Article
Chemistry, Multidisciplinary
Sophia Bailey, Erik Hopkins, Naomi Baxter, Isobel Whitehead, Javier Read de Alaniz, Maxwell Wilson
Summary: This study demonstrates a light-guided patterning platform using natural extracellular matrix (ECM) proteins as a substrate to program cellular behaviors. The platform enables the patterning of common ECM proteins with commercially available functional small molecules and growth factors. It also highlights the ability to spatially control cell behavior through patterned chemical modification of natural ECM.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Tomasz Galek, Ernest Szajna, Dariusz Bogdal, Miroslaw Tupaj
Summary: The study focuses on the preparation and evaluation of chitosan-derived natural biomaterials containing Kalanchoe pinnata extract, with potential application as a blood-clotting agent. These materials were obtained under microwave-assisted conditions in two different forms (granules/dressing) and their chemical structure and morphology were studied. The chitosan-derived hemostatic agents showed superior blood sorption abilities and were non-cytotoxic to L929 mouse fibroblasts, with differences in biological properties depending on their preparation method.
Article
Polymer Science
Pierre C. Dromel, Deepti Singh, Alfredo Alexander-Katz, Motoichi Kurisawa, Myron Spector, Michael Young
Summary: Engineering matrices for cell therapy require design criteria that include the ability of these materials to support, protect, and enhance cellular behavior in vivo. The chemical and mechanical formulation of the biomaterials can influence not only target cell phenotype but also cellular differentiation. By manipulating the stiffness of the hydrogel, the differentiation potential of human retinal progenitor cells can be controlled.
Review
Biotechnology & Applied Microbiology
Yuling Huang, Xin Li, Lina Yang
Summary: Hydrogels, as representatives of biomaterials, have attracted much attention in the medical field. This review studies the safety and feasibility of hydrogel-encapsulated mesenchymal stem cells (MSCs), as well as the enhancement of therapeutic effect through hydrogels.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Lingyu Sun, Jiahui Guo, Hanxu Chen, Dagan Zhang, Luoran Shang, Bing Zhang, Yuanjin Zhao
Summary: Wettability, as a fundamental feature of solid surfaces, plays an increasingly important role in various fields, with particular attention to its applications in biomedical engineering in recent years.
Article
Materials Science, Multidisciplinary
Byungjun Lee, Suryong Kim, Jihoon Ko, Seung-Ryeol Lee, Youngtaek Kim, Seonghyuk Park, Jiho Kim, Sujin Hyung, Ho-Young Kim, Noo Li Jeon
Summary: This article introduces a new bioprinting method called 3D hybrid-micromesh assisted bioprinting (Hy-MAP). This method combines digital light projection (DLP) 3D-printed micromesh scaffold structures and sequential hydrogel patterning to enable rapid cell coculture. By extending micropost-based patterning from 2D microfluidic channels to 3D channel networks, complex 3D hydrogel structures at the mesoscale can be constructed. The design rules for Hy-MAP are established through analytical and experimental investigations, and the method has been successfully applied to the construction of vascularized tumor spheroids. This novel approach provides an alternative method for fabricating mesoscale implantable tissue engineering constructs and organ-on-a-chip applications.
NPG ASIA MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yue Wang, Jiahui Li, Yunfeng Li, Bai Yang
Summary: 3D bioprinting is a rapidly evolving technology that allows for the creation of biological tissue constructs closely mimicking the physiological features of native tissue, enabling innovative research directions in biomaterials and biomedical science. The development of bioinks remains a critical bottleneck in the field, with biomimetic nanofibrillar hydrogels showing promise as bioinks for 3D bioprinting. Further research into biomimetic bioinks based on nanofibrillar hydrogels is essential for advancing bioprinted therapies and driving innovation in 3D bioprinting.
Article
Nanoscience & Nanotechnology
Robin Wanka, Florian Koschitzki, Vuk Puzovic, Thorben Pahl, Emily Manderfeld, Kelli Z. Hunsucker, Geoffrey W. Swain, Axel Rosenhahn
Summary: A new dendritic PG-HEMA material was synthesized chemically and compared with commercially available hydrophilic monomers, showing that PPGMA exhibited better resistance to silt incorporation and outperformed PEGMA and PG(4)MA in the DSFE assay.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Shuihong Zhu, Yonghua Tang, Changxu Lin, Xiang Yang Liu, Youhui Lin
Summary: The latest advances in patterning natural polymers using nanofabrication techniques have been discussed, offering new opportunities for applications in tissue engineering, flexible electronics, and other fields in the future.
