Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjie Huang, Tingting Quan, Qin Zhao, Shuqi Li, Yi Cai, Jian Zhou, Chao Luo, Guangying Ruan, Chunyan Cui, Shaobo Liang, Haojiang Li, Lizhi Liu
Summary: The study found that the risk of death increased with the number of parapharyngeal subspaces involved. The degree of PPSI is recommended to optimize T3 heterogeneity.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Wenjie Huang, Shuqi Li, Chao Luo, Zhiying Liang, Shumin Zhou, Haojiang Li, Yi Cai, Shaobo Liang, Guangying Ruan, Peiqiang Cai, Lizhi Liu
Summary: MR-detected mandibular nerve involvement (MNI) is a significant prognostic factor for overall survival (OS) in T4 stage nasopharyngeal carcinoma (NPC) patients and it has valuable implications for induction chemotherapy (IC) administration. This retrospective study included 792 biopsy-proven NPC patients without metastasis. Univariate and multivariate analysis showed that MR-detected MNI was strongly associated with OS, and IC treatment had independent favorable effects on OS.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Shao-Bo Liang, Lu-Si Chen, Hai-Yang Chen, Xing-Li Yang, Dong-Hui Wang, Chun-Yan Cui, Chuan-Bo Xie, Li-Zhi Liu, Xiang-Ying Xu
Summary: The study evaluated the impact of prevertebral space involvement (PSI) and tumor extension on prognosis in nasopharyngeal carcinoma patients. Results show that PSI is an independent predictor of poor prognosis, with BPMI patients having lower survival rates than PMI patients, and NPC with PSI should be classified as T4 stage.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Roshini Kulanthaivelu, Andres Kohan, Ricarda Hinzpeter, Zhihui Amy Liu, Andrew Hope, Shao Hui Huang, John Waldron, Brian O'Sullivan, Claudia Ortega, Ur Metser, Patrick Veit-Haibach
Summary: The study examines the prognostic value of clinical and radiomic parameters derived from PET/CT and MR for predicting survival among NPC patients. The results indicate that combined radiomic signatures significantly improve survival prognostication when combined with baseline clinical and MR-based radiomic features.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tingting Quan, Wenlong Guan, Wenjie Huang, Chunyan Cui, Haojiang Li, Guangying Ruan, Lizhi Liu, Qin Zhao, Huali Ma
Summary: This study aimed to investigate the prognostic significance of carotid space involvement (CSI) in patients with nasopharyngeal carcinoma (NPC) and propose a treatment strategy. The study found that CSI was an independent negative prognostic factor for overall survival (OS) in NPC patients without induction chemotherapy (ICT), and it might serve as an imaging marker for identifying eligible candidates for ICT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Huali Ma, Yinyi Qiu, Haojiang Li, Fei Xie, Guangying Ruan, Lizhi Liu, Chunyan Cui, Annan Dong
Summary: Nodal matting was found to be an independent prognostic factor for distant metastasis-free survival in NPC patients, with potential to identify high-risk patients. The nomogram including nodal matting showed higher predictive accuracy compared to the nomogram without it.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Min-Jung Kim, Yangsean Choi, Yeoun Eun Sung, Youn Soo Lee, Yeon-Sil Kim, Kook-Jin Ahn, Min -Sik Kim
Summary: The study demonstrated that integrating MR-based radiomic features with clinical and staging variables significantly improved the prediction of progression-free survival in patients with nasopharyngeal carcinoma. The combination of radiomics with traditional prognostic factors showed enhanced prognostic performance, indicating a promising approach for improving patient outcome prediction in NPC.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Xiao-Yi Wang, Si-Yu Zhu, Wei-Jie Wu, Hao-Jiang Li, Jiao Li, Xiao-Feng Lin, Li Li, Li-Zhi Liu
Summary: Severe paranasal sinus involvement (PSI) is an independent negative prognostic factor in nasopharyngeal carcinoma, and it is recommended to be classified as T4 category in the 8th AJCC staging system for NPC.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Annan Dong, Wenjie Huang, Huali Ma, Chunyan Cui, Jian Zhou, Guangying Ruan, Shaobo Liang, Lizhi Liu, Haojiang Li
Summary: The study found that soft tissue involvement (STI) is an independent prognostic factor for overall survival (OS) and progression-free survival (PFS) in nasopharyngeal carcinoma (NPC) patients and may help improve the accuracy in predicting survival outcomes. Patients with severe STI might benefit from induction chemotherapy (IC) to improve OS.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Ying Bin, Zhen Meng, Lu-Lu Huang, Xue-Ying Hu, Jun-Mei Song, Yi-Ting Xie, Min Kang, Ren-Sheng Wang
Summary: This study aims to investigate the prognostic value of cervical lymph node necrosis (CNN) in patients with nasopharyngeal carcinoma (NPC). The study found that CNN is an adverse prognostic factor in NPC and the CNN ratio may be used as a reference factor in the formulation of individualized treatment plans.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Medicine, General & Internal
Woo-Hyun Lim, Hack-Lyoung Kim, Hyun Sung Joh, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
Summary: This study found that brachial-ankle pulse wave velocity (baPWV) can be used as a predictor of cardiovascular events in individuals with low socioeconomic status (SES). The predictive value of baPWV was stronger in the National Health Insurance Beneficiaries (NHIB) group than in the Medical Aid Beneficiaries (MAB) group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yulin Li, Liang Yue, Yanqing Li, Qinxiu Zhang, Xin Liang
Summary: Meta-analysis revealed that high Ki-67 expression was associated with poorer overall survival, disease-free survival, and local recurrence-free survival in nasopharyngeal carcinoma patients, but not with distant metastasis-free survival.
