Article
Neuroimaging
Martijn A. Nagtegaal, Ingo Hermann, Sebastian Weingaertner, Eloy Martinez-Heras, Elisabeth Solana, Sara Llufriu, Achim Gass, Dirk H. J. Poot, Matthias J. P. van Osch, Frans M. Vos, Jeroen de Bresser
Summary: This study focuses on white matter tissue changes in patients with multiple sclerosis (MS). By applying a fast, multi-parametric quantitative MRI method and using multi-component MR Fingerprinting (MC-MRF) analysis, the researchers found that patients with MS had a larger volume of the long-component in the white matter compared to healthy controls and this component had a moderate correlation with visible structural white matter changes on FLAIR scans. This highlights the importance of their method in quantifying the extent of white matter changes in MS patients.
NEUROIMAGE-CLINICAL
(2023)
Article
Neuroimaging
Charidimos Tsagkas, Emanuel Geiter, Laura Gaetano, Yvonne Naegelin, Michael Amann, Katrin Parmar, Athina Papadopoulou, Jens Wuerfel, Ludwig Kappos, Till Sprenger, Cristina Granziera, M. Mallar Chakravarty, Stefano Magon
Summary: This study investigates the longitudinal changes in deep gray matter (DGM) shape in relapse-onset multiple sclerosis (MS) and their relationship with clinical disability and white matter lesion-load. The study finds specific shape changes in DGM structures over time, but these changes are not associated with disease progression. However, there is a link between DGM shape and average disease severity as well as white matter lesion-load.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Xiaotao Xu, Qian Li, Yinfeng Qian, Huanhuan Cai, Cun Zhang, Wenming Zhao, Jiajia Zhu, Yongqiang Yu
Summary: Structural damage in the brain is a typical feature of schizophrenia. A neuroimaging meta-analysis of drug-naive first-episode schizophrenia patients revealed consistent reduction in gray matter volume (GMV) in the right superior temporal gyrus, right insula, and left inferior temporal gyrus. These GMV changes were found to be spatially associated with the expression levels of 1,201 genes, which exhibited diverse functional features.
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Cell & Tissue Engineering
Foteini Tsouki, Anna Williams
Summary: The review highlights the significant role of microglia in gray matter changes in MS, particularly in neuronal loss and cortical atrophy. Microglia exhibit regional heterogeneity within the central nervous system, showing their ability to provide context-dependent responses tailored to the demands of their microenvironment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Al-Radaideh, Imad Athamneh, Hadeel Alabadi, Majed Hbahbih
Summary: In patients with relapsing-remitting multiple sclerosis, deep gray matter (dGM) volumetric metrics and MTR values are significantly lower than in healthy controls, and have moderate associations with lesion load and iron concentration. T1 changes in dGM regions weakly correlate with T2 lesions, while iron concentration does not show any association with lesion metrics. Most dGM metrics do not correlate with disease severity, while most lesion metrics show weak associations with disease severity.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Biqiu Tang, Wenjing Zhang, Jiang Liu, Shikuang Deng, Na Hu, Siyi Li, Youjin Zhao, Nian Liu, Jiaxin Zeng, Hengyi Cao, John A. Sweeney, Qiyong Gong, Shi Gu, Su Lui
Summary: Understanding how structural connectivity alterations affect dynamic function in schizophrenia patients, this study investigated the capacity of brain regions/networks to shift the system into easy-to-reach states. The results showed reduced controllability in default mode network, visual network, and subcortical regions, and increased controllability in somatomotor network. These alterations were also associated with impaired functional topology and increased temporal variability in dynamic functional connectivity.
