Article
Cardiac & Cardiovascular Systems
Christie A. Boswell-Patterson, Marie-France Hetu, Abigail Kearney, Stephen C. Pang, M. Yat Tse, Julia E. Herr, Michaela Spence, Jianhua Zhou, Amer M. Johri
Summary: A novel phantom platform of neovascularized atherosclerotic plaque in the carotid artery was developed in this study, utilizing synthetic plaque models and commercially available technology for quantitative measurement of IPN. The analysis distinguished between neovascularized and calcified plaques, providing objective measures of IPN for improved clinical identification of vulnerable plaques.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shishir Dahal, Aamir Y. Raja, Emily Searle, Frances E. Colgan, Jonathan S. Crighton, Justin Roake, Luca Saba, Steven Gieseg, Anthony P. H. Butler
Summary: This study demonstrated the effectiveness of spectral photon-counting CT (SPCCT) in quantifying fibrous cap thickness, fibrous cap area, and lipid-rich necrotic core area in carotid atherosclerotic plaques.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yukichi Tanahashi, Shinichi Shoda, Hiroshi Kawada, Tomohiro Ando, Shoma Nagata, Masaki Takasu, Fuminori Hyodo, Satoshi Goshima, Takashi Mori, Masayuki Matsuo
Summary: This study evaluated the feasibility and image quality of intranodal dynamic contrast-enhanced CT lymphangiography (DCCTL) and dynamic contrast-enhanced MR lymphangiography (DCMRL) in microminipigs. The results showed that both DCCTL and DCMRL enabled excellent visualization of central lymphatic ducts and lymphatic leakage, indicating the research and clinical potential of both modalities.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
David C. Rotzinger, Virginie Magnin, Allard C. van der Wal, Silke Grabherr, Salah D. Qanadli, Katarzyna Michaud
Summary: Multiphase postmortem CT angiography (PMCTA) can be used to detect plaque enhancement as a surrogate marker of inflammation, providing a noninvasive method for evaluating inflammation in coronary plaques.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Huang, Xue-Qing Cheng, Ya-Ni Liu, Xiao-Jun Bi, You-Bin Deng
Summary: This study aimed to investigate the relationship between carotid plaque enhancement on perfluorobutane microbubble contrast-enhanced ultrasonography (CEUS) and future recurrent stroke, and to determine whether plaque enhancement can contribute to risk assessment for recurrent stroke compared with the Essen Stroke Risk Score (ESRS). The results showed that carotid plaque enhancement was an independent predictor of recurrent stroke and adding plaque enhancement to the ESRS improved risk stratification capability.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yajie Wang, Xiaoming Liu, Yishi Wang, Haikun Qi, Xian Liu, Xiangchuang Kong, Qiang Zhang, Jiaqi Dou, Jing Wang, Huijun Chen
Summary: This study aimed to investigate the effect of contrast injection protocol on carotid artery DCE-MRI and optimize the protocol. Through experiments on a digital model and seven patients, it was found that the protocol with an injection dose of 0.07 mmol/kg and effective injection rate of 0.06 mmol/sec had the smallest relative error and more accurate arterial input function.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Medicine, General & Internal
Ewa Kopyto, Marcin Czeczelewski, Eryk Mikos, Karol Stepniak, Maja Kopyto, Malgorzata Matuszek, Karolina Nieoczym, Adam Czarnecki, Maryla Kuczynska, Mateusz Cheda, Anna Drelich-Zbroja, Tomasz Jargiello
Summary: Carotid contrast-enhanced ultrasound (CEUS) has become increasingly important in evaluating carotid plaque, detecting surface irregularities and ulcerations, as well as intraplaque neovascularization and its alignment with histology. Initial indications suggest that CEUS might have the potential to predict cerebrovascular incidents, but further studies are needed to explore the relationship between CEUS observations and patient clinical outcomes in cases of carotid atherosclerotic disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Acoustics
Yuto Uchihara, Kozue Saito, Rie Motoyama, Hatsue Ishibashi-Ueda, Eriko Yamaguchi, Kinta Hatakeyama, Akito Tanaka, Hiroharu Kataoka, Koji Iihara, Kazuma Sugie, Masatoshi Koga, Kazunori Toyoda, Kazuyuki Nagatsuka, Masafumi Ihara
Summary: This study aimed to assess intraplaque neovessels using contrast-enhanced ultrasound and determine their connection to the vessel lumen histopathologically. Additionally, the study investigated whether plaque vulnerability could be more accurately assessed. The results showed that symptomatic plaques had stronger contrast effects from the luminal side and higher neovessel density compared to asymptomatic plaques.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Clinical Neurology
Yu Wang, Bohong Li, Yong Jiang, Runhua Zhang, Xia Meng, Xingquan Zhao, Yongjun Wang, Xihai Zhao, Gaifen Liu
Summary: This study found a significant association between high levels of YKL-40 and carotid plaque instability, even after adjusting for various risk factors. Individuals with high YKL-40 levels may have a higher risk of unstable carotid plaque.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lana Fani, Dianne H. K. Van Dam-Nolen, Meike Vernooij, Maryam Kavousi, Aad van der Lugt, Daniel Bos
Summary: The study suggests that innate immunity is linked to larger carotid atherosclerotic plaques, while adaptive immunity seems to be associated with smaller plaques and a lower frequency of intraplaque hemorrhage. This imbalance in innate and adaptive immunity may play a role in the vulnerability of carotid atherosclerotic plaques.
