News Item
Multidisciplinary Sciences
Asher Mullard
Summary: Researchers are investigating whether vaccines can prevent multiple sclerosis and other chronic conditions that may be triggered by viral infections.
Review
Biochemistry & Molecular Biology
Juan Antonio Ortega-Trejo, Norma A. A. Bobadilla
Summary: Acute kidney injury (AKI) is a global health problem and has recently been recognized as a risk factor for developing chronic kidney disease (CKD). Ischemic preconditioning (IPC) has emerged as a promising strategy to prevent renal tissue damage from AKI. Several studies have shown the effectiveness of IPC in reducing renal damage and efforts are being made to find the best strategy to activate reparative mechanisms. Remote IPC, inducing ischemia in distant tissues before renal ischemia-reperfusion, is also being studied. This review provides a comprehensive overview of existing studies on IPC strategies for AKI and their impact on renal function and structure in animal models and humans, as well as the prospects and challenges for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Liang Guo, Bin Wu, Xuhong Wang, Xiaoying Kou, Xiaohong Zhu, Kaijing Fu, Qian Zhang, Shaojun Hong, Xinjun Wang
Summary: Long-term low-dose ionizing radiation (LLIR) has potential pathogenic effects on cancer and cardiovascular diseases, but exploring the phenotypic changes caused by LLIR in human cohorts is technically and ethically challenging. This study found clear metabolic phenotypic differences between LLIR and non-LLIR exposed participants, and further categorized LLIR exposed workers into two types of metabolic phenotypes, corresponding to high and low damage types. 3-hydroxypropanoate and glycolaldehyde were identified as sensitive indicators to radiation damage, while taurine metabolism-related pathways were identified as the main differential metabolic pathway under LLIR induction.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Ecology
Feng Cheng, Xiaofei Huang, Qingao Qin, Zijian Chen, Fei Li, Wenchen Song
Summary: This study investigates the effects of long-term low-dose ionizing radiation on soil microbial systems. The results show that it has no significant effect on soil bacterial diversity but has a great impact on fungal diversity. It strongly affects soil microbial community structure and has promoting effects on iron-oxidizing bacteria and ectomycorrhizal fungi, while inhibiting predatory or parasitic fungi, leading to changes in the soil C/N ratio. This study is of great reference significance for future research on the impact of long-term low-dose ionizing radiation on soil ecosystems.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Medicine, Research & Experimental
Zahra Bardaghi, Arezoo Rajabian, Farimah Beheshti, Masoud Hashemi Arabi, Mahmoud Hosseini, Hossein Salmani
Summary: This study investigates the protective effect of memantine on the long-term consequences of sepsis on the brain. The results show that memantine can reduce brain inflammation and oxidative damage induced by sepsis, and prevent long-term behavioral abnormalities caused by sepsis.
Article
Cell Biology
Hitoshi Uchida, Matthew H. Ingalls, Eri O. Maruyama, Carl J. Johnston, Eric Hernady, Roberta C. Faustoferri, Catherine E. Ovitt
Summary: Radiation treatment for head and neck cancers often leads to decreased salivary gland function. Understanding the mechanisms of cellular damage caused by radiation is important for developing methods to protect against radiation. This study investigated the effects of radiation on mouse submandibular glands and found that radiation caused dynamic changes in mRNA and protein expression in both irradiated and non-irradiated glands.
DISEASE MODELS & MECHANISMS
(2022)
Article
Cell Biology
Venkata Naga Srikanth Garikipati, Arsen Arakelyan, Eleanor A. Blakely, Polly Y. Chang, May M. Truongcao, Maria Cimini, Vandana Malaredy, Anamika Bajpai, Sankar Addya, Malik Bisserier, Agnieszka Brojakowska, Abrisham Eskandari, Mary K. Khlgatian, Lahouaria Hadri, Kenneth M. Fish, Raj Kishore, David. A. Goukassian
Summary: The study suggests that high-charge-and-energy particle IR and gamma irradiation do not have clear radiation thresholds in cardiac tissue, with 12 common differentially expressed genes predicting various cardiovascular, pulmonary, metabolic diseases, cancer, and aging.
Article
Public, Environmental & Occupational Health
Omid Azimzadeh, Christine von Toerne, Vikram Subramanian, Wolfgang Sievert, Gabriele Multhoff, Michael J. Atkinson, Soile Tapio
Summary: This study investigated long-term serum proteome alterations following local heart irradiation in mice and identified biomarkers of radiation-induced cardiac toxicity. The analysis showed changes in levels of proinflammatory cytokines and cholesterol metabolism-related proteins in the serum of irradiated mice. These findings provide insights into systemic effects of heart irradiation and may be useful in understanding adverse cardiac effects after radiation therapy.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Economics
Satoshi Shimizutani, Hiroyuki Yamada
Summary: This paper examines the long-term consequences of the atomic bombing in Hiroshima in 1945, showing that survivors suffered significant disadvantages in some aspects including marriage status, work status, mental health, and expectations for the future. The study highlights how survivors have endured hardships for many years following the catastrophe.