Article
Psychiatry
Jia Cai, Min Xie, Liansheng Zhao, Xiaojing Li, Sugai Liang, Wei Deng, Wanjun Guo, Xiaohong Ma, Pak C. Sham, Qiang Wang, Tao Li
Summary: This study examined white matter abnormalities in adolescent early onset schizophrenia patients and found differences in several neural fiber tracts compared to healthy controls. Specifically, decreased mean diffusivity was found in the right hemisphere of schizophrenia patients. Furthermore, the fractional anisotropy values of certain neural fiber tracts were suggested to be associated with the severity of clinical symptoms in these patients.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Min Xie, Jia Cai, Yunjia Liu, Wei Wei, Zhengyang Zhao, Minhan Dai, Yulu Wu, Yunqi Huang, Yiguo Tang, Liling Xiao, Guangya Zhang, Chuanwei Li, Wanjun Guo, Xiaohong Ma, Wei Deng, Xiangdong Du, Qiang Wang, Tao Li
Summary: This study aimed to investigate the relationship between childhood trauma and white matter deficits in first-episode schizophrenia. The results showed that individuals with first-episode schizophrenia had lower fractional anisotropy (FA) values in several white matter bundles, which were inversely related to the total trauma questionnaire (CTQ) score. Additionally, higher CTQ scores may increase the risk of schizophrenia, while higher FA values may decrease the risk of schizophrenia.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Jiaxin Zeng, Wenjing Zhang, Yuan Xiao, Gui Fu, Lu Liu, Biqiu Tang, Na Hu, John A. Sweeney, Su Lui, Qiyong Gong
Summary: The study suggests that baseline neuroimaging changes may predict treatment response in schizophrenia patients. The related diffusion tensor imaging features demonstrate potential clinical applications.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
C. Wang, T. A. Tishler, K. H. Nuechterlein, B. M. Ellingson
Summary: This longitudinal study compared the effects of oral antipsychotics (OAP) and long-acting injectable antipsychotic, paliperidone palmitate (PP), on cortical thickness, gray-to-white matter contrast (GWC), and frontal lobe intracortical myelin (ICM) volume in first-episode schizophrenia (FES) patients. The results showed that OAP treatment resulted in more widespread cortical thickness reduction compared to PP treatment, suggesting that PP treatment may aid in the preservation of brain morphology.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Shihan Chen, Grant A. A. Mitchell, Jean-Francois Soucy, Julie Gauthier, Bernard Brais, Roberta La Piana
Summary: This study reports a patient with heterozygous variants in the TUFM gene who exhibited clinical features consistent with COXPD4 and radiological findings resembling multiple sclerosis. The findings expand the phenotypic and radiological spectrum of TUFM-related disorders, including milder and later onset forms in addition to the previously known severe early onset presentations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Qiyuan Zhu, Zichun Yan, Zhuowei Shi, Dan Luo, Shuang Ding, Xiaoya Chen, Yongmei Li
Summary: Specific biomarkers for cortical gray matter (cGM) pathology in multiple sclerosis (MS) are needed to understand the disease progression. Our study evaluated the association between different types of cortical lesions and cGM damage using diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI). We found that kurtosis fractional anisotropy (KFA) was the most sensitive in characterizing cGM damage, and leukocortical lesion (LCL) volume was more related to cGM damage.
Article
Psychiatry
XiaoE Lang, Dongmei Wang, Huixia Zhou, Li Wang, Thomas R. Kosten, Xiang-Yang Zhang
Summary: This study found that first-episode, treatment-naive schizophrenia patients have deficits in sensory gating and gray matter volume abnormalities. The latency of S2 is associated with positive and negative symptoms, as well as general psychopathology, while the latencies of S1 and S2 are associated with cognitive factors. Moreover, gray matter volumes in specific brain regions associated with P50 components are negatively correlated with psychopathological symptoms.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Immunology
Thecla A. van Wageningen, Nelda Antonovaite, Erik Paardekam, John J. P. Breve, Davide Iannuzzi, Anne-Marie van Dam
Summary: The biomechanical properties of microglia derived from white matter (WM) and gray matter (GM) show significant differences, with WM-derived microglia being more elastic and viscous than GM-derived microglia. Additionally, the response to inflammation and demyelination varies between WM- and GM-derived microglia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Neuroimaging
Maksim Shapiro, Eytan Raz, Erez Nossek, Kittipong Srivatanakul, Matthew Young, Vinayak Narayan, Aryan Ali, Vera Sharashidze, Rogelio Esparza, Peter Kim Nelson
Summary: Meaningful contributions to neurointerventional practice can be made by considering the dynamic aspects of angiography in addition to fixed morphologic information. This review emphasizes the importance of balance between alternative venous networks and their redundancy, as well as the problems that may arise when these systems are lacking. The role of veins in major neurovascular diseases is highlighted, with deficiencies in knowledge emphasized.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Neuroimaging
Eytan Raz, Erez Nossek, Daniel H. Sahlein, Vera Sharashidze, Vinayak Narayan, Aryan Ali, Rogelio Esparza, Simone Peschillo, Charlotte Chung, Francesco Diana, Safia Syed, Peter Kim Nelson, Maksim Shapiro
Summary: This article aims to describe the acquisition and reformatting of state of the art high resolution cone beam CT (HR-CBCT) and demonstrate its role in multiple neurovascular conditions as a tool to improve the understanding of disease and guide therapeutic decisions.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neurosciences
