Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Social
W. Roger Mills-Koonce, Maya Bracy, Michael T. Willoughby, Sarah J. Short, Cathi B. Propper
Summary: The study investigates the relationship between the Dark Triad traits (psychopathy, narcissism, and Machiavellianism) and verbal and physical intimate partner violence (IPV) among a racially and socioeconomically diverse sample of pregnant women (n = 203). The findings show that psychopathy predicts both verbal and physical IPV perpetration, while depression is a unique predictor of IPV victimization.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2023)
Article
Medicine, General & Internal
Erik Palsson, Lydia Melchior, Kristina Lindwall Sundel, Alina Karanti, Erik Joas, Axel Nordenskjold, Mattias Agestam, Bo Runeson, Mikael Landen
Summary: The Swedish National Quality Register for bipolar affective disorder, BipolaR, aims to provide nationwide indicators for quality assessment and development in the clinical care of individuals with bipolar spectrum disorder, and to provide data for bipolar disorder research. The register includes 39,583 individual patients with a total of 75,423 baseline and follow-up records.
Article
Clinical Neurology
Wenzhen Li, Dajie Chen, Wenyu Ruan, Ying Peng, Zuxun Lu, Dongming Wang
Summary: This study found that depression and sleep disorder are associated with increased risks of total and specific-cause mortality. Factors such as sex, age, and BMI may influence this association.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Wenzhen Li, Dajie Chen, Wenyu Ruan, Ying Peng, Zuxun Lu, Dongming Wang
Summary: The study found that depression and sleep disorder are associated with mortality, particularly with cardiovascular disease mortality. Men and older individuals are more susceptible to the effects of depression and sleep disorders. There is a dose-response relationship between depression scores, sleep duration and total mortality.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Jinghua Yin, Tianqi Ma, Jinchen Li, Guogang Zhang, Xunjie Cheng, Yongping Bai
Summary: This study reveals that mood disorders have a significant impact on the progression from single cardiometabolic diseases to multimorbidity or mortality. Patients with comorbid mood disorders, such as depression or bipolar disorder, are more likely to develop multimorbidity, and mood disorders also increase the overall mortality rate.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Markku Lahteenvuo, Ari Ahola-Olli, Kimmo Suokas, Minna Holm, Zuzanna Misiewicz, Tuomas Jukuri, Teemu Maennynsalo, Asko Wegelius, Willehard Haaki, Risto Kajanne, Aija Kyttala, Annamari Tuulio-Henriksson, Kaisla Lahdensuo, Katja Hakkinen, Jarmo Hietala, Tiina Paunio, Jussi Niemi-Pynttari, Tuula Kieseppa, Juha Veijola, Jouko Lonnqvist, Erkki Isometsa, Olli Kampman, Jari Tiihonen, Steven Hyman, Benjamin Neale, Mark Daly, Jaana Suvisaari, Aarno Palotie
Summary: The purpose of this study is to establish a large Finnish collection of psychosis cases, including diverse populations from Asia, Latin America, and Africa, in addition to known population isolates like Finland. A total of 10,474 individuals aged 18 years or older were recruited and genotyped. The future plans of this study include investigating the effects of common variants, rare variants, and copy number variations on the severity of psychotic illness, as well as tracking the longitudinal course of illness based on nationwide register data.
Article
Medicine, General & Internal
Ran Hao, Meng Zhang, Jinfan Zuo, Yixin Qi, Jie Hu
Summary: There is a relationship between illness uncertainty and demoralisation in breast cancer patients. Positive coping styles can reduce demoralisation, while negative coping styles can increase it. The findings emphasize the importance of reducing negative coping styles for the prevention and treatment of demoralisation in these patients.
Article
Clinical Neurology
Domenec Serrano, Ruth Marti-Lluch, Merida Cardenas, Pascual Solanas, Jaume Marrugat, Joan Vilalta-Franch, Josep Garre-Olmo
Summary: This study aimed to investigate the prevalence and course of subthreshold depressive symptomatology (sDS) and probable major depressive episode (MDE), and their association with personality traits. The results showed a higher gender gap in the prevalence and course of MDE. Personality traits were found to be differentially associated with the prevalence and course of depressive disorders between men and women.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Julia Boberg, Viktor Kaldo, David Mataix-Cols, James J. Crowley, Bjorn Roelstraete, Matthew Halvorsen, Erik Forsell, Nils H. Isacsson, Patrick F. Sullivan, Cecilia Svanborg, Evelyn H. Andersson, Nils Lindefors, Olly Kravchenko, Manuel Mattheisen, Hilda B. Danielsdottir, Ekaterina Ivanova, Magnus Boman, Lorena Fernandez de la Cruz, John Wallert, Christian Ruck
Summary: MULTI-PSYCH is a research project aimed at improving risk stratification, outcome prediction, and secondary preventive interventions for depression and anxiety disorders through highly structured internet-based cognitive-behaviour therapy (ICBT). The project combines clinical, genetic, and nationwide register data, and includes 2668 patients with depression and anxiety who underwent 12 weeks of ICBT at an internet psychiatry clinic in Stockholm, Sweden.
