Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cell Biology
Tien-Wei Hsu, Brendon Stubbs, Chih-Sung Liang, Tien-Yu Chen, Ta-Chuan Yeh, Chih-Chuan Pan, Che-Sheng Chu
Summary: This meta-analysis demonstrates that serotonergic antidepressants effectively alleviate overall neuropsychiatric symptoms, agitation, depressive symptoms, and care burden in patients with dementia, as well as improving cognitive function.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Medicine, General & Internal
Daniel Richter, Jeyanthan Charles James, Andreas Ebert, Aristeidis H. Katsanos, Lisa Mazul-Wach, Quirin Ruland, Ralf Gold, Georg Juckel, Christos Krogias
Summary: Early SSRI therapy is associated with a reduced risk of post-stroke depression, but increases the risk of bone fracture and nausea. Future research should focus on identifying high-risk individuals to improve the risk-benefit assessment of this therapy in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Tingyan Wu, Weili Cai, Xi Chen
Summary: Neurotransmission signaling is a conserved system with important regulatory events. The role of excitatory and inhibitory neurotransmitter systems in brain function is well established. Recent research has shown that epigenetic regulation plays a crucial role in controlling the expression of neurotransmitter-related genes and its dysregulation is associated with neurological disorders. This article explores the epigenetic regulation of dopamine, GABA, glutamate, and serotonin genes, and discusses how targeting these mechanisms can lead to improved treatments for neurological disorders.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: The exposure to antidepressants during pregnancy, especially SSRIs, is associated with a slightly increased risk of postpartum hemorrhage. However, the findings should be interpreted with caution, and precautionary measures are still recommended.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Martin J. Lan, Francesca Zanderigo, Spiro P. Pantazatos, M. Elizabeth Sublette, Jeffrey Miller, R. Todd Ogden, J. John Mann
Summary: Disturbance of serotonin system function is associated with both the diagnosis of BD and its severity of depression. Pretreatment 5HT1AR binding did not predict SSRI antidepressant outcome.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Oncology
Min-Jing Lee, Chien-Wei Huang, Yi-Lung Chen, Yao-Hsu Yang, Vincent Chin-Hung Chen
Summary: The study revealed an association between the use of SSRIs and decreased risk of kidney cancer, with citalopram and paroxetine showing protective effects in depressed patients with kidney cancer during a 2-year induction period.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Toshiya Funatsuki, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita, Masaki Kato
Summary: Individual responses to antidepressant treatment varies, and understanding the factors contributing to this variability is important. This study investigated the correlation between changes in plasma miRNA levels and treatment outcomes of MIR and SSRI monotherapy in MDD patients. The results suggest that specific miRNAs may serve as potential biomarkers for predicting treatment response in depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Soobeen Hwang, Jong-Hui Kim, Su-Hyun Jo
Summary: Paroxetine can acutely and directly modulate human Kv1.3 channels, inhibiting channel activity by accelerating steady-state inactivation, thus revealing a possible mechanism for acute immunosuppression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Psychiatry
Jeffrey R. Strawn, Jeffrey A. Mills, Vikram Suresh, Taryn Mayes, Melanie T. Gentry, Madhukar Trivedi, Paul E. Croarkin
Summary: Understanding how age affects antidepressant response is important for treatment selection. This study analyzed participant-level data from NIH-sponsored trials to identify the impact of age on antidepressant response.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Rafael R. Domingues, Hannah P. Fricke, Celeste M. Sheftel, Autumn M. Bell, Luma C. Sartori, Robbie S. J. Manuel, Chandler J. Krajco, Milo C. Wiltbank, Laura L. Hernandez
Summary: The effects of SSRI drugs on pregnancy and neonatal outcomes in mice were investigated. The study found that the high dose of fluoxetine led to a decrease in pregnancy rate and maternal weight gain, while both high and low doses of sertraline led to a decrease in the number of pups born and weaned. The study suggests that the effects of SSRI on neonatal mortality may be mediated by SSRI-induced placental insufficiency.
Review
Neurosciences
Robyn P. Thom, Michelle L. Palumbo, Claire Thompson, Christopher J. McDougle, Caitlin T. Ravichandran
Summary: The study found that the majority of adults with Down syndrome responded positively to a 12-week course of SSRI treatment for depression, with some experiencing adverse effects such as daytime sedation and anger. Controlled studies are needed to further evaluate the efficacy, tolerability, and safety of SSRIs in this population.