Review
Acoustics
Qiuping Li, Miaomiao Cai, Hui Wang, Libo Chen
Summary: This meta-analysis aimed to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) and high-resolution magnetic resonance imaging (HR-MRI) in patients with carotid vulnerable plaques. The study found that the sensitivity of CEUS was higher than that of HR-MRI, and the specificity was similar to HR-MRI. CEUS and HR-MRI showed similar diagnostic yield in detecting vulnerable plaques.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yanqin Guo, Xinghua Wang, Lu Wang, Xiaoli Wei, Yinling Duan, Xiaohuan Yang, Min Zhang, Bin Zhao
Summary: This study compared the consistency between superb microvascular imaging (SMI) and contrast-enhanced ultrasound (CEUS) for the detection of neovascularization in carotid plaques of different thicknesses and evaluated their diagnostic value. The results showed that SMI was able to detect neovascularization in carotid plaques and had good agreement with CEUS.
ACADEMIC RADIOLOGY
(2023)
Article
Computer Science, Software Engineering
Ruitao Zhou, Ruijie Zhou, Zhibo Zhu
Summary: The study demonstrated that ultrasound detection method based on KMC showed high sensitivity, specificity, and accuracy in diagnosing the vulnerability of carotid atherosclerotic plaque (CAA). Additionally, it had a higher detection rate in terms of artery bifurcation and CAA compared to angiography, and patients were more satisfied with this method.
SCIENTIFIC PROGRAMMING
(2021)
Article
Cardiac & Cardiovascular Systems
Janine E. van der Toorn, Daniel Bos, M. Kamran Ikram, Germaine C. Verwoert, Aad van der Lugt, M. Arfan Ikram, Meike W. Vernooij, Maryam Kavousi
Summary: The presence of intraplaque hemorrhage contributes to the prediction of incident ASCVD in women, beyond traditional cardiovascular risk factors, other plaque components, plaque size, and stenosis. However, in men, only carotid stenosis is statistically significantly associated with incident ASCVD, and the addition of other plaque characteristics does not improve the predictive model's performance.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ran Huo, Wanzhong Yuan, Huimin Xu, Dandan Yang, Huiyu Qiao, Hualu Han, Tao Wang, Ying Liu, Huishu Yuan, Xihai Zhao
Summary: This study aimed to investigate the associations between carotid plaque characteristics and postoperative silent stroke (SS) in patients undergoing carotid endarterectomy (CEA). The results showed that the presence and size of intraplaque hemorrhage (IPH), particularly Type-I IPH, were significantly associated with SS in patients with severe carotid stenosis. Additionally, the volume of Type-II IPH, and maximum-area-percentage of Type-II IPH and lipid-rich necrotic core (LRNC) were also significantly associated with SS. However, no significant associations were found between carotid plaque characteristics and SS in patients with moderate carotid stenosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Simon Schalla, Mitch J. F. G. Ramaekers, Elham Bidar, Casper Mihl, Joachim E. Wildberger, Bouke P. Adriaans
Summary: Acute type A aortic dissection (ATAAD) is a life-threatening condition that requires emergency surgery. Patients should undergo regular imaging examinations to evaluate the occurrence of complications.
Article
Cardiac & Cardiovascular Systems
Hedwig M. J. M. Nies, Suzanne Gommers, Geertruida P. Bijvoet, Luuk I. B. Heckman, Frits W. Prinzen, Gaston Vogel, Caroline M. Van de Heyning, Amedeo Chiribiri, Joachim E. Wildberger, Casper Mihl, Robert J. Holtackers
Summary: This study evaluated the performance of various semi-automated techniques for quantifying myocardial infarct size using histopathology as the reference standard. The results showed that the signal threshold vs. reference mean method with a threshold of 5 standard deviations demonstrated the most accurate quantification in both conventional bright-blood and novel dark-blood late gadolinium enhancement (LGE) images.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Pomme I. H. G. Simons, Olivier Valkenburg, Marjo P. H. van de Waarenburg, Marleen M. J. van Greevenbroek, M. Eline Kooi, Jacobus F. A. Jansen, Casper G. Schalkwijk, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers
Summary: Serum SHBG mediates the association between IHL content and type 2 diabetes, with a higher contribution in women.
