Review
Oncology
Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Vassiliki Saloura
Summary: Chromatin modifiers are enzymes that alter chromatin structure through various post-translational modifications, influencing transcription. SMYD3, a chromatin modifier implicated in cancer, has been shown to methylate not only histones but also non-histone substrates, impacting cancer prognosis and function. Ongoing efforts to develop inhibitors of SMYD3 for therapeutic use are underway, aiming to advance future discovery and treatment in cancer research.
CLINICAL EPIGENETICS
(2021)
Review
Biochemistry & Molecular Biology
Pavel P. Tregub, Irada Ibrahimli, Anton S. Averchuk, Alla B. Salmina, Peter F. Litvitskiy, Zaripat Sh. Manasova, Inga A. Popova
Summary: In recent times, there has been a growing interest among researchers in understanding the functions of microRNAs and their role in the development of various diseases. This review analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying Alzheimer's disease, cerebral ischemia and reperfusion injury, and blood-brain barrier dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Arailym Aronova, Federica Tosato, Nawraa Naser, Yaw Asare
Summary: Innate immune pathways play a crucial role in the development of atherosclerosis and targeting these pathways may effectively reduce the risk of cardiovascular disease. Understanding the interplay between these pathways and the long-term reprogramming of immune cells is essential for the development of targeted therapeutic interventions.
Article
Oncology
Kejia Hu, Chengshi Wang, Chuanxu Luo, Hong Zheng, Huan Song, Jacob Bergstedt, Katja Fall, Ting Luo, Kamila Czene, Unnur A. Valdimarsdottir, Fang Fang, Donghao Lu
Summary: This study found that somatic mutations in genes of neuroendocrine pathways, particularly in the glucocorticoid pathway, may influence breast cancer prognosis through dysregulated gene expression in tumor tissue.
Article
Pathology
Eunji Kim, Dong-Jin Han, Byoung Hyuck Kim, Jinseon Yoo, Hak Jae Kim, Hong-Gyun Wu, Kyung Su Kim, Han-Soo Kim, Ilkyu Han, Kyung Chul Moon, Jeong Hwan Park, Sanghyuk Song, Tae-Min Kim, Ji Hyun Chang
Summary: Radiation-induced sarcoma (RIS) is a rare and serious late complication of radiotherapy. This study analyzed the genomes of 11 RIS tumors and identified somatic alterations potentially associated with RIS development. The results revealed different types of genomic alterations in cancer-related genes and the prevalence of nonhomologous end joining pathway in RIS genomes. The findings provide valuable insights for the diagnosis and treatment of RIS.
Article
Multidisciplinary Sciences
Linshan Liu, Bin Xiao, Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Virginie Sanguin-Gendreau, Luke McCaffrey, Alice Jisoo Nam, William J. Muller
Summary: The regulation of gene expression through histone posttranslational modifications is crucial in breast cancer progression. Ezh2 integrates mTORC1 and Wnt signaling pathways in the early stages of mammary tumor progression, suggesting that targeting Ezh2 could be a potential treatment for early-stage luminal B breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Jin-Fen Xiao, Andrew W. Caliri, Jason E. Duex, Dan Theodorescu
Summary: This review discusses the presence of unfavorable genetic alterations in the FGFR3 gene in 20% of advanced bladder cancer patients and explores the potential therapeutic strategies targeting these alterations and mechanisms of drug resistance. It also highlights the clinical findings of combining FGFR inhibition with other targeted inhibitors and/or immunotherapy to improve outcomes for patients with suboptimal responses to FGFR3-directed monotherapy.
Article
Cell Biology
Zeli Song, Haoyue Mao, Jinxuan Liu, Wenchang Sun, Shengwen Wu, Xiaobo Lu, Cuihong Jin, Jinghua Yang
Summary: This study found that LaCl3 exposure can cause abnormal axons in offspring rats by interfering with the normal effects of LKB1 and downregulating the LKB1-MARK2 and LKB1-STK25-GM130 signaling pathways.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yoshikuni Kawaguchi, Timothy E. Newhook, Hop S. Tran Cao, Ching-Wei D. Tzeng, Yun Shin Chun, Thomas A. Aloia, Arvind Dasari, Scott Kopetz, Jean-Nicolas Vauthey
Summary: The study showed that FBXW7 alterations are associated with worse survival after colorectal liver metastases (CLMs) resection. In addition to FBXW7, other somatic gene alterations and clinicopathologic factors were also significantly associated with overall survival, emphasizing the importance of assessing multiple genetic markers for risk stratification and patient selection in CLM resection.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Oncology
Naoshi Nishida, Masatoshi Kudo
Summary: This article discusses the recent advancements in understanding the molecular characteristics of intrahepatic cholangiocarcinoma (iCCA), including the tumor immune microenvironment (TME) and driver mutations. It highlights the potential of combination approaches that target both the tumor and immune system for improving treatment outcomes in iCCA.