Chiara Marzi, Alessandro d'Ambrosio, Stefano Diciotti, Alvino Bisecco, Manuela Altieri, Massimo Filippi, Maria Assunta Rocca, Loredana Storelli, Patrizia Pantano, Silvia Tommasin, Rosa Cortese, Nicola De Stefano, Gioacchino Tedeschi, Antonio Gallo
Summary: This study used machine learning techniques to assess the relationship between brain MRI structural volumes and cognitive deficits in MS patients, and found that damage to gray matter structures is most closely related to cognitive performance.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Elisabetta Pagani, Loredana Storelli, Patrizia Pantano, Nikolaos Petsas, Gioacchino Tedeschi, Antonio Gallo, Nicola De Stefano, Marco Battaglini, Maria A. Rocca, Massimo Filippi
Summary: In patients with multiple sclerosis, the determination of brain atrophy in specific regions is clinically relevant. However, analyzing large datasets is challenging due to the increased variability in multicenter data. This study compared different methods to correct for center effects and investigated regional gray matter volume in patients with relapsing-remitting multiple sclerosis using a large multicenter dataset. The results showed that harmonization based on subsampling effectively reduced the residuals of the statistical model applied, and the multicenter results were more robust compared to findings from single-center analysis, highlighting the importance of data repositories from multiple centers.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Claudia Piervincenzi, Nikolaos Petsas, Alessandro Vigano, Valentina Mancini, Giulio Mastria, Marta Puma, Costanza Gianni, Vittorio Di Piero, Patrizia Pantano
Summary: Compared to migraine patients and healthy controls, patients with AIWS have specific alterations in brain functional connectivity, particularly in visual, salience, default mode, and executive control networks. These alterations are correlated with migraine frequency and are more pronounced compared to patients with typical aura
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Chiara Gaudino, Stefania Elena Navone, Valerio Da Ros, Laura Guarnaccia, Giovanni Marfia, Patrizia Pantano, Simone Peschillo, Fabio Maria Triulzi, Francesco Biraschi
Summary: The timing of endovascular treatment for ruptured intracranial aneurysms is associated with the risk of intra-procedural complications. Treatment delayed more than 36 hours after subarachnoid hemorrhage increases the risk of complications, such as thrombus formation and thromboembolic events.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neuroimaging
Eytan Raz, Vera Sharashidze, Erez Nossek, Daniel H. Sahlein, Sara Rostanski, Charlotte Y. Chung, Ayaz Mahmood Khawaja, Peter Kim Nelson, Maksim Shapiro
Summary: SuperDyna is a fusion imaging method that combines high-resolution CBCT and contrasted 3D-DSA to evaluate intracranial vasculature post-treatment. It allows for more comprehensive evaluation of the device position and apposition, aiding in treatment planning and patient education.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Editorial Material
Neuroimaging
Aryan Ali, Maksim Shapiro, Erez Nossek, Rogelio Esparza, Vinayak Narayan, Vera Sharashidze, Eytan Raz
Summary: Patients with acute basilar artery occlusion can benefit from endovascular thrombectomy. Unwanted events during thrombectomy procedures, such as device breakage, fragmentation, or intravascular migration, have been reported in several papers. These papers also suggest methods or techniques to retrieve defective devices, such as snare, retrievable stents, or balloons. Video 1 presents a case of basilar thrombectomy complicated with device fragmentation and distal migration, demonstrating a bailout technique based on fundamental neurointerventional concepts.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Neuroimaging
Madeline Hoover, Robert Berwanger, John A. Scott, Andrew DeNardo, Krishna Amuluru, Troy Payner, Charles Kulwin, Eytan Raz, Daniel Gibson, Daniel H. Sahlein
Summary: Epistaxis is a common condition affecting more than half the population, and about 10% of cases require procedural intervention. With an aging population and increased use of antiplatelets and anticoagulants, the frequency of severe epistaxis is expected to significantly rise in the next few decades. Sphenopalatine artery embolization has become the most common procedural intervention for severe epistaxis, but its effectiveness and safety rely on a thorough understanding of the anatomy, collateral circulation, and the impact of temporizing measures.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lukas Meyer, Paul Stracke, Gabriel Broocks, Mohamed Elsharkawy, Peter Sporns, Eike Piechowiak, Johannes Kaesmacher, Christian Maegerlein, Moritz Roman Hernandez Petzsche, Hanna Zimmermann, Weis Naziri, Nuran Abdullayev, Christoph Kabbasch, Elie Diamandis, Maximilian Thormann, Volker Maus, Sebastian Fischer, Markus Moehlenbruch, Charlotte S. Weyland, Marielle Ernst, Ala Jamous, Dan Meila, Milena Miszczuk, Eberhard Siebert, Stephan Lowens, Lars Udo Krause, Leonard Yeo, Benjamin Tan, Anil Gopinathan, Juan F. Arenillas-Lara, Pedro Navia, Eytan Raz, Maksim Shapiro, Fabian Arnberg, Kamil Zelenak, Mario Martinez-Galdamez, Maria Alexandrou, Andreas Kastrup, Panagiotis Papanagiotou, Andre Kemmling, Franziska Dorn, Marios Psychogios, Tommy Andersson, Rene Chapot, Jens Fiehler, Uta Hanning
Summary: The study compared the clinical and safety outcomes of mechanical thrombectomy and best medical treatment for distal medium vessel occlusions of the anterior cerebral artery. The results showed no significant differences in early clinical outcomes, favorable functional recovery, and mortality between thrombectomy and best medical treatment. This suggests that thrombectomy is a safe and technically feasible treatment option.
