Article
Computer Science, Interdisciplinary Applications
T. Munger, S. Desa
Summary: An important issue in machine learning is model selection for engineering applications, where external parameters such as feature engineering can significantly impact model performance. This article introduces a statistical design of experiment approach, based on the Taguchi method, to efficiently explore the experimental space and optimize model selection for real-world problems.
JOURNAL OF COMPUTING AND INFORMATION SCIENCE IN ENGINEERING
(2021)
Review
Biochemical Research Methods
James Gilman, Laura Walls, Lucia Bandiera, Filippo Menolascina
Summary: The design and optimization of biological systems is complex, and synthetic biology research often uses One Factor at A Time (OFAT) experimentation, which ignores interaction effects between factors. To overcome this limitation, studies are increasingly turning to Design of Experiments (DoE) methods for efficient and systematic exploration of complex design spaces.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Ghazanfar Ali Shah, Arnaud Polette, Jean-Philippe Pernot, Franca Giannini, Marina Monti
Summary: This paper proposes a method for enhancing the Reverse Engineering technique based on the Simulated Annealing algorithm. By identifying optimal default setting parameters, the method improves the fitting of CAD geometries to digitized parts' point clouds. The method utilizes sensitivity analysis, design of experiments, and similarity assessment to achieve better fitting efficiency.
ENGINEERING WITH COMPUTERS
(2023)
Article
Materials Science, Multidisciplinary
Zhenzhen Chen, Liang Shen, Xiong Zhao, Hongqiang Chen, Yaxuan Xiao, Yonghai Zhang, Xiaoping Yang, Jinhua Zhang, Jinjia Wei, Nanjing Hao
Summary: Microfluidics, especially acoustofluidics, offers new opportunities in chemical and biomedical engineering by manipulating fluids at the micrometer or submicrometer scale. This review discusses the utility of acoustofluidic technology, summarizes different types of acoustic micromixers, highlights their applications in various fields, and identifies the practical challenges that need to be addressed. Overall, this review provides valuable insights for both academic research and industrial applications.
APPLIED MATERIALS TODAY
(2022)
Article
Materials Science, Multidisciplinary
Jianxing Liu, Dongjia Yan, Wenbo Pang, Yihui Zhang
Summary: Soft network materials, with well-organized microarchitectures inspired by biological tissues, offer a unique combination of properties and design flexibility for customized mechanical performance, leading to a range of promising applications in cutting-edge technologies like bio-integrated electronics and regenerative medicine. Perspectives on remaining challenges and open opportunities are also provided.
Article
Chemistry, Multidisciplinary
Margaret M. Billingsley, Alex G. Hamilton, David Mai, Savan K. Patel, Kelsey L. Swingle, Neil C. Sheppard, Carl H. June, Michael J. Mitchell
Summary: Viral engineered chimeric antigen receptor (CAR) T cell therapies are potent cancer immunotherapies, but their permanent CAR expression can lead to severe adverse effects. Nonviral messenger RNA (mRNA) CAR T cells are being explored as a safer alternative, and this study demonstrates the improved mRNA delivery to T cells with low cytotoxicity using a new ionizable lipid nanoparticle (LNP) formulation (B10). Compared to electroporation, B10 LNPs induce similar CAR expression with reduced cytotoxicity and potent cancer cell killing.
Review
Biotechnology & Applied Microbiology
Joan Planas-Iglesias, Sergio M. Marques, Gaspar P. Pinto, Milos Musil, Jan Stourac, Jiri Damborsky, David Bednar
Summary: Enzymes are natural catalysts that execute biochemical reactions, and their effectiveness has been optimized through evolution. Biocatalysts from various sources are used in industrial production, environmental protection, and biomedical applications. Protein engineering and computational techniques can improve enzyme function for diverse applications.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Engineering, Biomedical
Xu Chen, Qianping Guo, Wei Chen, Wanli Xie, Yunlong Wang, Miao Wang, Tianyan You, Guoqing Pan
Summary: This review highlights the bio-inspired structure colors of photonic crystal (PC) materials, emphasizing their advancement in biosensing, bio-probing, bio-screening, tissue engineering, and more. In addition, it discusses emerging applications based on functional materials and newly developed material engineering technologies, providing insight for developing next generation smart biomedical materials or devices.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Civil
Henry Burton, Hongquan Xu, Zhengxiang Yi
Summary: Surrogate models are increasingly used in earthquake engineering to improve computational efficiency. This article discusses the design of computer experiments for developing seismic surrogate models, providing insights through a case study. The results show that a hybrid design combining orthogonal array-based composite design with a small number of Latin hypercube samples produces a surrogate model with superior predictive performance.
EARTHQUAKE SPECTRA
(2022)
Review
Biotechnology & Applied Microbiology
Dianelis T. Monterrey, Ivan Ayuso-Fernandez, Isabel Oroz-Guinea, Eduardo Garcia-Junceda
Summary: Fusion proteins have various applications in biotechnology, especially in biocatalysis. The proximity of active sites in multi-enzyme complexes can enhance catalytic efficiency, but it is not solely dependent on physical proximity. Factors such as the nature and length of the linker and the order of enzyme fusion need to be considered for optimal catalytic efficiency.
