期刊
RADIATION RESEARCH
卷 171, 期 4, 页码 484-493出版社
RADIATION RESEARCH SOC
DOI: 10.1667/RR1548.1
关键词
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资金
- NSCOR [NAG-1569]
- National Aeronautics and Space Administration
- U.S. Department of Energy [DE-FG02-05ER63946, DE-FG02-05ER63947]
- European Commission [FI6R-CT-2003-508842]
Chromosome aberrations in mitotic bone marrow cells of CBA/Ca and C57BL/6 mice were measured I day after exposure to 1 Gy of 1 GeV/nucleon Fe-56 ions or 3 Gy of gamma rays. The proportion that have lost a region of chromosome 2 containing the PU.1 gene could be explained by a model based on these measurements. The distribution of aberrations among cells was close to the expected Poisson for the gamma-irradiated cells, but for the HZE Fe-56 ions the distribution was highly dispersed. The observations were consistent with the results of an analysis similar to that of Edwards and co-workers; in 1980 after ex vivo irradiation of human blood with alpha particles. The analysis used to fit the current data was based on a compound Poisson process, also used previously by others, but in addition included the random nature of parameters involved such as cell nuclear diameter, particle traversal lengths through cell nuclei, production of aberrations, and cell cycle arrest per traversal. From the measured numbers of acentric fragments produced, the relative size of chromosome 2 and the region associated with PU.1 deletions, an independent prediction of PU.1 loss agreed well with measurements described in the accompanying paper. (C) 2009 by Radiation Research society
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