Article
Physics, Nuclear
T. Hashimoto, T. Nam, N. Muramatsu, J. K. Ahn, W. C. Chang, J. Y. Chen, M. L. Chu, S. Date, T. Gogami, H. Goto, H. Hamano, Q. H. He, K. Hicks, T. Hiraiwa, Y. Honda, T. Hotta, H. Ikuno, Y. Inoue, T. Ishikawa, I Jaegle, J. M. Jo, Y. Kasamatsu, H. Katsuragawa, S. Kido, Y. Kon, S. Masumoto, Y. Matsumura, M. Miyabe, K. Mizutani, T. Nakamura, T. Nakano, M. Niiyama, Y. Nozawa, Y. Ohashi, H. Ohnishi, T. Ohta, K. Ozawa, C. Rangacharyulu, S. Y. Ryu, Y. Sada, T. Shibukawa, H. Shimizu, R. Shirai, K. Shiraishi, E. A. Strokovsky, Y. Sugaya, M. Sumihama, S. Suzuki, S. Tanaka, Y. Taniguchi, A. Tokiyasu, N. Tomida, Y. Tsuchikawa, T. Ueda, H. Yamazaki, R. Yamazaki, Y. Yanai, T. Yorita, C. Yoshida, M. Yosoi
Summary: In this study, exclusive measurements for eta photoproduction on a proton target are reported, including the differential cross sections and photon beam asymmetries. The results reveal a bump structure at specific energy and angular ranges, which is likely associated with high-spin resonances.
Article
Oncology
Mario Ghosn, Ahmed S. Elsakka, Elena N. Petre, Christopher Cheleuitte-Nieves, Tuomas Tammela, Sebastien Monette, Etay Ziv, Kyle M. Schachtschneider, Govind Srimathveeravalli, Hooman Yarmohammadi, F. Edward Boas, Stephen B. Solomon
Summary: The study aimed to develop and histologically characterize a swine model of lung cancer for preclinical studies evaluating locoregional therapies. Tumors induced in the lungs of Oncopigs are fast growing poorly differentiated neoplasms associated with a marked inflammatory reaction. This large animal model might be suitable for interventional and surgical therapies of lung cancer.
Article
Neurosciences
Martin Tik, Maria Vasileiadi, Michael Woletz, David Linhardt, Anna-Lisa Schuler, Nolan Williams, Christian Windischberger
Summary: This study aims to establish the dose-response relationship of DLPFC stimulation through concurrent TMS/fMRI. The study found qualitative inter-subject variability in the dose-response relationship to TMS over left DLPFC, suggesting that the motor threshold may not be directly transferable to the excitability of the DLPFC. Therefore, concurrent TMS/fMRI may have the potential to improve response rates to TMS applications.
Article
Biology
Paula Bennett, Alicia M. Johnson, Sarah E. Ackerman, Pankaj Chaudhary, Deborah J. Keszenman, Paul F. Wilson
Summary: This study investigates the effects of low-dose exposures of accelerated protons on DNA damage induction, survival, and transformation in human fibroblasts. The results show that DNA double-strand breaks and clustered DNA damages induced by proton irradiation are dependent on dose-rate and linear energy transfer. The cell survival and transformation exhibit a dose-rate effect, which is more significant at SPE-like LDR doses.
RADIATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Thomas Lilienkamp, Ulrich Parlitz, Stefan Luther
Summary: The conventional termination technique for life threatening cardiac arrhythmia has severe side-effects. Using lower energy pulse sequences instead of single high-energy pulses is a promising approach to improve the current treatment. Numerical simulations show that the dose-response function of pulse sequences applied to spiral wave chaos exhibits non-monotonous increasing behavior and frequency dependence, providing a deeper understanding of termination mechanisms.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Edward J. Calabrese, Paul B. Selby
Summary: This paper identifies six major conceptual scientific errors made by Hermann Muller and explains how these errors led to the development of the linear no-threshold (LNT) dose response, which has been widely used worldwide for cancer risk assessments. The paper highlights the significant influence Muller had in the environmental movement, impacting risk assessment policies that are still in use even decades after his death. It also supports current research showing the limitations of the LNT model for cancer risk assessment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biology
F. Aguiar, P. Rhana, E. Bloise, C. B. Nunes, A. L. Rodrigues, E. Ferreira
Summary: The protein expression and subcellular localization of T-type voltage-dependent Ca2+ channels (Cav3) were evaluated in human breast tissue samples. It was found that the nuclear expressions of CaV3.1, CaV3.2, and CaV3.3 decreased in advanced stages of neoplastic transformation, while the cytoplasmic expression of CaV3.1 and CaV3.2 increased. The change in protein expression and subcellular localization of CaV3 corresponded with the neoplastic transformation stages, suggesting a possible involvement of CaV3 in the carcinogenic processes and its potential as a pharmacological target in breast cancer treatment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Fei Xiao, Ashley Bucsek, Xuejun Jin, Marcel Porta, Antoni Planes
Summary: This study reports that a large elastic-like strain of over 4% can be achieved in a tweed textured Fe-Pd single crystal under a compressive stress of 300 MPa. This giant elastic response gives rise to a significant and homogenous elastocaloric effect, which can sustain stable performance during a large number of mechanical cycles.