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Neurosciences
Sarah W. Yip, Sarah D. Lichenstein, Kathleen Garrison, Christopher L. Averill, Humsini Viswanath, Ramiro Salas, Chadi G. Abdallah
Summary: This study utilized a mixed design to investigate the effects of smoking status and state on whole-brain patterns of intrinsic connectivity, revealing differences in functional connectivity within specific networks and the impact of smoking state on brain function.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychology, Clinical
Thomas G. Adams, Josh M. Cisler, Benjamin Kelmendi, Jamilah R. George, Stephen A. Kichuk, Christopher L. Averill, Alan Anticevic, Chadi G. Abdallah, Christopher Pittenger
Summary: Neuromodulation targeting the mPFC can enhance therapeutic safety learning by modulating functional connectivity within the brain, especially reducing connectivity with the DMN and salience network. Patients with OCD who received active tDCS showed faster therapeutic safety learning during exposure-based therapy compared to those who received sham stimulation. These findings suggest that frontopolar tDCS may be a promising avenue for enhancing the effects of exposure-based psychotherapies.
DEPRESSION AND ANXIETY
(2022)
Editorial Material
Neurosciences
Chadi G. Abdallah, Graeme F. Mason
NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Lynnette A. Averill, Chadi G. Abdallah
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Neurosciences
Chadi G. Abdallah, John D. Roache, Ralitza Gueorguieva, Lynnette A. Averill, Stacey Young-McCaughan, Paulo R. Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A. Sherif, Eric J. Baltutis, Mohini Ranganathan, Deepak D'Souza, Brenda Martini, Steven M. Southwick, Ismene L. Petrakis, Rebecca R. Burson, Kevin B. Guthmiller, Argelio L. Lopez-Roca, Karl A. Lautenschlager, John P. McCallin, Matthew B. Hoch, Alexandar Timchenko, Sergio E. Souza, Charles E. Bryant, Jim Mintz, Brett T. Litz, Douglas E. Williamson, Terence M. Keane, Alan L. Peterson, John H. Krystal
Summary: This study examined the efficacy of intravenous ketamine doses in reducing symptoms of posttraumatic stress disorder (PTSD). The results showed that ketamine did not have a dose-related effect on PTSD symptoms, but the standard dose had rapid antidepressant effects.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Mario J. Al Sayah, Chadi Abdallah, Michel Khouri, Rachid Nedjai, Talal Darwish, Houssein Khatib
Summary: This study integrates land cover suitability, soil erosion, and sediment transport as complementary indicators within the Land Degradation Neutrality (LDN) framework. Using the Lebanese Nahr Ibrahim basin as a case study, the study demonstrates the effectiveness of LDN in improving land cover suitability and reducing soil erosion and sediment transport risks.
GEOCARTO INTERNATIONAL
(2022)
Article
Behavioral Sciences
Ashley N. Clausen, Kelene A. Fercho, Molly Monsour, Seth Disner, Lauren Salminen, Courtney C. Haswell, Emily Clarke Rubright, Amanda A. Watts, M. Nicole Buckley, Adi Maron-Katz, Anika Sierk, Antje Manthey, Benjamin Suarez-Jimenez, Bunmi O. Olatunji, Christopher L. Averill, David Hofmann, Dick J. Veltman, Elizabeth A. Olson, Gen Li, Gina L. Forster, Henrik Walter, Jacklynn Fitzgerald, Jean Theberge, Jeffrey S. Simons, Jessica A. Bomyea, Jessie L. Frijling, John H. Krystal, Justin T. Baker, K. Luan Phan, Kerry Ressler, Laura K. M. Han, Laura Nawijn, Lauren A. M. Lebois, Lianne Schmaall, Maria Densmore, Martha E. Shenton, Mirjam van Zuiden, Murray Stein, Negar Fani, Raluca M. Simons, Richard W. J. Neufeld, Ruth Lanius, Sanne van Rooij, Saskia B. J. Koch, Serena Bonomo, Tanja Jovanovic, Terri DeRoon-Cassini, Timothy D. Ely, Vincent A. Magnotta, Xiaofu He, Chadi G. Abdallah, Amit Etkin, Christian Schmahl, Christine Larson, Isabelle M. Rosso, Jennifer Urbano Blackford, Jennifer S. Stevens, Judith K. Daniels, Julia Herzog, Milissa L. Kaufman, Miranda Olff, Richard J. Davidson, Scott R. Sponheim, Sven C. Mueller, Thomas Straube, Xi Zhu, Yuval Neria, Lee A. Baugh, James H. Cole, Paul M. Thompson, Rajendra A. Morey
Summary: PTSD is associated with accelerated aging markers. Young males with PTSD showed higher brain age difference compared to male controls, while old males with PTSD exhibited lower brain age difference compared to male controls of all ages.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Lynnette A. Averill, Christopher L. Averill, Ralitza Gueorguieva, Samar Fouda, Mohamed Sherif, Kyung-Heup Ahn, Mohini Ranganathan, Deepak Cyril D'Souza, Steven M. Southwick, Gerard Sanacora, Ronald S. Duman, John H. Krystal, Chadi G. Abdallah
Summary: Ketamine has demonstrated rapid and robust improvements in suicidal ideation, but the mechanism and trajectory of its effects are still not well understood.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Correction
