Article
Medicine, General & Internal
Maartje Dijkstra, Henrieke Prins, Jan M. Prins, Peter Reiss, Charles Boucher, Annelies Verbon, Casper Rokx, Godelieve de Bree
Summary: The study focuses on individuals with early HIV infection who start combination antiretroviral therapy (cART) with the aim of investigating the size of the viral reservoir and HIV-specific immune responses in preparation for future HIV cure trials.
Article
Medicine, General & Internal
Nina Weis, Terese L. Katzenstein, Mathilde Orbaek, Merete Storgaard, Gitte Pedersen, Isik S. Johansen, Ellen Moseholm
Summary: The Danish HIV Birth Cohort (DHBC) aims to investigate the impact of HIV infection during pregnancy and after delivery in women living with HIV in Denmark, as well as their children. Findings reveal that HIV-exposed, but uninfected children born to these women have higher risks of low birth weight and intrauterine growth retardation compared to children born to the general population. Future plans include continued research on the significance of HIV infection and antiretroviral therapy in pregnant women living with HIV and their children, comparing these findings with children born to the general population.
Article
Medicine, General & Internal
William B. MacLeod, Jacob Bor, Sue Candy, Mhairi Maskew, Matthew P. Fox, Katia Bulekova, Alana T. Brennan, James Potter, Cornelius Nattey, Dorina Onoya, Koleka Mlisana, Wendy Stevens, Sergio Carmona
Summary: The NHLS National HIV Cohort collects laboratory data of almost all patients receiving HIV care in the public sector in South Africa since April 2004. Using an anonymised unique patient identifier, the cohort enables researchers to prospectively observe patients through their laboratory results as they receive HIV care and treatment.
Article
Medicine, General & Internal
Boyoung Park, Kyoung Hwan Ahn, Yunsu Choi, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Jun Young Choi, Joon Young Song, Eunjung Lee, Yoon Hee Jun, Young Kyung Yoon, Won Suk Choi, Myungsun Lee, Jaehyun Seong, Shin-Woo Kim
Summary: This study examined the cancer incidence and risk among HIV-infected individuals in Korea compared to the general population. The findings showed an increased risk of cancer, particularly AIDS-defining and virus-related cancers, in people with HIV. Efforts to improve cancer prevention, screening, and healthcare accessibility for HIV-infected individuals are necessary.
Article
Medicine, General & Internal
Christina Carlander, Johanna Brannstrom, Fredrik Mansson, Olof Elvstam, Pernilla Albinsson, Simon Blom, Lena Mattsson, Sanne Hovmoller, Hans Norrgren, Asa Mellgren, Veronica Svedhem, Magnus Gisslen, Anders Sonnerborg
Summary: The Swedish InfCareHIV cohort was established in 2003 to ensure equal and effective care for people living with HIV and enable long-term follow-up. It functions as both a decision support system and a quality registry, providing up-to-date data in real time. The cohort includes data on >99% of diagnosed HIV cases in Sweden and covers various aspects such as biomarkers, antiretroviral therapies, demographics, and patient-reported outcomes.
Article
Medicine, General & Internal
Mazvita Muchengeti, Lina Bartels, Victor Olago, Tafadzwa Dhokotera, Wenlong Carl Chen, Adrian Spoerri, Eliane Rohner, Lukas Butikofer, Yann Ruffieux, Elvira Singh, Matthias Egger, Julia Bohlius
Summary: The South African HIV Cancer Match (SAM) Study is a national cohort of people living with HIV, aiming to assess the spectrum and risk of cancer in PLWH to inform cancer prevention and control programmes in South Africa. The study includes over 5 million PLWH for the period 2004 to 2014, with a focus on enriching the research through record linkages with other laboratory data and socio-economic data to comprehensively study comorbidities among PLWH.
Article
Oncology
Isabelle Poizot-Martin, Caroline Lions, Cyrille Delpierre, Alain Makinson, Clotilde Allavena, Anne Fresard, Sylvie Bregigeon, Teresa Rojas Rojas, Pierre Delobel
Summary: This study aimed to investigate the prevalence and spectrum of second primary cancers in HIV-positive cancer survivors. The results showed that the pattern of subsequent cancers differed according to the type of first primary cancer and sex. Further research is needed to determine the excess risk of second primary cancers in this population and to determine the need for more appropriate screening procedures.
