Article
Multidisciplinary Sciences
Xuejiao Liu, Simin Zhao, Keke Wang, Liting Zhou, Ming Jiang, Yunfeng Gao, Ran Yang, Shiwen Yan, Wen Zhang, Bingbing Lu, Feifei Liu, Ran Zhao, Wenting Liu, Zihan Zhang, Kangdong Liu, Xiang Li, Zigang Dong
Summary: Spatial transcriptomics analysis revealed expression changes in TAGLN2 and CRNN during the progression from esophageal squamous precancerous lesions (ESPL) to esophageal squamous cell carcinoma (ESCC). TAGLN2 expression significantly increased, while CRNN expression decreased along with ESCC progression. These findings suggest that TAGLN2 and CRNN can serve as candidate indicators for predicting the risk of ESCC at the ESPL stage.
NATURE COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Oscar Rapado-Gonzalez, Nicolas Costa-Fraga, Aida Bao-Caamano, Jose Luis Lopez-Cedrun, Roberto Alvarez-Rodriguez, Ana Belen Crujeiras, Laura Muinelo-Romay, Rafael Lopez-Lopez, Angel Diaz-Lagares, Maria Mercedes Suarez-Cunqueiro
Summary: This is the first large-scale genome-wide DNA methylation study on OTSCC, identifying a group of novel tumor-specific DNA methylation markers with diagnostic potential in saliva.
Article
Oncology
Jing Guo, Qiuxing Yang, Sheng Wei, Jingjing Shao, Tianye Zhao, Liyuan Guo, Jia Liu, Jia Chen, Gaoren Wang
Summary: The role of PRDM5 in esophageal squamous cell carcinoma (ESCC) was investigated in this study. It was found that high expression of PRDM5 was associated with better survival outcomes in ESCC patients. PRDM5 may affect ESCC cell proliferation, migration, and invasion capacity by influencing the WNT/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Wenting He, Shiyong Lin, Yi Guo, Yuanzhong Wu, Lu-Lu Zhang, Qiling Deng, Zi-Ming Du, Mingbiao Wei, Weijie Zhu, Wan-Juan Chen, Jian-Yong Shao, Guo-Liang Xu
Summary: Zinc finger protein 154 (ZNF154) is hypermethylated at the promoter in esophageal squamous carcinoma (ESCC), leading to downregulation of the tumor suppressor gene and promoting cell proliferation and migration. Epigenetic editing using CRISPR/dCas9 technology can reverse the hypermethylation and inhibit ESCC cells. Furthermore, ZNF154 acts as a transcription factor to upregulate the expression of ESCC-associated tumor suppressor genes.
Review
Oncology
Xiaoqing Zhang, Ning Lu, Li Wang, Yixuan Wang, Minna Li, Ying Zhou, Manli Cui, Mingxin Zhang, Lingmin Zhang
Summary: In recent years, research on m(6)A methylation as a research hotspot in bioscience has shown its potential in regulating RNA functions and its implications in tumor biology. Studies on m(6)A methylation in esophageal squamous cell carcinoma have indicated its potential as a new diagnostic biomarker and therapeutic target.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Wei He, Shuai Gong, Xin Wang, Xinhua Dong, Hua Cheng
Summary: This study revealed that OCT1 was upregulated while OCT4, OCT6, and OCT11 were downregulated in ESCC, with their expression levels correlated with the methylation status of their respective promoters. OCT2, OCT7, and OCT9 were undetected in all samples.
Article
Medicine, General & Internal
Kevin Roth, Louis Coussement, Elena V. Knatko, Maureen Higgins, Sandra Steyaert, Charlotte M. Proby, Tim de Meyer, Albena T. Dinkova-Kostova
Summary: The study found increased average methylation levels in mouse cSCC, especially in stem-cell like human cSCC. There were striking similarities in differentially methylated genes between mouse and human cSCC, with locus specific methylation changes occurring in potential regulatory regions. Dysregulation of DNA methylation, particularly in the Filip1l gene, appears to contribute to the silencing of tumor suppressor genes in both murine and human cSCC.
Article
Immunology
Zhiwei Wang, Ling Ran, Chunxia Chen, Ranran Shi, Yu Dong, Yubing Li, Xiuman Zhou, Yuanming Qi, Pingping Zhu, Yanfeng Gao, Yahong Wu
Summary: In this study, 35 HLA-A2-restricted mutant peptides from ESCC were selected, with seven of them showing strong binding affinity to HLA-A*0201 molecules and forming stable complexes. Three of these mutant peptides were immunogenic and able to induce CTL recognition in an HLA-A2-restricted and MUT peptide-specific manner. Enhancing CTL response in immunized mice was achieved by coupling MUT peptides with a peptide delivery carrier targeting DCs.