Article
Clinical Neurology
Eytan Raz, Gopi Nayak, Vera Sharashidze, Erez Nossek, Wassim Malak, Hugo Bueno, Masaki Komiyama, Peter Kim Nelson, Maksim Shapiro
Summary: This study presents an extremely rare case of a transclival persistent carotid-vertebrobasilar anastomosis in a 10-month-old infant, which does not fit into any of the traditionally described categories such as the trigeminal artery, hypoglossal artery, or proatlantal artery.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Eytan Raz, Vera Sharashidze, Scott Grossman, Aryan Ali, Vinayak Narayan, Erez Nossek, Evan Stein, Peter Kim Nelson, Maksim Shapiro
Summary: There are various treatment options for cavernous dAVFs, with transvenous routes being the most commonly used. Among these routes, the occluded inferior petrosal sinus has been well-documented and is not only imaginative and elegant but also safe and effective. In this article, we describe the application of this method for accessing the fistulous pouch of a cavernous dAVF via an occluded superior petrosal sinus.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Nora C. Kim, Karl L. Sangwon, Eytan Raz, Maksim Shapiro, Caleb Rutledge, Peter K. Nelson, Howard A. Riina, Erez Nossek
Summary: Using 3D virtual reality models for preoperative planning of STA-MCA bypass surgery can enhance surgical results without significant impact on procedure time and craniotomy size. VR preoperative planning tool can enhance visualization of the spatial relationship between STA and MCA, improving surgical outcomes.
WORLD NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Claudia Piervincenzi, Antonio Suppa, Nikolaos Petsas, Andrea Fabbrini, Alessandro Trebbastoni, Francesco Asci, Costanza Gianni, Alfredo Berardelli, Patrizia Pantano
Summary: This study used multimodal magnetic resonance imaging to investigate the relationship between parkinsonism and brain structure and function in patients with frontotemporal degeneration (FTD). The results showed that patients with and without parkinsonism exhibited similar patterns of cortical thinning and reduced thalamic volume, but only patients with parkinsonism showed reduced putaminal volume and decreased connectivity between the supplementary motor area and putamen. These findings suggest that FTD patients with parkinsonism have specific neurodegenerative processes in the corticobasal ganglia-thalamocortical motor loops.
Article
Clinical Neurology
Micol Avenali, Roberta Zangaglia, Giada Cuconato, Ilaria Palmieri, Alberto Albanese, Carlo Alberto Artusi, Marco Bozzali, Giovanna Calandra-Buonaura, Francesco Cavallieri, Roberto Cilia, Antoniangela Cocco, Filippo Cogiamanian, Fabiana Colucci, Pietro Cortelli, Alessio Di Fonzo, Roberto Eleopra, Giulia Giannini, Alberto Imarisio, Gabriele Imbalzano, Claudia Ledda, Leonardo Lopiano, Maria Chiara Malaguti, Francesca Mameli, Raffaella Minardi, Pierfrancesco Mitrotti, Edoardo Monfrini, Francesca Spagnolo, Cristina Tassorelli, Francesca Valentino, Franco Valzania, Claudio Pacchetti, Enza Maria Valente, PARKNET Study Gp
Summary: This study evaluated the long-term impact of GBA variants in a large Italian DBS-PD cohort and supported the role of DBS surgery as a valid therapeutic strategy in GBA-PD, with long-term benefit on motor performance and ICD. Despite the selective worsening of cognitive scores since 3 years post-DBS, the majority of GBA-PD had not developed dementia at 5-year follow-up.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
