Review
Oncology
Ilaria Saltarella, Concetta Altamura, Carmen Campanale, Paola Laghetti, Angelo Vacca, Maria Antonia Frassanito, Jean-Francois Desaphy
Summary: Angiogenesis is a critical factor in multiple myeloma, affecting patients' prognosis, survival, and drug resistance. Various anti-angiogenic drugs targeting angiogenic cytokines and their receptors have been developed, along with standard antimyeloma drugs that also exhibit anti-angiogenic effects. This review examines the pharmacological profile and in vitro and in vivo anti-angiogenic effects of these therapies. Although direct targeting of angiogenic cytokines/receptors has shown limited efficacy, there is a need for a deeper understanding of the bone marrow angiogenic niche to develop novel multi-targeting anti-angiogenic therapies.
Article
Oncology
Shwetha H. Manjunath, Adam D. Cohen, Simon F. Lacey, Megan M. Davis, Alfred L. Garfall, J. Joseph Melenhorst, Russell Maxwell, W. Tristram Arscott, Amit Maity, Joshua A. Jones, John P. Plastaras, Edward A. Stadtmauer, Bruce L. Levine, Carl H. June, Michael C. Milone, Ima Paydar
Summary: This study evaluated the safety and feasibility of bridging radiation in CART-BCMA therapy for r/rMM patients. Results showed that bridging radiation may decrease certain grades of toxicities, but larger studies are needed for definitive conclusions.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Yang Cao, Huizhuang Shan, Meng Liu, Jia Liu, Zilu Zhang, Xiaoguang Xu, Yue Liu, Hanzhang Xu, Hu Lei, Miao Yu, Xingming Zhang, Wanting Liu, Zhilei Bu, Zhixiao Fang, Yanjie Ji, Hua Yan, Weiying Gu, Yingli Wu
Summary: The study demonstrates that anlotinib exhibits significant anti-myeloma effects by inducing cell cycle arrest, apoptosis, and inhibiting multiple signaling pathways. Notably, it also targets c-Myc and enhances ubiquitin proteasomal degradation, leading to apoptosis. Additionally, anlotinib shows cytotoxicity against bortezomib-resistant MM cells, suggesting its potential clinical application for human MM treatment.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Roberto Ronca, Sara Taranto, Michela Corsini, Chiara Tobia, Cosetta Ravelli, Sara Rezzola, Mirella Belleri, Floriana De Cillis, Annamaria Cattaneo, Marco Presta, Arianna Giacomini
Summary: This study demonstrates the anti-angiogenic role of PTX3 produced by multiple myeloma cells, showing that induced expression of PTX3 can impede MM neovascularization, prevent the formation of a proficient BM vascular niche, and ultimately reduce tumor growth and dissemination. PTX3 overexpression leads to a significant reduction in tumor burden in both subcutaneously grafted and systemic MM models, paving the way for potential anti-angiogenic strategies in MM treatment.
Review
Oncology
Raquel Lopes, Bruna Velosa Ferreira, Joana Caetano, Filipa Barahona, Emilie Arnault Carneiro, Cristina Joao
Summary: Multiple myeloma is a hematological malignancy arising from the proliferation of tumor antibody-producing cells in the bone marrow. Immunotherapy is a form of cancer treatment that aims to stimulate the immune system to fight back tumor cells, but has not yet been able to cure multiple myeloma completely.
Article
Oncology
Liting Zhong, Dehua Wu, Weiwei Peng, Hailong Sheng, Yazhi Xiao, Xuebing Zhang, Yuli Wang
Summary: The combination of PD-1/PD-L1 inhibitors with palliative radiotherapy and anti-angiogenic therapy appears to be safe and effective in treating hepatocellular carcinoma, with a significant impact on patient survival. Further studies are needed to explore the clinical benefits of this triple therapy approach.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Menglan Zhai, Zixuan Zhang, Haihong Wang, Jinghua Ren, Sheng Zhang, Mingjie Li, Lichao Liu, Lisha Li, Lan Zhang, Xin Li, Tao Zhang, Zhenyu Lin
Summary: This study retrospectively analyzed data from colorectal cancer patients who received targeted therapy and immunotherapy, and the results showed that combining radiotherapy with targeted therapy and immunotherapy can improve the survival outcomes of the patients. The effectiveness of radiotherapy sequential/simultaneous with targeted therapy and immunotherapy was superior to targeted therapy and immunotherapy sequential with radiotherapy.