Article
Multidisciplinary Sciences
Ivan Batalov, Kelly R. Stevens, Cole A. DeForest
Summary: Hydrogel biomaterials derived from natural biopolymers, such as fibrin and collagen, have advantages in cytocompatibility and biological integration. However, they lag behind synthetic alternatives in tunability, requiring further research to selectively modulate their biochemical properties.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Biomedical
Duo-Mei Tian, Huan-Huan Wan, Jia-Reng Chen, Yong-Bin Ye, Yong He, Yu Liu, Lu-Yao Tang, Zhong-Yuan He, Kai-Zheng Liu, Chong-Jian Gao, Sheng-Lin Li, Qian Xu, Zheng Yang, Chen Lai, Xiao-Jun Xu, Chang-Shun Ruan, Yun-Sheng Xu, Chao Zhang, Liang Luo, Le-Ping Yan
Summary: This study developed bioactive elastin-based hydrogels that can recruit and modulate innate immune cells, accelerate angiogenesis, and improve wound regeneration. The hydrogels showed tunable mechanical properties and were able to mimic the dermal microenvironment. In vitro co-culture experiments demonstrated that the derived conditioned medium from the hydrogels promoted the expression of M1 and M2 markers in macrophages and induced superior tube formation in endothelial cells. In a mouse wound model, the hydrogels attracted neutrophils and M2 macrophages to the wound, leading to enhanced angiogenesis, collagen deposition, and dermal regeneration.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Rui-Chian Tang, Lily Shang, Philip O. Scumpia, Dino Di Carlo
Summary: Researchers have developed a novel crescent-shaped hydrogel scaffold with a microporous structure that allows for improved cell infiltration and expansion. With the use of microfluidic fabrication, the size of the cavities in the scaffold can be adjusted, leading to enhanced cellular network formation in vitro and in vivo. The results suggest that this new scaffold has the potential for superior functionality in tissue engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Xiuli Ren, Zepeng Liang, Xingjun Zhao
Summary: In this study, imidazolium-based ionic liquids (ILs) were used as templates to control the crystallization of hydroxyapatite (HAP) nanofibers, which were then composited into polyvinyl alcohol-sodium alginate (PVA-Alg) hydrogel. The HAP@H hydrogel showed improved porous structure, tensile performance, and compressive performance compared to the pure hydrogel.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ming Sun, Lidi Cheng, Zexian Xu, Liqiang Chen, Yanshan Liu, Yaoxiang Xu, Dongyang Zhou, Xiuxiu Zhang, Qihui Zhou, Jian Sun
Summary: This study aims to explore the potential feasibility of a novel temperature-sensitive hydrogel-based dual sustained-release system for the repair and treatment of infectious jaw defects. The results indicate that the system shows outstanding sustained-release ability, biocompatibility, and antibacterial properties. This study provides new insights for the treatment of infectious jaw defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Shuze Wang, Yueyang Qiu, Liu Qu, Qiang Wang, Qing Zhou
Summary: Hydrogels, a novel treatment approach for osteoarthritis, have shown promise with their good biocompatibility and biodegradability. Recent research progress in the past three years has focused on the required properties and applications of hydrogels in the treatment of osteoarthritis. The challenges and future development prospects for hydrogels in different types of osteoarthritis were also discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Thorsten Gehrke, Lara Althaus, Philip Linke, Jochen Salber, Veit Krenn, Mustafa Citak
Summary: This study retrospectively analyzed 66 patients who underwent revision surgery for arthrofibrosis after primary THA. All patients had limited range of motion before revision, with a mean flexion of 90 degrees, mean internal rotation of 10 degrees, and mean external rotation of 20 degrees. Histological examination revealed that all patients had SLIM type V arthrofibrosis, with 10.6% being particle-induced and 89.4% being non-particle-induced. This study is the first to describe endoprosthesis-associated arthrofibrosis after primary THA based on a well-established histological classification, which may lead to new therapeutic and diagnostic opportunities in patients with this condition. Surgeons should consider arthrofibrosis as a possible cause for stiffness and pain after primary THA.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Timo Scholz, Mustafa Akkaya, Philip Linke, Sophia-Marlene Busch, Thorsten Gehrke, Jochen Salber, Mustafa Citak
Summary: This study aimed to investigate whether the anatomical shape of the distal femur is an independent risk factor for aseptic loosening (AL) following one-stage septic knee revision using rotating hinge implants. The results showed that Type C configurations of the distal femur represent an independent risk factor for AL with a significantly higher risk compared to Type A and Type B.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Mustafa Akkaya, Georges Vles, Iman Godarzi Bakhtiari, Amir Sandiford, Jochen Salber, Thorsten Gehrke, Mustafa Citak
Summary: This study provides novel insights into the microbiological changes following septic failure after a one-stage exchange for prosthetic joint infection of the knee. A higher prevalence of more difficult-to-treat bacteria might increase the complexity of subsequent procedures.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Orthopedics