BIOSCIENCE REPORTS
(2021)
Article
Otorhinolaryngology
Gilad Horowitz, John R. De Almeida, Ilyes Berania, David P. Goldstein, Hugo Fontan Koehler, Luiz Paulo Kowalski, Leandro Luongo Matos, Adi Brenner-Ullman, Dan M. Fliss, Nidal Muhanna, Daniel Halpern, Narin Nard-Carmel, Omer J. Ungar, Anton Warshavsky
Summary: In patients with oral cavity squamous cell carcinoma (OCSCC), masticator space involvement may result in positive surgical margins in tumors extending above the supra-mandibular notch.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Medicine, General & Internal
Donghyuk Kang, Tae Hyun Ban, Ho Jun Chin, Hajeong Lee, Se Won Oh, Cheol Whee Park, Chul Woo Yang, Bum Soon Choi
Summary: This study aimed to predict renal outcomes in patients with IgA nephropathy using chronicity grading, which is closely related to adverse renal outcomes and could provide additional information in clinical practice alongside the Oxford classification.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Veria Vacchiano, Vitantonio Di Stasi, Giovanni Rizzo, Maria Pia Giannoccaro, Vincenzo Donadio, Ilaria Bartolomei, Sabina Capellari, Fabrizio Salvi, Patrizia Avoni, Rocco Liguori
Summary: Needle electromyography (EMG) genioglossus involvement is a prognostic factor in ALS, indicating shorter survival time, earlier onset of swallowing difficulties, and severity of dysarthria. Clinical bulbar lower motor neuron (LMN) signs only lead to earlier onset of swallowing difficulties, while EMG masseter abnormalities are not statistically significant in predicting clinical milestones.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Lan, Ying Huang, Chun-Yan Chen, Fei Han, Shao-Xiong Wu, Li Tian, Lie Zheng, Tai-Xiang Lu
Article
Biotechnology & Applied Microbiology
Guo-Yi Zhang, Yue-Jian Wang, Jian-Ping Liu, Xin-Han Zhou, Zhi-Feng Xu, Xiang-Ping Chen, Tao Xu, Wei-Hong Wei, Yang Zhang, Ying Huang
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Biotechnology & Applied Microbiology
Guo-Yi Zhang, Ying Huang, Xue-Feng Hu, Xiang-Ping Chen, Tao Xu, Li-Zhi Liu, Wei-Hong Wei, Guo-Sen Huang, Miao-Miao Zhou, Ze-Li Huang, Yue-Jian Wang
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Oncology
Yun-ming Tian, Chong Zhao, Ying Guo, Ying Huang, Shao-Min Huang, Xiao-Wu Deng, Cheng-Guang Lin, Tai-xiang Lu, Fei Han
Article
Otorhinolaryngology
Lei Zeng, Xue-Ming Sun, Chun-Yan Chen, Fei Han, Ying Huang, Wei-Wei Xiao, Shuai Liu, Yun-Ming Tian, Xiao-Wu Deng, Tai-Xiang Lu
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2014)
Article
Biochemistry & Molecular Biology
Zhong Guan, Jialiang Zhang, Jing Wang, Hefei Wang, Feimeng Zheng, Jieren Peng, Yaodong Xu, Min Yan, Bing Liu, Bai Cui, Ying Huang, Quentin Liu
Article
Multidisciplinary Sciences
Lei Zeng, Yun-Ming Tian, Ying Huang, Xue-Ming Sun, Feng-Hua Wang, Xiao-Wu Deng, Fei Han, Tai-Xiang Lu
Article
Oncology
Hao Peng, Binbin Chen, Shuiqing He, Li Tian, Ying Huang
Summary: The study results indicated that induction docetaxel plus cisplatin and 5-fluorouracil (TPF) plus concurrent chemoradiotherapy (CRT) and docetaxel plus cisplatin (TP) plus CRT regimens were superior to cisplatin plus 5-fluorouracil (PF) plus CRT in improving the 10-year overall survival of patients with locoregionally advanced nasopharyngeal carcinoma (NPC).
