Article
Multidisciplinary Sciences
Elisabeth Solana, Eloy Martinez-Heras, Victor Montal, Eduard Vilaplana, Elisabet Lopez-Soley, Joaquim Radua, Nuria Sola-Valls, Carmen Montejo, Yolanda Blanco, Irene Pulido-Valdeolivas, Maria Sepulveda, Magi Andorra, Joan Berenguer, Pablo Villoslada, E. H. Martinez-Lapiscina, Ferran Prados, Albert Saiz, Juan Fortea, Sara Llufriu
Summary: In multiple sclerosis, the diffusion rate and volume changes of gray matter show differential spatial predominance in different brain regions as the disease progresses. Furthermore, microstructural integrity loss and atrophy at different stages are associated with white matter lesion load and physical and cognitive disability.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
J. A. Kimpton, D. Batalle, M. L. Barnett, E. J. Hughes, A. T. M. Chew, S. Falconer, J. D. Tournier, D. Alexander, H. Zhang, A. D. Edwards, S. J. Counsell
Summary: The study explored the microstructural maturation of white matter in preterm neonates using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics, finding that NODDI provides more accurate estimations of neurite architecture compared to DTI. Through analyzing DTI and NODDI metrics, the researchers discovered asynchronous white matter maturation within and between tracts in preterm neonates with normal neurodevelopmental outcomes.
Article
Nutrition & Dietetics
Antonios Gounaris, Rozeta Sokou, Martha Theodoraki, Eleni Gounari, Polytimi Panagiotounakou, George Antonogeorgos, Georgios Ioakeimidis, Stavroula Parastatidou, Aikaterini Konstantinidi, Ioanna N. Grivea
Summary: This study found that aggressive and individualized feeding policies for very preterm neonates during hospitalization did not significantly affect their BMI and obesity rates at ages 2 and 8 years.
Article
Multidisciplinary Sciences
Matthias W. Wagner, Delvin So, Ting Guo, Lauren Erdman, Min Sheng, S. Ufkes, Ruth E. Grunau, Anne Synnes, Helen M. Branson, Vann Chau, Manohar M. Shroff, Birgit B. Ertl-Wagner, Steven P. Miller
Summary: This study aims to predict adverse neurodevelopmental outcomes in very preterm neonates. By using brain MRI and extracting radiomic features, it was found that radiomic features outperformed clinical variables in predicting motor outcomes, and combining the two improved predictive performance.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lewis Winning, Celine De Looze, Silvin P. Knight, Daniel Carey, James F. Meaney, Rose Anne Kenny, Brian O'Connell
Summary: Tooth loss is associated with regional grey matter volume (GMV) in community dwelling older men and women from Ireland. Participants with 1-19 teeth and >20 teeth showed increased GMV in the paracentral lobule and cuneus cortex compared to edentates. This finding may provide a potential explanatory link to the association between tooth loss and cognitive decline.
JOURNAL OF DENTISTRY
(2023)
Article
Obstetrics & Gynecology
Leilah D. Zahedi-Spung, Nandini Raghuraman, George A. Macones, Alison G. Cahill, Joshua Rosenbloom
Summary: Cesarean delivery for very preterm neonates may decrease the risk of death in the delivery room or within 24 hours post-delivery, but is not associated with an improvement in overall morbidity or mortality.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Neurosciences
Xinting Ge, Yuanjie Zheng, Yuchuan Qiao, Ningning Pan, Julia Pia Simon, Mitchell Lee, Wenjuan Jiang, Hosung Kim, Yonggang Shi, Mengting Liu
Summary: Premature birth may lead to asymmetric impairment in hippocampal development, with smaller volumes observed in the right hippocampi of premature infants. Lower thickness of the hippocampal head was found in both hemispheres for preterm neonates, and a more pronounced age-related change in hippocampal thickness was observed in the left hippocampi. In addition, the structural covariance between the left hippocampi and the limbic lobe was severely impaired in premature infants.
