Review
Surgery
Hao Deng, Botao Xiong, Yuan Gao, Yang Wu, Wei Wang
Summary: This systematic review and meta-analysis evaluated the effect of combining radiosurgery and immune checkpoint inhibitors in the treatment of brain metastasis. The results showed that combination therapy significantly improved overall survival, local control, and distant brain control compared to radiosurgery alone, but the effect varied for different pathological types.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Review
Oncology
Filippo Gagliardi, Pierfrancesco De Domenico, Silvia Snider, Francesca Roncelli, Edoardo Pompeo, Lina Raffaella Barzaghi, Alessandra Bulotta, Vanesa Gregorc, Chiara Lazzari, Stefano Cascinu, Gaetano Finocchiaro, Pietro Mortini
Summary: The combination of stereotactic radiosurgery with immunotherapy in patients with melanoma and non-small cell lung cancer brain metastases significantly improves overall survival and lesion response, without increasing complications like radionecrosis or hemorrhage.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Eun Jung Lee, Kyu-Sun Choi, Eun Suk Park, Young Hyun Cho
Summary: HF-SRS results in better local control of large BMs and improved overall survival compared to SF-SRS, while simultaneously reducing the incidence of radiation toxicity.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Alejandro Bugarini, Evan Meekins, Joshua Salazar, Andrea L. Berger, Michel Lacroix, Edward A. Monaco III, Andrew R. Conger, Anand Mahadevan
Summary: Neoadjuvant stereotactic radiosurgery (SRS) may reduce the incidence of radionecrosis (RN) and decrease radiation to normal tissue in patients with cerebral metastatic disease. A retrospective analysis of 47 brain metastases patients showed that neoadjuvant SRS was associated with reduced radiotherapy doses, improved conformality profile, and decreased radiation to normal tissue, supporting its use in the treatment of brain metastases.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pyeong Hwa Kim, Chong Hyun Suh, Ho Sung Kim, Kyung Won Kim, Dong Yeong Kim, Ayal A. Aizer, Rifaquat Rahman, Jeffrey P. Guenette, Raymond Y. Huang
Summary: The study compared the incidence of treatment-related necrosis in patients with brain metastases receiving combination SRS+ICI therapy versus SRS therapy alone. Results showed a significantly higher incidence of necrosis in the combination therapy group.
EUROPEAN RADIOLOGY
(2021)
Review
Oncology
Marion Tonneau, Raphaelle Mouttet-Audouard, Florence Le Tinier, Xavier Mirabel, David Pasquier
Summary: SBRT appears to be a safe, effective, and rapid treatment option for palliative patients, as shown by a study on five patients treated with SBRT for IMM.
Review
Oncology
Nima Rostampour, Samireh Badrigilan, Shahab Rezaeian, Parvin Sarbakhsh, Antonio Meola, Jalal Choupani, Amin Doosti-irani, Hossein Nemati, Tinoosh Almasi, Steven D. Chang
Summary: A network meta-analysis and direct comparison of cohort studies were conducted to evaluate the efficacy of stereotactic radiosurgery (SRS) in treating brain metastases (BMs). The results showed that SRS had better overall survival (OS) compared to SRS+whole-brain radiotherapy (WBRT) and WBRT alone. SRS+WBRT also demonstrated improved progression-free survival (PFS), local brain control (LBC), and distant brain control (DBC) compared to WBRT alone and SRS alone. However, there were no significant differences in neurological death (ND) and complications between SRS and other treatment groups. Therefore, SRS alone may be a preferable alternative.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Article
Clinical Neurology
Yuping Derek Li, Andrew T. Coxon, Jiayi Huang, Christopher D. Abraham, Joshua L. Dowling, Eric C. Leuthardt, Gavin P. Dunn, Albert H. Kim, Ralph G. Dacey, Gregory J. Zipfel, John Evans, Eric A. Filiput, Michael R. Chicoine
Summary: Neoadjuvant SRS, as a new treatment paradigm, shows the potential for improved outcomes compared with postoperative SRS, mitigating the limitations of the latter.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
Diana A. Roth O'Brien, Sydney M. Kaye, Phillip J. Poppas, Sean S. Mahase, Anjile An, Paul J. Christos, Benjamin Liechty, David Pisapia, Rohan Ramakrishna, A. G. Wernicke, Jonathan P. S. Knisely, Susan C. Pannullo, Theodore H. Schwartz
Summary: This study evaluated the real-world local recurrence of all brain metastasis patients referred for adjuvant stereotactic radiosurgery (SRS) and identified predictors of SRS timing. The timing of SRS was found to be associated with local recurrence rate and LRFS, with receiving SRS within 4 weeks postoperatively potentially reducing the recurrence rate.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Constantine L. Karras, Pavlos Texakalidis, Jeffrey Z. Nie, S. Joy Trybula, Mark W. Youngblood, Sean Sachdev, Tarita O. Thomas, John Kalapurakal, James P. Chandler, Stephen T. Magill
Summary: This study provides a systematic review and retrospective analysis to evaluate the use of stereotactic radiosurgery (SRS) for foramen magnum meningiomas (FMMs). The results suggest that SRS is an effective and safe treatment option for carefully selected patients with FMMs.
