Editorial Material
Oncology
Anil K. Chaturvedi, Neal D. Freedman, Christian C. Abnet
Summary: This article introduces the etiology and prevention measures of oropharyngeal cancers. Early studies showed associations between smoking and alcohol consumption with oropharyngeal cancers, while recent research has identified human papillomavirus (HPV) as the major cause. Therefore, controlling smoking and alcohol use, as well as HPV vaccination, are the most effective methods for preventing oropharyngeal cancers. Additionally, the carcinogenic effects of alternative tobacco products are also being investigated.
Article
Oncology
Yuanxin Xi, Marcelo V. Negrao, Keiko Akagi, Weihong Xiao, Bo Jiang, Sarah C. Warner, Joe Dan Dunn, Jing Wang, David E. Symer, Maura L. Gillison
Summary: This study evaluated the use of targeted sequencing of oral rinse samples (ORS) for non-invasive mutational profiling of oral squamous cell carcinomas (OSCC). The results showed that targeted sequencing of ORS can effectively detect single nucleotide variants (SNVs) in OSCC. This technology provides moderate sensitivity and specificity and requires further optimization.
Review
Oncology
Xiaofeng Duan, Stephen Iwanowycz, Soo Ngoi, Megan Hill, Qiang Zhao, Bei Liu
Summary: GRP94 plays a crucial role in tumor development by promoting survival signals, modulating immune responses, and correlating with aggressive phenotypes and poor clinical outcomes. It has the potential to be a therapeutic target in malignancies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Ronald S. Wang, Michael S. Chow, Alex J. Gordon, Michele Santacatterina, Alec E. Vaezi, Moses M. Tam, Babak Givi
Summary: This study investigated the impact of adjuvant radiotherapy in isolated locally advanced oral cavity cancers without adverse features. The findings showed that adjuvant radiotherapy was associated with improved survival. However, a significant proportion of patients did not receive adjuvant radiotherapy, highlighting the need for continued efforts to promote guideline-recommended care.
Review
Oncology
Irina Larionova, Militsa Rakina, Elena Ivanyuk, Yulia Trushchuk, Alena Chernyshova, Evgeny Denisov
Summary: Radiotherapy is a standard treatment for many solid cancers, but the resistance of tumor cells to radiation is a major challenge. This review discusses potential universal biomarkers associated with radioresistance and poor prognosis, as well as the overlap of these biomarkers in multiple cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Hitesh Rajendra Singhavi, Sudhir Nair, Manish Mair, Rachit Mathur, Arjun Singh, Ameya Pai, Akshay Patil, Deepa Nair, Pankaj Chaturvedi
Summary: Evidence for the efficacy of contralateral neck dissection (CND) in recurrent oral cavity squamous cell cancers (OCSCC) is still lacking. Depth of invasion (DOI) greater than 10mm is a significant factor influencing contralateral nodal metastasis (CNM) in ipsilateral recurrence of OCSCC. Imaging has suboptimal positive predictive value (PPV) but high negative predictive value (NPV) in diagnosing nodal metastasis in recurrent OCSCC.