Article
Oncology
Akira Takemoto, Kousuke Tanimoto, Seiichi Mori, Jun Inoue, Naoto Fujiwara, Tetsuo Noda, Johji Inazawa
Summary: The study revealed frequent variants and copy number amplifications in cancer-related genes among esophageal squamous cell carcinoma (ESCC) patients, with two mutational signatures observed in Japanese cases. Aberrant DNA methylation in imprinted genes and frequent nonsynonymous single-nucleotide variants in FAT family genes were also identified. The integrative genome-wide analyses showed altered gene regulation in ESCC.
Article
Cell Biology
Hui Chen, Qin Qin, Zhipeng Xu, Tingting Chen, Xijuan Yao, Bing Xu, Xinchen Sun
Summary: Esophageal carcinoma is characterized by genetic and epigenetic alterations, with DNA methylation being a key factor in its pathogenesis. By analyzing data from TCGA database, specific DNA methylation sites were identified to impact patient prognosis, leading to the classification of patients into seven clusters with distinct characteristics. Further analysis revealed genes and pathways associated with cellular metabolism and autophagy, and the construction of a prognostic prediction model for individualized treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Wei Guo, Fengwei Tan, Qilin Huai, Zhen Wang, Fei Shao, Guochao Zhang, Zhenlin Yang, Renda Li, Qi Xue, Shugeng Gao, Jie He
Summary: This study established a strong prognostic signature for ESCC patients based on m6A RNA methylation regulators, accurately predicting patient prognosis. m6A methylation regulators may serve as key mediators of PD-L1 expression and immune cell infiltration, strongly impacting the TIME of ESCC.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Sha Sumei, Kong Xiangyun, Chen Fenrong, Sun Xueguang, Hu Sijun, Bai Bin, Shi Xiaolei, Tu Yongjiu, Wu Kaichun, Zhao Qingchuan, Nie Yongzhan, Xu Bin
Summary: This study revealed that DHRS3 is hypermethylated and downregulated in gastric cancer, associated with histological type and differentiation of tumors. Patients with high levels of CpG 9.10 methylation in DHRS3 had shorter survival times.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Qiuning Yu, Namei Xia, Yanteng Zhao, Huifang Jin, Renyin Chen, Fanglei Ye, Liyinghui Chen, Ying Xie, Kangkang Wan, Jun Zhou, Dihan Zhou, Xianping Lv
Summary: This study investigated the methylation profiles of esophageal squamous cell carcinoma (ESCC) using whole-genome bisulfite sequencing (WGBS) data. Differentially methylated CpG sites, differentially methylated regions, and differentially methylated genes were identified. The hypermethylated HOXL subclass homeobox genes were found to have potential applications for early detection of ESCC.
BMC MEDICAL GENOMICS
(2022)
Article
Medicine, General & Internal
Weiwei Zhang, Wenji Yan, Niansong Qian, Quanli Han, Weitao Zhang, Guanghai Dai
Summary: The PAX5 gene is downregulated by methylation in esophageal squamous cell carcinoma (ESCC) and has been found to inhibit cell proliferation, promote apoptosis, and activate the p53 signaling pathway. Restoring PAX5 expression can suppress tumor growth and increase chemosensitivity. PAX5 may serve as a potential marker for the chemosensitivity of ESCC.
CHINESE MEDICAL JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Ken Kato, Yoshinori Ito, Isao Nozaki, Hiroyuki Daiko, Takashi Kojima, Masahiko Yano, Masaki Ueno, Satoru Nakagawa, Masakazu Takagi, Shigeru Tsunoda, Tetsuya Abe, Tetsu Nakamura, Morihito Okada, Yasushi Toh, Yuichi Shibuya, Seiichiro Yamamoto, Hiroshi Katayama, Kenichi Nakamura, Yuko Kitagawa
Summary: The study concluded that for T1bN0M0 ESCC, CRT is noninferior to surgery in terms of overall survival rate. CRT showed good treatment efficacy and tolerability compared to surgery.