Article
Medicine, General & Internal
Margaret Heslin, Amelia Jewell, Sara Croxford, Cuong Chau, Shubulade Smith, Rudiger Pittrof, Elana Covshoff, Ann Sullivan, Valerie Delpech, Alison Brown, Helena P. King, Mina Kakaiya, Lucy Campbell, Elizabeth Hughes, Robert Stewart
Summary: A retrospective cohort study in the UK found that the prevalence of HIV in people who have used secondary mental health services was 2.47%, which is approximately 2.5 times higher than the general population in the same geographical area. Further research is needed to investigate risk factors and disparities in HIV outcomes between those with and without mental health service contact.
Article
Medicine, General & Internal
Shrikala Acharya, Amol Palkar, Anwar Parvez Sayed, Maninder Singh Setia
Summary: This retrospective cohort analysis of 2224 children living with HIV/AIDS in government ART centers in Mumbai, India, found that survival was significantly associated with ART adherence and CD4 cell count levels. Adherence counseling and early initiation of ART medication are crucial for improving survival outcomes for CLHAs.
Article
Medicine, General & Internal
Cybele L. Abad, Jia An G. Bello, Angela Beatriz Cruz, Aleksandra Danilovic, Juan Elias, James W. Bremer, Diana D. Huang
Summary: HIV subtypes in the Philippines are increasingly diverse, potentially impacting treatment outcomes. A study on treatment-naive patients found a predominance of males with a median age of 30, among whom 61 were MSM. Around 17.6% of patients carried baseline drug resistance mutations.
Article
Medicine, General & Internal
Cecilia T. Costiniuk, Joel Singer, Marc-Andre Langlois, Iva Kulic, Judy Needham, Ann Burchell, Mohammad-Ali Jenabian, Sharon Walmsley, Mario Ostrowski, Colin Kovacs, Darrell Tan, Marianne Harris, Mark Hull, Zabrina Brumme, Mark Brockman, Shari Margolese, Enrico Mandarino, Jonathan B. Angel, Jean-Pierre Routy, Aslam H. Anis, Curtis Cooper
Summary: This study aims to determine the efficacy of COVID-19 vaccines in people living with HIV, comparing their immune responses to HIV-negative individuals. The findings will contribute to future clinical trials, dosing strategies, and guidelines for HIV patients.
Article
Medicine, General & Internal
Silvia Nozza, Angelo Roberto Raccagni, Riccardo Lolatto, Daniele Ceccarelli, Laura Galli, Francesca Alberton, Elena Bruzzesi, Diana Canetti, Martina Strano, Marco Ripa, Costanza Bertoni, Antonella Castagna
Summary: This study describes the characteristics of a cohort of men who have sex with men (MSM) receiving pre-exposure prophylaxis (PrEP) for HIV prevention. The study found an unbalanced access to PrEP among key populations, with high-risk behaviors and sexually transmitted infections (STIs) frequently observed.
Article
Public, Environmental & Occupational Health
Ying Liu, Yiwei Hao, Jiang Xiao, Liang Wu, Hongyuan Liang, Junyan Han, Hongxin Zhao
Summary: This study examined the trends in hospitalization rates and causes among people living with HIV who initiated antiretroviral therapy (ART) in a designated HIV hospital in China. The results showed that although hospitalization rates decreased, AIDS-related events remained the leading cause of hospitalizations among HIV patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Thokozile R. Malaba, Landon Myer, Clive Gray, Marie-Louise Newell
Summary: The PIMS study in South Africa investigates the relationship between ART use, preterm delivery, and small-for-gestational age live births. Preliminary findings suggest that ART treatment during pregnancy and ART-induced hypertension may be associated with adverse birth outcomes.