Article
Nutrition & Dietetics
Antonios K. K. Gounaris, Rozeta Sokou, Eleni A. A. Gounari, Polytimi Panagiotounakou, Ioanna N. N. Grivea
Summary: There is an ongoing debate about the optimal feeding mode and growth standard for very premature neonates (VPN) over the last few decades. Despite the American Academy of Pediatrics' declaration, differences in opinion and changing feeding policies still exist. Even the appropriate terminology for expressing poor postnatal growth remains a subject of discussion. Recent publications and position papers emphasize the importance of implementing breast milk fortification, monitoring growth, adjusting nutrition, and providing targeted nutritional support to achieve optimal growth for VPN. Adoption of a universal protocol for nutrition and growth is necessary for better long-term monitoring and outcomes.
Review
Pediatrics
Megan Dibble, Jin Zhe Ang, Liam Mariga, Eleanor J. Molloy, Arun L. W. Bokde
Summary: White matter abnormalities, as measured by diffusion tensor imaging, are more significant in very preterm infants compared to moderate-late preterm infants and full-term controls at term-equivalent age. These microstructural changes may contribute to the increased risk of neurodevelopmental disability in preterm infants later in life, making diffusion tensor imaging a potentially useful prognostic tool.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Katherine Ann Bell, Lillian G. Matthews, Sara Cherkerzian, Anna K. Prohl, Simon K. Warfield, Terrie E. Inder, Shun Onishi, Mandy B. Belfort
Summary: This study found that lean mass was associated with larger brain volume and differences in white matter microstructure among very preterm infants at term equivalent age, suggesting that lean mass growth may index brain growth and development.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Clinical Neurology
Dalit Cayam-Rand, Ting Guo, Anne Synnes, Vann Chau, Connor Mabbott, Isabel Benavente-Fernandez, Ruth E. Grunau, Steven P. Miller
Summary: In very preterm-born children, neonatal thalamic growth and WMI volume predict school-age thalamic volumes. An interaction between FA and WMI impacts school-age thalamic volume, affecting cognition and motor outcomes.
ANNALS OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Szala-Pozdziej, Anna S. S. Swierzko, Gabriela Gajek, Maja Kufelnicka-Babout, Karolina Chojnacka, Paulina Kobiela, Dariusz Jarych, Katarzyna Sobczuk, Jan Mazela, Iwona Domzalska-Popadiuk, Jaroslaw Kalinka, Hideharu Sekine, Misao Matsushita, Maciej Cedzynski
Summary: This study explored the relationship between single nucleotide polymorphisms (SNPs) in the promoter region of the FCN2 gene and clinical complications in preterm babies. The results showed that certain SNPs were associated with very low birthweight (VLBW) and gestational age, suggesting that ficolin-2 is an important factor in fetal development and intrauterine growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Pratheek S. S. Bobba, Clara F. F. Weber, Adrian R. Acuna Higaki, Pratik Mukherjee, Dustin Scheinost, R. Todd Constable, Laura Ment, Sarah N. N. Taylor, Seyedmehdi Payabvash
Summary: Birth weight and postnatal weight gain of very preterm infants are associated with white matter maturation, especially in the corpus callosum and sagittal striatum. These neuroimaging metrics can be potential biomarkers for early nutritional interventions in brain development of VPIs.