Article
Oncology
Guru P. Maiti, Sutapa Sinha, Hasan Mahmud, Justin Boysen, Mariana T. Mendez, Sara K. Vesely, Jennifer Holter-Chakrabarty, Neil E. Kay, Asish K. Ghosh
Summary: Mitochondrial metabolism in CLL cells is the key source of abundant ROS, with SOD2 and catalase being abnormally activated leading to increased H2O2 accumulation. Aberrant CpG island methylation in CLL cells can be targeted with demethylating agents to increase catalase levels and reduce ROS accumulation.
BLOOD CANCER JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Al-Hassan M. Mustafa, Oliver H. Kramer
Summary: Janus kinase (JAK) signaling is a common drug target for human cancers. However, various mutant JAK molecules and drug resistance mechanisms limit the effectiveness of JAK inhibitors. Research has shown that epigenetic mechanisms, specifically histone deacetylases (HDAC), also play a role in controlling JAK-dependent signaling. Inhibitors of HDACs have been found to suppress oncogenic JAK-dependent signaling, providing new opportunities for cancer treatment.
PHARMACOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Hirosato Ideno, Kent Imaizumi, Hiroko Shimada, Tsukasa Sanosaka, Akisa Nemoto, Jun Kohyama, Hideyuki Okano
Summary: This study identified fibroblast growth factor (FGF) signaling as a key factor in feeder-free human pluripotent stem cell (PSC) maintenance, determining the differentiation towards cerebral organoids. Inhibition of FGF signaling rescued organoid generation in feeder-free PSCs by inducing DNA methylation at the WNT5A locus, which suppressed future activation of non-canonical Wnt signaling after differentiation.
Article
Medicine, General & Internal
Madhumitha Kedhari Sundaram, Abdulmajeed G. Almutary, Ahmad Alsulimani, Syed Rehan Ahmad, Pallavi Somvanshi, Tulika Bhardwaj, Rinaldo Pellicano, Sharmila Fagoonee, Arif Hussain, Shafiul Haque
Summary: Sulforaphane modulates the transcriptional status of genes involved in proliferation, metastasis, inflammation, and signal transduction pathways by reducing the enzymatic activity of epigenetic enzymes. It competitively inhibits DNA methyl transferases and histone deacetylases, leading to demethylation and re-expression of tumor suppressor genes. This study highlights the mechanism behind the anticancer effect of sulforaphane on HeLa cells.
Article
Multidisciplinary Sciences
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Summary: This study provides multi-omics profiling of malignant germ cell tumors (GCTs) across different age groups, showing that the WNT signaling pathway is activated in GCTs and is associated with poor clinical outcomes.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Narges Ansari, Sahar Najafi, Saied Shahrabi, Najmaldin Saki
Summary: PEAR1, a platelet receptor, is crucial for hemostasis by mediating platelet adhesion and aggregation. Dysfunctional PEAR1 can disrupt platelet aggregation in CVDs patients. Studies suggest that PEAR1 polymorphisms could affect homeostasis and the function of cardiac drugs, indicating potential implications for patient treatment.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Review
Oncology
Hassan Rafieemehr, Masumeh Maleki Behzad, Saeed Azandeh, Niloofar Farshchi, Mohammad Ghasemi Dehcheshmeh, Najmaldin Saki
Summary: The BM niche is a specific microenvironment for HSCs and non-hematopoietic cells, and evidence suggests that chemo/radiotherapy can disrupt the balance within the marrow cavity, leading to bone loss, abnormal hematopoiesis, and enhanced differentiation potential of mesenchymal stem cells towards adipogenesis. Understanding the mechanisms behind these changes may help in the development of therapeutic interventions to prevent BM niche defects.
CANCER INVESTIGATION
(2021)
Review
Cell Biology
Sahar Najafi, Majid Ghanavat, Saied Shahrabi, Zahra Gatavizadeh, Najmaldin Saki
Summary: Inflammatory cytokines play a critical role in the differentiation of HSCs, stimulating or inhibiting hematopoietic progenitors to combat inflammation and leukemic conditions.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Habib Hybar, Najmaldin Saki, Mohsen Maleknia, Mana Moghaddasi, Armin Bordbar, Maliheh Naghavi
Summary: AERD is characterized by immune cells dysfunction, with ILC-2 playing a significant role in disease progression by producing cytokines that induce allergic reactions and activate mast cells and basophils, ultimately exacerbating the condition. Monoclonal antibody therapy and Aspirin desensitization have been identified as potential treatment strategies for prevention and management.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Cell Biology
Mohammad R. Javan, Najmaldin Saki, Bahareh Moghimian-Boroujeni
Summary: Aplastic anemia is an autoimmune disorder characterized by bone marrow and peripheral blood pancytopenia, with the pathogenesis remaining unclear. The disease involves impairment of both hematopoietic stem cells and mesenchymal stromal cells, leading to changes in T lymphocyte ratio and disease progression. The most common mechanism of AA is damage by the immune system, causing increased apoptosis in progenitor cells.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Oncology
Daryush Purrahman, Arshid Yousefi Avarvand, Agnieszka Paradowska-Gorycka, Najmaldin Saki, Hossein Karimpourian, Hossein Jodat, Mohammad-Reza Mahmoudian-Sani
Summary: Breast cancer is a common cancer among women, and its exact cause is still unknown. The association between human papillomavirus (HPV) and breast cancer has been explored in numerous studies, but contradictory results have been obtained. This review examines the existing evidence and hypotheses about the association between HPV infection and breast cancer, as well as the potential mechanisms involved.
