Article
Emergency Medicine
Richard T. Griffey, Ryan M. Schneider, Alexandre A. Todorov
Summary: The Emergency Department Trigger Tool (EDTT) is a novel approach to detecting adverse events in the ED and can be used for quality improvement. This study analyzed data from a retrospective observational study and categorized the adverse events detected by place of occurrence, severity, omission/commission, and type. The results showed that the EDTT identified a broad spectrum of adverse event types and most events resulted in temporary harm. The study highlights the opportunities for targeted improvement in the ED.
ANNALS OF EMERGENCY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Angela Kannukene, Carola Orrego, Margus Lember, Anneli Uuskula, Kaja Polluste
Summary: This study aims to evaluate the characteristics and occurrence of adverse events (AEs) in multimorbid patients in hospitalised internal medicine patients of Estonia, and describes the development of a trigger tool for this purpose. The study will search for evidence on measuring AEs in multimorbid patients and translate triggers from English to Estonian. The results will be disseminated to healthcare providers and stakeholders at national and international conferences.
Article
Multidisciplinary Sciences
Mareen Broesterhaus, Antje Hammer, Rosalie Gruber, Steffen Kalina, Stefan Grau, Anjali A. Roeth, Hany Ashmawy, Thomas Gross, Marcel Binneboesel, Wolfram Trudo Knoefel, Tanja Manser
Summary: This study qualitatively and systematically assessed the GTT implementation process in three departments of German university hospitals, and identified the facilitators and obstacles in the process.
Article
Pediatrics
Pernilla Dillner, Maria Unbeck, Mikael Norman, Per Nydert, Karin Pukk Harenstam, Synnove Lindemalm, Dirk Wackernagel, Ulrika Forberg
Summary: This study aimed to investigate the occurrence and characteristics of inpatient neonatal adverse events in a Swedish setting. A retrospective record review was performed using a trigger tool by registered nurses and a neonatologist at a University Hospital. The results showed that adverse events were common in neonatal care, with a high rate of preventable events occurring during the first week of admission.
Article
Medicine, General & Internal
Martin Magneli, Paula Kelly-Pettersson, Cecilia Rogmark, Max Gordon, Olof Skoldenberg, Maria Unbeck
Summary: This study aimed to explore the timing, severity, and preventability of adverse events (AEs) in patients undergoing hip arthroplasty surgery. The majority of AEs occurred perioperatively and postoperatively, with a wide range of median days for different AE types. Most AEs were deemed preventable and/or of major severity, emphasizing the need for a better understanding of the timing and occurrence of AEs to improve patient safety in hip arthroplasty surgery.
Review
Medicine, General & Internal
Nan Yu, Liuyun Wu, Qinan Yin, Shan Du, Xinxia Liu, Shan Wu, Rongsheng Tong, Junfeng Yan, Yuan Bian
Summary: This study demonstrated the value of Global Trigger Tool (GTT) in detecting adverse drug events (ADEs) in elderly inpatients in China. A high incidence of ADEs was found, with gastrointestinal and metabolic/nutritional disorders being the most commonly affected. Most ADEs were caused by drugs used for cardiovascular diseases. The number of medications was found to have a significant correlation with ADEs.
FRONTIERS IN MEDICINE
(2023)
Review
Multidisciplinary Sciences
Luisa C. Eggenschwiler, Anne W. S. Rutjes, Sarah N. Musy, Dietmar Ausserhofer, Natascha M. Nielen, Rene Schwendimann, Maria Unbeck, Michael Simon
Summary: This study conducted a systematic review and meta-analysis to assess the incidence of adverse events (AEs) in acute care inpatient settings. The findings revealed significant variations in reported AE incidence rates, which can be partially explained by study characteristics and quality.
