Article
Dermatology
Jason Thomson, Findlay Bewicke-Copley, Chinedu Anthony Anene, Abha Gulati, Ai Nagano, Karin Purdie, Gareth J. Inman, Charlotte M. Proby, Irene M. Leigh, Catherine A. Harwood, Jun Wang
Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
D. Y. Lee, B. R. Kim, S. Yang, M. Kim, T. Y. Yoon, S. W. Youn
Summary: This study quantitatively assessed histopathological findings of actinic keratosis (AK) and identified bowenoid type, epidermal thickening, and higher proportion of keratinocytic atypia as significant factors associated with progression to invasive squamous cell carcinoma (SCC). Multivariate analysis revealed that the proportion of keratinocytic atypia was the only independent predisposing factor for SCC progression.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This analysis reviewed the literature related to the management of AK to provide evidence-based recommendations for treatment. Strong recommendations were made for using ultraviolet protection, topical medications, and cryosurgery to treat AK. Conditional recommendations were made for photodynamic therapy and diclofenac for the treatment of AK.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Todd Schlesinger, Eggert Stockfleth, Ayman Grada, Brian Berman
Summary: This article summarizes the preclinical and clinical evidence of tirbanibulin as an effective and safe treatment option for actinic keratosis. Tirbanibulin significantly inhibits cell proliferation, tumor growth, and down-regulates Src signaling. Early phase and Phase III trials have shown high lesion clearance, compliance, and few side effects of once daily tirbanibulin treatment.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Vincenza Chiantore, Marco Iuliano, Roberta Maria Mongiovi, Fabiola Luzi, Giorgio Mangino, Lorenzo Grimaldi, Luisa Accardi, Gianna Fiorucci, Giovanna Romeo, Paola Di Bonito
Summary: Actinic keratosis (AK) is a precursor to cutaneous squamous cell carcinoma (cSCC) and is highly prevalent in the elderly population, particularly among those with sun-exposed skin. This study identified 43 dysregulated microRNAs (miRNAs) in AK samples and validated the expression of several key miRNAs. Pathway analysis revealed that these miRNAs targeted pathways involved in tumorigenesis, highlighting the importance of miRNA regulation in keratinocyte cancer.
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This study provides a summary of 18 evidence-based recommendations for the treatment of actinic keratoses, highlighting the effectiveness of treatments such as ultraviolet protection, topical medications, and cryosurgery. The recommendations are subject to limitations, and future research may alter current treatment guidelines.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Michael Constantin Kirchberger, Michael Gfesser, Michael Erdmann, Stefan Schliep, Carola Berking, Markus Vincent Heppt
Summary: The study found that tirbanibulin 1% ointment significantly and rapidly reduced the AKASI score in a real-world setting, achieving similar clearance rates as observed in the pivotal trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Dermatology
Matthew Hedberg, T. John Seykora
Summary: The study examined genetic alterations in actinic keratoses, a precancerous lesion that often leads to cutaneous squamous cell carcinoma, identifying mutated drivers related to risk factors like UVR or azathioprine and potential signaling pathways regulating the transformation process.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Seung-Ah Yoo, Yeong-Ho Kim, Ju-Hee Han, Chul-Hwan Bang, Young-Min Park, Ji-Hyun Lee
Summary: This study compared different treatment modalities for actinic keratosis (AK), including cryotherapy, imiquimod (IMQ), and photodynamic therapy (PDT). The results showed that PDT had the highest clearance rate, the lowest recurrence rate, and the shortest treatment duration and number of visits. Therefore, PDT could be considered as the first choice for AK treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Andrea Citarella, Davide Moi, Luca Pinzi, Davide Bonanni, Giulio Rastelli
Summary: The hydroxamic acid (HA) moiety has gained notoriety in synthetic medicinal chemistry since the approval of three HDAC inhibitors as anticancer drugs. HAs are known for their ability to chelate metal ions, particularly Fe(III) and Zn(II), making them attractive metal binding groups with wide applications as metalloenzymes inhibitors. This review discusses the physicochemical characteristics of HAs, methods for their introduction into organic substrates, and their uses in medicinal chemistry.
Editorial Material
Dermatology
Klara Mosterd, Patricia J. Nelemans, Nicole W. J. Kelleners-Smeets
Summary: This comment discusses a network meta-analysis evaluating the ranking of treatments for actinic keratosis outside the head and neck. The limited and heterogeneous studies contrast with those in the head and neck area, raising uncertainty about generalizability to larger treatment fields or areas with extensive field cancerization.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biology
Flavia Persechino, Danilo Ranieri, Luisa Guttieri, Monica Nanni, Maria Rosaria Torrisi, Francesca Belleudi
Summary: In this study, the modulation of FGFRs, differentiation markers, and EMT-related markers in different grades of AK lesions was analyzed to predict AK progression. Downregulation of differentiation markers correlated with AK progression, while modulation of EMT markers did not. Modulation of FGFR isoforms and upregulation of FGFR4 were associated with early steps of AK pathogenesis, while increased expression of FGFR3c correlated with late progression. Strong modulation of certain markers in KIN I lesions may predict progression to SCC.