Review
Oncology
Su-Jung Choi, Neeti Swarup, Ji-Ae Shin, Seong-Doo Hong, Sung-Dae Cho
Summary: Mcl-1 expression is associated with the progression of oral cavity cancers, and the molecular mechanism and pathways of Mcl-1 in oral cavity cancers have been highlighted. Various therapeutic agents targeting Mcl-1 have been documented.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Anastasiya Muntyanu, Vladimir Nechaev, Elena Pastukhova, James Logan, Elham Rahme, Andrei Zubarev, Elena Netchiporouk, Ivan V. Litvinov
Summary: This study examines the occurrence and risk factors of lip and oral cavity cancers in Russia from 2007 to 2018. The findings indicate regional disparities in incidence and mortality rates, with high alcohol and smoking rates positively associated with both. These results highlight the importance of tobacco/alcohol control measures and cessation programs for public health, particularly for females.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Alice Renou, Anne-Valerie Guizard, Emilien Chabrillac, Gautier Defossez, Pascale Grosclaude, Sophie Deneuve, Sebastien Vergez, Benedicte Lapotre-Ledoux, Sandrine D. Plouvier, Agnes Dupret-Bories, FRANCIM Network
Summary: This study analyzed the evolution of the incidence of oral cavity cancers (OCC) among elderly patients in France from 1990 to 2018 and compared it to other cancers sharing the same main risk factors. The results showed a 72% increase in the number of OCC cases in women over 70 years old, while the number of cases in men remained stable. For laryngeal and hypopharyngeal cancers, there was a decrease in incidence in elderly men and an increase in elderly women, but to a lesser extent than OCC. Therefore, the incidence of OCC has been increasing in elderly subjects in France, particularly in women, since the 1990s, and cannot be solely explained by population aging, growth, or alcohol and tobacco consumption.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Salma Ramadan, Jake J. Lee, Ray Wang, Ryan S. Jackson, Patrik Pipkorn, Jason Rich, R. Alex Harbison, Paul Zolkind, Stephen Y. Kang, Sidharth Puram, Angela L. Mazul
Summary: This study aims to explore the association between neighborhood socioeconomic status, race, and the incidence rate of oral cavity cancer. The results indicate that there are differences in the incidence rate of oral cavity cancer among different races and socioeconomic statuses, and the trends in incidence rates also vary. Further research is needed to understand the risk factors and develop interventions targeting vulnerable groups.
Article
Biochemistry & Molecular Biology
Shin Pai, Vijesh Kumar Yadav, Kuang-Tai Kuo, Narpati Wesa Pikatan, Chun-Shu Lin, Ming-Hsien Chien, Wei-Hwa Lee, Michael Hsiao, Shao-Chih Chiu, Chi-Tai Yeh, Jo-Ting Tsai
Summary: High expression of PDK1 is associated with poor prognosis in OSCC, and it is related to glycolytic re-programming and chemo/radioresistance. The study found important associations between PDK1/CD47/LDHA expression in OSCC. The combination of PDK1 inhibitor BX795, cisplatin, and radiotherapy could effectively target OSCC by inhibiting oncogenic and glycolytic signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
M. Lapeyre, S. Racadot, S. Renard, J. Biau, J. F. Moreira, M. C. Biston, Y. Pointreau, J. Thariat, P. Graff-Cailleaud
Summary: This article provides a detailed overview of the application and technical details of intensity-modulated radiation therapy and brachytherapy in the treatment of oral cavity cancers.
CANCER RADIOTHERAPIE
(2022)
Article
Biochemistry & Molecular Biology
Yunxia Wan, Xi Zhang, Kai Dun Tang, Tony Blick, Liz Kenny, Erik W. Thompson, Chamindie Punyadeera
Summary: The study found that overexpression of miR-9-5p in oral cavity cancer leads to increased apoptosis, reduced cell proliferation and migration, and increased secretion and export of Galectin-3. MiR-9-5p may modulate Galectin-3 via the AKT/gamma-catenin pathway. The positive correlation between the expression levels of miR-9-5p and secreted Galectin-3 in saliva highlights their importance in the progression of oral cavity cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Medicine, Research & Experimental
Nicholas Fung, Cara M. Fleseriu, Randall J. Harley, Nayel I. Khan, Seungwon Kim
Summary: Perineural invasion subcategorization in oral cavity squamous cell carcinoma can help stratify recurrence-free survival and overall survival, with extratumoral and peripheral PNI associated with worse outcomes compared to PNI negative disease. Intratumoral PNI did not show significant differences in outcomes compared to PNI negative disease.
