Article
Biochemistry & Molecular Biology
Yu-Hung Chen, Kun-Han Lue, Chih-Bin Lin, Kuang-Chi Chen, Sheng-Chieh Chan, Sung-Chao Chu, Bee-Song Chang, Yen-Chang Chen
Summary: This study found that the entropy-based radiogenomic features are more reliable than median-based features, and PET-based glycolytic entropy is insensitive to image matrix size change and significantly associated with tumor metabolic volume and cancer staging. These findings suggest that radiogenomic and glycolytic entropy can serve as ideal biomarkers for NSCLC research and clinical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jun Shao, Jiechao Ma, Shu Zhang, Jingwei Li, Hesen Dai, Shufan Liang, Yizhou Yu, Weimin Li, Chengdi Wang
Summary: Actional mutations and PD-L1 expression are crucial for the precision treatment of lung cancer. Radiogenomics, combining radiologic images and genomic data through artificial intelligence, enables non-invasive assessment of genes. However, most studies in this field are limited to single gene mutation prediction. This study proposes a multi-label multi-task deep learning system that can predict molecular status based on routinely acquired CT images, achieving superior performance in identifying multiple genes simultaneously. This system has the potential to be an auxiliary support tool for precision oncology.
Article
Oncology
Zizong Wang, Yushuai Han, Houquan Tao, Mengxiang Xu, Zhengchuang Liu, Jianhua Zhu, Wei Li, Jie Ma, Zhifang Liu, Weiran Wang, Tonghui Ma
Summary: ALK rearrangement, also known as the 'diamond mutation' in non-small cell lung cancer (NSCLC), plays a crucial role in determining the suitable candidates for ALK inhibitors. In this study, DNA-based next-generation sequencing (NGS) was used to identify ALK rearrangement-positive NSCLC cases and analyze their genomic breakpoints. The findings highlight the necessity of using RNA-based assays to confirm functional RNA fusions in cases with uncommon or frameshift rearrangements.
MOLECULAR ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Haoyue Hu, Songtao Tan, Meng Xie, Peng Guo, Qiang Yu, Juan Xiao, Kangrui Zhao, Qiong Liao, Yi Wang
Summary: In non-small cell lung cancer, concurrent genetic alterations of epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are rare, but their clinical and pathological characteristics are not well-defined, and the optimal treatment approach remains controversial. This report presents a case of stage IV lung adenocarcinoma with both EGFR and ALK mutations, along with high PD-L1 expression. The patient initially received treatment with EGFR tyrosine kinase inhibitors (TKIs), but the disease progressed, and regression was achieved following a switch to ALK-TKI therapy and local radiotherapy. Our report also provides a comprehensive summary of the clinical and pathological features, as well as treatment strategies, for NSCLC patients with concurrent EGFR mutation and ALK rearrangement.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Aaron C. Tan, Nick Pavlakis
Summary: The management of advanced lung cancer has been transformed by the identification of targetable oncogenic driver alterations, including ALK gene rearrangements. ALK tyrosine kinase inhibitors have become the first-line treatment options for advanced ALK rearranged NSCLC. However, drug resistance remains a challenge, and the role of anti-angiogenic therapy in ALK rearranged NSCLC needs further exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marianne Oulhen, Patrycja Pawlikowska, Tala Tayoun, Marianna Garonzi, Genny Buson, Claudio Forcato, Nicolo Manaresi, Agathe Aberlenc, Laura Mezquita, Yann Lecluse, Pernelle Lavaud, Charles Naltet, David Planchard, Benjamin Besse, Francoise Farace
Summary: Gatekeeper mutations are only identified in 50% of cases at resistance to ALK-TKIs. Circulating tumor cells (CTCs) are useful tools in identifying additional resistance mechanisms and can be sequenced at the single-cell level. Comprehensive analysis of CTCs reveals wide copy number alteration (CNA) heterogeneity and high chromosomal instability (CIN) at resistance to ALK-TKIs, providing valuable insights for precision medicine and overcoming resistance to ALK-targeted therapies.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Ines Mota, Enrico Patrucco, Cristina Mastini, Navin R. Mahadevan, Tran C. Thai, Elisa Bergaggio, Taek-Chin Cheong, Giulia Leonardi, Elif Karaca-Atabay, Marco Campisi, Teresa Poggio, Matteo Menotti, Chiara Ambrogio, Dario L. Longo, Susan Klaeger, Hasmik Keshishian, Zsofia M. Sztupinszki, Zoltan Szallasi, Derin B. Keskin, Jonathan S. Duke-Cohan, Bruce Reinhold, Steven A. Carr, Catherine J. Wu, Kelly D. Moynihan, Darrell J. Irvine, David A. Barbie, Ellis L. Reinherz, Claudia Voena, Mark M. Awad, Rafael B. Blasco, Roberto Chiarle
Summary: Mota et al. demonstrate that immunogenic ALK peptides can enhance the response to immune checkpoint blockade in ALK-rearranged NSCLC mouse models. They also identify immunogenic human ALK peptides for future translational research.
