Article
Chemistry, Medicinal
Oleksandr Grytsai, Iuliia Myrgorodska, Stephane Rocchi, Cyril Ronco, Rachid Benhida
Summary: This paper provides a comprehensive overview of the history and therapeutic applications of biguanides, with a focus on the mechanisms of currently marketed biguanide-containing drugs. It highlights the research progress on biguanides in oncology and discusses future perspectives for the design of new drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Multidisciplinary Sciences
Yuncheng Mu, Ziyu He, Kun Wang, Xiaodong Pi, Shu Zhou
Summary: This comprehensive review discusses the recent progress in the synthesis and characterization of halide perovskite nanocrystals (NCs), as well as the methods to tailor their optical and electronic properties. The potential of halide perovskite NCs in advancing optoelectronic applications, such as LEDs, solar cells, scintillators, and X-ray imaging, is extensively discussed. The review also highlights the future development prospects of halide perovskite NCs.
Review
Anesthesiology
Giuseppe Sepolvere, Francesco Coppolino, Mario Tedesco, Loredana Cristiano
Summary: Fascial plane blocks are anesthetic procedures used to manage perioperative and chronic pain, with recent advances in techniques such as ultrasound parasternal blocks. These blocks offer effective anesthesia and analgesia with low risk, particularly targeting the antero-medial chest wall to provide pain relief for various surgeries and pain management situations.
MINERVA ANESTESIOLOGICA
(2021)
Review
Chemistry, Physical
Umar Farooq, Muhammad Ishaq, Usman Ali Shah, Shuo Chen, Zhuang-Hao Zheng, Muhammad Azam, Zheng-Hua Su, Rong Tang, Ping Fan, Yang Bai, Guang-Xing Liang
Summary: Hybrid lead-halide perovskite materials have impressive optoelectronic properties, but the toxic nature of lead and instability issues have led researchers to explore low-toxic substitutes like antimony and bismuth ternary halide perovskites. These new materials are considered promising for next-generation photovoltaic technology due to their stability and high absorption coefficient. However, they still face challenges such as large bandgaps and dimer phases, requiring further research and improvement.
Review
Clinical Neurology
Fabio Perversi, Cinzia Costa, Angelo Labate, Simona Lattanzi, Claudio Liguori, Marta Maschio, Stefano Meletti, Lino Nobili, Francesca Felicia Operto, Andrea Romigi, Emilio Russo, Carlo Di Bonaventura
Summary: Glutamate is the brain's main excitatory neurotransmitter, and an imbalance of excitatory and inhibitory activities may lead to epilepsy or other neurological and psychiatric conditions. AMPA receptors, as the predominant mediator of glutamate-induced excitatory neurotransmission, are a major drug target for modulating brain functions. Perampanel (PER), a selective AMPA antagonist, has shown potential in treating various conditions beyond epilepsy. Evaluating new studies on AMPA antagonism and PER in different neurological conditions, this review aims to provide insights for future research on the use of PER and other AMPA receptor antagonists.