Letter
Dermatology
Vinzent Kevin Ortner, John R. Zibert, Ionela Manole, Alejandro Castillo Mondragon, Anders Daniel Andersen, Merete Haedersdal
Summary: Despite the increasing interest in telemedicine for dermatology, there is a lack of validation for conventional scoring systems in remote assessment of actinic keratosis (AK). This study examines the agreement between in-clinic and remote assessments of AK using different scoring systems. The results suggest the use of patient-obtained smartphone photographs for standardized remote assessment, but highlight the need for improvements to the existing scoring systems to enhance reliability. These findings may facilitate the implementation of remote assessments of AK in clinical management plans.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Brandon Worley, Vishnu Harikumar, Kelly Reynolds, McKenzie A. Dirr, Rachel E. Christensen, Noor Anvery, Michael D. Yi, Emily Poon, Murad Alam
Summary: This review compares different therapeutic options for actinic keratosis (AK). The greatest improvement in AK was seen with photodynamic therapy (PDT) used in combination with other modalities. Various treatments were similarly effective in clearing AK, except for diclofenac sodium. 5-fluorouracil (5-FU), combination PDT, and combination 5-FU with calcipotriol were most beneficial for AK on the head and neck.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Oncology
Anja Wessely, Theresa Steeb, Franz Heppt, Annkathrin Hornung, Matthias D. Kaufmann, Elias A. T. Koch, Frederic Toussaint, Michael Erdmann, Carola Berking, Markus Heppt
Summary: This study evaluated three guidelines for the treatment of actinic keratoses (AK) published in the last 5 years, finding that the German guideline scored the highest while the Canadian guideline scored lower. Stakeholder involvement and values and preferences were identified as methodological weaknesses that require particular attention and improvement.
Correction
Biochemistry & Molecular Biology
S. Borrelli, E. Candi, D. Alotto, C. Castagnoli, G. Melino, M. A. Vigano, R. Mantovani
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Biochemistry & Molecular Biology
Terenzio Cosio, Filadelfo Coniglione, Valeria Flaminio, Roberta Gaziano, Deborah Coletta, Rosalba Petruccelli, Emi Dika, Luca Bianchi, Elena Campione
Summary: Immunotherapy in oncology is replacing traditional therapies due to its specific action and limited side effects. However, bacterial infections can still occur as side effects. This case report highlights the importance of considering lifestyle and cutaneous background before starting immunotherapy for cancer treatment, with a focus on pharmacogenomics and the possibility of modified skin microbiota predisposing to cutaneous infections in patients treated with PD-1 inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alice Romeo, Giulia Cappelli, Federico Iacovelli, Vittorio Colizzi, Mattia Falconi
Summary: In this study, computational simulations and experimental results supported the role of phthalocyanine and hypericin as potential inhibitors of SARS-CoV-2 entry into cells. The simulations showed their binding to key protein functional regions and their ability to insert in the viral membrane. In vitro experiments demonstrated strong inhibition of viral entry, consistent with previous literature on the efficacy of these compounds against SARS-CoV-2.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Medicine, General & Internal
Cosimo Di Raimondo, Paolo Lombardo, Cristiano Tesei, Fabiana Esposito, Federico Meconi, Roberto Secchi, Flavia Lozzi, Alessandro Monopoli, Maria Grazia Narducci, Enrico Scala, Cecilia Angeloni, Alberto De Stefano, Siavash Rahimi, Luca Bianchi, Maria Cantonetti
Summary: The neutrophil/lymphocyte ratio (NLR) is found to be associated with the severity and prognosis of various cancers, but its role in mycosis fungoides (MF) is unclear. This study aimed to assess the association of NLR with different stages of MF and determine if higher values are related to a more aggressive MF. The retrospective analysis of 302 MF patients found that higher NLR values were significantly associated with advanced stages of MF, suggesting that NLR can serve as a marker for advanced MF, guiding physicians in patient management.
Article
Chemistry, Medicinal
Elena Campione, Sara Lambiase, Ruslana Gaeta Shumak, Marco Galluzzo, Caterina Lanna, Gaetana Costanza, Cristiana Borselli, Fabio Artosi, Terenzio Cosio, Lorenzo Tofani, Annunziata Dattola, Francesca Di Daniele, Luca Bianchi
Summary: Tildrakizumab is an approved treatment for moderate-to-severe plaque-type psoriasis, targeting the p19 subunit of interleukin IL-23. A study was conducted on 53 psoriatic patients who received Tildrakizumab every 12 weeks for 52 weeks, showing significant improvement in Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), Nail Psoriasis Severity Index (NAPSI), and Palmoplantar Psoriasis Physician Global Assessment (PPPGA). Disease remission was achieved from week 16 and maintained until week 52.