JOURNAL OF NEUROIMAGING
(2023)
Article
Psychiatry
Stuart B. Murray, Christina J. Duval, Ane A. Balkchyan, Ryan P. Cabeen, Jason M. Nagata, Arthur W. Toga, Steven J. Siegel, Kay Jann
Summary: Early-onset binge eating disorder (BED) may be characterized by diffuse morphological abnormalities in gray matter density, suggesting alterations in cortical architecture which may reflect decreased synaptic pruning and arborization, or decreased myelinated fibers and therefore inter-regional afferents.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Rebecca G. Brenner, Christopher D. Smyser, Rachel E. Lean, Jeanette K. Kenley, Tara A. Smyser, Peppar E. P. Cyr, Joshua S. Shimony, Deanna M. Barch, Cynthia E. Rogers
Summary: The study found that aberrations in the anterior portion of the right cingulum bundle may underlie the early development of the preterm behavioral phenotype in very preterm infants, providing a foundation for future investigations into the role of the anterior cingulum in the development of psychopathology in this population.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Yin Ming Kwan, Achire Mbanwi, Nicholas Cofie, Christina Rogoza, Omar Islam, Andrew D. Chung, Nancy Dalgarno, Damon Dagnone, Xi Wang, Ben Mussari
Summary: This report describes the implementation of a competency-based medical education curriculum in the Queen's University Diagnostic Radiology Residency Program. The curriculum was developed using the RCPSC competency continuum and CanMEDS framework, with new committees and assessment strategies established. Challenges include increased resident assessments, establishing learner expectations, and creating guidelines for case reporting and procedures.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2021)
Article
Multidisciplinary Sciences
Antara Chatterjee, Rojan Saghian, Anna Dorogin, Lindsay S. Cahill, John G. Sled, Stephen Lye, Oksana Shynlova
Summary: The cervix plays a crucial role in maintaining pregnancy and its timely remodeling is essential for proper delivery. Cervical insufficiency may lead to preterm birth, with detrimental effects on infant health worldwide. Using a mouse model, researchers studied the cervical structure through histology, immunohistochemistry, and MRI imaging, revealing distinct differences between the endocervix and ectocervix. MRI detected three specific zones in the pregnant mouse endocervix, and diffusion MRI showed potential for non-invasive monitoring of cervical changes preceding labor in women at risk for preterm delivery.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Leah Paranavitana, Melissa Walker, Anjana Ravi Chandran, Natasha Milligan, Shiri Shinar, Clare L. Whitehead, Sebastian R. Hobson, Lena Serghides, W. Tony Parks, Ahmet A. Baschat, Christopher K. Macgowan, John G. Sled, John C. Kingdom, Lindsay S. Cahill
Summary: The study found that there is no difference in uterine artery pulsatility index (PI) between female and male fetuses in normal pregnancies, but in complicated pregnancies (preeclampsia, preterm birth, or fetal growth restriction), the trajectory of PI varies by fetal sex, with male fetuses showing a more progressive deterioration in uteroplacental perfusion over gestation. This highlights the importance of considering fetal sex when interpreting hemodynamic markers of placental maturation, as observed through changes in uterine artery PI.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Endocrinology & Metabolism
Dakshita Jagota, Hannah George, Melissa Walker, Anjana Ravi Chandran, Natasha Milligan, Shiri Shinar, Clare L. Whitehead, Sebastian R. Hobson, Lena Serghides, W. Tony Parks, Ahmet A. Baschat, Christopher K. Macgowan, John G. Sled, John C. Kingdom, Lindsay S. Cahill
Summary: The study showed that in healthy pregnancies, Doppler ultrasound parameters for some vessels are dependent on fetal sex, while for others they are not. Further research is needed to understand the physiological mechanisms behind these sex differences and their relevance for disease processes in pregnancy.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Immunology
Ellinore R. Doroshenko, Paulina C. Drohomyrecky, Annette Gower, Heather Whetstone, Lindsay S. Cahill, Milan Ganguly, Shoshana Spring, Tae Joon Yi, John G. Sled, Shannon E. Dunn
Summary: The study found that PPAR-delta plays a crucial role in microglia in limiting bystander tissue damage during neuroinflammation. Deficiency of PPAR-delta may lead to exacerbated neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kevin Cheung, Christina Rogoza, Andrew D. Chung, Benjamin Yin Ming Kwan
Summary: This study investigated the additional administrative burden of assessments in the competency-based medical education system. The results showed that the time spent on assessments was relatively small, suggesting that the added burden may be reasonable.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Arsalan P. Rizwan, Nicholas Cofie, Benedetto Mussari, Andrew D. Chung, Benjamin Y. M. Kwan