Article
Nanoscience & Nanotechnology
Jianguo Sun, Huiling Nie, Panpan Pan, Qin Jiang, Chang Liu, Min Wang, Yonghui Deng, Biao Yan
Summary: In this study, a dual-drug nanocomposite formulation was developed for the treatment of ocular vascular diseases. The formulation, CBC-MCC@hMSN(SM) complex, effectively suppressed angiogenesis and inflammatory responses both in vitro and in vivo. A single intraocular injection of this complex showed sustained efficacy for up to 6 months in treating diabetes-induced retinal vascular dysfunction and choroidal neovascularization.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Immunology
Zheng Yan, Jialin Ma, Shuna Yao, Zhihua Yao, Haiying Wang, Junfeng Chu, Shuang Zhao, Yanyan Liu
Summary: The study analyzed the data of cHL patients who failed prior immunotherapy and received low-dose apatinib plus camrelizumab combination therapy, showing promising treatment outcomes with good tolerability. Two patients achieved complete response, suggesting this combination therapy as a potential treatment option for refractory cHL patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Danfeng Zhang, Jingcao Huang, Fangfang Wang, Hong Ding, Yushan Cui, Yan Yang, Juan Xu, Hongmei Luo, Yuhan Gao, Ling Pan, Yu Wu, Yuping Gong, Liping Xie, Zhigang Liu, Ying Qu, Li Zhang, Weiping Liu, Wenyan Zhang, Sha Zhao, Qing Yi, Ting Niu, Yuhuan Zheng
Summary: Multiple myeloma is a malignancy characterized by plasma cell accumulation in the bone marrow. Within the tumor microenvironment, macrophages in multiple myeloma exhibit pro-myeloma functions, which are modulated by the polycomb-group protein BMI1. Knockout of BMI1 in MM-associated macrophages leads to reduced proliferation, decreased expression of angiogenic factors, and loss of protection against chemotherapy-induced cell death, ultimately negating the pro-myeloma effects of these cells.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Rui Liu, Yuping Zhong, Rui Chen, Chengchao Chu, Gang Liu, Yong Zhou, Yazhu Huang, Zhihong Fang, Huan Liu
Summary: This study demonstrates that myeloma cells hnRNPA2B1 mediates microRNAs processing, leading to activation of osteoclastogenesis and suppression of osteoblastogenesis. Clinical studies show a positive correlation between myeloma cells hnRNPA2B1 level and osteolytic bone lesions.
Article
Hematology
Nicolas Gazeau, David Beauvais, Ibrahim Yakoub-Agha, Suman Mitra, Timothy B. Campbell, Thierry Facon, Salomon Manier
Summary: The recent emergence of anti-B-cell maturation antigen (BCMA) therapies, including CAR T cells, bispecific antibodies, and antibody-drug conjugates, holds great promise in changing the strategy for treating multiple myeloma. Understanding the different mechanisms of resistance to these therapies, such as antigen escape and T-cell exhaustion, will be crucial in guiding sequential treatments with anti-BCMA therapies.
Editorial Material
Medicine, General & Internal
Magda Zanelli, Stefano Ricci, Maurizio Zizzo, Francesca Sanguedolce, Federica De Giorgi, Andrea Palicelli, Giovanni Martino, Stefano Ascani
Summary: A 79-year-old woman presented with peripheral eosinophilia, with a history of colonic polyposis and subsequent right hemicolectomy. Laboratory tests revealed mild macrocitic anaemia, elevated beta 2 microglobulin and serum tryptase levels, and the presence of IgA/kappa monoclonal protein and Bence-Jones protein. Bone marrow biopsy showed two neoplastic components - mast cells and plasma cells, with molecular analysis demonstrating mutations and chromosomal abnormalities. The rare coexistence of systemic mastocytosis and multiple myeloma led to treatment with midostaurin therapy.
Article
Oncology
Emma Liljedahl, Elise Konradsson, Emma Gustafsson, Karolina Fornvik Jonsson, Jill K. Olofsson, Kurt Osther, Crister Ceberg, Henrietta Nittby Redebrandt
Summary: Radiotherapy combined with complement activating therapy can effectively prolong survival in subcutaneous tumor models, but has limited effects in intracranial tumor models.
Editorial Material
Cell Biology
Christopher Lischer, Heiko Bruns
Summary: In their study, Cheng et al.1 demonstrate that NEK2 loss can alter the tumor microenvironment, leading to a reduction in tumor-associated macrophages and alleviating T cell exhaustion. This ultimately enhances the immune system's ability to fight against multiple myeloma.
CELL REPORTS MEDICINE
(2023)
Article
Biology
Gunnar Boysen, Azemat Jamshidi-Parsian, Mary A. Davis, Eric R. Siegel, Christine M. Simecka, Rajshekhar A. Kore, Ruud P. M. Dings, Robert J. Griffin
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Oncology
Santosh K. Paidi, Paola Monterroso Diaz, Sina Dadgar, Samir Jenkins, Charles M. Quick, Robert J. Griffin, Ruud P. M. Dings, Narasimhan Rajaram, Ishan Barman
Editorial Material
Biology
Igor Koturbash, Robert J. Griffin
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Pranshu Mohindra, Amit Sawant, Robert J. Griffin, Narottam Lamichhane, Erina Vlashi, Meng Xu-Welliver, Michael Dominello, Michael C. Joiner, Jay Burmeister
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2019)
Article
Nanoscience & Nanotechnology
Marta Pogribna, Nathan A. Koonce, Ammu Mathew, Beverly Word, Anil K. Patri, Beverly Lyn-Cook, George Hammons
Article
Biology
Fatemeh Pakniyat, Hassan Ali Nedaie, Hossein Mozdarani, Aziz Mahmoudzadeh, Mahdieh Salimi, Robert J. Griffin, Somayeh Gholami
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2020)
Article
Materials Science, Multidisciplinary
Samir Jenkins, Seunghyun Jung, Shruti Shah, Paul C. Millett, Ruud P. M. Dings, Michael J. Borrelli, Robert J. Griffin
Summary: The combination of biological variation and nanomaterial heterogeneity complicates the study of interactions between cells and nanoparticles. A platform has been designed to determine the number of nanoparticles needed to induce desired effects on cells and deliver precise thermal doses following laser irradiation. The platform showed effects vastly different than anticipated based on bulk measurements, highlighting the potential for optimized application of nanomedicine.
