Article
Radiology, Nuclear Medicine & Medical Imaging
Sirui Li, Yuan Zheng, Wenbo Sun, Samo Lasic, Filip Szczepankiewicz, Qing Wei, Shihong Han, Shuheng Zhang, Xiaoli Zhong, Liang Wang, Huan Li, Yuxiang Cai, Dan Xu, Zhiqiang Li, Qiang He, Danielle van Westen, Karin Bryskhe, Daniel Topgaard, Haibo Xu
Summary: The DIVIDE technique shows promise for characterizing and diagnosing gliomas, with the potential to differentiate between different grades, molecular features, and microstructural characteristics of tumors. The diffusion metrics obtained from DIVIDE imaging are able to accurately distinguish between high-grade and low-grade gliomas, as well as between wild-type and mutated IDH tumors.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Narciso, Tracy Ssali, Linshan Liu, Sarah Jesso, Justin W. Hicks, Udunna Anazodo, Elizabeth Finger, Keith St Lawrence
Summary: This study proposes an alternative hybrid PET/MR imaging method for quantification of CBF, which calibrates an IDIF extracted from a WB [O-15]H2O time-activity curve using PC MRI measurements of WB CBF. The results demonstrate the high accuracy of this method and its ability to avoid invasive arterial sampling.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahe Guo, Xiuwei Fu, Yiming Li, Haolang Ming, Yu Lin, Shengping Yu, Huijie Wei, Cuiyun Sun, Kai Zhang, Xuejun Yang
Summary: The histogram parameters derived from high b-value ADC maps were found to be more effective for differentiating molecular grades of WHO4 adult-type diffuse glioma than for differentiating histological grades.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Fatemeh Arzanforoosh, Sebastian R. R. van der Voort, Fatih Incekara, Arnaud Vincent, Martin Van den Bent, Johan M. M. Kros, Marion Smits, Esther A. H. Warnert
Summary: Reliable insight into tumor microvasculature is crucial for disease monitoring and treatment response. Vessel size imaging (VSI), an emerging MRI technique, has demonstrated potential in accurately revealing microvasculature information in gliomas. However, its clinical application is limited, which was investigated in this study.
Article
Oncology
Johannes Haubold, Rene Hosch, Vicky Parmar, Martin Glas, Nika Guberina, Onofrio Antonio Catalano, Daniela Pierscianek, Karsten Wrede, Cornelius Deuschl, Michael Forsting, Felix Nensa, Nils Flaschel, Lale Umutlu
Summary: The study aimed to investigate the diagnostic accuracy of a radiomics analysis based on a fully automated segmentation and a simplified MR imaging protocol for predicting the grading and genetic profile of cerebral gliomas. The results showed that the fully automated approach using simplified MR protocols provided an efficient method for non-invasive tumor decoding.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongming Dai, Wentao Hu, Guangyu Wu, Dongmei Wu, Mengying Zhu, Yuansheng Luo, Jieying Wang, Yan Zhou, Peng Hu
Summary: The study assessed the performance of diffusion relaxation correlation spectroscopic imaging (DR-CSI) in grading ccRCC and found that the DR-CSI parameters are correlated with ccRCC grades, and may help to differentiate ccRCC grades.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Lelio Guida, Vittorio Stumpo, Jacopo Bellomo, Christiaan Hendrik Bas van Niftrik, Martina Seboek, Moncef Berhouma, Andrea Bink, Michael Weller, Zsolt Kulcsar, Luca Regli, Jorn Fierstra
Summary: This first part of the review series provides an overview and critical discussion of the hemodynamic imaging applications in diffuse gliomas and highlights the challenges and limitations in current standard neuroimaging.
Article
Endocrinology & Metabolism
Alicen A. Whitaker, Saniya Waghmare, Robert N. Montgomery, Stacey E. Aaron, Sarah M. Eickmeyer, Eric D. Vidoni, Sandra A. Billinger
Summary: Individuals post-stroke had lower middle cerebral artery blood velocity during high-intensity interval training compared to their peers, and this difference persisted 30 minutes after training. Arterial stiffness may contribute to the lower cerebrovascular responsiveness post-stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Minkook Seo, Yangsean Choi, Youn Soo Lee, Kook-Jin Ahn, Bum-soo Kim, Jae-Sung Park, Sin-Soo Jeon
Summary: The diagnostic accuracy of dynamic susceptibility contrast, dynamic contrast-enhancement, MR spectroscopy (MRS), and diffusion-weighted imaging for differentiating high-grade (HGGs) from low-grade gliomas (LGGs) was assessed.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Krishnapriya Venugopal, Fatemeh Arzanforoosh, Danielle van Dorth, Marion Smits, Matthias J. P. van Osch, Juan A. A. Hernandez-Tamames, Esther A. H. Warnert, Dirk H. J. Poot
Summary: Characterizing tumor microvasculature is crucial for tumor assessment and treatment response studies. This study proposes a magnetic resonance vascular fingerprinting (MRVF) technique using hybrid echo planar imaging (HEPI) based on dynamic susceptibility contrast (DSC). The approach was tested in patients with gliomas, enabling the simultaneous estimation of vessel radius and relative cerebral blood volume. The results were consistent with those obtained using the vessel size imaging (VSI) technique, and MRVF showed robustness in noise estimation. DSC-HEPI-based MRVF allows for efficient characterization of glioma microvasculature and can be further improved for better understanding of tumor physiology.