NEUROSURGICAL FOCUS
(2022)
Review
Oncology
Paolo Palmisciano, Gianluca Ferini, Ramlah Khan, Othman Bin-Alamer, Giuseppe E. Umana, Kenny Yu, Aaron A. Cohen-Gadol, Tarek Y. El Ahmadieh, Ali S. Haider
Summary: Pre-operative neoadjuvant stereotactic radiotherapy shows promise as an effective treatment for brain metastases, with comparable rates of local control and overall survival to adjuvant postoperative stereotactic radiotherapy and low rates of treatment-related complications. Ongoing clinical trials aim to further evaluate the long-term outcomes of this treatment approach.
Review
Oncology
Xiang-Lin Tan, Amy Le, Emilie Scherrer, Huilin Tang, Nick Kiehl, Jiali Han, Ruixuan Jiang, Scott J. Diede, Irene M. Shui
Summary: This study provides a summary of clinical outcomes and prognostic factors in melanoma brain metastases (MBM) patients, highlighting the impact of immunotherapy (IO) and stereotactic radiosurgery (SRS) on patient survival.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Kelly H. Yoo, David J. Park, John H. Choi, Neelan J. Marianayagam, Michael Lim, Antonio Meola, Steven D. Chang
Summary: Solid tumors metastasizing to the brain are a common occurrence, and conventional treatments like surgical resection and whole-brain radiotherapy have limitations in long-term survival and local control outcomes. Stereotactic radiosurgery (SRS) has emerged as an alternative approach to improve control rates, and the use of high-dose radiation has sparked interest in eliciting antitumor immunity. The blood-brain barrier has traditionally posed a challenge to systemic therapy, but recent developments in immunotherapy show promise in managing intracranial metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Su Hyun Park, Jiali Yao, Xin Hui Chua, Suresh Rama Chandran, Daphne S. L. Gardner, Chin Meng Khoo, Falk Mueller-Riemenschneider, Clare Whitton, Rob M. van Dam
Summary: We investigated the impact of dietary and physical activity behaviors on blood glucose fluctuations in individuals at high risk for diabetes. The study found that higher BMI, body fat, and markers of hyperglycemia and insulin resistance were linked to higher mean glucose levels over the seven-day period. However, engaging in moderate-to-vigorous physical activity and consuming polyunsaturated fats were associated with less variation in glucose levels, while higher protein and polyunsaturated fat intake were associated with more time-in-range. On the other hand, higher carbohydrate intake was associated with less time-in-range. These findings suggest that a diet high in polyunsaturated fat and protein, along with regular moderate-to-vigorous physical activity, may help reduce glucose fluctuations in individuals at high risk for diabetes.
Review
Medicine, General & Internal
Benny Kai Guo Loo, Benedict Tan, Michael Yong Hwa Chia, Poh Chong Chan, Dinesh Sirisena, Mohammad Ashik Zainuddin, Jean Yin Oh, Oon Hoe Teoh, Teresa Shu Zhen Tan, Micheal Chee Meng Lim, Ethel Jie Kai Lim, Falk Muller-Riemenschneider, Ngiap Chuan Tan, Ratnaporn Siriamornsarp, Terry Chin Chye Teo, Phaik Ling Quah, Victor Samuel Rajadurai, Kok Hian Tan, Kee Chong Ng
Summary: This set of recommendations provides guidance for Singaporean children and adolescents to adopt health-beneficial activities within a 24-hour period.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Public, Environmental & Occupational Health
Yen Sin Koh, P. Asharani, Fiona Devi, Kumarasan Roystonn, Peizhi Wang, Janhavi Ajit Vaingankar, Edimansyah Abdin, Chee Fang Sum, Eng Sing Lee, Falk Muller-Riemenschneider, Siow Ann Chong, Mythily Subramaniam
Summary: This study examined the prevalence of perceived barriers to physical activity in Singapore's adult population and their associations with physical activity and sedentary behavior. Lack of time, fatigue, and pollution were identified as the top barriers. External barriers such as weather and lack of pavements or parks, as well as internal barriers such as age, cost, and fatigue, were found to be associated with physical activity and sedentary behavior.
