Article
Oncology
Carmen Ortiz-Sanchez, Jarline Encarnacion-Medina, Jong Y. Park, Natasha Moreno, Gilberto Ruiz-Deya, Jaime Matta
Summary: This study evaluated variations in DNA repair capacity (DRC) in Puerto Rican men with prostate cancer (PCa). The results showed that PCa cases had lower DRC levels compared to controls. Additionally, DRC levels may have the potential to discriminate between aggressive and indolent PCa cases.
Article
Multidisciplinary Sciences
Daniel Heylmann, Viviane Ponath, Thomas Kindler, Bernd Kaina
Summary: The research investigated the radiation sensitivity of different human blood cell populations obtained from healthy volunteers. T and B cells were found to be highly sensitive to radiation, but displayed DNA repair competence. In terms of cell death/apoptosis, T cells, NK cells, and B cells showed higher sensitivity compared to monocytes, macrophages, and immature dendritic cells.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Yuchuan Zhou, Chunlin Shao
Summary: Histone methylation plays a crucial role in cellular radiosensitivity by affecting DNA damage repair. Both high and low levels of histone methylation can impede DNA repair processes. Inhibitors of histone methyltransferases and histone demethylases may be helpful in developing new drugs for the therapy of radioresistant tumors.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xin Yan, Bo Yang, Yourong Chen, Yifan Song, Jing Ye, Yufan Pan, Bini Zhou, Yuqing Wang, Fengbiao Mao, Yuanchen Dong, Dongsheng Liu, Jiakuo Yu
Summary: The DNA supramolecular hydrogel has been shown to provide excellent protection for MSCs against shear forces, promoting quality cartilage formation, reducing osteophyte formation, and normalizing subchondral bone under high friction conditions of OA. This material has potential as a promising cell delivery system for various MSCs therapies.
ADVANCED MATERIALS
(2021)
Article
Immunology
Sukru Cekic, Huzeyfe Huriyet, Melika Hortoglu, Nurhan Kasap, Ahmet Ozen, Elif Karakoc-Aydiner, Ayse Metin, Gokhan Ocakoglu, Candan Demiroz Abakay, Sehime G. Temel, Sebnem Ozemri Sag, Safa Baris, Tolga Cavas, Sara Sebnem Kilic
Summary: STAT3 plays a crucial role in various pathways, but its transcriptional activity is controlled by ZNF341. This study found that patients with STAT3 loss-of-function and ZNF341 deficiency showed increased radiosensitivity and impaired DNA repair mechanisms, potentially leading to malignant transformation.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Cell Biology
Qingju Li, Yinchuan Xu, Kaiqi Lv, Yingchao Wang, Zhiwei Zhong, Changchen Xiao, Keyang Zhu, Cheng Ni, Kan Wang, Minjian Kong, Xuebiao Li, Youqi Fan, Fengjiang Zhang, Qi Chen, Yi Li, Qian Li, Chengjia Liu, Jinyun Zhu, Shuhan Zhong, Jingyi Wang, Yongjian Chen, Jing Zhao, Dan Zhu, Rongrong Wu, Jinghai Chen, Wei Zhu, Hong Yu, Reza Ardehali, Jianyi (Jay) Zhang, Jian'an Wang, Xinyang Hu
Summary: This study highlights the key role of sEV miR-486-5p in promoting cardiac angiogenesis. miR-486-5p acts on the fibroblastic MMP19-VEGFA signaling pathway to promote cardiac recovery. Delivery of miR-486-5p-engineered sEVs safely enhanced angiogenesis and cardiac function in a nonhuman primate (NHP) MI model, potentially promoting cardiac repair.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Kun Cao, Yuanyuan Chen, Songyun Zhao, Yijuan Huang, Tingting Liu, Hu Liu, Bailong Li, Jianguo Cui, Jianming Cai, Chong Bai, Yanyong Yang, Fu Gao
Summary: This study revealed the significant role of Sirt3 in radioresistance of NSCLC, with knockdown of Sirt3 increasing cellular sensitivity to radiation while overexpression promoting resistance. Additionally, Sirt3 was found to play a critical role in the activation of the ATM-Chk2 pathway.