Review
Hematology
Siavash Vaziri, Maryam Mirzaei, Fakhredin Saba, Kharaman Salehi Zahabi, Saleh Salehi Zahabi, Morteza Arab-Zozani
Summary: This study aimed to investigate the impact of occupational exposure to X-ray on hematological parameters. Through a systematic search and evaluation of methodological quality, it was found that long-term low-dose radiation may not have a significant effect on blood parameters, except for an increase in red blood cell count. Future studies could consider using additional tests for a more comprehensive evaluation.
EXPERT REVIEW OF HEMATOLOGY
(2022)
Article
Chemistry, Applied
Mehdi Firouzi, Maryam Ehteshamzadeh, Fakhredin Saba, Gholam Reza Khayati
Summary: Researchers extracted and identified natural mineral particles from the Gishki hot spring in Iran. They studied the cytotoxicity and antibacterial properties of these particles when in contact with two common hospital pathogens. The results showed that the mineral nanoparticles were able to kill the bacteria and could potentially be used to improve antimicrobial efficiency in healthcare and pharmaceutical industries.
JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY
(2023)
Review
Virology
Alireza Mohebbi, Habib Haybar, Fatemeh Nakhaei Moghaddam, Zahra Rasti, Mohammad Amin Vahid, Najmaldin Saki
Summary: This study found that COVID-19 patients had endothelial dysfunction and elevated levels of endothelial biomarkers. Patients with poor outcome had higher levels of von Willebrand factor, Ang-2, E-selectin, P-selectin, syndecan-1, MR-proADM, vascular endothelial growth factor, sFLT-1, and lower levels of ADAMTS13 compared to patients with good outcome.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhaleh Fakhri, Nasser Karimi, Fakhredin Saba, Mohesn Zhaleh
Summary: In this study, bio-modified Fe3O4 nanoparticles were prepared and their physicochemical properties were analyzed. The results showed that these nanoparticles have good antibacterial effect and biocompatibility without causing any harm to blood cells and tissues. Therefore, these biosynthesized Fe3O4 nanoparticles have great potential in medical applications.
BIOORGANIC CHEMISTRY
(2023)
Article
Pediatrics
Fatemeh Zeylabi, Mohammad Taha Jalali, Gholam-Abbas Kaydani, Kaveh Jaseb, Najmaldin Saki
Summary: Immune thrombocytopenic purpura (ITP) is an immune bleeding disorder associated with genetic factors and interleukin-10 (IL-10) rs1800890 polymorphism. This study found that individuals with the AA genotype were less likely to develop ITP, while the AT genotype was more common in ITP patients. However, there was no significant association between rs1800890 genotypes in the acute and chronic groups. Additionally, women had a higher frequency of this polymorphism and the rs1800890 AA genotype was associated with higher platelet counts.
JOURNAL OF PEDIATRIC GENETICS
(2023)
Article
Environmental Sciences
Mehdi Firouzi, Maryam Ehteshamzadeh, Fakhredin Saba, Gholam Reza Khayati
Summary: This study evaluated the antiviral properties of mineral nanoparticles obtained from thermal spring water against COVID-19. The results showed that the MNPs had a destructive effect on a portion of COVID-19 cases.
ENVIRONMENTAL HEALTH ENGINEERING AND MANAGEMENT JOURNAL
(2023)
Review
Genetics & Heredity
Habib Haybar, Narjes Sadat Sadati, Daryush Purrahman, Mohammad Reza Mahmoudian-Sani, Najmaldin Saki
Summary: Cardiovascular diseases (CVDs) are major causes of death worldwide. Understanding the molecular mechanisms and signaling pathways involved in CVD pathogenesis is crucial for the development of accurate diagnostic techniques, effective prognostic markers, and potential therapeutic targets. Recent research suggests that the lncRNA TUG1 can serve as a biomarker for predicting the prognosis of CVD.
Review
Biochemistry & Molecular Biology
Ali Gholami, Khosro Farhadi, Fatemeh Sayyadipour, Masoud Soleimani, Fakhredin Saba
Summary: This review summarizes the role of lncRNAs in lymphomas and their potential clinical value. It has been found that lncRNAs play a critical role in lymphoma carcinogenesis by affecting apoptosis, cell proliferation, invasion, and response to chemotherapy.