Article
Multidisciplinary Sciences
Margaux Roques, Isabelle Catalaa, Magali Raveneau, Justine Attal, Aurore Siegfried, Jean Darcourt, Christophe Cognard, Nicolas Menjot de Champfleur, Fabrice Bonneville
Summary: This study developed a parameter based on volume analysis to assess the hypervascularized fraction of GBMs and found that this parameter has higher accuracy in diagnosing pseudoprogression.
Article
Clinical Neurology
R. Sky Jones, Manus J. Donahue, L. Taylor Davis, Sumit Pruthi, Spencer L. Waddle, Chelsea Custer, Niral J. Patel, Michael R. DeBaun, Adetola A. Kassim, Mark Rodeghier, Lori C. Jordan
Summary: This study evaluated the reduction of gray matter volume (GMV) and white matter volume (WMV) in children and young adults with sickle cell disease (SCD) using high-resolution MRI. The results showed an association between anemia, low arterial oxygen content, and decreased GMV and WMV. Increased gray matter cerebral blood flow and infarct burden were also associated with reduced volume in subcortical structures. This highlights the potential of brain volume as a biomarker of brain injury in SCD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takashi Hashido, Shigeyoshi Saito, Takayuki Ishida
Summary: This study evaluated various radiomics-based machine learning classification models using ADC and CBF maps to differentiate between high-grade and low-grade gliomas. Different machine learning classifiers showed sufficient diagnostic performance on both the training and test sets, indicating the usefulness of radiomics-based models in this differentiation task.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom Finck, Jens Gempt, Claus Zimmer, Jan S. Kirschke, Nico Sollmann
Summary: The study suggests that CE BB imaging can significantly improve the delineation of therapy-naive HGGs compared to traditional TFE imaging, indicating a potential supplementary role for CE BB sequences in MRI protocols for brain tumors.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chao Yang, Ye Wu, Lin Wang, Sidi Li, Junhu Zhou, Yanli Tan, Jia Song, Huike Xing, Kaikai Yi, Qi Zhan, Jin Zhao, Qixue Wang, Xubo Yuan, Chunsheng Kang
Summary: Exosomes are small extracellular vehicles that can transport genetic materials and proteins between cells. This study explores the mechanisms of exosome-mediated manipulation of brain microvascular endothelial cells and the potential therapeutic role of choline-containing nanocapsules and AKT pathway inhibitors in treating glioblastoma and brain tumor metastasis. The results provide important insights into strategies for BBB penetrating therapies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Siri Flogstad Svensson, Elies Fuster-Garcia, Anna Latysheva, Jorunn Fraser-Green, Wibeke Nordhoy, Omar Isam Darwish, Ivar Thokle Hovden, Sverre Holm, Einar O. Vik-Mo, Ralph Sinkus, Kyrre Eeg Emblem
Summary: Understanding the relationship between mechanical properties and functional changes can explain different treatment responses in glioblastoma patients. This study found that tumor stiffness and viscosity were lower than normal tissue, and tumors showed heterogeneity among patients. Adding MR Elastography measurements improved perfusion prediction.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jan Petr, Louise Hogeboom, Pavel Nikulin, Evita Wiegers, Gwen Schroyen, Jesper Kallehauge, Marek Chmelik, Patricia Clement, Ruben E. Nechifor, Liviu-Andrei Fodor, Philip C. De Witt Hamer, Frederik Barkhof, Cyril Pernet, Maarten Lequin, Sabine Deprez, Radim Jancalek, Henk J. M. M. Mutsaerts, Francesca B. Pizzini, Kyrre E. Emblem, Vera C. Keil
Summary: This systematic review provides an overview of quantitative tomographic imaging methods for identifying adverse side effects of cancer therapy in normal-appearing brain tissue, with the potential to pave the way towards more personalized treatment planning.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Clinical Neurology
Martin Hasselblatt, Christian Thomas, Aniello Federico, Susanne Bens, Mats Hellstrom, Olivera Casar-Borota, Uwe Kordes, Julia E. Neumann, Matthias Dottermusch, Fausto J. Rodriguez, Andrea C. Lo, Sylvia Cheng, Glenda Hendson, Juliette Hukin, Christian Hartmann, Arend Koch, David Capper, Reiner Siebert, Werner Paulus, Karolina Nemes, Pascal D. Johann, Michael C. Fruehwald, Marcel Kool
Summary: Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a distinctive low-grade lesion found in older children and young adults, showing epigenetic similarity with ATRT-MYC and having the potential for malignant progression.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Oncology
Constantinos Harkos, Siri Flogstad Svensson, Kyrre E. Emblem, Triantafyllos Stylianopoulos
Summary: This study utilizes magnetic resonance elastography to extract biomechanical properties of tissue from glioblastoma patients and a healthy subject, and incorporates the data into a mathematical model to simulate tumor growth. By incorporating elastography data, the model provides a more accurate calculation of mechanical stresses within the tumor and enables a better understanding of subsequent events related to tumor development and drug delivery.