Article
Nutrition & Dietetics
Airu Chia, Alexandra Descarpentrie, Rene N. Cheong, Jia Ying Toh, Padmapriya Natarajan, Ray Sugianto, Shirong Cai, Cecilia Saldanha-Gomes, Patricia Dargent-Molina, Blandine De Lauzon-Guillain, Sabine Plancoulaine, Carla Lanca, Seang Mei Saw, Keith M. Godfrey, Lynette P. Shek, Kok Hian Tan, Marie-Aline Charles, Yap Seng Chong, Barbara Heude, Johan G. Eriksson, Falk Muller-Riemenschneider, Sandrine Lioret, Mary F-F Chong, Jonathan Y. Bernard
Summary: Integrated patterns of energy balance-related behaviors of preschool children in Asia are sparse. The study characterized lifestyle patterns of children in Singapore and France, identifying three broadly similar patterns. Proximal factors were more common than distal factors, and cohort-specific family-focused contextual factors likely reflect differences in social and cultural settings.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2022)
Article
Sport Sciences
Eun-Young Lee, An-Chi Shih, Maia Collins, Yeong-Bae Kim, Patrick Abi Nader, Jasmin Bhawra, Tarun Reddy Katapally, Chiaki Tanaka, Pairoj Saonuam, Piyawat Katewongsa, Dyah Anantalia Widyastari, Wendy Y. Huang, Stephen H. Wong, Asaduzzaman Khan, Narayan Subedi, Susan Paudel, Chen-Kang Chang, Ching-Lin Wu, Justin Y. Jeon, Yeon Soo Kim, Tom Loney, Falk Muller-Riemenschneider, Bozhi Chen, Jonathan Y. Cagas, Jyh Eiin Wong, Mohd Razif Shahril, Agus Mahendra, Mark S. Tremblay
Summary: This study summarizes the current status and trends of physical activity participation among children and adolescents in 18 Asian countries and identifies existing problems. The findings show that physical activity levels among children and adolescents in the Asian region are low, but there is a growing enthusiasm and support for global physical activity promotion efforts. Therefore, promoting a physically active lifestyle among children and adolescents should be a collective interest and priority in the Asian region.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Public, Environmental & Occupational Health
Gregory Ang, Sarah Martine Edney, Chuen Seng Tan, Nicole Lim, Jeremy Tan, Falk Mueller-Riemenschneider, Cynthia Chen
Summary: Physical inactivity is a global health challenge, and a population-wide mobile health intervention in Singapore (NSC3) was found to be effective in increasing participants' daily step counts. Two booster challenges, Personal Pledge and Corporate Challenge, were associated with additional increases in step counts.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Sport Sciences
Zoey Tay, Bozhi Chen, Kiran Yan Kui, Natarajan Padmapriya, Mary Foong-Fong Chong, Andre Matthias Muller, Eer Ling Lee, Engle Troy, Falk Muller-Riemenschneider
Summary: This article provides an overview of the development of the 2022 Active Healthy Kids Singapore Report Card and its results, as well as highlights limitations and gaps in the available evidence on physical activity among children and adolescents in Singapore. The study used the Global Matrix 4.0 method and synthesized data from various sources. Grades were assigned to different indicators and provide baseline scores for future comparisons. This is the first comprehensive evaluation of physical activity among children and adolescents in Singapore.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Public, Environmental & Occupational Health
Jacqueline Louise Mair, Oscar Castro, Alicia Salamanca-Sanabria, Bea Franziska Frese, Florian von Wangenheim, E. Shyong Tai, Tobias Kowatsch, Falk Mueller-Riemenschneider
Summary: Changing lifestyle patterns in Asia have led to an increase in non-communicable diseases and mental health disorders. Mobile health interventions, including chatbots, may be a cost-effective approach to prevent these conditions. However, understanding end-users' perspectives is crucial for ensuring uptake and engagement with such interventions. This study aimed to explore perceptions, barriers, and facilitators to the use of mobile health interventions for lifestyle behavior change in Singapore.