Article
Genetics & Heredity
Hua Wang, Yong-Zi Chen, Wan-Hu Li, Ying Han, Qi Li, Zhaoxiang Ye
Summary: This study aimed to identify CT imaging biomarkers based on radiomic features for predicting brain metastases (BM) in patients with ALK-rearranged non-small cell lung cancer (NSCLC). The results showed that radiomic features extracted from pretreatment thoracic CT images can serve as independent predictors of BM and combining them with clinical features improves the accuracy of prediction. The individualized BM-predicting model can be visualized by the nomogram.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Serena Ceddia, Giovanni Codacci-Pisanelli
Summary: Brain metastases are common in patients with ALK-translocated non-small cell lung cancer and are typically treated with radiotherapy. However, this can lead to severe late toxic side effects, prompting the use of ALK inhibitors such as crizotinib, alectinib, and brigatinib which have shown excellent activity against brain metastases. Starting treatment with specific inhibitors in asymptomatic patients and using radiotherapy when needed provides the best quality of life for patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Kamya Sankar, Sunitha Nagrath, Nithya Ramnath
Summary: Non-small cell lung cancer is commonly associated with ALK rearrangements, with approximately 5-6% of cases affected. Although ALK-rearranged tumors respond well to targeted therapies, they are often resistant to immunotherapies. This article explores the mechanisms behind this immune evasion and discusses the potential of novel immunotherapeutic approaches for ALK-rearranged non-small cell lung cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giorgio Maria Agazzi, Marco Ravanelli, Elisa Roca, Daniela Medicina, Piera Balzarini, Carlotta Pessina, William Vermi, Alfredo Berruti, Roberto Maroldi, Davide Farina
Summary: The study aimed to develop a CT texture-based model to predict EGFR-mutated, ALK-rearranged lung adenocarcinomas and distinguish them from wild-type tumors. Results showed that texture analysis, particularly skewness values, could be promising for noninvasive characterization of lung adenocarcinoma with respect to EGFR and ALK mutations, achieving an average accuracy of 81.76% on the validation set.
Review
Oncology
Yu Lei, Yan Lei, Xiang Shi, Jingjing Wang
Summary: Non-small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality rate, and the EML4-ALK fusion gene is one of the most important pathogenic driver genes of NSCLC. With the development of molecular targeted research, the introduction of four generations of targeted drugs for EML4-ALK has significantly benefited patients.
Review
Oncology
Yue Pan, Chao Deng, Zhenhua Qiu, Chenghui Cao, Fang Wu
Summary: This review discusses the resistance mechanisms of ALK TKIs in advanced NSCLC, providing a theoretical basis and research ideas for solving the problem of ALK drug resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mei Elsayed, Farastuk Bozorgmehr, Daniel Kazdal, Anna-Lena Volckmar, Holger Sueltmann, Jurgen R. Fischer, Mark Kriegsmann, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
Summary: The study retrospectively analyzed the treatment flow of 145 ALK(+) NSCLC patients receiving TKI therapy, finding that approximately 25-30% of patients forego subsequent systemic therapy due to rapid clinical deterioration. Most patients died under the first failing therapy, indicating the need for closer patient monitoring and broader profiling to support earlier and better directed use of available therapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Florian Janke, Arlou Kristina Angeles, Anja Lisa Riediger, Simone Bauer, Martin Reck, Albrecht Stenzinger, Marc A. Schneider, Thomas Muley, Michael Thomas, Petros Christopoulos, Holger Sueltmann
Summary: This study demonstrates the potential of DNA methylation biomarkers in prognosis and therapy monitoring of ALK-positive NSCLC patients. The research highlights the suitability of cfDNA methylation as a non-invasive biomarker for tumor detection and its correlation with other genomic alterations.
CLINICAL EPIGENETICS
(2022)
Review
Medicine, General & Internal
Daniel Crawford, Sailen Naidu, Indravadan Patel, Grace Knuttinen, Sadeer Alzubaidi, Rahmi Oklu
Summary: Transarterial embolization shows promise as a safe and effective treatment for benign liver lesions, including hemangiomas, FNH, and HA. However, the response to treatment may vary depending on the tumor type and embolization materials used.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Nicole Segaran, Gia Saini, Joseph L. Mayer, Sailen Naidu, Indravadan Patel, Sadeer Alzubaidi, Rahmi Oklu
Summary: Preoperative planning is crucial for surgical success, and traditional 2D imaging may not accurately depict anatomical structures, leading to the need for innovative solutions like 3D printing.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jingjie Hu, Hassan Albadawi, Zefu Zhang, Marcela A. Salomao, Seyda Gunduz, Suliman Rehman, Luciana D'Amone, Joseph L. Mayer, Fiorenzo Omenetto, Rahmi Oklu
Summary: A novel silk-based embolic material (SEM) has been developed and optimized for embolization and therapeutic drug delivery. In vitro studies show sustained release of drugs from SEM over 28 days, while in vivo experiments demonstrate successful embolization and drug delivery in porcine arteries. SEM has the potential to be a next-generation embolic agent for treating vascular diseases, including tumors.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zefu Zhang, Hassan Albadawi, Richard J. Fowl, Izzet Altun, Marcela A. Salomao, Jama Jahanyar, Brian W. Chong, Joseph L. Mayer, Rahmi Oklu
Summary: Saccular aneurysms are outpouchings from artery walls and have limitations with current treatment options. A nanoclay-based hydrogel, called STH, is developed and shows promising results in preclinical studies, effectively treating saccular aneurysms and potentially changing medical practice.