Article
Cardiac & Cardiovascular Systems
Kim van Kuijk, Ian R. McCracken, Renee J. H. A. Tillie, Sebastiaan E. J. Asselberghs, Dlzar A. Kheder, Stan Muitjens, Han Jin, Richard S. Taylor, Ruud Wichers Schreur, Christoph Kuppe, Ross Dobie, Prakesh Ramachandran, Marion J. Gijbels, Lieve Temmerman, Phoebe M. Kirkwoord, Joris Luyten, Yanming Li, Heidi Noels, Pieter Goossens, John R. Wilson-Kanamori, Leon J. Schurgers, Ying H. Shen, Barend M. E. Mees, Erik A. L. Biessen, Neil C. Henderson, Rafael Kramann, Andrew H. Baker, Judith C. Sluimer
Summary: This study established specific markers for adventitial fibroblasts and analyzed their heterogeneity in response to cardiovascular diseases and risk factors. The findings revealed the functional diversity and gene expression differences among different fibroblast clusters, which are associated with cardiovascular diseases. Therefore, this study is important for understanding cardiovascular diseases and developing targeted therapies.
CARDIOVASCULAR RESEARCH
(2023)
Review
Oncology
Lidewij M. F. H. Neeter, M. M. Quirien. Robbe, Thiemo J. A. van Nijnatten, Maxine S. Jochelson, H. P. J. Raat, Joachim E. Wildberger, Marjolein L. Smidt, Patty J. Nelemans, Marc B. I. Lobbes
Summary: This study compared the diagnostic accuracy of contrast-enhanced mammography (CEM) and standard contrast-enhanced breast magnetic resonance imaging (breast MRI). The results showed that both CEM and breast MRI had high sensitivity and moderate specificity in detecting breast tumors, and the overall diagnostic performance of breast MRI was better than CEM. However, current scientific evidence is insufficient to prematurely consider CEM as an alternative to breast MRI.
Article
Oncology
Cornelis M. de Mooij, Thiemo J. A. van Nijnatten, Briete Goorts, Loes F. S. Kooreman, Isabel W. M. Raymakers, Silke P. L. van Meijl, Maaike de Boer, Kristien B. M. I. Keymeulen, Joachim E. Wildberger, Felix M. Mottaghy, Marc B. I. Lobbes, Marjolein L. Smidt
Summary: This study investigated the feasibility of sequential hybrid [18F]FDG PET/MRI in predicting the treatment response in breast cancer patients undergoing neoadjuvant chemo(targeted) therapy. The qualitative or quantitative evaluation of PET/MRI after therapy was found to be unreliable in predicting the response of the primary tumor and axillary lymph nodes. However, combining the relative decrease in PET and MR imaging variables halfway through therapy improved the diagnostic accuracy, especially for predicting the response of axillary lymph nodes. These findings suggest that sequential hybrid [18F]FDG PET/MRI may have complementary value in the early prediction of treatment response in breast cancer.
Review
Radiology, Nuclear Medicine & Medical Imaging
Thomas Sartoretti, Joachim E. Wildberger, Thomas Flohr, Hatem Alkadhi
Summary: Since the 1970s, X-ray CT has become a significant diagnostic imaging technology in modern medicine, thanks to technological advances improving image quality and diagnostic value. Photon-counting detector (PCD)-CT, a novel technology, has emerged with the potential to overcome limitations of current CT systems and offer improved capabilities. This review summarizes the first clinical experience of PCD-CT, focusing on recent prototypes and clinically approved systems, presenting initial publications and corresponding clinical cases.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohamed Kassem, Kelly P. H. Nies, Ellen Boswijk, Jochem van der Pol, Mueez Aizaz, Marion J. J. Gijbels, Debiao Li, Jan Bucerius, Werner H. Mess, Joachim E. Wildberger, Robert J. van Oostenbrugge, Rik P. M. Moonen, Zhaoyang Fan, M. Eline Kooi
Summary: This study compares the quantification of plaque composition with MATCH and multi-sequence MRI. The results show that MATCH can effectively quantify LRNC and IPH, but is not effective for calcifications. MATCH has the advantage of shorter scan time and inherent co-registration, despite lower image quality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mitch J. F. G. Ramaekers, Jos J. M. Westenberg, Bouke P. Adriaans, Estelle C. Nijssen, Joachim E. Wildberger, Hildo J. Lamb, Simon Schalla
Summary: Four-dimensional flow magnetic resonance imaging is a promising technique for diagnosing and stratifying the risk of aortic disease. This review aims to provide clinicians with a guide to the basics of flow imaging, commonly used flow-related parameters, and their relevance in the context of aortic disease.