FRONTIERS IN NEUROLOGY
(2023)
Review
Chemistry, Medicinal
Milo Gatti, Massimo Andreoni, Federico Pea, Pierluigi Viale
Summary: Dalbavancin is a novel, long-acting lipoglycopeptide with excellent in vitro activity against multidrug-resistant Gram-positives, and evidence supports its efficacy in long-term therapy for osteomyelitis, prosthetic joint infections, endocarditis, and bloodstream infections. Its unique pharmacokinetic/pharmacodynamic properties make it a valuable alternative in treating long-term Gram-positive infections, especially in scenarios like COVID-19 where hospitalization and territorial medicine empowerment are unavoidable.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Chemistry, Medicinal
Pragya Tiwari, Mangalam Bajpai, Abhishek Sharma
Summary: The rising statistics of antimicrobial resistance pose a serious concern for mankind. The excessive use of antibiotics in various fields has led to the emergence of drug-resistant microbes. Phytotherapeutics, derived from plants, offer a potential solution to combat these drug-resistant microbes. However, there are challenges to overcome in order to fully utilize phytotherapeutics.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Review
Infectious Diseases
Lucas Armange, Adele Lacroix, Paul Petitgas, Cedric Arvieux, Caroline Piau-Couapel, Patrice Poubeau, Matthieu Revest, Pierre Tattevin
Summary: Paradoxical reaction (PR) and immune reconstitution inflammatory syndrome (IRIS) are common complications of tuberculosis treatment. Corticosteroids are first-line treatment for severe PR or IRIS, particularly neurological. TNF-alpha antagonists are safe and effective as salvage or corticosteroid-sparing therapeutic for severe PR or IRIS during tuberculosis treatment.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Review
Biotechnology & Applied Microbiology
Piotr Eder, Aleksandra Zielinska, Jacek Karczewski, Agnieszka Dobrowolska, Ryszard Slomski, Eliana B. Souto
Summary: Despite significant advancements in the treatment of inflammatory bowel disease in recent years, there is still a large room for improvement. Oral anti-TNF-alpha antibody therapy is hypothesized to provide targeted anti-inflammatory effects without significant systemic exposure, potentially improving long-term treatment outcomes and safety. Various attempts have been made to design oral formulations of these molecules, aiming to enter a new era of treatment for IBD.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Ophthalmology
Biao Li, Haoran Li, Qun Huang, Yanlin Zheng
Summary: Behcet's uveitis (BU), a serious complication of Behcet's disease, is challenging to manage due to its chronic and recurrent nature. This review discusses the role of biologic therapies in BU treatment and provides a comprehensive overview of their effectiveness and limitations. Biologic therapies, specifically TNF-alpha inhibitors, have shown promise in controlling ocular inflammation and preserving vision. However, accessibility, cost, and limited long-term safety data pose obstacles to their widespread use. Continued research and development of novel biologic agents, as well as personalized medicine approaches, are needed to address these challenges and improve patient outcomes.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Women's Studies
Lee Mandelo
Summary: Using Clare Hemmings's framework, this article examines the critical functions of storytelling in feminist praxis, and argues that Annalee Newitz's novel The Future of Another Timeline exemplifies the historical presence and ongoing necessity of coalitional solidarity in feminist theory/practice through citational practice and affect. Through a close reading of the novel's various timelines and perspectives, it explores how Newitz constructs an ethicopolitically grounded approach to critical hope that carries the possibilities of coalitional solidarity into the future(s).
Article
Health Care Sciences & Services
Ciro Manzo, Elvis Hysa, Alberto Castagna, Marco Isetta
Summary: Anti-TNF-alpha drugs have been used in addition to glucocorticoids in PMR patients, but have had limited success. However, new administration schedules and study designs may lead to better outcomes for PMR patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Infectious Diseases
Lale Turkmen, Hakan Tekedere
Summary: This study aims to understand the impact of the SARS-CoV-2 pandemic on Turkish youth and their attitude toward future prospects. The majority of Turkish young people believe that the pandemic will negatively affect their future in terms of educational opportunities, job prospects, physical and mental health, economic and financial stability.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2023)
Article
Sociology
Ying-Syuan Huang, Blane Harvey
Summary: Facilitated learning methods are increasingly utilized to improve climate and sustainability collaborations across different disciplines and scales. This paper introduces a new method for studying social learning in large research programs, aiming to enhance our understanding of learning and change processes for pursuing sustainability transformations.
FRONTIERS IN SOCIOLOGY
(2021)
Article
Tropical Medicine
Amal A. El-Moamly, Mohamed A. El-Sweify
Summary: This article reviews the history and development stages of malaria vaccines, including the recent approval of the RTS,S/AS01 vaccine by the World Health Organization. It explores other potential vaccine candidates and suggests their further development. Multi-component vaccines may play a crucial role in eradicating malaria.
