Anne-Mette Iversen, Marco Bo Hansen, Jan Alsner, Brian Kristensen, Svend Ellermann-Eriksen
Summary: Nudging with sensor lights can improve and sustain the hand hygiene compliance of physicians and nurses, reducing hospital-acquired infections.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Biochemistry & Molecular Biology
Salvia Sajid, Lilia Hernandez Salas, Maria Rafiq, Torben Lund, Mikkel Girke Jorgensen, Bent Honore, Lars Porskaer Christensen, Paul Robert Hansen, Henrik Franzyk, Osman Mirza, Bala Krishna Prabhala
Summary: Membrane transport proteins play a crucial role in maintaining cellular homeostasis by facilitating the transport of various molecules across the cell membrane. Overexpression of these proteins has been shown to alter the metabolomic and proteomic profiles of host cells. In this study, we investigated the physiological consequences of overexpressing the membrane transport protein YdgR from E. coli in two different strains. We observed significant differences in the metabolomics and proteomics profiles between cells expressing functional YdgR and attenuated YdgR. The findings suggest a potential role of YdgR in the transport of proline-containing tripeptides.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Ophthalmology
Danson Vasanthan Muttuvelu, Lasse Jorgensen Cehofski, Misk Ghassan Farik Muhammad, Xiangjun Chen, Tor Paaske Utheim, Asif Manzoor Khan, Ahmed Basim Abduljabar, Kasper Kristensen, Marie Louise Roed Rasmussen, Henrik Vorum, Steffen Heegaard, Bent Honore
Summary: In this study, proteome analysis was used to investigate the biological mechanisms underlying anterior blepharitis. The results showed that anterior blepharitis is associated with high levels of certain cytoskeletal proteins and lower levels of immunoglobulin chains and CXCL17.
Article
Oncology
Marie Louise Holm Milo, Ditte Slot Moller, Tine Bisballe Nyeng, Lone Hoffmann, Henrik Dahl Nissen, Ingelise Jensen, Ebbe Laugaard Lorenzen, Lise Bech Jellesmark Thorsen, Kirsten Melgaard Nielsen, Soren Paaske Johnsen, Jan Brink Valentin, Jan Alsner, Birgitte Vrou Offersen
Summary: This study aimed to report the radiation therapy (RT) doses to the heart and cardiac substructures in breast cancer patients treated with CT-based RT and investigate the potential dose-response relationship between RT dose and coronary artery disease (CAD). The results showed that CAD tended to occur in the part of the heart with the highest left-minus-right dose difference, but no significant risk of CAD was observed at a median follow-up of 7 years.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Cathrine Bang Overgaard, Fardous Reaz, Mateusz Sitarz, Per Poulsen, Jens Overgaard, Niels Bassler, Cai Grau, Brita Singers Sorensen
Summary: This study introduced an experimental radiobiological setup for in vivo irradiation of a mouse leg target along a proton beam path. The setup was used to investigate normal tissue and tumor models with varying linear energy transfer. The results showed that acute skin damage was reversible, while radiation-induced late damage was irreversible.
Article
Ophthalmology
Danson Vasanthan Muttuvelu, Lasse Jorgensen Cehofski, Tor Paaske Utheim, Xiangjun Chen, Henrik Vorum, Marie Louise Roed Rasmussen, Steffen Heegaard, Asif Manzoor Khan, Ahmed Basim Abduljabar, Bent Honore
Summary: The study found that treatment with dexamethasone/tobramycin solution could reverse the expression of plakin proteins in patients with anterior blepharitis, potentially restoring ocular surface integrity. Further exploration of topical solutions inhibiting plakin protein expression is warranted.
ACTA OPHTHALMOLOGICA
(2023)
Article
Neurosciences
Tenna Bering, Camilla Gadgaard, Henrik Vorum, Bent Honore, Martin Fredensborg Rath
Summary: Proteomic analysis of the mouse cerebral cortex revealed approximately 2700 proteins associated with the circadian clock. Among these proteins, 15 showed significant expression differences between day and night in the neocortex, while only 3 in the hippocampus. The deletion of the clock gene Bmal1 led to increased astrocyte activity in the cerebral cortex and behavioral changes.
