期刊
QUIMICA NOVA
卷 34, 期 7, 页码 1224-1230出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0100-40422011000700022
关键词
thermal analysis; pharmaceutical industry; characterization
THERMAL ANALYSIS APPLIED TO DRUGS AND PHARMACEUTICAL FORMULATIONS IN PHARMACEUTICAL INDUSTRY. Several matters of the pharmaceutical demonstrate the great importance of thermal analysis application, especially TG and DSC for the pharmaceutical industry future, namely: characterization of the drugs with the thermal events definition, in studies of drug purity, in the polymorphs identification, in compatibility studies of solid dosage pharmaceutical formulations, in drugs and pharmaceutical formulations thermal stability, and in determination of shelf life for isothermal degradation kinetics by extrapolation using the Arrhenius equation. Thus, the test results obtained from thermal analysis are directly related to the quality of a pharmaceutical product, whether the stability or bioavailability of the pharmaceutical product.
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