TROPICAL MEDICINE AND HEALTH
(2023)
Review
Rheumatology
Dimitrios Daoussis, Georgia Konstantopoulou, Pantelis Kraniotis, Lazaros Sakkas, Stamatis-Nick Liossis
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2019)
Article
Rheumatology
Lazaros I. Sakkas, Dimitrios Daoussis, Athanasios Mavropoulos, Stamatis-Nick Liossis, Dimitrios P. Bogdanos
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2019)
Article
Rheumatology
Ioannis Antonopoulos, Dimitrios Daoussis, Maria-Eleni Lalioti, Theodora E. Markatseli, Alexandros A. Drosos, Stavros Taraviras, Andrew P. Andonopoulos, Stamatis-Nick C. Liossis
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Respiratory System
Argyris Tzouvelekis, Theodoros Karampitsakos, Evangelos Bouros, Vassilios Tzilas, Stamatis-Nick Liossis, Demosthenes Bouros
CLINICS IN CHEST MEDICINE
(2019)
Editorial Material
Rheumatology
Dimitrios Daoussis, Pantelis Kraniotis, Stamatis-Nick Liossis
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Zinovia-Maria Kefalopoulou, Stamatis-Nick Liossis, Theodora Sagona, Dimitra Veltsista, Petros Zampakis, Pantelis Kraniotis, Aikaterini Solomou, John Ellul, Elisabeth Chroni
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Editorial Material
Rheumatology
Dimitrios Daoussis, Pantelis Kraniotis, Asimina-Maria Tsimeka, Menelaos Kanakis, Stamatis-Nick Liossis
Review
Rheumatology
Christina Salamaliki, Elena E. Solomou, Stamatis-Nick C. Liossis
RHEUMATOLOGY AND THERAPY
(2020)
Review
Medicine, General & Internal
Stamatis Nick Liossis, Chrysanthi Staveri
Summary: Systemic lupus erythematosus is a chronic autoimmune disease with diverse manifestations, prompting the need for novel treatment options. Recent data highlights ongoing research on severe lupus manifestations, indicating a variety of therapeutic options under investigation despite occasional trial failures.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Constantina A. Bounia, Stamatis-Nick C. Liossis
Summary: Treatment with rituximab (RTX) significantly reduces circulating Th17 cell percentages in patients with RA, while Tregs remain stable. Reduction of Th17 cells is particularly evident in responders to RTX treatment, ACPA+ and RF (-) patients with RA.
CLINICAL IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Constantina A. Bounia, Eftichia N. Theodoropoulou, Stamatic-Nick C. Liossis
Summary: Renal failure can be a clinical manifestation of rheumatic diseases, and treatment with DMARDs or biologic drugs may lead to nephrotoxicity. Anti-TNF-alpha treatment in patients with SpA may induce renal failure, particularly in cases of IgA nephropathy. It is important to be cautious when using anti-TNF-alpha agents in patients with rheumatic diseases presenting with renal manifestations.
BIOLOGICS-TARGETS & THERAPY
(2021)
Article
Rheumatology
Dimitrios Daoussis, Pantelis Kraniotis, Alexandra Filippopoulou, Rafaella Argiriadi, Spyridoula Theodoraki, Thomas Makatsoris, Angelos Koutras, Ioannis Kehagias, Dionysios J. Papachristou, Aikaterini Solomou, Haralabos Kalofonos, Stamatis-Nick Liossis
Article
Rheumatology
S. Panopoulos, K. Chatzidionysiou, M. G. Tektonidou, V. K. Bournia, A. A. Drosos, Stamatis-Nick C. Liossis, T. Dimitroulas, L. Sakkas, D. Boumpas, P. V. Voulgari, D. Daoussis, K. Thomas, G. Georgiopoulos, G. Vosvotekas, P. Sidiropoulos, G. Bertsias, D. Vassilopoulos, P. P. Sfikakis
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Medicine, General & Internal
Lazaros I. Sakkas, Dimitrios P. Bogdanos, Dimitrios Boumpas, Zisis Mamouris, Athanasios Gkoutzourelas, Athanasios Mavropoulos, Zisis Tsouris, Stamatis-Nickolaos Liossis, Dimitrios Daoussis, Dimitrios Vasilopoulos, Maria Tektonidou, Athanasios Tzioufas, George Efthymiou, Efthymios Dardiotis, George Kitas, Kassem Sharif, Miri Blank, Dimitrios Karussis, Doron Rimar, Gleb Slobodin, Bat-Sheva Porat-Katz, Zahava Vadasz, Howard Amital, Elias Toubi, Yehuda Shoenfeld
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2019)
Review
Medicine, General & Internal
Theodoros Karampitsakos, Argyro Vraka, Demosthenes Bouros, Stamatis-Nick Liossis, Argyris Tzouvelekis
FRONTIERS IN MEDICINE
(2019)