Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Qiulian Zhou, Danni Meng, Feng Li, Xiao Zhang, Li Liu, Yujiao Zhu, Shuqin Liu, Minjun Xu, Jiali Deng, Zhiyong Lei, Joost P. G. Sluijter, Junjie Xiao
Summary: In this study, HIPK2 inhibition was found to protect against pathological cardiac remodeling by reducing the expression of EGR3 and CLEC4D in cardiomyocytes, and by suppressing the phosphorylation of Smad3 in cardiac fibroblasts.
Article
Food Science & Technology
Chaohua Tang, Shuang Li, Kai Zhang, Jing Li, Yunsheng Han, Qingyu Zhao, Xiaoqing Guo, Yuchang Qin, Jingdong Yin, Junmin Zhang
Summary: A study using a pig model investigates the effects of selenium deficiency on the heart. The study reveals that selenium deficiency leads to cardiac oxidative stress, disordered energy production, lipid metabolic vulnerabilities, and inflammation initiation pathways. These findings provide potential targets for treating cardiac diseases induced by redox imbalance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Immunology
Mengmeng Zhao, Jishou Zhang, Yao Xu, Jianfang Liu, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Shuwan Xu, Wei Pan, Menglong Wang, Jun Wan
Summary: The study revealed that the NLRP3 inhibitor MCC950 could reverse cardiac remodeling induced by transverse aortic constriction (TAC), improving cardiac dysfunction, reducing cardiac hypertrophy and fibrosis, and decreasing inflammation and macrophage infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yi Wang, Linnan Bai, Jiejun Wen, Fangfei Zhang, Sijie Gu, Feng Wang, Jianyong Yin, Niansong Wang
Summary: This study examined the cardioprotective role of RNLS in CKD-induced cardiac remodeling. RNLS may be a potential therapeutic factor that exerts an anti-fibrotic effect in pathological cardiac remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Article
Medicine, General & Internal
Anwen Yin, Ruosen Yuan, Qingqing Xiao, Weifeng Zhang, Ke Xu, Xiaoxiao Yang, Wentao Yang, Lei Xu, Xia Wang, Fei Zhuang, Yi Li, Zhaohua Cai, Zhe Sun, Bin Zhou, Ben He, Linghong Shen
Summary: This study reveals that exercise induces the expression of CCDC80 protein and the release of its derivative, CCDC80tide, into the circulation via vesicles. Cardiac-specific expression of CCDC80tide protects the heart from pathological cardiac remodeling and exerts cardioprotective effects by inhibiting the STAT3 signaling pathway.
Review
Pharmacology & Pharmacy
Shaowei Fan, Yuanhui Hu, Yaping You, Wenjing Xue, Ruoning Chai, Xuesong Zhang, Xintian Shou, Jingjing Shi
Summary: Cardiovascular disease is a group of diseases with high mortality. Pathological cardiac remodeling is the most common cardiac pathological change, and inhibiting it can delay the development of cardiovascular diseases. Resveratrol, a polyphenol compound, has various cardiovascular protective effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Pei Wang, Shangcheng Xu, Jiqian Xu, Yanguo Xin, Yan Lu, Huiliang Zhang, Bo Zhou, Haodong Xu, Shey-Shing Sheu, Rong Tian, Wang Wang
Summary: This study reveals that chronic stress can upregulate the expression of mitochondrial calcium uniporter (MCU), preserving calcium homeostasis and cardiomyocyte viability to counteract stress-induced pathological cardiac remodeling.
Article
Pharmacology & Pharmacy
Jian He, Dengyue Xu, Lu Wang, Xiaohong Yu
Summary: Cardiovascular disease is a major threat to human health and the leading cause of death. It is characterized by cardiac remodeling, including hypertrophy, fibrosis, inflammation, and oxidative stress. Farrerol has been found to be effective in treating inflammation, endothelial injury, and tumors, and it may also play a role in mitigating cardiac hypertrophy and remodeling.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jiayu Lv, Shuqing Shi, Bingxuan Zhang, Xia Xu, Haoran Zheng, Yumeng Li, Xiangning Cui, Huaqin Wu, Qingqiao Song
Summary: Cardiac remodeling is a crucial part of the progression of cardiovascular disease, and puerarin has shown significant potential in preventing and reversing pathological ventricular remodeling by improving cardiac structure and function through various mechanisms.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ryan M. Burke, Ronald A. Dirkx, Pearl Quijada, Janet K. Lighthouse, Amy Mohan, Meghann O'Brien, Wojciech Wojciechowski, Collynn F. Woeller, Richard P. Phipps, Jeffrey D. Alexis, John M. Ashton, Eric M. Small
Summary: Salinomycin as an antifibrotic agent demonstrates potent anti-fibrotic activity in cardiac fibroblasts, prevents cardiac fibrosis and functional decline in mouse models of ischemic and nonischemic heart disease, and inhibits cardiac fibroblast activation by targeting p38/MAPK and Rho signaling. Moreover, salinomycin promotes cardiomyocyte survival and improves coronary vessel density, showing promise for the treatment of heart failure patients.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Hongmei Zhao, Hongqin Yang, Chi Geng, Yang Chen, Junling Pang, Ting Shu, Meijun Zhao, Yaqin Tang, Zhiwei Li, Baicun Li, Cuiliu Hou, Xiaomin Song, Aoxue Wu, Xiaoxiao Guo, Si Chen, Bin Liu, Chen Yan, Jing Wang
Summary: The study found that IgE plays a causative role in pathological cardiac remodeling, at least partially through activating IgE-Fc epsilon R1 signaling in cardiomyocytes and cardiac fibroblasts. Therapeutic strategies targeting the IgE-Fc epsilon R1 axis may be effective for managing IgE-mediated cardiac remodeling.
Article
Engineering, Electrical & Electronic
A. Morana, C. Campanella, M. Aubrey, E. Marin, A. Boukenter, Y. Ouerdane, S. Girard
Summary: The combined effects of temperature and radiation on the transmission of Ge-doped optical fibers were studied. It was found that the radiation-induced attenuation (RIA) levels were higher at low temperatures. A model was proposed to predict the vulnerability of the fibers under different mission profiles.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Plant Sciences
Chengyi Dai, Wu Luo, Yanghao Chen, Siyuan Shen, Zhe Wang, Ruijie Chen, Jun Wang, Nipon Chattipakorn, Weijian Huang, Guang Liang
Summary: This study found that Tab protects the heart from Ang II-induced injuries by targeting TAK1 and inhibiting TAK1-mediated inflammatory cascade and response. The protective effects of Tab were observed in both mouse models and in vitro experiments, showing reduced cardiac inflammation and fibrosis. These findings suggest that Tab may be a potential therapeutic candidate for hypertensive heart failure.