Article
Oncology
Elies Fuster-Garcia, Ivar Thokle Hovden, Siri Flogstad Svensson, Christopher Larsson, Jonas Vardal, Atle Bjornerud, Kyrre E. Emblem
Summary: This study proposes an automated method to quantify subtle deformations in the peritumoral region and identifies compression biomarkers associated with patient progression and prognosis. The compression biomarkers have the ability to stratify patients based on their survival. This study highlights the importance of compression biomarkers in early treatment assessment.
Article
Biochemical Research Methods
Cecilia Lindskog, Loren Mear, Johan Virhammar, David Faellmar, Eva Kumlien, Goeran Hesselager, Olivera Casar-Borota, Elham Rostami
Summary: The expression of ACE2 protein in the brain differs between normal individuals and COVID-19 patients, with an upregulation observed in certain patients' endothelial cells. Further study is needed to understand the role of endothelial cells in COVID-19 disease and neurological symptoms.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Clinical Neurology
David Bouget, Andre Pedersen, Asgeir S. Jakola, Vasileios Kavouridis, Kyrre E. Emblem, Roelant S. Eijgelaar, Ivar Kommers, Hilko Ardon, Frederik Barkhof, Lorenzo Bello, Mitchel S. Berger, Marco Conti Nibali, Julia Furtner, Shawn Hervey-Jumper, Albert J. S. Idema, Barbara Kiesel, Alfred Kloet, Emmanuel Mandonnet, Domenique M. J. Muller, Pierre A. Robe, Marco Rossi, Tommaso Sciortino, Wimar A. van den Brink, Michiel Wagemakers, Georg Widhalm, Marnix G. Witte, Aeilko H. Zwinderman, Philip C. De Witt Hamer, Ole Solheim, Ingerid Reinertsen
Summary: This study focuses on prognosis estimation and treatment decisions for brain tumor patients. Through the analysis of four cohorts of patients, the most occurring brain tumor types were investigated, and tumor segmentation models were trained using the AGU-Net architecture. Two software solutions, Raidionics and Raidionics-Slicer, have been developed for easy use of the trained models and standardized generation of clinical reports. The segmentation performances were quite homogeneous across different brain tumor types, with high accuracy. The study provides important insights for brain tumor treatment and standardized clinical report generation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Mathematical & Computational Biology
Jon Andre Ottesen, Darvin Yi, Elizabeth Tong, Michael Iv, Anna Latysheva, Cathrine Saxhaug, Kari Dolven Jacobsen, Aslaug Helland, Kyrre Eeg Emblem, Daniel L. Rubin, Atle Bjornerud, Greg Zaharchuk, Endre Grovik
Summary: This study proposes a deep learning segmentation network for brain metastases, which can accurately detect and segment lesions. The 2.5D and 3D models achieved similar results in different MRI datasets, while nnU-Net had the fewest false positive predictions but the lowest detection rate.