Article
Immunology
Jiaye Liu, Yuying Hou, Liqin Sun, Lifeng Wang, Yun He, Yang Zhou, Liumei Xu, Xiaoning Liu, Fang Zhao, Lukun Zhang, Hui Wang, Fu-Sheng Wang
Summary: The study found that in HIV-infected individuals undergoing long-term ART, the incidence and mortality of non-AIDS-defining diseases (NADs) are increasing. Modifiable risk factors contributing to NADs include smoking, hypertension, diabetes, chronic hepatitis B and C virus infections. Individual-level interventions and population-level policy-making are crucial for preventing NADs in the long-term management of HIV infection.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Raul U. Hernandez-Ramirez, Li Qin, Haiqun Lin, Wendy Leyden, Romain S. Neugebauer, Keri N. Althoff, Nancy A. Hessol, Chad J. Achenbach, John T. Brooks, M. John Gill, Surbhi Grover, Michael A. Horberg, Jun Li, W. Christopher Mathews, Angel M. Mayor, Pragna Patel, Charles S. Rabkin, Anita Rachlis, Amy C. Justice, Richard D. Moore, Eric A. Engels, Michael J. Silverberg, Robert Dubrow
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Cardiac & Cardiovascular Systems
Rine Nakanishi, Joseph A. Delaney, Wendy S. Post, Christopher Dailing, Michael J. Blaha, Frank Palella, Mallory Witt, Todd T. Brown, Lawrence A. Kingsley, Kazuhiro Osawa, Indre Ceponiene, Negin Nezarat, Sina Rahmani, Mitsuru Kanisawa, Lisa Jacobson, Matthew J. Budoff
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2020)
Article
Infectious Diseases
R. M. Brusca, D. B. Hanna, N. Wada, J. N. Blankson, M. D. Witt, L. P. Jacobson, L. Kingsley, F. J. Palella, M. Budoff, T. T. Brown, K. Anastos, J. M. Lazar, W. J. Mack, P. Bacchetti, P. C. Tien, Y. Golzar, M. Plankey, E. Golub, R. C. Kaplan, W. S. Post
Article
Public, Environmental & Occupational Health
Pamela J. Surkan, Ruibin Wang, Yuru Huang, Ron Stall, Michael Plankey, Linda A. Teplin, Richard G. Wight, Lisa P. Jacobson, Alison G. Abraham
Article
Immunology
Jose R. Castillo-Mancilla, Todd T. Brown, Frank J. Palella, Bernard J. C. Macatangay, Elizabeth C. Breen, Lisa P. Jacobson, Nikolas I. Wada
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Psychiatry
Benjamin W. Barrett, Alison G. Abraham, Lorraine T. Dean, Michael W. Plankey, M. Reuel Friedman, Lisa P. Jacobson, Linda A. Teplin, Pamina M. Gorbach, Pamela J. Surkan
Summary: This study found that income and social-environmental stress were the largest contributors to racial/ethnic disparities in risk for depressive symptoms among men who have sex with men. Reducing socioeconomic inequalities and stressful experiences may be effective public health targets to decrease these disparities.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2021)
Article
Immunology
Shehnaz K. Hussain, Asieh Golozar, Daniel P. Widney, Giovanna Rappocciolo, Sudhir Penugonda, Jay H. Bream, Otoniel Martinez-Maza, Lisa P. Jacobson
Summary: Immune activation and inflammation are common in chronic HIV infection and are linked to major causes of morbidity. Statin therapy is associated with reduced levels of certain biomarkers of immune activation and inflammation in cART users, potentially reducing the burden of disease.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2021)
Article
Mathematical & Computational Biology
Zheng Wang, Yu Cheng, Eric C. Seaberg, Leah H. Rubin, Andrew J. Levine, James T. Becker
Summary: Motivated by the Multicenter AIDS Cohort Study (MACS), this study developed classification procedures for cognitive impairment based on longitudinal measures, adapting the cross-sectional multivariate normative comparisons (MNC) method to control family-wise error. The study proposed longitudinal MNC procedures based on multivariate mixed effects models to effectively control family-wise error at a predetermined level, using a dataset from a neuropsychological substudy of the MACS to illustrate the applications of the proposed classification procedures.
