P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets

(2011) S. Nisar et al.   BLOOD

Extracellular Ca2+ modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation

(2011) Sarah Jones et al.   BRITISH JOURNAL OF HAEMATOLOGY

Clopidogrel, a P2Y12 Receptor Antagonist, Potentiates the Inflammatory Response in a Rat Model of Peptidoglycan Polysaccharide-Induced Arthritis

(2011) Analia E. Garcia et al.   PLoS One

P2 receptors and platelet function

(2011) Béatrice Hechler et al.   Purinergic Signalling

The P2Y12 receptor as a target of antithrombotic drugs

(2011) Stephen O’Connor et al.   Purinergic Signalling

Molecular defects of the platelet P2 receptors

(2011) Marco Cattaneo   Purinergic Signalling

Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate

(2011) Marco Cattaneo   THROMBOSIS AND HAEMOSTASIS

Adenosine Diphosphate Receptor P2Y12-Mediated Migration of Host Smooth Muscle-Like Cells and Leukocytes in the Development of Transplant Arteriosclerosis

(2011) Kosuke Harada et al.   TRANSPLANTATION

Ticagrelor Effectively and Reversibly Blocks Murine Platelet P2Y 12 -Mediated Thrombosis and Demonstrates a Requirement for Sustained P2Y 12 Inhibition to Prevent Subsequent Neointima

(2010) Shankar B. Patil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelets

(2010) Shashank Jain et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Functionally Active P2Y12 ADP Receptors by Thrombin in Human Smooth Muscle Cells and the Presence of P2Y12 in Carotid Artery Lesions

(2010) Bernhard H. Rauch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects

(2010) M. Cattaneo   BLOOD

New P2Y 12 Inhibitors

(2010) Marco Cattaneo   CIRCULATION

P2Y nucleotide receptors: promise of therapeutic applications

(2010) Kenneth A. Jacobson et al.   DRUG DISCOVERY TODAY

Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets

(2010) Dongjun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP

(2010) A. Ben Addi et al.   JOURNAL OF IMMUNOLOGY

TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression

(2010) Roberta De Simone et al.   JOURNAL OF NEUROCHEMISTRY

Quantification of recombinant and platelet P2Y1 receptors utilizing a [125I]-labeled high-affinity antagonist 2-iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate ([125I]MRS2500)

(2010) Philippe Ohlmann et al.   PHARMACOLOGICAL RESEARCH

CalDAG-GEFI and platelet activation

(2010) Lucia Stefanini et al.   PLATELETS

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes

(2009) Philipp Diehl et al.   BASIC RESEARCH IN CARDIOLOGY

Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study

(2009) M. E. Daly et al.   BLOOD

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis

(2009) S. Amadio et al.   CEREBRAL CORTEX

The reversible oral P2Y12 antagonist AZD6140 inhibits ADP-induced contractions in murine and human vasculature

(2009) Carl Högberg et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12receptor

(2009) Sailaja Paruchuri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice

(2009) Arnon Afek et al.   MICROVASCULAR RESEARCH

 -Arrestin-2 Interaction and Internalization of the Human P2Y1 Receptor Are Dependent on C-Terminal Phosphorylation Sites

(2009) S. Reiner et al.   MOLECULAR PHARMACOLOGY

Existence of a microRNA pathway in anucleate platelets

(2009) Patricia Landry et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prasugrel in Clinical Practice

(2009) Deepak L. Bhatt   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Attenuation of Transplant Arteriosclerosis With Clopidogrel Is Associated With a Reduction of Infiltrating Dendritic Cells and Macrophages in Murine Aortic Allografts

(2009) Silke Abele et al.   TRANSPLANTATION

Involvement of Platelet Activation by P2Y12 Receptor in the Development of Transplant Arteriosclerosis in Mice

(2009) Kenichi Yashiro et al.   TRANSPLANTATION

Platelet P2Y 12 Receptor Influences the Vessel Wall Response to Arterial Injury and Thrombosis

(2008) D.J.W. Evans et al.   CIRCULATION

Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene

(2008) Peter Staritz et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Gi-coupled P2Y12 Receptor Regulates Diacylglycerol-mediated Signaling in Human Platelets

(2008) Gianni F. Guidetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist-selective, Receptor-specific Interaction of Human P2YReceptors with β-Arrestin-1 and -2

(2008) Carsten Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

P2Y12 Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

(2008) K. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

Formation of coated platelets is regulated by the dense granule secretion of adenosine 5′diphosphate acting via the P2Y12 receptor

(2008) Y. N. KOTOVA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12receptor

(2008) I. ALGAIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE

Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism

(2007) Robert Y.L. Zee et al.   ATHEROSCLEROSIS