Article
Immunology
Kerstin Felgentreff, Ulrich Baumann, Christian Klemann, Catharina Schuetz, Dorothee Viemann, Martin Wetzke, Ulrich Pannicke, Sandra von Hardenberg, Bernd Auber, Klaus-Michael Debatin, Eva-Maria Jacobsen, Manfred Hoenig, Ansgar Schulz, Klaus Schwarz
Summary: DNA damage is a common event in every cell, and proteins of the DNA damage response network play a crucial role in sensing and repairing DNA lesions. Genetic defects in DNA repair proteins can lead to immunodeficiency, bone marrow failure syndromes, and increased cancer susceptibility. DDR biomarkers are useful for diagnosing NHEJ defects and AT, with some limitations depending on the specific DNA repair deficiency.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Kyung Hwan Kim, Han Sang Kim, Seung-Seob Kim, Hyo Sup Shim, Andrew Jihoon Yang, Jason Joon Bock Lee, Hong In Yoon, Joong Bae Ahn, Jee Suk Chang
Summary: This study investigated the role of mutations in DNA damage repair genes on treatment outcomes after radiotherapy (RT). The results suggest that tumors with mutations in ATM and BRCA1/2 genes exhibit superior tumor response and local control after RT.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Cell Biology
Leon J. Blankenstein, Nils Cordes, Leoni A. Kunz-Schughart, Anne Vehlow
Summary: In this study, PAK4 was identified as the main regulator of invasion and radio-chemotherapy resistance in glioblastoma cells. By enhancing the number of DNA double-strand breaks and reducing the expression of DNA repair proteins, PAK4 inhibition could improve the radiosensitivity and impair DNA repair in glioblastoma.
Article
Multidisciplinary Sciences
Jiajia Xu, Zhao Li, Robert J. Tower, Stefano Negri, Yiyun Wang, Carolyn A. Meyers, Takashi Sono, Qizhi Qin, Amy Lu, Xin Xing, Edward F. McCarthy, Thomas L. Clemens, Aaron W. James
Summary: Bone regeneration following injury is coordinated by inflammatory signals and sensory nerve infiltration. This study demonstrates that nerve growth factor (NGF) signals through p75 to affect migration of mesenchymal osteogenic precursors, thereby impacting bone healing. Lack of NGF or p75 results in delayed bone repair.
Review
Oncology
Ting Jiang, Jinfeng Chen, Zhenzhen Wang, Xiaofei Wang, Jun Ma, Fei Zhao, Chen Huang, Yanke Chen
Summary: In this study, the functional roles and target genes of miR-4796 and miR-1287 in breast cancer cells in response to radiation were investigated. It was found that miR-4796 can enhance radiation-induced cell death by targeting multiple DNA damage response and repair components, and repress NHEJ and HR DNA repair pathways. miR-4796 can act as an effective radiation sensitising agent.
Article
Oncology
Wenfeng Gou, Xiaojun Yu, Shaohua Wu, Hongying Wu, Huajie Chang, Leyuan Chen, Huiqiang Wei, Changfen Bi, Hongxin Ning, Yingliang Wu, Wenbin Hou, Daiying Zuo, Yiliang Li
Summary: This study investigated the impact of AND-1 on the radiosensitivity of non-small cell lung cancer (NSCLC) and found that AND-1 inhibition significantly increased the radiosensitivity of NSCLC cells, likely by regulating the cell cycle and enhancing DNA damage.
Review
Nanoscience & Nanotechnology
Shengyu Jing, Hongjie Li, Hongbo Xu
Summary: In the latest research, mesenchymal stem cells derived exosomes (MSC-Exos) are identified as a potential alternative for treating refractory diabetic wounds. They have similar biological activity but less immunogenicity compared to MSCs. This review focuses on summarizing the effects of different MSC-Exos on diabetic wounds based on their origins and contents, discussing experimental conditions, target cells/pathways, and mechanisms. Additionally, the combination of MSC-Exos and biomaterials is explored to improve therapy efficacy and utilization. The clinical value and application prospects of exosome therapy, as well as the development trends of using exosomes as carriers for targeted delivery, are highlighted.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Oncology
Siyao Deng, Tijana Vlatkovic, Moying Li, Tianzuo Zhan, Marlon R. Veldwijk, Carsten Herskind
Summary: This review focuses on the role of DNA damage response and repair pathways in radiotherapy, and the potential for enhancing the sensitivity of colorectal cancer to radiotherapy by targeting cell-cycle checkpoint proteins.