JOURNAL OF MATERIALS SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Rabab N. Hamzah, Karrer M. Alghazali, Alexandru S. Biris, Robert J. Griffin
Summary: Exosomes are small vesicles produced by various cell types that can transfer cellular components to target cells and affect cell signaling. Recent research suggests that the outcomes of exosome communication depend on the cell type and host cell environment. Key questions remain in cancer research regarding the selectivity of exosome uptake, methods for tracing uptake selectivity, and the impact of donor cell growth environment on cell interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Seunghyun Jung, Nathaniel Harris, Isabelle I. Niyonshuti, Samir V. Jenkins, Abdallah M. Hayar, Fumiya Watanabe, Azemat Jamshidi-Parsian, Jingyi Chen, Michael J. Borrelli, Robert J. Griffin
Summary: Strategies involving using gold nanocages on glass coverslips to culture rat neural stem cells have shown to enhance neuronal differentiation compared to traditional laminin-coated surfaces. Laser-induced thermal stimulation further increases neuronal differentiation, with enhanced expression of heat shock proteins and improved dendritic complexity. Cells grown on these surfaces post laser irradiation exhibit action potentials and increased expression of voltage-gated Na+ channels, showing potential for transplantation in damaged central nervous systems.
Article
Integrative & Complementary Medicine
A. Selma Dagtas, Robert J. Griffin
Summary: The water-based extract of N. sativa seeds showed significant cytotoxic effects on oral cancer and pre-cancerous leukoplakia cells in vitro at a lower concentration than expected. The study suggests that alpha-hederin, rather than thymoquinone, is the major component responsible for the inhibitory effect in vitro.
JOURNAL OF HERBAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Claire Stenhouse, Katherine M. Halloran, Amelia R. Tanner, Larry J. Suva, Paul J. Rozance, Russell Anthony, Fuller W. Bazer
Summary: This study used lentiviral-mediated RNA interference to investigate the regulatory role of chorionic somatomammotropin hormone (CSH) in the utilization of calcium, phosphate, and vitamin D in late gestation in sheep. The study found that CSH RNAi significantly affected the uptake and concentration of calcium, phosphate, and vitamin D, as well as the expression levels of several candidate mRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Amanda J. Stolarz, Bijay P. Chhetri, Michael J. Borrelli, Samir Jenkins, Azemat Jamshidi-Parsian, Joshua H. Phillips, Daniel Fologea, Jay Gandy, Robert J. Griffin
Summary: The use of liposomes triggered by ionizing radiation has potential for targeted drug delivery and enhanced therapeutic effect. The mechanism involves the release of protons through the organic halogen chloral hydrate, causing a drop in internal pH and destabilization of the liposomal bilayer. Experimental results demonstrate preferential drug release at the site of tumor irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Beatriz E. Amendola, Anand Mahadevan, Jesus Manuel Blanco Suarez, Robert J. Griffin, Xiaodong Wu, Naipy C. Perez, Daniel S. Hippe, Charles B. Simone Ii, Majid Mohiuddin, Mohammed Mohiuddin, James W. Snider, Hualin Zhang, Quynh-Thu Le, Nina A. Mayr
Summary: SFRT shows promising potential as a new treatment modality for challenging tumors. However, the development of clinical trials is hindered by the variability in SFRT methods and the unfamiliarity with heterogeneous dosing, requiring a broad consensus.
Article
Biochemistry & Molecular Biology
Valentina K. Todorova, Stephanie D. Byrum, Samuel G. Mackintosh, Azemat Jamshidi-Parsian, Allen J. Gies, Charity L. Washam, Samir V. Jenkins, Timothy Spiva, Emily Bowman, Nathan S. Reyna, Robert J. Griffin, Issam Makhoul
Summary: This study characterized the microRNA and proteins released in vitro from HBV-related HCC cell lines and normal hepatocyte cell lines using microRNA sequencing and mass spectrometry. The dysregulation of these molecules in exosomes from HCC cells was associated with pathways related to HBV, tumor activity, exosome formation, and protein binding. The results provide insight into the role of HBV infection in HCC development and potential targets for treatment and predictive biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Emilie Darrigues, Zeid A. Nima, Robert J. Griffin, James M. Anderson, Alexandru S. Biris, Analiz Rodriguez
NANOSCALE HORIZONS
(2020)