Article
Biochemistry & Molecular Biology
Feifei Li, Zhitong Bing, Weiqiang Chen, Fei Ye, Yan Liu, Lan Ding, Xiaodong Jin
Summary: Radiotherapy plays a major role in NSCLC treatment, but radioresistance affects the curative efficacy of advanced NSCLC. Proteomic analysis identified up-regulated proteins like CRIP2, ARHGDIB, and PADI3 in radioresistant cells. These proteins may serve as potential biomarkers for diagnosis and prognosis prediction, affecting X-ray radiosensitivity of NSCLC through regulating apoptosis and cell cycle arrest.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Yin-Ju Chen, Guo-Rung You, Meng-Yu Lai, Long-Sheng Lu, Chang-Yu Chen, Lai-Lei Ting, Hsin-Lun Lee, Yuzuka Kanno, Jeng-Fong Chiou, Ann-Joy Cheng
Article
Oncology
Kang-Hsing Fan, Chih-Hua Yeh, Sheng-Ping Hung, Chung-Jan Kang, Shiang-Fu Huang, Kai-Ping Chang, Hung-Ming Wang, Jason Chia-Hsun Hsieh, Chien-Yu Lin, Ann-Joy Cheng, Shu-Hang Ng, Joseph Tung-Chieh Chang
Summary: The study indicated that the presence of rENE in hypopharyngeal cancer patients is associated with lower overall survival and recurrence-free survival rates. rENE may serve as a criterion for clinical ENE in future staging systems.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yin-Juz Chen, Joseph T. Chang, Guo-Rung You, Chun-Yu Huang, Kang-Hsing Fan, Ann-Joy Cheng
Summary: Identifying six hub molecules associated with cell invasion is crucial for accurately predicting prognosis and providing potential therapeutic targets in precision medicine for head-neck cancers.
BIOMARKERS IN MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yao-Yu Wu, Kang-Hsing Fan
Summary: Proton therapy for localized prostate cancer offers similar efficacy to standard photon therapy or brachytherapy, but may not be cost-effective. Advancements in radiation delivery and construction of PT centers may help reduce costs and improve overall efficacy.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
Chung-Jan Kang, Chi-Ying Tsai, Li-Yu Lee, Chien-Yu Lin, Lan-Yan Yang, Nai-Ming Cheng, Chuen Hsueh, Kang-Hsing Fan, Hung-Ming Wang, Chia-Hsun Hsieh, Shu-Hang Ng, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Tuan-Jen Fang, Shiang-Fu Huang, Li-Ang Lee, Ku-Hao Fang, Yu-Chien Wang, Wan-Ni Lin, Li-Jen Hsin, Tzu-Chen Yen, Chun-Ta Liao
Summary: The clinical outcomes of patients with pT4a and pT4b OCSCC are similar, while those with pT3-4N3b disease have a less favorable 5-year prognosis. Therefore, it is recommended to continue classifying pT3-4N3b disease as pStage IVB, while pT4bN0-2 and pT1-2N3b diseases should be downstaged to pStage IVA.
Article
Medicine, General & Internal
Ann-Joy Cheng, Guo-Rung You, Che-Jui Lee, Ya-Ching Lu, Shang-Ju Tang, Yi-Fang Huang, Yu-Chen Huang, Li-Yu Lee, Kang-Hsing Fan, Yen-Chao Chen, Shiang-Fu Huang, Joseph Tung-Chieh Chang
Summary: Liquid biopsy is a rapidly growing field for minimally invasive pathological data acquisition. The study identified salivary miR-196b as an effective biomarker for oral precancer lesion and early detection of head-neck squamous carcinoma, providing potential for early screening high-risk groups.
Article
Oncology
Chia-Hsin Lin, Chien-Yu Lin, Kang-Hsing Fan, Sheng-Ping Hung, Yung-Chih Chou, Chia-Jen Liu, Wen-Chi Chou, Yen-Chao Chen, Shiang-Fu Huang, Chung-Jan Kang, Kai-Ping Chang, Hung-Ming Wang, Ann-Joy Cheng, Joseph Tung-Chieh Chang
Summary: The study retrospectively reviewed the clinical records of 186 patients with ENE+ BMSCC who received postoperative RT during 1997-2016. Propensity score matching was used to establish comparable cohorts, showing no significant differences in survival outcomes between unilateral and bilateral RT, with number of ENEs >= 4 being a significant prognostic factor for all clinical outcomes.
