Article
Biochemistry & Molecular Biology
Pedro P. C. de Souza, Petra Henning, Ulf H. Lerner
Summary: Oncostatin M (OSM) is a potent stimulator of osteoclast formation and plays a significant role in bone remodeling by inducing RANKL in osteoblasts. Gene deletion of Osmr in mice leads to decreased osteoclast numbers and increased trabecular bone thickness. OSM can promote osteoblast differentiation and mineralization, but in vivo administration in adult animals does not significantly increase osteoclast formation due to the negative feedback loop through the osteoclastogenesis inhibitor WNT16.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Patrick Lau, Laurence Vico, Joern Rittweger
Summary: The dissociation of bone formation and resorption is an important physiological process during spaceflight and other special conditions. The interplay between known myokines and osteokines and their mutual regulation is highlighted. However, the long-term changes in bone microarchitecture and the recovery of bone loss in the absence of gravity remain largely unknown.
Review
Biochemistry & Molecular Biology
Jiayuan Fang, Xunming Zhang, Xi Chen, Zhaoguo Wang, Shuo Zheng, Yunyun Cheng, Songcai Liu, Linlin Hao
Summary: Insulin-like growth factor (IGF)-1 is a polypeptide hormone that plays a vital role in bone cells. Abnormal expression of IGF-1 affects bone growth and remodeling, leading to significant changes in bone mass and development. This review highlights the functions and mechanisms of IGFs in bone and emphasizes the critical role of IGF-1 in bone remodeling through both bone resorption and bone formation. It provides a theoretical basis for further research on the maintenance of bone mass and homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
Xiaoming Jiang, Jiali Cai, Lanlan Liu, Zhenfang Liu, Wenjie Wang, Jinhua Chen, Chao Yang, Jie Geng, Caihui Ma, Jianzhi Ren
Summary: The present study evaluated the predictive power of conventional morphological evaluation in predicting blastocyst formation. The results showed that routine morphology observation can be used as a feasible tool to support decision-making regarding the day of transfer. However, models combining cycle characteristics and embryo morphology did not significantly increase the predictive power.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Siwang Hu, Shuangshuang Wang
Summary: SIRT3 is an enzyme that regulates mitochondrial morphology and function, and it has been shown to play a role in many aging-related diseases. Osteoporosis, a common aging-related disease, is characterized by decreased bone mass and fragility fractures, but the specific effects and mechanisms of SIRT3 in osteoporosis are not yet clear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Hirohito Hirata, Asana Kamohara, Masatoshi Murayama, Kenichi Nishioka, Hiroaki Honda, Yasuteru Urano, Hidenobu Soejima, Shinya Oki, Toshio Kukita, Shunsuke Kawano, Masaaki Mawatari, Akiko Kukita
Summary: Bhlhe40 is a crucial regulator of osteoclast differentiation and function, and its deficiency leads to increased bone volume and reduced bone resorption activity. Analysis of potential target genes reveals their association with proton transport and intracellular vesicle acidification.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Qing-Chang Chen, Yan Zhang
Summary: Bone diseases are the main causes of disability and impaired quality of life. Neuropeptide Y plays important roles in bone tissue by regulating bone metabolism and disease progression through its receptors. This review provides a brief overview of recent progress in understanding the regulatory mechanism of bone physiology and pathological metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiajia Zhang, Stefan Wirtz
Summary: This article reviews the molecular mechanisms of pyroptosis and discusses its possible role in inflammasome-related disorders, providing new insights for future therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yan Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Xiaofeng Zhu, Li Han, Ronghua Zhang, Huaqin Tian, Panpan Wang
Summary: Bone reconstruction relies on the balance between bone formation and bone absorption. Polyphenols found in Chinese herbal medicines can affect this balance and have potential therapeutic effects on bone metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hye Jung Ihn, Jiwon Lim, Kiryeong Kim, Sang-Hyeon Nam, Soomin Lim, Su Jeong Lee, Jong-Sup Bae, Tae Hoon Kim, Jung-Eun Kim, Moon-Chang Baek, Yong Chul Bae, Eui Kyun Park
Summary: Ciclopirox effectively inhibits osteoclast differentiation and bone resorption both in vitro and in vivo, making it a potential candidate for preventing osteoporosis and other osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Chen Huang, Jian Li, Chenliang Zhang
Summary: Pyroptosis, a caspase-dependent cell death, plays a complex role in cancer development. It can be both anti-tumor and pro-tumor. Pyroptosis provides potential new targets for cancer treatment and helps optimize the use of existing drugs. Immunotherapy is a hot research direction in the field of cancer treatment.
MOLECULAR METABOLISM
(2022)
Review
Nutrition & Dietetics
Aleksandra Beata Juszczak, Maciej Kupczak, Tomasz Konecki
Summary: This narrative review summarizes 98 studies of chronic kidney disease (CKD) and the effects of vitamin supplementation on patients on dialysis. The findings suggest potential effectiveness of certain vitamins, such as B, D, or C, but recommendations for vitamins A and K are still unclear due to potential toxicity. Further research is needed to evaluate the effectiveness and risks of vitamin supplementation for CKD patients.
Review
Endocrinology & Metabolism
Wacili Da, Lin Tao, Yue Zhu
Summary: In recent years, research on the mechanism underlying bone metabolic disorders based on energy metabolism has made significant progress, focusing on the impact of osteoclast energy metabolism disorder on bone homeostasis and proposing a compensatory recovery mechanism as a new approach for the treatment of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Chengxiang Li, Guofu Pi, Feng Li
Summary: The intestinal flora, considered as the second gene pool of the human body, has a complex symbiotic relationship with the host and can regulate bone homeostasis through the host immune, metabolic, and endocrine systems. Changing the composition and function of the intestinal flora using probiotics, prebiotics, and fecal microbiota transplantation is being explored as a potential novel approach for regulating bone homeostasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