Article
Oncology
Qing Liu, Meng Liang, Tao Liu, Lucine Vuitton, Shutao Zheng, Xiangpeng Gao, Mang Lu, Xiuling Li, Ilyar Sheyhidin, Xiaomei Lu
Article
Oncology
Shutao Zheng, Chenchen Yang, Tao Liu, Qing Liu, Fang Dai, Ilyar Sheyhidin, Xiaomei Lu
Article
Pathology
Shutao Zheng, Chenchen Yang, Mang Lu, Qing Liu, Tao Liu, Fang Dai, Xiangpeng Gao, Ilyar Sheyhidin, Xiaomei Lu
Article
Biochemistry & Molecular Biology
Chenchen Yang, Shutao Zheng, Tao Liu, Qing Liu, Fang Dai, Jian Zhou, Yumei Chen, Ilyar Sheyhidin, Xiaomei Lu
Article
Oncology
Zhichao Hou, Abulajiang Abudureheman, Lei Wang, Ayshamgul Hasim, Julaiti Ainiwaer, Haiping Zhang, Madiniyat Niyaz, Halmurat Upur, Ilyar Sheyhidin
Article
Medicine, Research & Experimental
Lei Wang, Haiping Zhang, Ayshamgul Hasim, Abuduaini Tuerhong, Zhichao Hou, Ablajan Abdurahmam, Ilyar Sheyhidin
MEDICAL SCIENCE MONITOR
(2017)
Article
Oncology
Lei Wang, Zhichao Hou, Ayshamgul Hasim, Abulajiang Abuduerheman, Haiping Zhang, Madiniyat Niyaz, Idiris Awut, Halmurat Upur, Ilyar Sheyhidin
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Oncology
Abulajiang Abudureheman, Julaiti Ainiwaer, Zhichao Hou, Madiniyat Niyaz, Abdugheni Turghun, Ayshamgul Hasim, Haiping Zhang, Xiaomei Lu, Ilyar Sheyhidin
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2018)
Article
Oncology
Madiniyet Niyaz, Julaiti Ainiwaer, Abulajiang Abudureheman, Liwei Zhang, Ilyar Sheyhidin, Abduheny Turhong, Ren Cai, Zhichao Hou, Edris Awut
Article
Biotechnology & Applied Microbiology
Julaiti Ainiwaer, Liwei Zhang, Maidiniyeti Niyazi, Edris Awut, Shutao Zheng, Ilyar Sheyhidin, JiangHong Dai
Summary: ALPK2 promotes the development of esophageal cancer by enhancing cell proliferation and migration, as well as suppressing apoptosis. It functions through the regulation of its downstream gene ITGA11. Therefore, ALPK2 may serve as a potential target for the treatment of esophageal cancer.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Kawuli Jumai, Tangjuan Zhang, Bingzhang Qiao, Julaiti Ainiwaer, Haiping Zhang, Zhichao Hou, Idris Awut, Madinyat Niyaz, Liwei Zhang, Ilyar Sheyhidin
Summary: This study screened the downstream functional genes of THSD7A and identified SCARA5 as the driving gene. SCARA5 promoted tumor growth and migration while inhibiting apoptosis in ESCC. The opposite functions of SCARA5 in EC and LC were observed. These findings suggest that SCARA5 may serve as a potential diagnostic and therapeutic target for ESCC.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Weijie Yu, Ruixue Liu, Zhoulin Miao, Liwei Zhang, Ilyar Sheyhidin, Julaiti Ainiwaer
Summary: This meta-analysis indicates that circRNAs are highly useful diagnostic biomarkers for NSCLC in China. Further prospective studies on the diagnostic value of circRNAs should be conducted in multiple countries.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Bingzhang Qiao, Kawuli Jumai, Julaiti Ainiwaer, Madinyat Niyaz, Yingxin Zhang, Yuqing Ma, Liwei Zhang, Wesley Luh, Ilyar Sheyhidin
Summary: Confirming histological patterns of lung carcinoma is crucial for patient treatment and prognosis. However, this task is challenging and requires the input of experienced pathologists. Computer-aided diagnosis has the potential to speed up the diagnosis process by reducing the need for manual annotation by pathologists.
Article
Biochemistry & Molecular Biology
Haiping Zhang, Lei Wang, Zhichao Hou, Hong Ma, Batur Mamtimin, Ayshamgul Hasim, Ilyar Sheyhidin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Oncology
Alimujiang Kelimu, Juret Anwer, Yanchao Deng, Ayshamgul Hasim, Desheng Li, Liwei Zhang, Ilyar Sheyhidin
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2016)