Article
Nutrition & Dietetics
Karen M. L. Tan, Jolene Chee, Kezlyn L. M. Lim, Maisie Ng, Min Gong, Jia Xu, Felicia Tin, Padmapriya Natarajan, Bee Lan Lee, Choon Nam Ong, Mya Thway Tint, Michelle Z. L. Kee, Falk Muller-Riemenschneider, Peter D. Gluckman, Michael J. Meaney, Mukkesh Kumar, Neerja Karnani, Johan G. Eriksson, Bindu Nandanan, Adrian Wyss, David Cameron-Smith
Summary: The study aimed to investigate the safety and pharmacokinetics of oral beta-cryptoxanthin supplementation over 8 weeks. The results showed that supplementation of 3 or 6 mg/day of beta-cryptoxanthin was safe and well tolerated in healthy women. There was a significant increase in plasma beta-cryptoxanthin concentration in the 6 mg/day group compared to the 3 mg/day group and placebo after 8 weeks, without impacting other carotenoids.
Review
Medicine, General & Internal
Shenglin Zheng, Sarah Martine Edney, Jacqueline Louise Mair, Tobias Kowatsch, Oscar Castro, Alicia Salamanca-Sanabria, Falk Mueller-Riemenschneider
Summary: Maintaining physical and mental health is crucial for healthy ageing and can be achieved by modifying lifestyle factors. Holistic interventions integrating physical activity, diet and mental health may promote healthy ageing. However, evidence on the characteristics and effectiveness of holistic mHealth interventions is limited. This paper presents a protocol for a systematic review aiming to provide an overview of the current evidence for holistic mHealth interventions and their effects on general adult populations.
Article
Public, Environmental & Occupational Health
Alexander Wilhelm Gorny, Jonathan Yap, Jia Wei Neo, Wei En Chow, Khung Keong Yeo, Chuen Seng Tan, Falk Mueller-Riemenschneider
Summary: This study investigated the association between cardiorespiratory fitness, body mass index (BMI), incidence of major acute cardiovascular events (MACE), and all-cause mortality (ACM). The study included 212,631 healthy young men aged 16 to 25 years who had undergone medical examination and fitness testing. Lower cardiorespiratory fitness and higher BMI were associated with increased hazards of MACE and ACM.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Thitikorn Topothai, Viroj Tangcharoensathien, Rapeepong Suphanchaimat, Nicholas Alexander Petrunoff, Orana Chandrasiri, Falk Mueller-Riemenschneider
Summary: This study investigated the prevalence of physical activity and sedentary behavior in the Thai population, as well as their sociodemographic correlates and the contribution of different domains to total physical activity. The findings showed that a significant proportion of the population engaged in sufficient physical activity, but there were also a substantial number of individuals with high levels of sedentary behavior. Policies should focus on promoting transportation and recreational physical activity, as well as activities that break up sedentary behavior.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Health Care Sciences & Services
Xiang Cong Tham, Clare Whitton, Falk Mueller-Riemenschneider, Nicholas Alexander Petrunoff
Summary: This study aimed to investigate the use patterns of mobile food delivery apps (MFDAs) among young adults during the COVID-19 pandemic. The results showed that frequent users of MFDAs were more likely to have unhealthy eating habits, emphasizing the need for interventions to promote healthy dietary patterns in this group. The study also highlighted the importance of public health policies in making healthy food options more affordable and accessible.
JMIR FORMATIVE RESEARCH
(2023)
Review
Health Care Sciences & Services
Benny Kai Guo Loo, Anthony Okely, Rachael Taylor, Rachel Novotny, Pujitha Wickramasinghe, Falk Mueller-Riemenschneider, Gade Waqa, Aman Pulungan, Satoshi Kusuda, Kok Hian Tan
Summary: Early childhood is a crucial period for development and growth. Promoting beneficial lifestyle behaviours during this period can have long-term positive effects on children's health and protect against non-communicable diseases. However, there is a high prevalence of adverse metabolic risk factors and unhealthy lifestyle behaviours among children in the Asia-Pacific region.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Health Care Sciences & Services
Oscar Castro, Jacqueline Louise Mair, Alicia Salamanca-Sanabria, Aishah Alattas, Roman Keller, Shenglin Zheng, Ahmad Jabir, Xiaowen Lin, Bea Franziska Frese, Chang Siang Lim, Prabhakaran Santhanam, Rob M. van Dam, Josip Car, Jimmy Lee, E. Shyong Tai, Elgar Fleisch, Florian von Wangenheim, Lorainne Tudor Car, Falk Mueller-Riemenschneider, Tobias Kowatsch
Summary: This paper describes the development of LvL UP 1.0 & DPRIME, a smartphone-based lifestyle intervention aimed at preventing non-communicable diseases and common mental disorders. The intervention is designed to be scalable and engaging, and it incorporates components such as health literacy coaching, daily activity suggestions, and progress feedback.
FRONTIERS IN DIGITAL HEALTH
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
