Article
Multidisciplinary Sciences
Sarah Dalle, Christophe Snoeck, Amanda Sengelov, Kevin Salesse, Marta Hlad, Rica Annaert, Tom Boonants, Mathieu Boudin, Giacomo Capuzzo, Carina T. Gerritzen, Steven Goderis, Charlotte Sabaux, Elisavet Stamataki, Martine Vercauteren, Barbara Veselka, Eugene Warmenbol, Guy De Mulder
Summary: The high temperatures of cremation destroy organic matter, making traditional isotopic methods unusable for dietary reconstructions. However, analyzing strontium isotope and concentration in cremated human remains provides a new way to assess changes in consumption patterns in past populations that practiced cremation.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima, Kunio Ishikawa
Summary: The study evaluated the effects of different channel and micropore volumes in carbonate apatite honeycomb (HC) scaffolds on bone reconstruction. Channels were found to affect early bone ingrowth, while micropores affected scaffold resorption and bone formation. Additionally, scaffolds with large volumes of both channels and micropores formed a significantly larger amount of new bone, thereby bridging the host bone stumps.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Maab Elsheikh, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa
Summary: In this study, porous blocks with different pore interconnectivity were fabricated using crystal growth, a method which has not been achieved using conventional methods. The study found that interconnected pores promoted bone ingrowth and replacement of the material with new bone, providing useful guidance for designing bone substitutes for rapid bone regeneration.
REGENERATIVE BIOMATERIALS
(2022)
Article
Chemistry, Physical
Xiaoxu Zhang, Ikiru Atsuta, Ikue Narimatsu, Nobuyuki Ueda, Ryosuke Takahashi, Yuki Egashira, Jing-Qi Zhang, Jiong-Yan Gu, Kiyoshi Koyano, Yasunori Ayukawa
Summary: The study investigated the bone graft substitute CO(3)Ap's effect on bone formation compared to autogenous bone. Results showed that CO(3)Ap facilitated bone formation and was gradually absorbed and replaced by bone cells, similar to autogenous bone. This suggests that CO(3)Ap could be an effective alternative for bone grafting.
Article
Materials Science, Ceramics
Masaya Shimabukuro, Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
Summary: Increasing CO32- concentration in Na2HPO4 solution accelerates the fabrication rate of CO3Ap and results in changes in crystal shape and crystallite size. Higher CO32- concentration leads to more CO3 content in CO3Ap, larger pores, and altered pore distribution.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Keisuke Tanaka, Akira Tsuchiya, Yoichiro Ogino, Yasunori Ayukawa, Kunio Ishikawa
Summary: This study compares the use of vaterite and calcite as precursors for the fabrication of CO(3)Ap artificial bone. The results show that vaterite leads to faster bone remodeling compared to calcite.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Masako Fujioka-Kobayashi, Youji Miyamoto, Kunio Ishikawa, Takafumi Satomi, Benoit Schaller
Summary: In vitro experiments showed that CO(3)Ap provided a more favorable surface for osteoclast and osteoblast differentiation compared to DBBM.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Chemistry, Physical
Ikiru Atsuta, Tokihisa Mizokami, Yohei Jinno, Bin Ji, Tingyu Xie, Yasunori Ayukawa
Summary: The combination of CO(3)Ap and AB has been demonstrated as a clinically effective bone substitute. While Mix did not increase the number of osteoclasts or osteoblasts in vitro, it significantly increased the rate of bone replacement in dome-shaped areas in vivo.
Article
Materials Science, Multidisciplinary
Nguyen Xuan Thanh Tram, Kunio Ishikawa, Tran Hoang Minh, David Benson, Kanji Tsuru
Summary: Chicken bone by-product can be used as a source of CO(3)Ap for bone grafts. Chemical treatment and calcination are important processes, with CO(3)Ap prepared at 500 degrees Celsius showing excellent biological response. This research offers a promising biomaterial for bone substitutes and adds value to food waste through recycling.
MATERIALS RESEARCH EXPRESS
(2021)
Article
Materials Science, Ceramics
Naoyuki Fukuda, Kunio Ishikawa, Youji Miyamoto
Summary: Granular-shaped carbonate apatite (CO3Ap) bone substitute shows good potential for alveolar ridge preservation by promoting bone growth and maintaining height and morphology of the alveolar bone during the 9-week post-surgery period. Therefore, CO3Ap granules may have promising clinical applications for alveolar ridge preservation.
CERAMICS INTERNATIONAL
(2022)
Article
Geochemistry & Geophysics
Tetsuro Kono, Toshiro Sakae, Hiroshi Nakada, Takashi Kaneda, Hiroyuki Okada
Summary: The purpose of this article is to prevent further confusion regarding the naming of biological apatite and provide a clear definition. According to the International Mineralogical Association, biological apatite is a carbonated hydroxyapatite, which is distinct from carbonate apatite. The authors hope that this defined classification will be widely adopted in various research and applied fields to eliminate confusion.
Article
Hematology
Marco Pizzi, Gianni Binotto, Giulia Rigoni Savioli, Angelo Paolo Dei Tos, Attilio Orazi
Summary: Bone marrow studies are essential for the diagnosis of haematological disorders and can be traced back to the work of Giovanni Ghedini. His research was based on his clinical experience and the scientific developments of his time.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Engineering, Biomedical
Yuta Sakemi, Koichiro Hayashi, Akira Tsuchiya, Yasuharu Nakashima, Kunio Ishikawa
Summary: The study introduced honeycomb scaffolds containing carbonate apatite for bone reconstruction in orthopedic surgery, demonstrating comparable efficacy to protein and cell scaffolds but at a lower cost and increased safety.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Pery Freitas, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro, Kunio Ishikawa
Summary: This study demonstrates the successful fabrication of carbonate apatite (CO3Ap) blocks using a salt leaching method, which were implanted into rabbit femur defects to promote new bone growth. CO3Ap blocks with a pore size of 100-200 μm showed the most effective outcome in bone ingrowth.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Engineering, Biomedical
Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio, Koichiro Hayashi, Kunio Ishikawa, Youji Miyamoto
Summary: CO(3)Ap honeycomb blocks show good biocompatibility and osteoconductivity in the reconstruction of rabbit mandibular bone defects.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)