Review
Biochemistry & Molecular Biology
Cosimo Di Raimondo, Flavia Lozzi, Pier Paolo Di Domenico, Elena Campione, Luca Bianchi
Summary: Melanoma, the deadliest form of skin cancer, accounts for almost 90% of skin cancer mortality. Despite advances in immune and targeted therapies, many patients still experience disease progression. Skin metastases, a common occurrence in melanoma, can be treated through various methods including surgery, injections, and systemic therapies. Further research is needed to understand the underlying mechanisms and differences in behavior and prognosis among melanoma patients with skin metastases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Cristina Rapanotti, Elisa Cugini, Elena Campione, Cosimo Di Raimondo, Gaetana Costanza, Piero Rossi, Amedeo Ferlosio, Sergio Bernardini, Augusto Orlandi, Anastasia De Luca, Luca Bianchi
Summary: The most promising method for monitoring patients with minimal morbidity is the detection of circulating melanoma cells (CMCs). We have shown that CD45(-)CD146(+)ABCB5(+) CMCs are a rare primitive stem/mesenchymal CMCs population associated with disease progression. Investigating the gene expression of isolated CMCs' epithelial-to-mesenchymal transition (EMT) gene signature can provide potential clinical value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Terrinoni, Gabriele Sala, Ernesto Bruno, Consuelo Pitolli, Marilena Minieri, Massimo Pieri, Alessandra Gambacurta, Elena Campione, Riccardo Belardi, Sergio Bernardini
Summary: Ichthyoses are genetically determined cornification disorders of the epidermis. Phenotypic overlap among different genetic entities can occur due to variable penetrance of mutations. This study identified a family with mild phenotypes resembling erythrokeratodermia variabilis (EKV), but genetic analysis revealed double heterozygosity for two different mutations in the ABCA12 gene responsible for harlequin ichthyosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Cristina Piro, Valeria Gasperi, Alessandro De Stefano, Lucia Anemona, Claudio Raffaele Cenciarelli, Manuela Montanaro, Alessandro Mauriello, Maria Valeria Catani, Alessandro Terrinoni, Alessandra Gambacurta
Summary: The dynamic structure of chromatin, controlled by epigenetic alterations of histones and DNA, plays a crucial role in cellular plasticity and the rewiring of epigenetic landscape for cell differentiation or reprogramming. This study investigates the epigenetic switch in cancer cells by analyzing Histone 3 (H3) modifications during osteogenic differentiation and examining methylation states of H3K27, H3K9, and H3K79 in different types of tumors. The findings suggest that the decreased levels of H3K9me2 and H3K79me3 in cancer specimens, compared to healthy tissues, may serve as important epigenetic barriers to tumorigenesis, making them potential diagnostic markers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Cartesio D'Agostini, Jacopo M. Legramante, Marilena Minieri, Vito N. Di Lecce, Maria Stella Lia, Massimo Maurici, Ilaria Simonelli, Marco Ciotti, Carla Paganelli, Alessandro Terrinoni, Alfredo Giovannelli, Massimo Pieri, Mariacarla Gallu, Vito Dell'Olio, Carla Prezioso, Dolores Limongi, Sergio Bernardini, Antonio Orlacchio, Aw Tar-Choon
Summary: The study aimed to assess the association between CT scan results and MR-proADM levels in order to improve the prediction of in-hospital mortality of COVID-19 patients at the triage. The key role of CT score and MR-proADM levels in determining the correct clinical setting for these patients was also evaluated. The results showed that using CT score in combination with MR-proADM levels was particularly effective in risk stratification and decision-making in the emergency department, optimizing hospital resources.
Article
Dermatology
Elena Campione, Monia Di Prete, Gaetana Costanza, Andrea Saggini, Sara Agostinelli, Alessandro Terrinoni, Federica Centofanti, Maria Cristina Rapanotti, Luca Bianchi, Amedeo Ferlosio, Maria Giovanna Scioli, Augusto Orlandi
Summary: Research found that non-mutated patients with uterine leiomyomas have a higher occurrence of skin tumors, specifically cutaneous leiomyomas (CLs) and dermatofibromas (DFs), which may be linked to vitamin D deficiency.
Article
Medicine, Research & Experimental
Eleonora Nicolai, Serena Sarubbi, Martina Pelagalli, Valerio Basile, Alessandro Terrinoni, Marilena Minieri, Oreste Cennamo, Sandro Grelli, Sergio Bernardini, Massimo Pieri
Summary: Infectious diseases like HIV and HBV have a global impact on public health and healthcare costs. Timely diagnosis plays a central role in controlling the spread of these infections. This study compared the performance of the Abbott system and the new analyser Mindray 1200i in detecting HBV and HIV infections. Clinical serum samples from randomly selected patients were tested and compared with the routine instrument, Abbott Architect. The results showed that the Mindray CL-1200i platform offers high-level performance with accurate and consistent test results, making it a valuable tool for routine analysis.