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew D. Chung, Benjamin Y. M. Kwan, Natalie Wagner, Heather Braund, Tessa Hanmore, Andrew Koch Hall, Laura McEwan, Nancy Dalgarno, Jeffrey Damon Dagnone
Summary: The study evaluated the Queen's University diagnostic radiology residency program after transitioning to a competency-based medical education (CBME) curriculum using Rapid Evaluation methodology. Strengths of CBME implementation included more frequent and timely feedback and the role of the Academic Advisor, but frontline faculty felt unsupported in theory and practical implementation of the new curriculum. Improvement areas identified were additional faculty and resident education workshops and changes to assessment tools for increased clarity. Residents overall viewed the changes favorably, with a desire for increased feedback among traditional stream residents.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andres Camacho, Andrew D. Chung, Francesca Rigiroli, Mehmet Ali Sari, Alexander Brook, Bettina Siewert, Muneeb Ahmed, Olga Rachel Brook
Summary: This study aims to evaluate the impact of discordance between pathology results and imaging findings in CT-guided biopsies. The study found that 11% of biopsies showed discordance, with 57% of these cases proving to be malignant. Reintervention with biopsy and surgery yielded a shorter time to definitive diagnosis compared to imaging follow-up.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Datta Singh Goolaub, Jiawei Xu, Eric M. Schrauben, Davide Marini, John C. Kingdom, John G. Sled, Mike Seed, Christopher K. Macgowan
Summary: The paper presents a method for volumetric imaging of fetal flow using MRI. The method overcomes the challenges of small vascular structures and unpredictable motion through the use of orthogonal multislice stacks and motion correction. The results demonstrate the feasibility of the method in both adult and late gestation fetus, providing insights into complex flow pathways in human fetal circulation.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hadas Benhabib, Priscila Sacilotto Crivellaro, Heba Osman, Senthujan Gunaseelan, Andrew Chung, Jason Y. Lee, Errol Colak, Vincent Leung, Joseph O'Sullivan, Cynthia Walsh, Ania Kielar
Summary: This study aimed to evaluate the improvement of preoperative assessment reports for potential renal transplant donors through the use of standardized templates. The results showed a significant increase in the comprehensiveness of reports after the implementation of standardized templates, helping urologists determine suitable transplant donors and reduce potential complications.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2023)
Article
Computer Science, Interdisciplinary Applications
Nikan Fakhari, Julien Aguet, Minh Nguyen, Luc Mertens, David Barron, Christoph Haller, John G. Sled, Olivier Villemain, Jeirome Baranger
Summary: In this study, the variations of cerebral blood volume (CBV) in human neonates during cardiac surgery were measured using Ultrafast Power Doppler and freehand scanning. The study found significant variations of CBV during bypass and demonstrated the clinical translation of ultrafast power Doppler with diverging-waves and freehand scanning.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Computer Science, Artificial Intelligence
Ricky Hu, Arsalan Rizwan, Zoe Hu, Anthony Li, Andrew David Chung, Benjamin Y. M. Kwan
Summary: This study developed and implemented an AI workshop for radiology residents. The workshop provided a condensed introduction to AI fundamentals and improved participants' knowledge and confidence in AI concepts.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2023)
Article
Gastroenterology & Hepatology
Michael Youssef, Mary Sedarous, Andrea Grin, Andrew Chung, Lawrence Hookey
Summary: Granulomatosis with polyangiitis (GPA) is a rare form of vasculitis characterized by inflammation in small-sized arteries and gastrointestinal involvement is extremely rare. This case report presents a patient with recurrent acute pancreatitis as the initial symptom of GPA. Diagnosis was based on radiological and pathological findings of acute pancreatitis combined with positive anti-PR3 antibody, which is strongly associated with GPA. Early diagnosis and treatment are crucial for achieving remission and improving survival rates in systemic vasculitides.
ACG CASE REPORTS JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julian G. Rubino, Amir Reza Nasirzadeh, Christian B. van der Pol, Kiret Dhindsa, Andrew D. Chung
Summary: This study assessed the diagnostic performance of CT imaging features for hepatic cirrhosis, revealing that liver surface nodularity is the optimal feature for diagnosis.
ABDOMINAL RADIOLOGY
(2022)