期刊
DIABETOLOGY & METABOLIC SYNDROME
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1758-5996-7-4
关键词
Bilirubin; Oxidized-LDL; Oxidative stress; Atherosclerosis; Pediatric obesity
资金
- European Regional Development Fund (FEDER, Europe) funds through the Operational Competitiveness Programme (COMPETE, Portugal)
- National Funds through Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/0393/2012)]
- Fundação para a Ciência e a Tecnologia [PTDC/DTP-DES/0393/2012] Funding Source: FCT
Background: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals. Findings: 125 obese patients (13.4 years; 53.6% females) were studied. TB, lipid profile including Ox-LDL, markers of glucose metabolism, and levels of C-reactive protein (CRP) and adiponectin were determined. Anthropometric data was also collected. In all patients, Ox-LDL correlated positively with BMI, total cholesterol, LDLc, triglycerides (TG), CRP, glucose, insulin and HOMAIR; while inversely with TB and HDLc/Total cholesterol ratio (P < 0.05 for all). In multiple linear regression analysis, LDLc, TG, HDLc and TB levels were significantly associated with Ox-LDL (standardized Beta: 0.656, 0.293, -0.283, -0.164, respectively; P < 0.01 for all). After removing TG and HDLc from the analysis, HOMAIR was included in the regression model. In this new model, LDLc remained the best predictor of Ox-LDL levels (beta = 0.665, P < 0.001), followed by TB (beta = -0.202, P = 0.002) and HOMAIR (beta = 0.163, P = 0.010). Conclusions: Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk.
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