JOURNAL OF THE JAPANESE AND INTERNATIONAL ECONOMIES
(2021)
Article
Virology
Jukka Mustonen, Antti Vaheri, Ilkka Porsti, Satu Makela
Summary: Several viral infections can lead to both acute and long-term complications. There have been numerous reports in the past two years about post-infectious symptoms experienced by COVID-19 patients. Serious complications may occasionally arise during the acute phase of Puumala orthohantavirus-induced nephropathia epidemica, but severe long-term consequences are rare. Fatigue lasting for several weeks is quite common, and hormonal insufficiencies should be ruled out if the patient does not recover normally.
Article
Materials Science, Multidisciplinary
Magaly Tribet, Caroline Marques, Sarah Mougnaud, Veronique Broudic, Christophe Jegou, Sylvain Peuget
Summary: The investigation on the effects of alpha radiation on the long-term chemical reactivity of high-level nuclear glasses showed that the residual alteration rate is relatively insensitive to the alpha dose rate under disposal conditions, but significantly influenced by the alpha decay dose. The damaged glasses exhibited an enhanced residual alteration rate compared to the annealed glasses, indicating that the ballistic effects of the recoil nuclei play a role in this increase.
NPJ MATERIALS DEGRADATION
(2021)
Article
Oncology
Amit Maity, Rosemarie Mick, Ramesh Rengan, Tara C. Mitchell, Ravi K. Amaravadi, Lynn M. Schuchter, Daniel A. Pryma, Dana M. Patsch, Alisha P. Maity, Andy J. Minn, Robert H. Vonderheide, John N. Lukens
Summary: This study reports the final full clinical analysis of a phase I trial of radiation with ipilimumab in patients with melanoma. Radiotherapy followed by ipilimumab was well tolerated and yielded a response rate that compares favorably to ipilimumab alone. The recommended dose for subsequent phase 2 trials was 8 Gy x 3 doses, based on these results.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmad Neishabouri, Niklas Wahl, Andrea Mairani, Ullrich Koethe, Mark Bangert
Summary: The study investigates the feasibility and accuracy of using artificial neural networks for proton dose calculations in challenging 3D anatomies. Results show that LSTM networks are well suited for proton dose calculation tasks, achieving high gamma-index pass rates compared to Monte Carlo simulations and pencil beam dose calculations. Further research is needed to explore model generalization and computational performance in comparison to established dose calculation methods.
Editorial Material
Biochemistry & Molecular Biology
Alexis R. Barr, Sarah E. McClelland
Summary: Recent studies have revealed that prolonged use of Cdk4/6 inhibitors can induce cellular senescence, thereby enhancing anti-tumor effects and reducing therapy-induced side effects. This finding is of great significance in improving the efficacy of cancer treatment.
Article
Pediatrics
Gabriella A. C. Springall, Michelle Caughey, Diana Zannino, Kypros Kyprianou, Jonathan P. Mynard, Subashini Rudolph, Jeanie Cheong, Michele Yeo, Michael M. H. Cheung
Summary: This study investigated whether individuals who recovered from AN during adolescence experience long-term cardiovascular risk in early adulthood. The findings showed that young adults who recovered from adolescent AN exhibited persistent cardiovascular adaptations, including increased carotid artery stiffness, vagal hyperactivity, and endothelial dysfunction. Routine cardiovascular monitoring could manage potential disease risk.