Article
Oncology
Harry R. Haynes, Helen L. Scott, Clare L. Killick-Cole, Gary Shaw, Tim Brend, Kelly M. Hares, Juliana Redondo, Kevin C. Kemp, Lorena S. Ballesteros, Andrew Herman, Oscar Cordero-Llana, William G. Singleton, Francesca Mills, Tom Batstonew, Harry Bulstrode, Risto A. Kauppinen, Heiko Wurdakb, James B. Uney, Susan C. Short, Alastair Wilkins, Kathreena M. Kurian
JOURNAL OF PATHOLOGY
(2019)
Editorial Material
Oncology
J. R. Powell, L. Murray, N. G. Burnet, S. Fernandez, Z. Lingard, L. McParland, D. J. O'Hara, G. A. Whitfield, S. C. Short
Article
Multidisciplinary Sciences
Floris P. Barthel, Kevin C. Johnson, Frederick S. Varn, Anzhela D. Moskalik, Georgette Tanner, Emre Kocakavuk, Kevin J. Anderson, Olajide Abiola, Kenneth Aldape, Kristin D. Alfaro, Donat Alpar, Samirkumar B. Amin, David M. Ashley, Pratiti Bandopadhayay, Jill S. Barnholtz-Sloan, Rameen Beroukhim, Christoph Bock, Priscilla K. Brastianos, Daniel J. Brat, Andrew R. Brodbelt, Alexander F. Bruns, Ketan R. Bulsara, Aruna Chakrabarty, Arnab Chakravarti, Jeffrey H. Chuang, Elizabeth B. Claus, Elizabeth J. Cochran, Jennifer Connelly, Joseph F. Costello, Gaetano Finocchiaro, Michael N. Fletcher, Pim J. French, Hui K. Gan, Mark R. Gilbert, Peter V. Gould, Matthew R. Grimmer, Antonio Iavarone, Azzam Ismail, Michael D. Jenkinson, Mustafa Khasraw, Hoon Kim, Mathilde C. M. Kouwenhoven, Peter S. LaViolette, Meihong Li, Peter Lichter, Keith L. Ligon, Allison K. Lowman, Tathiane M. Malta, Tali Mazor, Kerrie L. McDonald, Annette M. Molinaro, Do-Hyun Nam, Naema Nayyar, Ho Keung Ng, Chew Yee Ngan, Simone P. Niclou, Johanna M. Niers, Houtan Noushmehr, Javad Noorbakhsh, D. Ryan Ormond, Chul-Kee Park, Laila M. Poisson, Raul Rabadan, Bernhard Radlwimmer, Ganesh Rao, Guido Reifenberger, Jason K. Sa, Michael Schuster, Brian L. Shaw, Susan C. Short, Peter A. Sillevis Smitt, Andrew E. Sloan, Marion Smits, Hiromichi Suzuki, Ghazaleh Tabatabai, Erwin G. Van Meir, Colin Watts, Michael Weller, Pieter Wesseling, Bart A. Westerman, Georg Widhalm, Adelheid Woehrer, W. K. Alfred Yung, Gelareh Zadeh, Jason T. Huse, John F. De Groot, Lucy F. Stead, Roel G. W. Verhaak
Article
Immunology
H. J. Close, L. F. Stead, J. Nsengimana, K. A. Reilly, A. Droop, H. Wurdak, R. K. Mathew, R. Corns, J. Newton-Bishop, A. A. Melcher, S. C. Short, G. P. Cook, E. B. Wilson
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nina Struve, Zev A. Binder, Lucy F. Stead, Tim Brend, Stephen J. Bagley, Claire Faulkner, Leonie Ott, Justus Mueller-Goebel, Anna-Sophie Weik, Konstantin Hoffer, Leonie Krug, Thorsten Rieckmann, Lara Bussmann, Marvin Henze, Jennifer J. D. Morrissette, Kathreena M. Kurian, Ulrich Schueller, Cordula Petersen, Kai Rothkamm, Donald M. O'Rourke, Susan C. Short, Malte Kriegs
Article
Biology
Sophie Ketchen, Arndt Rohwedder, Sabine Knipp, Filomena Esteves, Nina Struve, Michelle Peckham, John E. Ladbury, Alistair Curd, Susan C. Short, Anke Bruning-Richardson
Article
Oncology
Florien W. Boele, David Meads, Femke Jansen, Irma M. Verdonck-de Leeuw, Jan J. Heimans, Jaap C. Reijneveld, Susan C. Short, Martin Klein
JOURNAL OF NEURO-ONCOLOGY
(2020)
Review
Oncology