Letter
Oncology
Maja Ludvigsen, Amanda Jessica Campbell, Marie Beck Enemark, Trine Engelbrecht Hybel, Marja-Liisa Karjalainen-Lindsberg, Klaus Beiske, Mette Bjerre, Lars Moller Pedersen, Harald Holte, Sirpa Leppa, Judit Meszaros Jorgensen, Bent Honore
BLOOD CANCER JOURNAL
(2023)
Article
Immunology
Egle Paskeviciute, Mei Chen, Heping Xu, Bent Honore, Henrik Vorum, Torben Lykke Sorensen, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Mogens Holst Nissen, Maria Abildgaard Steffensen
Summary: Evidence suggests that immune privileged sites such as the CNS and retina may be more involved in the systemic response to infection than previously believed. A study showed that acute virus infection in mice leads to infiltration of CD8 T cells in the brain and retina, independent of virus infection inside the retina. The retina undergoes immune surveillance during systemic infection through mechanisms similar to non-privileged tissues.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Sofie Tilbaek, Ludvig Paul Muren, Anne Vestergaard, Liliana Stolarczyk, Heidi S. Ronde, Tanja S. Johansen, Jimmi Sondergaard, Morten HOyer, Jan Alsner, Lise Norgaard Bentzen, Stine Elleberg Petersen
Summary: The Danish Prostate Cancer Group is conducting a randomized trial comparing photons and protons for the treatment of high-risk prostate cancer. The aim of this study was to establish a feasible and robust strategy for conventionally fractionated proton therapy of the prostate and pelvic lymph nodes in preparation for this trial. Proton treatments are guided by imaging systems and optimized to minimize range uncertainties and reduce gastrointestinal toxicity.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Elnaz Naderi, Miguel E. Aguado-Barrera, Line M. H. Schack, Leila Dorling, Tim Rattay, Laura Fachal, Holly Summersgill, Laura Martinez-Calvo, Ceilidh Welsh, Tom Dudding, Yasmin Odding, Ana Varela-Pazos, Rajesh Jena, David J. Thomson, Roel J. H. M. Steenbakkers, Joe Dennis, Ramon Lobato-Busto, Jan Alsner, Andy Ness, Chris Nutting, Antonio Gomez-Caamano, Jesper G. Eriksen, Steve J. Thomas, Amy M. Bates, Adam J. Webb, Ananya Choudhury, Barry S. Rosenstein, Begona Taboada-Valladares, Carsten Herskind, David Azria, David P. Dearnaley, Dirk de Ruysscher, Elena Sperk, Emma Hall, Hilary Stobart, Jenny Chang-Claude, Kim De Ruyck, Liv Veldeman, Manuel Altabas, Maria Carmen De Santis, Marie-Pierre Farcy-Jacquet, Marlon R. Veldwijk, Matthew R. Sydes, Matthew Parliament, Nawaid Usmani, Neil G. Burnet, Petra Seibold, R. Paul Symonds, Rebecca M. Elliott, Renee Bultijnck, Sara Gutierrez-Enriquez, Meritxell Molla, Sarah L. Gulliford, Sheryl Green, Tiziana Rancati, Victoria Reyes, Ana Carballo, Paula Peleteiro, Paloma Sosa-Fajardo, Chris Parker, Valerie Fonteyne, Kerstie Johnson, Maarten Lambrecht, Ben Vanneste, Riccardo Valdagni, Alexandra Giraldo, Monica Ramos, Brenda Diergaarde, Geoffrey Liu, Suzanne M. Leal, Melvin L. K. Chua, Miranda Pring, Jens Overgaard, Luis M. Cascallar-Caneda, Frederic Duprez, Christopher J. Talbot, Gillian C. Barnett, Alison M. Dunning, Ana Vega, Christian Nicolaj Andreassen, Johannes A. Langendijk, Catharine M. L. West, Behrooz Z. Alizadeh, Sarah L. Kerns
Summary: This study identified shared genetic susceptibility for acute radiation-induced toxicity across different cancer types, with a shared SNV-based heritability estimated at around 10%. Higher heritability rates were found for prostate, head and neck, and breast cancers. Additionally, several potentially associated SNVs and gene sets related to acute toxicity were discovered.
JNCI CANCER SPECTRUM
(2023)
Article
Ophthalmology
Lasse Jorgensen Cehofski, Kentaro Kojima, Natsuki Kusada, Maja Rasmussen, Danson Vasanthan Muttuvelu, Jakob Grauslund, Henrik Vorum, Bent Honore
Summary: Proteomic analysis of aqueous humor in patients with central retinal vein occlusion (CRVO) revealed differential expression of various proteins that correlated with visual acuity and macular edema severity, including fibrinogen, fibronectin, and immunoglobulins.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Review
Medicine, General & Internal
Mads Odgaard Maeng, Nirrooja Roshanth, Anders Kruse, Jonas Ellegaard Nielsen, Benedict Kjaergaard, Bent Honore, Henrik Vorum, Lasse Jorgensen Cehofski
Summary: Retinal vein occlusion (RVO) is a common cause of visual impairment. Treatment of RVO is challenging for clinicians due to the recurrent nature of macular edema and the need for long-term intravitreal injections. Understanding the molecular mechanisms of RVO is essential for improving treatment approaches.
MEDICINA-LITHUANIA
(2023)
Article
Health Care Sciences & Services
Lasse Jorgensen Cehofski, Anders Kruse, Mads Odgaard Maeng, Benedict Kjaergaard, Jakob Grauslund, Bent Honore, Henrik Vorum
Summary: Bevacizumab intervention results in altered levels of retinal proteins, including components of bevacizumab itself. The changes suggest a narrow mechanism of action.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)