FRONTIERS IN NEUROINFORMATICS
(2023)
Review
Endocrinology & Metabolism
Pia Burman, Olivera Casar-Borota, Luis Gustavo Perez-Rivas, Olaf M. Dekkers
Summary: Aggressive pituitary tumors (APTs) and pituitary carcinomas (PCs) are heterogeneous in terms of clinical presentation and response to therapy. Mutation detection of TP53 and ATRX can help identify aggressive forms early. Treatment involves surgery, radiotherapy, and drugs, with temozolomide being the recommended first-line chemotherapy. Checkpoint inhibitors have shown promise as second-line therapy for PCs. Management should be discussed in expert teams considering clinical findings and patient's condition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Gilbert Hangel, Barbara Schmitz-Abecassis, Nico Sollmann, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas Booth, Marta Calvo-Imirizaldu, Guilherme Cassia, Marek Chmelik, Patricia Clement, Ece Ercan, Maria A. Fernandez-Seara, Julia Furtner, Elies Fuster-Garcia, Matthew Grech-Sollars, N. Tugay Guven, Gokce Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A. F. Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Ozcan, Esin Ozturk-Isik, Senol Piskin, Kathleen M. Schmainda, Siri F. Svensson, Chih-Hsien Tseng, Saritha Unnikrishnan, Frans Vos, Esther Warnert, Moss Y. Zhao, Radim Jancalek, Teresa Nunes, Lydiane Hirschler, Marion Smits, Jan Petr, Kyrre E. Emblem
Summary: Preoperative clinical MRI protocols for gliomas still rely on conventional structural MRI, which does not provide information on tumor genotype and has limitations in the delineation of diffuse gliomas. The GliMR COST action aims to raise awareness about advanced MRI techniques in gliomas and their potential clinical translation. This review summarizes current methods, limitations, and applications of advanced MRI for the preoperative assessment of glioma, and evaluates the level of clinical validation of different techniques.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Lydiane Hirschler, Nico Sollmann, Barbara Schmitz-Abecassis, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas Booth, Marta Calvo-Imirizaldu, Guilherme Cassia, Marek Chmelik, Patricia Clement, Ece Ercan, Maria A. Fernandez-Seara, Julia Furtner, Elies Fuster-Garcia, Matthew Grech-Sollars, Nazmiye Tugay Guven, Gokce Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A. F. Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Oezcan, Esin Ozturk-Isik, Senol Piskin, Kathleen Schmainda, Siri F. Svensson, Chih-Hsien Tseng, Saritha Unnikrishnan, Frans Vos, Esther Warnert, Moss Y. Zhao, Radim Jancalek, Teresa Nunes, Kyrre E. Emblem, Marion Smits, Jan Petr, Gilbert Hangel
Summary: This article introduces the preoperative clinical magnetic resonance imaging (MRI) protocols for gliomas, which still rely on conventional structural MRI. However, this method lacks information on tumor genotype and has limitations in delineating diffuse gliomas. The GliMR COST action aims to raise awareness and discuss the clinical translation of advanced MRI techniques for gliomas.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Endocrinology & Metabolism
Anders Jensen Kolnes, Kristin Astrid Berland oystese, Evelina Sjoestedt, Nicoleta Cristina Olarescu, Ansgar Heck, Jens Pahnke, Daniel Dahlberg, Jon Berg-Johnsen, Geir Ringstad, Olivera Casar-Borota, Jens Bollerslev, Anders Palmstrom Jorgensen
Summary: This study found that transforming growth factor-beta receptor 3-like (TGFBR3L) is selectively expressed in gonadotroph cells and is associated with LH beta expression and plasma gonadotropin concentrations in patients with non-functioning pituitary neuroendocrine tumors (NF-PitNETs).
Meeting Abstract
Oncology
Meenal Datta, Sampurna Chatterjee, Elizabeth Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy Chen, Kamila Naxerova, Ashwin Kumar, Mitrajit Ghosh, Kyrre Emblem, Rosa Ng, William Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria Speranza, Martha Neagu, David A. Reardon, Arlene Sharpe, Gordon Freeman, Mario Suva, Lei Xu, Rakesh Jain
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
E. Lysvik, E. Fuster-Garcia, M. Revheim, S. F. Svensson, G. Ager-Wick, R. Bugge, O. M. Geier, K. Skogen, H. Blakstad, P. Brandal, K. E. Emblem, T. Hjornevik
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Endocrinology & Metabolism
Kristin Astrid B. Oystese, Olivera Casar-Borota, Jon Berg-Johnsen, Jens Petter Berg, Jens Bollerslev
Summary: This study characterizes the distribution of E- and N-cadherin in different types of clinically non-functioning pituitary neuroendocrine tumors (NF-PitNETs) and links it to the course of the tumors. The results indicate that high levels of N-cadherin and downregulation of membranous E-cadherin are not associated with a more aggressive tumor behavior in these subgroups of NF-PitNETs.