Article
Nutrition & Dietetics
Elisabeth Bluethner, Ulrich-Frank Pape, Frank Tacke, Sophie Greif
Summary: This study aims to analyze the changes in quality of life (QoL) of teduglutide-treated patients with chronic intestinal failure (cIF) and compare them to a non-treated cIF control group. The results show significant improvements in SBS-QoL and SF-36 scores in teduglutide-treated patients compared to the non-treated group in a real-world setting. There are also significant differences in QoL changes between the treated and non-treated patients.
Article
Nutrition & Dietetics
Zuzanna Zaczek, Paulina Jurczak-Kobus, Mariusz Panczyk, Joanna Braszczynska-Sochacka, Krystyna Majewska, Marek Kunecki, Karolina Dabrowska, Jacek Sobocki
Summary: In this study, patients receiving home parenteral nutrition after discontinuation of TED treatment were followed up for 9 years, showing that the PN volume requirements increased within 4-5 years after treatment cessation and in some cases even exceeded pretreatment values.
Review
Nutrition & Dietetics
Giovanni Boroni, Filippo Parolini, Maria Vittoria Stern, Cristina Moglia, Daniele Alberti
Summary: Short bowel syndrome is the most common cause of intestinal failure in children. Autologous intestinal reconstruction surgery can improve intestinal autonomy and maximize the absorptive potential of the remaining gut.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Jeffery Bettag, Loren Po, Cassius Cunningham, Rahul Tallam, Kento Kurashima, Aakash Nagarapu, Chelsea Hutchinson, Sylvia Morfin, Mustafa Nazzal, Chien-Jung Lin, Amit Mathur, Rajeev Aurora, Ajay K. Jain
Summary: Short bowel syndrome is a serious condition characterized by the inability of the small intestine to absorb sufficient nutrients, leading to severe illness and potential death. Total parental nutrition, as a treatment method, has its challenges such as liver injury and altered signaling. This manuscript summarizes the systemic effects of total parental nutrition on various systems and discusses novel therapeutic strategies.
Article
Surgery
Savas T. Tsikis, Scott C. Fligor, Thomas I. Hirsch, Paul D. Mitchell, Amy Pan, Kamila Moskowitzova, Ashlyn E. Whitlock, Greta Loring, Eric First, Arthur Nedder, Kathleen M. Gura, Mark Puder
Summary: In a porcine model of short bowel syndrome with intestinal failure, the use of an immobilized lipase cartridge (ILC) in conjunction with enteral feeding reduced parenteral nutrition (PN) dependence, improved nutrient absorption, and increased bowel growth.
Review
Nutrition & Dietetics
Astrid Verbiest, Palle Bekker Jeppesen, Francisca Joly, Tim Vanuytsel
Summary: Short bowel syndrome (SBS) is a rare gastrointestinal condition caused by extensive surgical resection, resulting in less than 200 cm of remaining small intestine. This condition is associated with a high risk for intestinal failure (IF) and requires parenteral support (PS). This review focuses on the role of the colon in SBS-IF, including intestinal adaptation, energy salvage, and the impact of the microbiota. Additionally, the effects of glucagon-like peptide-2 (GLP-2) analogs, a disease-modifying treatment, in SBS-IF patients with and without a colon are discussed. Overall, this review emphasizes the importance of preserving the colon in SBS-IF.
Review
Nutrition & Dietetics
Maria Giovanna Puoti, Jutta Koglmeier
Summary: This paper discusses the nutritional strategies available for clinicians caring for pediatric patients with short bowel syndrome. The research found that there is currently no consensus on the best way to feed these patients, and there are significant variations in practice between different centers. Therefore, more research is needed to establish common treatment protocols.
Review
Nutrition & Dietetics
Jasmine Carter, Jeffery Bettag, Sylvia Morfin, Chandrashekhara Manithody, Aakash Nagarapu, Aditya Jain, Hala Nazzal, Sai Prem, Meghan Unes, Matthew McHale, Chien-Jung Lin, Chelsea Hutchinson, Grace Trello, Arti Jain, Edward Portz, Arun Verma, Marzena Swiderska-Syn, Daniel Goldenberg, Kento Kurashima
Summary: Short bowel syndrome (SBS) is a condition caused by a reduction in the length or functional capacity of the intestine. The gut microbiome plays a significant role in modulating disease progression in SBS patients. The composition and shifts of gut bacteria in SBS and the resulting systemic effects have been extensively studied, revealing the variability and dependence on multiple factors. The bidirectional communication between the gut and the brain, regulated by the microbiome, known as the gut-brain axis (GBA), also has implications in SBS.