Article
Biochemistry & Molecular Biology
Yen -Chao Chen, Kang-Hsing Fan, Chien -Yu Lin, Chung-Jan Kang, Shiang-Fu Huang, Hung-Ming Wang, Ann -Joy Cheng, Joseph Tung-Chieh Chang
Summary: This study identified performance status and a re-RT dose >= 60 Gy as predictors for LRPFS and OS. Surgery before re-RT might improve OS. However, the treatment results of re-RT for OSCC were suboptimal.
BIOMEDICAL JOURNAL
(2022)
Article
Chemistry, Physical
Yi-Chun Tsai, Kang-Hsing Fan, Tzung-Lin Tsai, Chung-Chi Lee, Tsukasa Aso, Shu-Wei Wu, Chien-Yu Lin, Chien-Kai Tseng, Chia-Ray Chen, Selvaraj Balaji, Tsi-Chian Chao
Summary: The advantage of proton therapy is the Bragg peak, but the range uncertainties can cause dose deviation. In this study, a discrete range modulation (DRM) method is introduced and compared with the continuous range modulation (CRM) method. The results show that the DRM method has better image quality and is applicable to different phantoms.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Cell Biology
Guo-Rung You, Joseph T. Chang, Hsiao-Fan Li, Ann-Joy Cheng
Summary: NDRG1 has diverse oncogenic functions in head and neck cancer cells, including stress response, cell motility, and upregulation of stemness-related markers. The 3R motif of NDRG1 plays a crucial role in cell motility, as phosphorylation at serine residues leads to nuclear translocation and promotes motility.
Review
Biochemistry & Molecular Biology
Hsin-Ying Chen, Ann-Joy Cheng
Summary: Cancer stemness, characterized by unlimited self-renewal, low percentage, asymmetric/symmetric cell division, and different nature for absorbing external substances, is proposed to be the main cause of metastasis and tumor relapse. Glucose-regulated protein 78 (GRP78) plays a key role in cancer stemness and could serve as a feasible target for eradicating cancer stem cells.
Article
Cell Biology
Guo-Rung You, Joseph T. Chang, Yan-Liang Li, Chi-Wei Huang, Yu-Liang Tsai, Kang-Hsing Fan, Chung-Jan Kang, Shiang-Fu Huang, Po-Hung Chang, Ann-Joy Cheng
Summary: The study discovered that MYH9 is overexpressed in head and neck cancer, and is associated with poor prognosis. MYH9 promotes cell motility and modulates the extracellular matrix, and is also related to radioresistance and the expression of anti-apoptotic molecules. Mechanically, MYH9 suppresses cellular ROS levels by activating the MAPK-Nrf2-GCLC signaling pathway.
Article
Biochemistry & Molecular Biology
Shang-Ju Tang, Kang-Hsing Fan, Guo-Rung You, Shiang-Fu Huang, Chung-Jan Kang, Yi-Fang Huang, Yu-Chen Huang, Joseph Tung-Chieh Chang, Ann-Joy Cheng
Summary: The study identified a specific profile of miRNAs in head and neck cancer cells, further revealing the role of miR-503 as a tumor suppressor gene, inhibiting cell invasion through the Wnt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kang-Hsing Fan, Chung-Jan Kang, Chien-Yu Lin, Shu-Hang Ng, Hung-Ming Wang, Chia-Hsun Hsieh, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Shiang-Fu Huang, Ku-Hao Fang, Yu-Chien Wang, Joseph Tong-Chieh Chang, Chun-Ta Liao, Li-Yu Lee
Summary: In this retrospective study, the quantification of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) was performed using S100 staining. The results showed that a greater amount of PNI identified by S100 staining indicated a poorer time-to-recurrence (TTR), regardless of stage and other prognostic factors. Therefore, quantification of PNI by S100 immunohistochemistry is a potential method for prognosis prediction in OSCC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Oncology
Tsung-Min Hung, Kang-Hsing Fan, Chung-Jan Kang, Shiang-Fu Huang, Chien-Yu Lin, Albert Tsung-Ying Ho, Hung-Ming Wang, Jason Chia-Hsun Hsieh, Ann-Joy Cheng, Shu-Hang Ng, Joseph Tung-Chieh Chang