Alzheimer Disease: New Concepts on Its Neurobiology and the Clinical Role Imaging Will Play

Microstructural Diffusion Changes are Independent of Macrostructural Volume Loss in Moderate to Severe Alzheimer's Disease

(2017) Elisa Canu et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Transforming cerebrospinal fluid Aβ42 measures into calculated Pittsburgh compound B units of brain Aβ amyloid

(2011) Stephen D. Weigand et al.   Alzheimers & Dementia

Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer’s disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Amyloid-beta plaque growth in cognitively normal adults: Longitudinal [11C]Pittsburgh compound B data

(2011) Andrei G. Vlassenko et al.   ANNALS OF NEUROLOGY

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

Role of Family History for Alzheimer Biomarker Abnormalities in the Adult Children Study

(2011) Chengjie Xiong   ARCHIVES OF NEUROLOGY

Effect of APOE ε4 Status on Intrinsic Network Connectivity in Cognitively Normal Elderly Subjects

(2011) Mary M. Machulda   ARCHIVES OF NEUROLOGY

Longitudinal Patterns of β-Amyloid Deposition in Nondemented Older Adults

(2011) Jitka Sojkova et al.   ARCHIVES OF NEUROLOGY

Evidence for Ordering of Alzheimer Disease Biomarkers

(2011) Clifford R. Jack   ARCHIVES OF NEUROLOGY

Using Positron Emission Tomography and Florbetapir F 18 to Image Cortical Amyloid in Patients With Mild Cognitive Impairment or Dementia Due to Alzheimer Disease

(2011) Adam S. Fleisher   ARCHIVES OF NEUROLOGY

Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease

(2011) Bradley T. Hyman   ARCHIVES OF NEUROLOGY

Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer’s disease

(2011) Gaël Chételat et al.   BRAIN

Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition

(2011) Prashanthi Vemuri et al.   BRAIN

Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden

(2011) Alexander Drzezga et al.   BRAIN

Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging

(2011) Elizabeth C. Mormino et al.   CEREBRAL CORTEX

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias

(2011) V. L. Villemagne et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

(2011) Henryk Barthel et al.   LANCET NEUROLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Multi-template tensor-based morphometry: Application to analysis of Alzheimer's disease

(2011) Juha Koikkalainen et al.   NEUROIMAGE

Accurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry

(2011) Xue Hua et al.   NEUROIMAGE

Algorithms, atrophy and Alzheimer's disease: Cautionary tales for clinical trials

(2011) Nick C. Fox et al.   NEUROIMAGE

Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND

(2011) Prashanthi Vemuri et al.   NEUROIMAGE

Default mode network connectivity in stable vs progressive mild cognitive impairment

(2011) J. R. Petrella et al.   NEUROLOGY

Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

(2011) Y. Chen et al.   NEUROLOGY

Amyloid PET imaging in patients with mild cognitive impairment: A 2-year follow-up study

(2011) J. Koivunen et al.   NEUROLOGY

Age-related changes in the default mode network are more advanced in Alzheimer disease

(2011) D. T. Jones et al.   NEUROLOGY

Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer’s Disease

(2011) Laurence O'Dwyer et al.   PLoS One

Multicenter stability of diffusion tensor imaging measures: A European clinical and physical phantom study

(2011) Stefan J. Teipel et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Classification of Alzheimer Disease, Mild Cognitive Impairment, and Normal Cognitive Status with Large-Scale Network Analysis Based on Resting-State Functional MR Imaging

(2011) Gang Chen et al.   RADIOLOGY

Testing the Right Target and Right Drug at the Right Stage

(2011) R. A. Sperling et al.   Science Translational Medicine

2010 Alzheimer's disease facts and figures

(2010)   Alzheimers & Dementia

Update on the Magnetic Resonance Imaging core of the Alzheimer's Disease Neuroimaging Initiative

(2010) Clifford R. Jack et al.   Alzheimers & Dementia

Measuring cognitive reserve based on the decomposition of episodic memory variance

(2010) B. R. Reed et al.   BRAIN

Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer’s disease

(2010) Juan Zhou et al.   BRAIN

Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment

(2010) M. Gallagher et al.   Current Alzheimer Research

APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF A 42

(2010) Y. I. Sheline et al.   JOURNAL OF NEUROSCIENCE

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

(2010) Harald Hampel et al.   NATURE REVIEWS DRUG DISCOVERY

Automated MRI measures predict progression to Alzheimer's disease

(2010) Rahul S. Desikan et al.   NEUROBIOLOGY OF AGING

The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort

(2010) A. Caroli et al.   NEUROBIOLOGY OF AGING

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease

(2010) Walter Koch et al.   NEUROBIOLOGY OF AGING

Measurement of hippocampal atrophy using 4D graph-cut segmentation: Application to ADNI

(2010) Robin Wolz et al.   NEUROIMAGE

Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging

(2010) Duygu Tosun et al.   NEUROIMAGE

High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

(2010) Michael A. Yassa et al.   NEUROIMAGE

Serial MRI and CSF biomarkers in normal aging, MCI, and AD

(2010) P. Vemuri et al.   NEUROLOGY

Distinct cerebral perfusion patterns in FTLD and AD

(2010) W. T. Hu et al.   NEUROLOGY

Resting Brain Connectivity: Changes during the Progress of Alzheimer Disease

(2010) Hong-Ying Zhang et al.   RADIOLOGY

White Matter Damage in Alzheimer Disease and Its Relationship to Gray Matter Atrophy