Review
Nutrition & Dietetics
Yolanda Ber, Santiago Garcia-Lopez, Carla J. Gargallo-Puyuelo, Fernando Gomollon
Summary: This article discusses the different functions of the small intestine and large intestine in nutrient absorption, as well as the causes, consequences, and management of malnutrition in patients with inflammatory bowel diseases, short bowel syndrome, and malignant and benign digestive tumors.
Article
Nutrition & Dietetics
Karen Bannert, Cathleen Karbe, Robert H. Foerster, Lea F. Sautter, Fatuma Meyer, Luzia Valentini, Mats L. Wiese, Luise Ehlers, Peggy Berlin, Robert Jaster, Ali A. Aghdassi, Markus M. Lerch, Georg Lamprecht
Summary: This exploratory study aimed to assess the nutritional, muscular, and functional status of orally compensated short bowel syndrome/intestinal insufficiency (SB/II) patients. The results showed that SB/II patients had lower body weight, but most of them had normal BMI. The prevalence of malnutrition was high, but it may be overestimated due to malabsorption and hyperphagia. Muscle mass reduction was common but rarely accompanied by functional impairment leading to sarcopenia diagnosis. Therefore, SB/II patients long term after termination of parenteral support may be malnourished but usually do not develop sarcopenia.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Igor Sukhotnik, Reut Levi, Hadar Moran-Lev
Summary: Essential amino acids are crucial in promoting intestinal adaptation after significant small gut resection. The role of dietary amino acids in the nutritional management of infants and children with intestinal failure and short bowel syndrome (SBS) has been extensively studied over the past three decades. Breast milk is recommended as the first-line enteral regimen for infants with SBS, and hydrolyzed formulas or amino acid formulas are recommended when breast milk is not available or tolerated. The superiority of amino acid formulas over hydrolyzed formulas has not been proven. Glutamine supplementation in SBS infants does not affect their dependence on parenteral nutrition. Circulating citrulline is considered an important indicator of survival and nutritional prognosis in SBS patients. Early enteral nutrition and dietary amino acid supplementation are essential for intestinal adaptation and reducing the reliance on parenteral nutrition after bowel resection in children.
Article
Construction & Building Technology
Xiaolong Yang, Chunhong Peng, Jiangcai Chen, Guiyong Liu, Xinyi He
Summary: By analyzing the rheological properties of bio-asphalt, the effectiveness of bio-asphalt as a substitute for petroleum asphalt has been explored. The addition of bio-asphalt improves the low-temperature rheological properties of modified asphalt while reducing the high-temperature rheological properties. The combination of bio-asphalt, SBS, and PPA exhibits excellent performance in high and low-temperature conditions. This study reveals the mechanism of bio-asphalt improving the compatibility of SBS and PPA in asphalt.
CASE STUDIES IN CONSTRUCTION MATERIALS
(2023)
Article
Engineering, Biomedical
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
Summary: A nutrient carrier platform constructed with green tea catechin and ferrous ions effectively prolongs the residence and absorption time of nutrients in the intestine, improving the nutritional status, anemia, immune function, intestinal tissue growth, and integrity of the intestinal barrier in a rat model of short bowel syndrome. The platform also modulates gut microbial dysbiosis and increases the abundance of beneficial bacteria. This study provides evidence for the use of polyphenol-based nanocomplexes as enteral nutrition preparation for SBS treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Gastroenterology & Hepatology
Jamie Bering, John K. DiBaise
Summary: Short bowel syndrome is a rare disorder characterized by severe intestinal dysfunction, leading to malabsorption and the need for parenteral nutrition support. Treatment is complex and involves various approaches such as nutrition support, fluid and electrolyte management, and pharmacologic therapies.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Pediatrics
Julian L. Muff, Filipp Sokolovski, Zarah Walsh-Korb, Rashikh A. Choudhury, James C. Y. Dunn, Stefan G. Holland-Cunz, Raphael N. Vuille-dit-Bille
Summary: Short bowel syndrome is a devastating disorder with increasing prevalence. It can be caused by congenital or secondary factors, and the current treatment is primarily focused on conservative therapies such as parenteral nutrition. Surgical interventions have greatly improved patient outcomes, and future developments may involve regenerative medicine.