BIOTECHNOLOGY ADVANCES
(2022)
Review
Biochemical Research Methods
Woo Dae Jang, Gi Bae Kim, Yeji Kim, Sang Yup Lee
Summary: This paper reviews recent studies on AI-aided protein engineering and design, focusing on directed evolution that uses AI approaches to efficiently construct mutant libraries. Additionally, recent works on AI-aided pathway design strategies, including template-based and template-free approaches, are discussed.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Marco Meloni, Jianguo Cai, Qian Zhang, Daniel Sang-Hoon Lee, Meng Li, Ruijun Ma, Teo Emilov Parashkevov, Jian Feng
Summary: Origami-based designs involve applying the ancient art of origami to solve engineering problems, with a focus on cross-disciplinary interest. This article reviews recent origami-based applications in engineering, design methods and tools in various fields, and discusses future challenges and open questions.
Article
Engineering, Environmental
Lei Guo, Xinbin Wang, Fuwei Jiang, Youqian Liu, Qihao Yu, Yanhui You, Jinchang Wang
Summary: This article discusses the influence of four important parameters on the simulation accuracy and application results of two-phase closed thermosyphons (TPCTs) based on numerical simulations. The parameters include model size, daily variations in air and ground surface temperatures, decreasing cooling power of a TPCT, and adiabatic section. The results show that these parameters have a significant impact on the thermal influence of TPCTs and can help optimize their field applications in cold regions.
COLD REGIONS SCIENCE AND TECHNOLOGY
(2022)
Article
Construction & Building Technology
Hui Wei, Yudan Wang, Jue Li, Yuhao Zhang, Guoping Qian
Summary: This study investigates the effect of the compositions and contents of cold patching asphalt liquid (CPAL) on its road performance through multivariate analysis and develops a low-cost and storable CPAL. The optimal design scheme of CPAL is 20% diesel, 0.6% diethylene glycol, 6% oleic acid, and 6% coconut oil acid diethanolamine, which exhibits high adhesion, strength, and good storage stability in pavement engineering.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Zhengshan Luo, Yifan Yan, Shanshan Du, Yifan Zhu, Fei Pan, Rui Wang, Zheng Xu, Xiaoqi Xu, Sha Li, Hong Xu
Summary: Bacillus amyloliquefaciens, a Gram-positive bacterium, has unique characteristics that make it suitable for industrial applications. Through systems biology and synthetic biology techniques, its productivity characteristics have been optimized. Researchers discuss the potential advantages and recent advancements of B. amyloliquefaciens as a platform for metabolic engineering and industrial applications.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Elisabeth Viles, Javier Santos, Andres Munoz-Villamizar, Paloma Grau, Tamara Fernandez-Arevalo
Summary: This paper demonstrates the importance of having detailed knowledge on water consumption in industries through a multi-case study in the agri-food industry, where monitoring water consumption and applying lean-green practices lead to a zero-waste strategy for this critical resource.
Article
Construction & Building Technology
Inigo Martinez, Jan L. Bruse, Ane M. Florez-Tapia, Elisabeth Viles, Igor G. Olaizola
Summary: Recent evidence suggests that the SARS-CoV-2 virus is mainly transmitted through airborne aerosols in indoor environments. This article introduces a novel agent-based simulator, ArchABM, designed to assist in creating or adapting buildings by estimating adequate room sizes, ventilation parameters, and testing the effect of policies on indoor air quality (IAQ) by considering complex human-building interaction patterns. The simulator incorporates a recently published aerosol model to calculate time-dependent concentrations of carbon dioxide (CO2) and virus quanta in each room, as well as the inhaled CO2 and virus quanta for each occupant over a day. The flexibility of ArchABM allows for the implementation of different aerosol models and building layouts.
BUILDING AND ENVIRONMENT
(2022)
Article
Engineering, Multidisciplinary
Inigo Martinez, Urtzi Otamendi, Igor G. Olaizola, Roger Solsona, Mikel Maiza, Elisabeth Viles, Arturo Fernandez, Ignacio Arzua
Summary: Accurate temperature measurements are crucial for monitoring and controlling industrial furnaces, but measurement uncertainty poses a risk. This paper discusses sources of error and uncertainty in spectral-band radiation thermometry techniques, and introduces a methodology for budgeting and a continuous monitoring system with a deep-learning-based correction model. A real-world application case in a petrochemical plant is presented to validate the proposed system's functionality in improving operational security and efficiency in energy-intensive systems.
Article
Engineering, Industrial
Florencia Kalemkerian, Javier Santos, Martin Tanco, Jose Arturo Garza-Reyes, Elisabeth Viles
Summary: This paper investigates the implementation of the Green Lean strategy and its contribution to Circular Economy. The findings suggest that while Green Lean focuses on waste reduction, it lacks a value creation focus through waste. The majority of Green Lean implementations aim at minimizing waste rather than closing production cycles. Therefore, the current contribution of Green Lean to circular practices is limited. The paper suggests redirecting Green Lean towards a value creation focus to integrate the circular philosophy.