INSIGHTS INTO IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Berta H. Ganizada, Koen D. Reesink, Shaiv Parikh, Mitch J. F. G. Ramaekers, Asim C. Akbulut, Pepijn J. M. H. Saraber, Gijs P. Debeij, Ehsan MUMC TAA Student Team, Armand M. Jaminon, Ehsan Natour, Roberto Lorusso, Joachim E. Wildberger, Barend Mees, Geert Willem Schurink, Michael J. Jacobs, Jack Cleutjens, Ingrid Krapels, Alexander Gombert, Jos G. Maessen, Ryan Accord, Tammo Delhaas, Simon Schalla, Leon J. Schurgers, Elham Bidar
Summary: Current management guidelines for ascending thoracic aortic aneurysms (aTAA) suggest intervention once the diameter reaches 5-5.5 cm or shows a growth rate of >0.5 cm/year. However, aTAA dissections (aTAAD) often occur in vessels with diameters below the surgical intervention threshold. To improve understanding of aTAA pathophysiology, the MAPEX platform focuses on the interactions between vascular smooth muscle cells and extracellular matrix, aiming to narrow knowledge gaps and improve diagnostic and prognostic possibilities.
Article
Computer Science, Information Systems
Elizaveta Lavrova, Zohaib Salahuddin, Henry C. Woodruff, Mohamed Kassem, Robin Camarasa, Anja G. Der Van Kolk, Paul J. Nederkoorn, Daniel Bos, Jeroen Hendrikse, M. Eline Kooi, Philippe Lambin
Summary: We propose a fully automated method for carotid artery outer wall segmentation in black blood MRI using partially annotated data and compare it to state-of-the-art reference model. Our method achieves state-of-the-art results, outperforming top-ranked methods, with a Dice similarity coefficient of 91.7% and volumetric intraclass correlation of 0.90 on development data and 91.1% and 0.83 on external data. The uncertainty-based approach increases interpretability of the proposed method by providing an uncertainty map together with the segmentation.
Article
Clinical Neurology
Mohamed Kassem, Genevieve A. J. C. Crombag, Jens Stegers, Madieke I. Liem, Eline Koornstra, Floris H. B. M. Schreuder, Dianne H. K. van Dam-Nolen, Carlo Lucci, Rob J. van der Geest, Mat J. Daemen, Anton F. W. van der Steen, Jeroen Hendrikse, Werner H. Mess, Daniel Bos, Joachim E. Wildberger, Robert J. van Oostenbruggeb, Paul J. Nederkoorn, M. Eline Kooi
Summary: This study found that previous antiplatelet therapy is associated with the presence of IPH, but the initiation of antiplatelet therapy after TIA/stroke is not associated with the development of new IPH or progression of IPH volume over the subsequent two years.
CEREBROVASCULAR DISEASES
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Chemaly, D. Marlevi, M. -J. Iglesias, M. Lengquist, M. Kronqvist, D. Bos, D. H. K. Van Dam-Nolen, A. Van Der Kolk, J. Hendrikse, M. Kassem, L. Matic, J. Odeberg, M. R. De Vries, M. E. Kooi, U. Hedin
Article
Computer Science, Artificial Intelligence
Robin Camarasa, Hoel Kervadec, M. Eline Kooi, Jeroen Hendrikse, Paul J. Nederkoorn, Daniel Bos, Marleen de Bruijne
Summary: Most current deep learning based approaches for image segmentation require annotations of large datasets. This study proposes a method that optimizes a deep learning model based on diameter annotations to segment multiple nested star-shaped objects, showing good performance in experiments.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. C. Nijssen, P. J. Nelemans, R. J. Rennenberg, G. van Ommen, J. E. Wildberger
Summary: According to the latest ESUR contrast media guidelines, standard prophylaxis is no longer recommended for patients with moderate chronic kidney disease (CKD). The guideline updates are based on indirect evidence and expert opinion, as there is limited direct evidence supporting the withdrawal of standard prophylaxis in moderate CKD patients. The updated guideline recommendation has shown substantial benefits for patients and hospitals in terms of burden reduction.
EUROPEAN RADIOLOGY
(2023)