Article
Public, Environmental & Occupational Health
Nicholas Woodrow, Hannah Fairbrother, Katie Breheny, Katrina D'Apice, Patricia N. Albers, Clare Mills, Matthew Curtis, Lisa Hopkins, Sarah Tebbett, Rona Campbell, Frank De Vocht
Summary: This study explores the acceptability, utility, and effectiveness of a school-based online health and wellbeing screening tool. The findings show that the tool is effective in identifying and supporting unmet health needs, and is an efficient use of limited resources. However, there are barriers to school engagement that need to be addressed. Overall, the tool is seen as a valuable and effective resource, with a low burden on school staff.
Article
Ophthalmology
Jan Henrik Terheyden, Susanne G. Pondorfer, Charlotte Behning, Moritz Berger, Jill Carlton, Donna Rowen, Christine Bouchet, Stephen Poor, Ulrich F. O. Luhmann, Sergio Leal, Frank G. Holz, Thomas Butt, John E. Brazier, Robert P. Finger
Summary: This study aims to validate the Vision Impairment in Low Luminance (VILL) questionnaire for assessing visual functioning and vision-related quality of life (VRQoL) in patients with age-related macular degeneration (AMD) under low luminance, low-contrast conditions. The VILL questionnaire was translated into multiple languages and analyzed using Rasch analysis. The results supported the reliability and validity of the shortened version of the questionnaire, VILL-33, across all stages of AMD.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Nutrition & Dietetics
Ruth Salway, Charlie Foster, Frank de Vocht, Byron Tibbitts, Lydia Emm-Collison, Danielle House, Joanna G. Williams, Katie Breheny, Tom Reid, Robert Walker, Sarah Churchward, William Hollingworth, Russell Jago
Summary: The COVID-19 pandemic and associated restrictions have led to decreased physical activity levels for both children and parents. After the restrictions were lifted, children's activity levels remained lower than before the pandemic, while parents' activity levels remained similar.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2022)
Article
Environmental Sciences
Nicholas Woodrow, Hannah Fairbrother, Katrina D'Apice, Katie Breheny, Patricia Albers, Clare Mills, Sarah Tebbett, Rona Campbell, Frank De Vocht
Summary: Despite high levels of need, many young people do not seek or receive support for their health issues. The Digital Health Contact (DHC) program, conducted online, was found to be a useful approach for identifying health needs and providing support. Young people appreciated the online format of the DHC screening questionnaire, as it allowed for more honest responses compared to face-to-face approaches. They also felt that completing the questionnaire at home, rather than at school, provided more privacy and less time pressure, enabling them to give more honest and detailed responses. Young people's understanding of the screening process influenced their engagement and responses.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Jill Carlton, Philip Powell, Donna Rowen, Melanie Broadley, Frans Pouwer, Jane Speight, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Christopher J. Child, Jonathan Comins, Rory J. McCrimmon, Bastiaan de Galan, John Brazier
Summary: This study aims to develop a new hypoglycaemia-specific PROM to assess the impact of hypoglycaemia on quality of life in patients with diabetes. The study uses a mixed-methods, three-stage design, collecting information through qualitative interviews and validating it through psychometric testing, ultimately generating a hypoglycaemia-specific PROM and preference-based measure.
Article
Health Care Sciences & Services
Philip A. Powell, Milad Karimi, Donna Rowen, Nancy Devlin, Ben van Hout, John E. Brazier
Summary: This study explores the public understanding, opinions, and potential solutions to differences between hypothetical and experienced responses in the context of health resource allocation. Most participants found it difficult to imagine health states without experience, and favored experienced responses as more accurate. The study suggests recruiting people with greater experience or incorporating other views as acceptable solutions.