STATISTICS IN MEDICINE
(2021)
Article
Oncology
Lauren C. Peres, Mary K. Townsend, Brenda M. Birmann, Jose R. Conejo-Garcia, Yongjoo Kim, Laura D. Kubzansky, Larry Magpantay, Otoniel Martinez-Maza, Shelley S. Tworoger
Summary: This study found that elevated levels of CXCL13 may be associated with an increased risk of ovarian cancer, suggesting CXCL13 as a potential novel biomarker for the disease.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Laura E. Martinez, Shelly Lensing, Di Chang, Larry Magpantay, Ronald Mitsuyasu, Richard F. Ambinder, Joseph A. Sparano, Otoniel Martinez-Maza, Marta Epeldegui
Summary: This study identified that ARL patients who responded well to therapy had lower levels of inflammation and microbial translocation before treatment, as well as several biomarkers significantly decreased after treatment. Additionally, certain biomarkers were associated with overall and progression-free survival in ARL patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Laura E. Martinez, Tracy R. Daniels-Wells, Yu Guo, Larry Magpantay, Pierre Candelaria, Manuel L. Penichet, Otoniel Martinez-Maza, Marta Epeldegui
Summary: The anti-TfR1 antibody, ch128.1/IgG1, effectively inhibits the activation, growth, and immortalization of EBV+ human B-cells in vivo, as well as the development of these cells into lymphoma-like tumors in immunodeficient mice.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Traci A. Bekelman, Dana Dabelea, Jody M. Ganiban, Andrew Law, Alexandra McGovern Reilly, Keri N. Althoff, Noel Mueller, Carlos A. Camargo, Cristiane S. Duarte, Anne L. Dunlop, Amy J. Elliott, Assiamira Ferrara, Diane R. Gold, Irva Hertz-Picciotto, Tina Hartert, Alison E. Hipwell, Kathi Huddleston, Christine C. Johnson, Margaret R. Karagas, Catherine J. Karr, Gurjit K. Khurana Hershey, Leslie Leve, Somdat Mahabir, Cindy T. McEvoy, Jenae Neiderhiser, Emily Oken, Andrew Rundle, Sheela Sathyanarayana, Christine Turley, Frances A. Tylavsky, Sara E. Watson, Rosalind Wright, Mingyu Zhang, Edward Zoratti
Summary: This study found that individual-level characteristics and region of residence were associated with child BMI within different US Census regions, even after adjusting for sociodemographic characteristics. Understanding regional influences can inform targeted efforts to mitigate BMI-related disparities among children.
Article
Public, Environmental & Occupational Health
Nikos Stratakis, Erika Garcia, Aruna Chandran, Tingju Hsu, Akram Alshawabkeh, Izzuddin M. Aris, Judy L. Aschner, Carrie Breton, Allison Burbank, Carlos A. Jr Jr Camargo, Kecia N. Carroll, Zhanghua Chen, Erika C. Claud, Dana Dabelea, Anne L. Dunlop, Amy J. Elliott, Assiamira Ferrara, Jody M. Ganiban, James E. Gern, Diane R. Gold, William A. Gower, Irva Hertz-Picciotto, Margaret R. Karagas, Catherine J. Karr, Barry Lester, Leslie D. Leve, Augusto A. Litonjua, Yunin Ludena, Cindy T. McEvoy, Rachel L. Miller, Noel T. Mueller, Thomas G. O'Connor, Emily Oken, T. Michael O'Shea, Frederica Perera, Joseph B. Stanford, Katherine Rivera-Spoljaric, Andrew Rundle, Leonardo Trasande, Rosalind J. Wright, Yue Zhang, Yeyi Zhu, Kiros Berhane, Frank Gilliland, Lida Chatzi
Summary: This study found an association between childhood asthma and obesity, suggesting that asthma may contribute to the development of obesity in children. Additionally, the use of asthma medication was found to reduce this association.
Article
Cardiac & Cardiovascular Systems
Wendy S. Post, Sabina A. Haberlen, Mallory D. Witt, Long Zhang, Lisa P. Jacobson, Todd T. Brown, Joseph B. Margolick, Lawrence Kingsley, Frank J. Palella Jr., Matthew Budoff
Summary: This study reveals that the progression of coronary artery stenosis in HIV-positive individuals is associated with suboptimal HIV RNA suppression and antiretroviral therapy adherence. Effective ongoing HIV virologic suppression and adherence to antiretroviral therapy may help mitigate the risk of coronary disease events in people living with HIV.
Article
Psychology, Developmental
Kristen Lyall, Mina Hosseini, Christine Ladd-Acosta, Xuejuan Ning, Diane Catellier, John N. Constantino, Lisa A. Croen, Aaron J. Kaat, Kelly Botteron, Nicole R. Bush, Stephen R. Dager, Cristiane S. Duarte, M. Daniele Fallin, Heather Hazlett, Irva Hertz-Picciotto, Robert M. Joseph, Margaret R. Karagas, Susan Korrick, Rebecca Landa, Daniel Messinger, Emily Oken, Sally Ozonoff, Joseph Piven, Juhi Pandey, Sheela Sathyanarayana, Robert T. Schultz, Tanya St. John, Rebecca Schmidt, Heather Volk, Craig J. Newschaffer
Summary: This study compared the accuracy of predicting autism spectrum disorder between a shortened version and the full version of the Social Responsiveness Scale, finding that they were nearly identical. The findings support the comparability of shortened and full scores, suggesting opportunities to increase efficiency. Future research should confirm additional psychometric properties of shortened scores.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)