Iman Godarzi Bakhtiari, Georges Vles, Sophia-Marlene Busch, Lars Frommelt, Thorsten Gehrke, Jochen Salber, Mustafa Citak
Summary: The microbiological implications of septic failure after 1-stage exchange for prosthetic joint infection (PJI) of the hip are unclear. This study found that the majority of reinfections are caused by different infecting bacteria, indicating the need for a new diagnostic workup. The number of polymicrobial PJIs and high virulent microorganisms decreased, suggesting potential changes in the microbiology of septic failure after 1-stage exchange.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Polymer Science
Lysann Kassner, Xiaomin Zhu, Karola Schaefer, Zhi Chen, Martin Moeller, Tina Uhlig, Frank Simon, Doreen Dentel, Christoph Tegenkamp, Stefan Spange, Michael Mehring
Summary: Coating textile fibers with nanostructured organic-inorganic hybrid materials can improve their hydrophobicity, solvent resistance, and mechanical properties. By adjusting the ratio of organic and inorganic components, the performance of the coating can be controlled. The coating process can also be combined with other polymerization processes.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
J. Robin Hoehner, Rustam A. Gumerov, Igor I. Potemkin, Cesar Rodriguez-Emmenegger, Nina Yu Kostina, Ahmed Mourran, Jenny Englert, David Schroeter, Lennart Janke, Martin Moeller
Summary: The study focuses on the synthesis of hydrophilic arborescent polymers with high conformational flexibility through grafting-from procedure, showing a strong interfacial activity in liquid-liquid interfaces. The molecules exhibit globular conformation and maintain a high flexibility, contributing to their unique behavior in toluene-in-water suspensions.
Review
Biochemistry & Molecular Biology
[Anonymous]
Summary: Advancements in tissue engineering have led to the understanding of physiological basement membranes. Efforts have been made to synthesize biomimetic membranes for applications in organ models.
Article
Chemistry, Physical
A. A. Stupnikov, A. V. Bakirov, M. A. Shcherbina, U. Beginn, M. Moeller, S. N. Chvalun
Summary: Wedge-shaped dendrons based on benzenesulfonic acid can form different liquid crystal mesophases, such as ordered and disordered columnar hexagonal ones. The size and nature of focal groups as well as the length of aliphatic tails are important factors affecting the phase behavior of these materials. The study found that certain dendrons can form a 2D columnar ordered hexagonal mesophase with three annuli: a central channel, virtually hollow channel, and rigid aromatic part enveloped by an aliphatic matrix. The material shows promise for creating temperature-controlled ion-selective membranes.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Immunology
Victoria C. C. Brom, Andreas C. C. Strauss, Alexander Sieberath, Jochen Salber, Christof Burger, Dieter C. C. Wirtz, Frank A. A. Schildberg
Summary: Immune checkpoint inhibitors have been extensively researched in cancer treatment, but they often provoke auto-inflammatory reactions and have a significant effect on bone-resorbing cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Philip Linke, Peter Wilhelm, Ali Levent, Thorsten Gehrke, Jochen Salber, Mustafa Akkaya, Eduardo M. Suero, Mustafa Citak
Summary: This study investigated risk factors associated with aseptic loosening in total knee arthroplasty. The study found that younger age and previous surgeries were risk factors for aseptic loosening. Additionally, measurements of the inner diameter of the femur and tibia were also found to be associated with aseptic loosening, both in primary and revision surgeries.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Polymer Science
Chunchen Zhang, Dan Eugen Demco, Rahul Rimal, Jens Koehler, Rostislav Vinokur, Smriti Singh, Jan Tenbusch, Martin Moeller
Summary: This study demonstrates the reversible formation of hydrogels through hydrophobic interaction using poly(N-alkyl-N-vinylacetamide)s. The polymers with different lengths of alkyl chains can dissolve in ethanol and form thin films. When immersed in water, they swell and form biocompatible hydrogels. The hydrophobic association varies with the length of the alkyl substituents, with shorter chains leading to flowable hydrogels that segregate from excess water and longer chains yielding hydrogels with mechanical properties similar to permanently cross-linked hydrogels.
Article
Orthopedics
Pongsiri Piakong, Michel Pahl, Giorgio Delgado, Mustafa Akkaya, Sophia-Marlene Busch, Jochen Salber, Thorsten Gehrke, Mustafa Citak
Summary: The study demonstrates excellent long-term outcomes of the CFP stem, with a low rate of aseptic loosening and excellent survivorship over a period of 20 years.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Jochen Salber, Siegfried Shah
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Dierk Gruhn, Richard Viebahn, Jochen Salber
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Latifeh Karimzadeh, Jochen Salber, Ehsan Seyedjafari, Ghamartaj Hosein, Mohammad Nabiuni, Mohammadhosein Majlesara
TISSUE ENGINEERING PART A
(2022)