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Cheng Xu, Shu Zhang, Guang-Li Zhu, Kai-Bin Yang, Yuan Zhang, Yan-Ping Mao, Ling-Long Tang, Qing Liu, Ying Huang, Jun Ma
Summary: This study analyzed the disparities in positive results and dissemination patterns of randomized controlled trials (RCTs) in global immuno-oncology (IO). The results showed that positive trials were predominantly sponsored by pharmaceutical companies and focused on immune checkpoint inhibitors (ICIs) and multiple IO therapies. Factors such as recent trial start year, upfront registration, large sample size, strict criteria, and survival endpoints were associated with positive results. Trials from Mainland China had a faster publication timeline of positive results but lacked study diversity or full reporting of negative results compared to US and multinational trials. Positive trials had a shorter publication process, more secondary manuscripts, and better dissemination in high-quality journals compared to negative trials. The study suggests improvements in upfront registration, procedural integrity, and inclusion of rival trials reporting negative results for future IO-related reviews.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Oncology
Yan-Ling Wu, Kai-Bin Yang, Ying Huang, Jing-Rong Shi, Qing-Shui He, Lei Chen, Wen-Fei Li, Xiao-Dan Huang, Li Lin, Yu-Pei Chen, Yan-Ping Mao, Ling-Long Tang, Jun Ma
Summary: This study aimed to identify elderly nasopharyngeal carcinoma (NPC) patients who would benefit from chemotherapy using real-world evidence. The results showed that EBV DNA and T stage can predict the prognosis of patients, and chemoradiotherapy and different forms of chemotherapy can significantly improve overall survival for elderly NPC patients.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Shuiqing He, Yan-Ling Wu, Yongxiang Gao, Danjie He, Ying Huang
Summary: This study aimed to evaluate risk stratification and select beneficiaries from concurrent chemotherapy (CCRT) combined with induction chemotherapy (IC) in elderly Nasopharyngeal carcinoma (NPC) patients. Prognostic nomograms were generated based on clinical characteristics and serum biomarkers. The results showed that IC + CCRT significantly improved 5-year survival rates in the high-risk group, specifically in patients younger than 70 years old. TPF and three IC cycles were recommended for treatment.
Article
Biochemistry & Molecular Biology
Binbin Chen, Ying Huang, Shuiqing He, Peng Yu, Lirong Wu, Hao Peng
Summary: This study reveals that the elevated METTL5/TRMT112 and their mediated m6A modification at the 18S rRNA 1832 site (m6A1832) promote oncogenic transformation in nasopharyngeal carcinoma (NPC). The loss of catalytic activity of METTL5 abolishes its oncogenic functions. Mechanistically, the m6A1832 modification facilitates the assembly of 80S ribosome and promotes the translation of mRNAs with 50 terminal oligopyrimidine (50 TOP) motifs. Furthermore, METTL5 enhances the translation of HSF4b to activate HSP90B1 transcription, which prevents oncogenic mutant p53 (mutp53) protein from degradation and facilitates NPC tumorigenesis and chemoresistance. Overall, this study uncovers an innovative mechanism of rRNA epigenetic modification in cancer.
CELL CHEMICAL BIOLOGY
(2023)
Review
Oncology
Ying Huang, Wei Chen, Bin S. Teh, E. Brian Butler
JOURNAL OF RADIATION ONCOLOGY
(2015)
Meeting Abstract
Oncology
Tongyu Lin, Mengping Zhang, He Huang, Ying Huang, Chengcheng Guo, Xueying Li, Huangming Hong, Xiaojie Fang, Zhao Wang, Xiaoting Lin, Jia Tian Lin, Chaoyong Liang, Tingzhi Liu, Xiaohong Fu, Shanshan Li, Ying Tian, Pram Raj Shrestha, Yabing Cao, Linzhu Zhai, Taixiang Lu
JOURNAL OF CLINICAL ONCOLOGY
(2014)