JOURNAL OF MANUFACTURING TECHNOLOGY MANAGEMENT
(2022)
Article
Chemistry, Physical
Maria de las Nieves Camacho, Daniel Jurburg, Martin Tanco
Summary: This article synthesizes the available information about heavy-duty fuel cell trucks and suggests their deployment as a complementary solution to reducing CO2 emissions alongside electric vehicles. The main research topics in the past decade include public policies, hydrogen supply chain, environmental impact, drivetrain technology, fuel cell, and storage tank applications. However, there are still research gaps to be addressed.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Green & Sustainable Science & Technology
Elisabeth Viles, Florencia Kalemkerian, Jose Arturo Garza-Reyes, Jiju Antony, Javier Santos
Summary: The study aims to redefine the principles of Sustainable Production in the transition to Circular Economy and smart industry models. Through the Delphi Panel and Interpretative Structural Model techniques, ten principles have been identified, which provide new possibilities for researchers and help managers better understand sustainability in production.
SUSTAINABLE PRODUCTION AND CONSUMPTION
(2022)
Article
Environmental Studies
Florencia Kalemkerian, Silvia Lamela, Javier Santos, Martin Tanco
Summary: This research explores the relationship between cleaner production and sustainability, finding that the key factors for successful implementation are top management commitment and government support. However, most companies only apply cleaner production to comply with environmental laws, resulting in limited contribution to sustainability. Additionally, these companies lack standardized metrics to evaluate their sustainable performance, but cleaner production serves as a guide for decision-making.
INTERNATIONAL JOURNAL OF ENVIRONMENT AND SUSTAINABLE DEVELOPMENT
(2023)
Article
Environmental Studies
M. Tanco, M. S. Cavallieri, M. Levy, S. Rossi, D. Jurburg
Summary: This paper aims to study the current fleet of freight vehicles in Uruguay and calculate the greenhouse gas emissions caused by road freight transport using international methodologies. It establishes three future scenarios with different powertrain technologies and considers the transition from Euro III to Euro V regulations. By projecting the levels of future emissions, this study provides valuable information for the development of policies in the road freight transport sector.
TRANSPORTATION RESEARCH PART D-TRANSPORT AND ENVIRONMENT
(2023)
Article
Management
Jiju Antony, Laynes Lauterbach, Elisabeth Viles, Martin Tanco, Sandy Furterer, Ronald D. D. Snee
Summary: This article presents a novel case study that analyzes the applicability of DoE in the curling sport in order to improve their own performance and the performance of its athletes. The study found that factors such as routine, stress, release, balance, and previous play situation have a significant impact on the score of the player's draw game, but have no significant impact on the average distance to the center of the target.
Article
Development Studies
Elisabeth Viles, Maria Sol Cavallieri, Florencia Kalemkerian, Jairo R. Montoya-Torres, Javier Santos
Summary: This study presents a framework with 39 indicators to assist manufacturing companies in implementing sustainable development strategies and aligning with global goals. The Sankey diagram visualizes the connections between the selected indicators and the Sustainable Development Goals.
SUSTAINABLE DEVELOPMENT
(2023)
Proceedings Paper
Automation & Control Systems
Javier Santos, Elisabeth Viles, Florencia Kalemkerian
Summary: This paper presents the results of a research project that used low-cost technology to monitor water consumption in the food industry. The project conducted 43 monitoring campaigns in 17 companies and identified a potential saving of over 1 million liters of water per day. The project also found significant water savings in cleaning and sterilization processes. Additionally, the study identified four barriers that hinder the use of technology for sustainable water management.
IOT AND DATA SCIENCE IN ENGINEERING MANAGEMENT
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Inigo Martinez, Elisabeth Viles, Igor G. Olaizola
Summary: This study presents a closed-form expression for the solution of ODE and its gradient under continuous piecewise-affine velocity functions. The authors also provide a highly optimized implementation of the results on CPU and GPU. Extensive experiments demonstrate the generalization ability of the model to unseen data, showing significant improvements in terms of efficiency and accuracy.
INTERNATIONAL CONFERENCE ON MACHINE LEARNING, VOL 162
(2022)
Article
Management
Matias Escuder, Martin Tanco, Andres Munoz-Villamizar, Javier Santos
Summary: This study aims to explore the potential of applying Lean principles to reduce waste in urban logistics. Through field research and validation meetings, the authors found that most of the shipper's time is spent on waiting, and by deploying Lean thinking, urban logistics can be significantly improved with up to 25% increase in the number of stores served per shift. From an academic perspective, this study emphasizes the importance of applying Lean practices in transportation contexts, and from a company's perspective, the authors provide propositions to reduce waste and improve the efficiency of urban transportation.
INTERNATIONAL JOURNAL OF PRODUCTIVITY AND PERFORMANCE MANAGEMENT
(2022)