Patrick Y. Wen, Michael Weller, Eudocia Quant Lee, Brian M. Alexander, Jill S. Barnholtz-Sloan, Floris P. Barthel, Tracy T. Batchelor, Ranjit S. Bindra, Susan M. Chang, E. Antonio Chiocca, Timothy F. Cloughesy, John F. DeGroot, Evanthia Galanis, Mark R. Gilbert, Monika E. Hegi, Craig Horbinski, Raymond Y. Huang, Andrew B. Lassman, Emilie Le Rhun, Michael Lim, Minesh P. Mehta, Ingo K. Mellinghoff, Giuseppe Minniti, David Nathanson, Michael Platten, Matthias Preusser, Patrick Roth, Marc Sanson, David Schiff, Susan C. Short, Martin J. B. Taphoorn, Joerg-Christian Tonn, Jonathan Tsang, Roel G. W. Verhaak, Andreas von Deimling, Wolfgang Wick, Gelareh Zadeh, David A. Reardon, Kenneth D. Aldape, Martin J. van den Bent
Article
Biochemistry & Molecular Biology
M. Boissinot, H. King, M. Adams, J. Higgins, G. Shaw, T. A. Ward, L. P. Steele, D. Tams, R. Morton, E. Polson, B. da Silva, A. Droop, J. L. Hayes, H. Martin, P. Laslo, E. Morrison, D. C. Tomlinson, H. Wurdak, J. Bond, S. E. Lawler, S. C. Short
Letter
Oncology
S. Fernandez, M. Beasley, J. Lilley, L. Murray, S. C. Short
Article
Oncology
Michael Weller, Martin van den Bent, Matthias Preusser, Emilie Le Rhun, Jorg C. Tonn, Giuseppe Minniti, Martin Bendszus, Carmen Balana, Olivier Chinot, Linda Dirven, Pim French, Monika E. Hegi, Asgeir S. Jakola, Michael Platten, Patrick Roth, Roberta Ruda, Susan Short, Marion Smits, Martin J. B. Taphoorn, Andreas von Deimling, Manfred Westphal, Riccardo Soffietti, Guido Reifenberger, Wolfgang Wick
Summary: The European Association of Neuro-Oncology (EANO) has released guidelines for the diagnosis, treatment, and follow-up of adult patients with diffuse gliomas, incorporating major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System, as well as evidence from recent large clinical trials.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Oncology
Chris Twelves, Michael Sabel, Daniel Checketts, Sharon Miller, Bola Tayo, Maria Jove, Lucy Brazil, Susan C. Short
Summary: The study found that with personalized dosing, nabiximols demonstrated acceptable safety and tolerability with no drug-drug interactions identified. The observed survival differences support further exploration in a well-powered randomized controlled trial.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Tereza Andreou, Jennifer Williams, Rebecca J. Brownlie, Robert J. Salmond, Erica Watson, Gary Shaw, Alan Melcher, Heiko Wurdak, Susan C. Short, Mihaela Lorger
Summary: The study focuses on using hematopoietic stem cell (HSC) gene therapy to target tumor-infiltrating myeloid cells in glioblastoma (GBM), achieving specific gene delivery through a lentiviral vector, blocking TGFβ in combination with radiotherapy significantly reduced tumor burden and prolonged survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Kelly J. McKelvey, Erica B. Wilson, Susan Short, Alan A. Melcher, Michael Biggs, Connie Diakos, Viive M. Howell
Summary: Study found that dual targeting of glycolytic and FAO metabolic pathways is a potential treatment approach that can improve survival rates for GBM patients, warranting further research.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Emilie Le Rhun, Michael Weller, Simone P. Niclou, Susan Short, Karin Piil, Florien Boele, Roberta Ruda, Marilena Theodorou, Dieta Brandsma, Martin van den Bent, Linda Dirven
NEURO-ONCOLOGY PRACTICE
(2020)