Neurosciences
Chadi G. Abdallah, John D. Roache, Ralitza Gueorguieva, Lynnette A. Averill, Stacey Young-McCaughan, Paulo R. Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A. Sherif, Eric J. Baltutis, Mohini Ranganathan, Deepak D'Souza, Brenda Martini, Steven M. Southwick, Ismene L. Petrakis, Rebecca R. Burson, Kevin B. Guthmiller, Argelio L. Lopez-Roca, Karl A. Lautenschlager, John P. McCallin, Matthew B. Hoch, Alexandar Timchenko, Sergio E. Souza, Charles E. Bryant, Jim Mintz, Brett T. Litz, Douglas E. Williamson, Terence M. Keane, Alan L. Peterson, John H. Krystal
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Neurosciences
Sophie E. Holmes, Chadi Abdallah, Irina Esterlis
Summary: Major depressive disorder is a common and heterogeneous illness, with treatment resistance observed in at least 50% of patients. Initial research focused on the monoamine system, but recent studies have explored other mechanisms, including synaptic involvement in depression. This article discusses reductions in synaptic density, dendritic spines, boutons, and glia associated with stress and depression, as well as the potential of drugs like ketamine to restore or generate synapses. Neuroimaging techniques, such as MRI and PET, are valuable tools for assessing these synaptic changes in vivo and monitoring synaptic restoration after ketamine administration. While more research is needed, these techniques enhance our understanding of depression and contribute to the development of targeted and effective treatments.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebecca B. Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L. Woody, Elizabeth D. Ballard, Carlos A. Zarate, William Deakin, Chadi G. Abdallah, Adriana Feder, Dennis S. Charney, Michael F. Grunebaum, J. John Mann, Sanjay J. Mathew, Bronagh Gallagher, Declan M. McLoughlin, James W. Murrough, Suresh Muthukumaraswamy, Rebecca McMillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L. Phillips, Pierre Blier, Paulo Shiroma, Peter Sos, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T. Wilkinson, Meredith L. Wallace
Summary: Ketamine has rapid antidepressant effects and can reduce depressive symptoms in a variety of patients. It is particularly effective in patients who have been resistant to previous medications. However, there are currently no specific clinical or demographic characteristics that can guide treatment decisions for ketamine.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Chadi G. Abdallah, Sameer A. Sheth, Eric A. Storch, Wayne K. Goodman
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Ian H. Stanley, Brian P. Marx, Brooke A. Fina, Stacey Young-McCaughan, Hannah C. Tyler, Denise M. Sloan, Abby E. Blankenship, Katherine A. Dondanville, James L. Walker, Joseph W. Boffa, Craig J. Bryan, Lily A. Brown, Casey L. Straud, Jim Mintz, Chadi G. Abdallah, Sudie E. Back, Tabatha H. Blount, Bryann B. DeBeer, Julianne Flanagan, Edna B. Foa, Peter T. Fox, Steffany J. Fredman, John Krystal, Meghan E. McDevitt-Murphy, Donald D. McGeary, Kristi E. Pruiksma, Patricia A. Resick, John D. Roache, Paulo Shiroma, Daniel J. Taylor, Jennifer Schuster Wachen, Alexander M. Kaplan, Argelio L. Lopez-Roca, Karin L. Nicholson, Richard P. Schobitz, Christian C. Schrader, Allah-Fard M. Sharrieff, Jeffrey S. Yarvis, Brett T. Litz, Terence M. Keane, Alan L. Peterson
Summary: This study evaluated the Self-Injurious Thoughts and Behaviors Interview-Short Form (SITBI-SF) in military service members and veterans with PTSD. The SITBI-SF showed high reliability and validity, with comparable results across both groups. Approximately 8% of participants who denied suicidal ideation on the SITBI-SF reported it on a separate questionnaire. These participants had higher levels of PTSD symptoms. The SITBI-SF is a reliable measure for suicide-related thoughts and behaviors, and combining it with a self-report measure can enhance suicide risk assessment.
Article
Neurosciences
Amanda J. F. Tamman, Dora Koller, Sheila Nagamastu, Brenda Cabrera-Mendoza, Chadi Abdallah, John H. Krystal, Joel Gelernter, Janitza L. Montalvo-Ortiz, Renato Polimanti, Robert H. Pietrzak
Summary: This study examined the association between GrimAge and genetic predisposition for systemic inflammation, as well as the moderating effect of psychosocial factors. The results showed that certain inflammatory markers were associated with accelerated GrimAge, and this association was influenced by modifiable psychosocial variables such as exercise and gratitude. Furthermore, gene enrichment analysis identified potential anti-inflammatory and antihistamine drugs that affect genes represented in the inflammatory markers.
NEUROPSYCHOPHARMACOLOGY
(2023)
Meeting Abstract
Neurosciences
Harald Murck, Chadi Abdallah
BIOLOGICAL PSYCHIATRY
(2022)