PEDIATRIC RESEARCH
(2023)
Article
Oncology
Manuela Buonanno, Veljko Grilj, David J. Brenner
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Sofia Barbieri, Gabriele Babini, Jacopo Morini, Werner Friedland, Manuela Buonanno, Veljko Grilj, David J. Brenner, Andrea Ottolenghi, Giorgio Baiocco
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Ling F. Ye, Kunal R. Chaudhary, Fereshteh Zandkarimi, Andrew D. Harken, Connor J. Kinslow, Pavan S. Upadhyayula, Athanassios Dovas, Dominique M. Higgins, Hui Tan, Yan Zhang, Manuela Buonanno, Tony J. C. Wang, Tom K. Hei, Jeffrey N. Bruce, Peter D. Canoll, Simon K. Cheng, Brent R. Stockwell
ACS CHEMICAL BIOLOGY
(2020)
Article
Cell Biology
Alessandro Ottaiano, Luisa Circelli, Angela Lombardi, Stefania Scala, Nicola Martucci, Jerome Galon, Manuela Buonanno, Giosue Scognamiglio, Gerardo Botti, Fabienne Hermitte, Giovanni Savarese, Luigi D'Amore, Fabiana Tatangelo, Annabella Di Mauro, Giuseppina Liguori, Anna Maria Trotta, Maria Napolitano, Monica Capozzi, Salvatore Tafuto, Francesco Perri, Antonello La Rocca, Michele Caraglia, Guglielmo Nasti
CELL DEATH & DISEASE
(2020)
Article
Multidisciplinary Sciences
Manuela Buonanno, David Welch, Igor Shuryak, David J. Brenner
SCIENTIFIC REPORTS
(2020)
Article
Engineering, Aerospace
Arman Seuylemezian, Manuela Buonanno, Lisa Guan, David J. Brenner, David Welch
Summary: This study investigates 222 nm far-UVC light as a new microbial reduction tool for planetary protection purposes, finding it to be effective in decontaminating proxy spacecraft materials.
ADVANCES IN SPACE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Manuela Buonanno, David Welch, David J. Brenner
Summary: Far-UVC radiation is effective at killing airborne microbes with minimal risk to skin and eyes. Using a filter can significantly reduce exposure risks.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Rolf Bergman, David Brenner, Manuela Buonanno, Ewan Eadie, Paul Donald Forbes, Paul Jensen, Edward A. Nardell, David Sliney, Richard Vincent, David Welch, Kenneth Wood
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David Welch, Marilena Aquino de Muro, Manuela Buonanno, David J. Brenner
Summary: The effectiveness of far-UVC in reducing airborne disease transmission has been confirmed. A study using a 3-D human skin model found that far-UVC wavelengths from 215 to 235 nm did not cause an increase in DNA damage in the epidermis, but significant DNA damage was observed at wavelengths of 240-255 nm.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Review
Biology
Manuela Buonanno, Geraldine Gonon, Badri N. Pandey, Edouard I. Azzam
Summary: Insights into intercellular communication gained from studying radiation bystander effects are contributing to a basic understanding of cellular responses under oxidative stress. Understanding these mechanisms may help predict adverse health effects following radiation exposure and improve outcomes of cancer radiotherapy.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David Welch, Norman J. Kleiman, Peter C. Arden, Christine L. Kuryla, Manuela Buonanno, Brian Ponnaiya, Xuefeng Wu, David J. Brenner
Summary: This study found no evidence of skin cancer or abnormal skin growths in hairless mice exposed to chronic long-term far-UVC radiation, supporting the long-term safety of far-UVC as an antimicrobial approach to reduce viral and bacterial loads in indoor settings.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biology
Ziyang Guo, Manuela Buonanno, Andrew Harken, Guangming Zhou, Tom K. Hei
Summary: Radiation therapy plays an important role in cancer treatment, but normal tissue toxicity limits its efficacy. Compared to conventional radiation therapy, proton FLASH irradiation at high dose rates reduces adverse side effects in normal tissues. This study found that proton FLASH irradiation preserves the mitochondrial function of normal cells, possibly through the induction of phosphorylated Drp1.
RADIATION RESEARCH
(2022)
Article
Virology
David Welch, Manuela Buonanno, Andrew G. Buchan, Liang Yang, Kirk D. Atkinson, Igor Shuryak, David J. Brenner
Summary: Recent research suggests that far-UVC radiation with wavelengths in the 200-235 nm range can be directly used for continuous disinfection in occupied indoor spaces. The results show that the inactivation of human coronavirus OC43 is better described using a bi-exponential dose-response relation. These findings provide further evidence of the efficacy of far-UVC in inactivating airborne pathogens.
Article
Multidisciplinary Sciences
Ewan Eadie, Waseem Hiwar, Louise Fletcher, Emma Tidswell, Paul O'Mahoney, Manuela Buonanno, David Welch, Catherine S. Adamson, David J. Brenner, Catherine Noakes, Kenneth Wood
Summary: Krypton Chloride (KrCl) excimer lamps, also known as Far-UVC, can efficiently inactivate pathogens in the air, including coronaviruses. Lab tests show the lamps do not have adverse effects on the skin or eyes. The lamps have been proven effective in reducing the pathogen load in a room-sized chamber.
SCIENTIFIC REPORTS
(2022)
Article
Biology
V Grilj, M. Buonanno, D. Welch, D. J. Brenner
RADIATION RESEARCH
(2020)