Article
Hematology
Paul Robach, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Matthieu Roustit, Carsten Lundby, Anne-Kristine Lundby, Pierre Bouzat, Samuel Verges, Guillaume Sechaud, Pierluigi Banco, Mario Uhr, Catherine Cornu, Pierre Sallet, Gaetano Cairo
Summary: The study demonstrates that in healthy humans, ERFE responds to slight increases in Epo levels without Hb mass expansion, and downregulates hepcidin in an apparently iron-independent manner. Notably, ERFE levels are positively correlated with micro-dose Epo administration, suggesting its potential as a new biomarker for doping detection.
Article
Multidisciplinary Sciences
Masayuki Naito, Satoshi Kodaira
Summary: Shielding from space radiation, especially galactic cosmic rays (GCRs), is a significant safety challenge for future human activities in deep space. In this study, the shielding performances of potential materials [aluminum (Al), polyethylene (PE), and carbon fiber reinforced plastic (CFRP)] were investigated using Geant4 Monte Carlo simulation considering two types of biological scale parameters, the International Commission on Radiological Protection (ICRP) quality factor (QF(ICRP)) and the plausible biological effectiveness (RBE gamma acute), for GCRs. It was found that spacecraft made from CFRP had better radiation shielding performance than conventional Al-based spacecraft. The contribution of heavy ions for QFICRP based effective dose equivalent was larger compared to that for RBE gamma acute based effective dose equivalent. It is necessary to establish a standard parameter specified for a mixed radiation environment occupied by protons and heavy ions for practical dose assessment in deep space.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Hui Li, Meng Zhang, Qianling Dong, Qifeng Fan, Tiantian Gong, Wenbing Wang
Summary: This study investigates the transport and attenuation of PFOA induced by iron (hydr)oxide dynamic transformation and reveals that groundwater type does not affect the pathway of PFOA attenuation, but it controls the differences in iron (hydr)oxide dynamic transformation. The dynamic transformation of iron (hydr)oxide significantly affects the transport behavior of PFOA.
ENVIRONMENTAL POLLUTION
(2024)
Article
Engineering, Environmental
Si-Ying Yu, Yang Shi, Chuan-Shu He, Yu-Dan Dong, Si Sun, Ru-Yan Ning, Zhao-Kun Xiong, Peng Zhou, Heng Zhang, Bo Lai
Summary: The introduction of chloride ions in the iron-based PAA system can enhance the reaction rate and improve the removal capacity for contaminants. The presence of chloride ions induces the generation and conversion of ROSs, leading to effective decontamination. The treatment with iron-based PAA can also alleviate the biological toxicity of pollutants.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Food Science & Technology
Jie-Hua Chen, Yiyuan Wang, Jialiang Pan, Louise Weiwei Lu, Jianfeng Yu, Bin Liu, Feng Chen, Hong Deng
Summary: This study investigates the mechanism of how GOS/FOS affect iron absorption in an iron-deficient rat model and determines the optimum dose of GOS.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Nutrition & Dietetics
Hossein Shahinfar, Ahmad Jayedi, Sakineh Shab-Bidar
Summary: Higher heme iron intake is associated with an increased risk of type 2 diabetes, with a 16% higher risk for each 1 mg/day increment in heme iron intake.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Andrey Khlopkov, Oksana Sherstneva, Maria Ladeynova, Marina Grinberg, Lyubov Yudina, Vladimir Sukhov, Vladimir Vodeneev
Summary: Electrical signals in plants can induce physiological responses, and the role of calcium ions in the respiratory response induced by electrical signals has been investigated. The activation of respiration is likely associated with calcium-mediated activation of alternative NADPH dehydrogenases in mitochondria.
PLANT SIGNALING & BEHAVIOR
(2021)