ADVANCED MATERIALS
(2022)
Article
Urology & Nephrology
John Fasolino, Rahmi Oklu, Jeanne Palmer, Musab S. Hommos
JOURNAL OF NEPHROLOGY
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Haluk B. Sayman, Fatih Gulsen, Sait Sager, Elife Akgun, Nami Yeyin, Seckin Bilgic, Kubra N. Toplutas, Feifei An, Fatih Beytur, Rahmi Oklu, Omer Aras
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Review
Medicine, General & Internal
Sadeer J. Alzubaidi, Harris Liou, Gia Saini, Nicole Segaran, J. Scott Kriegshauser, Sailendra G. Naidu, Indravadan J. Patel, Rahmi Oklu
Summary: Percutaneous image-guided lung ablation, including cryoablation, is considered a promising treatment option for lung tumors, with recent encouraging results in protocol optimization for cryoablation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Sailendra G. Naidu, Harish Narayanan, Gia Saini, Nicole Segaran, Sadeer J. Alzubaidi, Indravadan J. Patel, Rahmi Oklu
Summary: PAE is a novel treatment option for LUTS due to BPH, offering clinical efficacy comparable to TURP but with fewer complications and side effects, without the need for general anesthesia or hospitalization.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Gia Saini, Nicole Segaran, Joseph L. Mayer, Aman Saini, Hassan Albadawi, Rahmi Oklu
Summary: Regenerative medicine focuses on restoring and regenerating damaged tissue, with tissue engineering as an application seeking to create functional tissue components and organs using 3D printing technologies. The use of 3D bioprinting has advanced tissue engineering by creating specialized tissue models, which could improve upon conventional methods.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Kenneth S. Zurcher, Sasha O. Staack, E. Brooke Spencer, Addison Liska, Sadeer J. Alzubaidi, Indravadan J. Patel, Sailendra G. Naidu, Rahmi Oklu, Ryanne A. Dymek, Martha-Gracia Knuttinen
Summary: The pelvic venous system is complex and has various collateral pathways. Knowledge of these pathways is important for diagnosis and treatment of related diseases in the field of medical imaging and surgery.
Review
Radiology, Nuclear Medicine & Medical Imaging
Kenneth S. Zurcher, Mathew Smith, Sailendra G. Naidu, Gia Saini, Indravadan J. Patel, M. Grace Knuttinen, J. Scott Kriegshauser, Rahmi Oklu, Sadeer J. Alzubaidi
Summary: Transsplenic access (TSA) is an effective and safe method for accessing the portal system in patients with contraindications to traditional approaches. It has a high technical success rate and low rate of procedural complications.
Editorial Material
Chemistry, Multidisciplinary
Warren C. W. Chan, Natalie Artzi, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Luis M. Liz-Marzan, Rahmi Oklu, Wolfgang J. Parak
Article
Chemistry, Multidisciplinary
Zefu Zhang, Hassan Albadawi, Richard J. Fowl, Joseph L. Mayer, Brian W. Chong, Rahmi Oklu
Summary: It is shown that instant hemostasis can be achieved by filling the aneurysm sac with a novel biomaterial, rescuing catastrophic bleeding in large-animal models. The optimized gel embolic agent with catheter-injectable and X-ray visible versions outperforms the control groups. The combinatorial approach using gel embolic agent and flow diverter stent may change medical practice and save lives.
ADVANCED MATERIALS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa Rotellini-Coltvet, Alex Wallace, Gia Saini, Sailendra Naidu, Jefferey Scott Kriegshauser, Indravadan Patel, Grace Knuttinen, Sadeer Alzubaidi, Rahmi Oklu
Summary: The study aimed to demonstrate the safety and effectiveness of percutaneous transesophageal gastrostomy (PTEG) as a palliative option for patients with malignant bowel obstructions (MBOs). The study also provided a comprehensive review of PTEG indications, placement technique, and short- and long-term outcomes. The results showed that PTEG is an effective and safe option for improving clinical symptoms and enhancing the quality of life in patients with MBOs.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Automation & Control Systems
Seyda Gunduz, Hassan Albadawi, Rahmi Oklu
Summary: Minimally invasive endovascular interventions are crucial in treating vascular diseases, but facing challenges when adopting an all-endovascular approach. Next-generation smart soft-body robots have the potential to replace existing clinical devices and set the future standards for minimally invasive endovascular therapies.
ADVANCED INTELLIGENT SYSTEMS
(2021)