(2010) Federica Agosta et al.   RADIOLOGY

Examination of default mode network activity along the cognitive continuum: Normal aging, MCI and AD

(2009) Mary M. Machulda et al.   Alzheimers & Dementia

Diffusion Tensor Imaging of the Posterior Cingulate is a Useful Biomarker of Mild Cognitive Impairment

(2009) Terence C. Chua et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

The neuropathology of probable Alzheimer disease and mild cognitive impairment

(2009) Julie A. Schneider et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Mild Cognitive Impairment

(2009) Ronald C. Petersen et al.   ARCHIVES OF NEUROLOGY

Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid

(2009) Timo Grimmer et al.   BIOLOGICAL PSYCHIATRY

Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

(2009) Yvette I. Sheline et al.   BIOLOGICAL PSYCHIATRY

MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers

(2009) N. Schuff et al.   BRAIN

Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index

(2009) C. Davatzikos et al.   BRAIN

White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI

(2009) Y. Zhang et al.   BRAIN

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

(2009) Clifford R. Jack et al.   BRAIN

CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment

(2009) Niklas Mattsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden

(2009) T. Hedden et al.   JOURNAL OF NEUROSCIENCE

Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

(2009) R. L. Buckner et al.   JOURNAL OF NEUROSCIENCE

Relationship of Cerebrospinal Fluid Markers to 11C-PiB and 18F-FDDNP Binding

(2009) N. Tolboom et al.   JOURNAL OF NUCLEAR MEDICINE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: An ADNI study of 515 subjects

(2009) Xue Hua et al.   NEUROIMAGE

Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups

(2009) Adam S. Fleisher et al.   NEUROIMAGE

Impairment and compensation coexist in amnestic MCI default mode network

(2009) Zhigang Qi et al.   NEUROIMAGE

Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: Tissue-specific intensity normalization and parameter selection

(2009) Kelvin K. Leung et al.   NEUROIMAGE

MRI and CSF biomarkers in normal, MCI, and AD subjects: Diagnostic discrimination and cognitive correlations

(2009) P. Vemuri et al.   NEUROLOGY

Relationships between biomarkers in aging and dementia

(2009) W. J. Jagust et al.   NEUROLOGY

MRI and CSF biomarkers in normal, MCI, and AD subjects: Predicting future clinical change

(2009) P. Vemuri et al.   NEUROLOGY

Risk of dementia in MCI: Combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS

(2009) K. Kantarci et al.   NEUROLOGY

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Neurodegenerative Diseases Target Large-Scale Human Brain Networks

(2009) William W. Seeley et al.   NEURON

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

(2009) Reisa A. Sperling et al.   NEURON

Age, Neuropathology, and Dementia

(2009) George M. Savva et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subregional neuroanatomical change as a biomarker for Alzheimer's disease

(2009) D. Holland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diffusion tensor changes in patients with amnesic mild cognitive impairment and various dementias

(2009) Ta-Fu Chen et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Interaction of Neuritic Plaques and Education Predicts Dementia

(2008) Catherine M. Roe et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease

(2008) J.B. Brewer et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Alzheimer Disease and Cognitive Reserve

(2008) Catherine M. Roe et al.   ARCHIVES OF NEUROLOGY

Automatic classification of MR scans in Alzheimer's disease

(2008) S. Kloppel et al.   BRAIN

Episodic memory loss is related to hippocampal-mediated  -amyloid deposition in elderly subjects

(2008) E. C. Mormino et al.   BRAIN

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

(2008) Clifford R. Jack et al.   BRAIN

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

White matter tract integrity in aging and Alzheimer's disease

(2008) Jessica S. Damoiseaux et al.   HUMAN BRAIN MAPPING

The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods

(2008) Clifford R. Jack et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

One-hit stochastic decline in a mechanochemical model of cytoskeleton-induced neuron death III: Diffusion pulse death zones

(2008) Tatiana Lomasko et al.   JOURNAL OF THEORETICAL BIOLOGY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

White matter pathology isolates the hippocampal formation in Alzheimer's disease

(2008) D.H. Salat et al.   NEUROBIOLOGY OF AGING

Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage

(2008) Prashanthi Vemuri et al.   NEUROIMAGE

Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects

(2008) Xue Hua et al.   NEUROIMAGE

Multimodal imaging in mild cognitive impairment: Metabolism, morphometry and diffusion of the temporal–parietal memory network

(2008) K.B. Walhovd et al.   NEUROIMAGE

The cortical signature of prodromal AD: Regional thinning predicts mild AD dementia

(2008) A. Bakkour et al.   NEUROLOGY

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

MRI correlates of neurofibrillary tangle pathology at autopsy: A voxel-based morphometry study

(2008) J. L. Whitwell et al.   NEUROLOGY

Neuropathological basis of magnetic resonance images in aging and dementia

(2007) William J. Jagust et al.   ANNALS OF NEUROLOGY

CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease

(2007) Niki S.M. Schoonenboom et al.   NEUROBIOLOGY OF AGING

PET imaging of amyloid deposition in patients with mild cognitive impairment

(2007) Anton Forsberg et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease diagnosis in individual subjects using structural MR images: Validation studies

(2007) Prashanthi Vemuri et al.   NEUROIMAGE

Interpreting scan data acquired from multiple scanners: A study with Alzheimer's disease

(2007) Cynthia M. Stonnington et al.   NEUROIMAGE