Article
Health Care Sciences & Services
Hugh Chen, Scott M. Lundberg, Gabriel Erion, Jerry H. Kim, Su-In Lee
Summary: The article introduces a transferable embedding method named PHASE for accurately forecasting adverse surgical outcomes based on physiological signals. Through comparison on over 50,000 surgeries and ICU data, it is found that PHASE outperforms other state-of-the-art approaches in predicting six distinct outcomes.
NPJ DIGITAL MEDICINE
(2021)
Article
Oncology
Chieh Yang Koo, Bee-Choo Tai, Dedrick Kok Hong Chan, Li Ling Tan, Ker Kan Tan, Chi-Hang Lee
Summary: Among colorectal cancer patients undergoing surgical resection, there is a high incidence of MACCE. Diabetes mellitus and prior cardiovascular disease are associated with an increased risk of MACCE. Chemotherapy is associated with a lower risk of MACCE, but further research is needed to confirm this association.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sandna Larissa Freitas dos Santos, Ana Paula Soares Gondim
Summary: The goal of this study was to use global trigger tool trackers to identify adverse drug events in children using psychotropic drugs in Child-adolescent Psychosocial Care Centers. A total of 42 adverse drug events were found in 36 medical records, with agitation and aggression being the most frequent symptoms. The study showed that the global trigger tool can detect adverse drug events in children and provide interventions to improve psychiatric therapy in community services.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pediatrics
Ramnath Balasubramanian, Rachel Folwell, Arran Wheatley, Heidi Ramsey, Carmen Barton, Christopher J. D. Reid, Manish D. Sinha
Summary: This study developed a paediatric haemodialysis trigger tool (pHTT) to systematically monitor adverse events in children undergoing intermittent in-centre haemodialysis. The use of the pHTT significantly reduced harm rates per dialysis session, and the identified triggers could potentially improve patient safety.
PEDIATRIC NEPHROLOGY
(2022)
Article
Health Care Sciences & Services
Kun Feng, Li Zhang, Huayun He, Xueqin You, Qiannan Zhang, Hong Wei, Ziyu Hua
Summary: This study aimed to develop and validate a trigger tool for detecting adverse events (AEs) in neonates. The trigger tool was developed using the random forest algorithm and validated using medical records of neonates. The tool efficiently and reliably identified AEs in hospitalized neonates.
JOURNAL OF PATIENT SAFETY
(2022)
Article
Health Care Sciences & Services
Maria Dolores Toscano Guzman, Mercedes Galvan Banqueri, Maria Jose Otero, Susana Sanchez Fidalgo, Isabel Font Noguera, Maria Concepcion Perez Guerrero
Summary: The study evaluated the performance of an initial list developed to detect adverse drug events in elderly patients with multimorbidity, and found that the final validated TRIGGER-CHRON tool is an efficient list for identifying ADEs in this population, detecting ADEs in one-fourth of hospitalized patients in internal medicine or geriatric units.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Oncology
Carolina A. Ferreira, Pedram Heidari, Bahar Ataeinia, Nicoleta Sinevici, Meghan E. Sise, Robert B. Colvin, Eric Wehrenberg-Klee, Umar Mahmood
Summary: Cancer immunotherapy has greatly improved patient prognosis, but immune-related adverse events remain a challenge. This study demonstrates the use of a granzyme B-targeted PET imaging agent to identify and visualize such events in a murine model, providing potential clinical applications.
CLINICAL CANCER RESEARCH
(2021)
Article
Engineering, Aerospace
Zhiwei Xiang, Zhenxing Gao, Jiming Liu, Yangyang Zhang
Summary: Discovering and mitigating potential risks in advance is crucial for preventing aviation accidents. However, explaining group-scale precursors using existing methods is challenging because of the assumption about the number of risky flights and the reliance on non-domain knowledge. To address this, we propose a novel technique called CMCA, which accurately characterizes group-scale precursors based on energy management performance. By applying CMCA to a combination of labeled and unlabeled flights, we successfully identify precursors with energy management issues, demonstrating the effectiveness of our method. These findings suggest the importance of pilots' energy management awareness in flight safety.