QUALITY OF LIFE RESEARCH
(2023)
Article
Economics
Sarah Acaster, Clara Mukuria, Donna Rowen, John E. Brazier, Claire E. Wainwright, Bradley S. Quon, Jamie Duckers, Alexandra L. Quittner, Yiyue Lou, Patrick R. Sosnay, Lisa J. McGarry
Summary: This study developed a preference-based utility measure for cystic fibrosis (CF) based on the CFQ-R questionnaire, which is the first disease-specific scoring algorithm for CF. It allows for estimation of disease-specific utilities and can be used in cost-effectiveness analysis.
Article
Public, Environmental & Occupational Health
Patricia E. Jessiman, Victoria R. Carlisle, Katie Breheny, Rona Campbell, Russell Jago, Marcus Robinson, Steve Strong, Judi Kidger
Summary: In the UK, one in five households with children experienced food insecurity. This study evaluated the feasibility, acceptability, cost implications, and implementation lessons of universal free school meals (UFSM) in two secondary schools in England.
Article
Nutrition & Dietetics
Russell Jago, Ruth Salway, Danielle House, Robert Walker, Lydia Emm-Collison, Kate Sansum, Katie Breheny, Tom Reid, Sarah Churchward, Joanna G. Williams, Charlie Foster, William Hollingworth, Frank de Vocht
Summary: The COVID-19 pandemic has had a significant impact on children's physical activity, resulting in a decrease in moderate-to-vigorous physical activity during lockdowns. While there was little change in parental activity levels post-COVID lockdown, it is important to examine if these patterns persist.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Clinical Neurology
Tom Denee, Cicely Kerr, Joe Eva, Sally-Anne Vincent, Nicholas Jacobsen, Allan H. Young, Mitesh Desai, Laura Baldock, Shanaya Rathod
Summary: This study explores the lived experiences of informal carers of people with depression, especially those with treatment-resistant depression. The results show that carers of individuals with treatment-resistant depression have impaired quality of life and work productivity. The study also suggests that successful treatment for depression benefits both patients and their carers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Robert Walker, Danielle House, Ruth Salway, Lydia Emm-Collison, Lara E. Hollander, Kate Sansum, Katie Breheny, Sarah Churchward, Joanna G. Williams, Frank de Vocht, William Hollingworth, Charlie Foster, Russell Jago
Summary: This study conducted interviews with parents, school staff, and children to analyze the impact of COVID-19 on children's physical activity. The study found that after the pandemic, children's physical activity habits changed, with a greater reliance on structured and organized activities, which may lead to decreased physical activity levels, especially for girls and children from lower socio-economic households. Therefore, affordable and equitable opportunities should be provided to prevent physical activity and health inequalities.
Article
Nutrition & Dietetics
Robert Walker, Ruth Salway, Danielle House, Lydia Emm-Collison, Katie Breheny, Kate Sansum, Sarah Churchward, Joanna G. Williams, Frank de Vocht, William Hollingworth, Russell Jago
Summary: This study examines the impact of the COVID-19 pandemic on the participation, costs, and provision of active clubs in schools and communities. The findings show that school-based club participation has increased, while community-based club participation has decreased. Children from lower education households are less likely to participate in active clubs, and girls are less likely to attend community clubs. The study also highlights the increase in club costs and the shift towards more affordable and convenient school-based clubs.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Psychiatry
Prianka Padmanathan, Rachel Cohen, David Gunnell, Lucy Biddle, Emma Griffith, Katie Breheny, Matt Hickman, Nik Munien, Anish Patel, Elaine Crocker, Paul Moran
Summary: This study aimed to develop a brief psychosocial intervention for individuals presenting to the emergency department with self-harm and co-occurring substance use problems. Through a modified Delphi method, expert consensus was achieved for 22 items, resulting in an intervention that includes weekly follow-up phone calls and support for accessing community services.
CRISIS-THE JOURNAL OF CRISIS INTERVENTION AND SUICIDE PREVENTION
(2023)
Meeting Abstract
Economics
P. Schneider, J. E. Brazier, N. Devlin, B. van Hout
Meeting Abstract
Economics
L. Broderick, M. Lauher, M. K. White, M. Kosinski, B. Mulhern, J. E. Brazier, J. B. Bjorner