Article
Neurosciences
Jaehyun Kim, Tae Hyon Ha, Kiwon Kim, Eun-Mi Lee, Hyekyeong Kim, Doh Kwan Kim, Hong-Hee Won, Matthew Lewis, Hyewon Lee, Woojae Myung
Summary: The study found that the use of atypical antipsychotic drugs in elderly individuals with depressive disorders is associated with a significantly higher risk of subsequent dementia. Risperidone showed the highest risk for dementia among atypical antipsychotics. Healthcare professionals should be aware of this potential long-term risk when prescribing these medications.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Yuanyuan Wang, Jens H. Bos, Catharina C. M. Schuiling-Veninga, H. Marike Boezen, Job F. M. van Boven, Bob Wilffert, Eelko Hak
Summary: The study found that there was a lower incidence of NPAEs among general population using varenicline compared to nicotine replacement therapy, while there was no significant difference in NPAEs incidence between COPD patients using varenicline and NRT.
Article
Medicine, General & Internal
Jacqueline Kiewa, Samantha Meltzer-Brody, Jeannette Milgrom, Elizabeth Bennett, Tracey Mackle, Jerry Guintivano, Ian B. Hickie, Lucia Colodro-Conde, Sarah E. Medland, Nick Martin, Naomi Wray, Enda Byrne
Summary: This study evaluated the prevalence, timing of onset, and duration of perinatal depression symptoms in women with a history of depression. The majority of women with lifetime depression experienced perinatal depressive symptoms, which were associated with more complex and severe depression. The findings highlight the importance of assessing perinatal depressive symptoms in women with a history of depression or childhood adverse experiences.
Article
Medicine, General & Internal
Thomas J. Moore, Phillip W. Wirtz, Jill N. Curran, G. Caleb Alexander
Summary: A study found that a large proportion of adults using Schedule II stimulant drugs are also exposed to other central nervous system (CNS)-active drugs, which may lead to tolerance, withdrawal effects, or non-medical use. These multi-drug combinations lack approved indications and limited clinical trial testing, and discontinuation may be challenging.
Article
Psychiatry
Ketsupar Jirakran, Asara Vasupanrajit, Chavit Tunvirachaisakul, Michael Maes
Summary: This study aimed to determine whether neuroticism is a feature of the acute state of major depressive disorder (MDD), including suicidal behaviors, and whether adverse childhood experiences are associated with neuroticism in MDD. The results showed that neuroticism was significantly higher in MDD patients compared to healthy controls, and it explained a large portion of the variance in the depression phenome. Neglect and abuse in childhood accounted for a significant portion of the variance in the latent vector representing MDD phenome, with neuroticism partially mediating the effects of neglect and completely mediating the effects of abuse.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Respiratory System
Marion Keirsbulck, Marine Savoure, Emeline Lequy, Jie Chen, Kees de Hoogh, Danielle Vienneau, Marcel Goldberg, Marie Zins, Nicolas Roche, Rachel Nadif, Benedicte Jacquemin
Summary: This study investigated the associations between PM2.5, black carbon, and NO2 exposure and asthma symptom score in adults. The results showed that each pollutant was associated with an increase in asthma symptom score.
Editorial Material
Psychiatry
Cedric Lemogne, Clement Gouraud, Victor Pitron, Brigitte Ranque
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nicolas Roche, Rachel Nadif, Caroline Fabry-Vendrand, Laura Pillot, Gabriel Thabut, C. Teissier, Stephane Bouee, Marcel Goldberg, Marie Zins
Summary: This study aimed to describe the burden of asthma in the French population according to GINA treatment steps. The results showed that the healthcare costs of asthma were higher for asthmatic patients compared to non-asthmatic individuals, and increased with higher GINA treatment steps.
RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Milena Foerster, Lucas Dufour, Wolfgang Baeumler, Ines Schreiver, Marcel Goldberg, Marie Zins, Khaled Ezzedine, Joachim Schuez
Summary: This study developed and validated a questionnaire tool for assessing tattoo ink exposure in tattooed populations for use in large epidemiological cohort studies. The results showed that self-reporting of tattoo ink exposure led to an overestimation of tattoo size, which calls for further research to identify potential influential factors and predictive patterns.
JMIR FORMATIVE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Omar Deraz, Billy Caceres, Carl G. Streed, Lauren B. Beach, Xavier Jouven, Mathilde Touvier, Marcel Goldberg, Marie Zins, Jean-Philippe Empana
Summary: This study examined the association between cardiovascular health scores and sexual minority status, finding disparities in cardiovascular health among sexual minority adults. Lesbian and bisexual women had lower cardiovascular health scores compared to heterosexual women, while gay and bisexual men had higher cardiovascular health scores compared to heterosexual men. Primordial prevention targeted at sexual minority populations may be necessary.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Genetics & Heredity
Aya Ayoub, Julie Lapointe, Hermann Nabi, Nora Pashayan
Summary: This study explored UK General Practitioners' knowledge of and attitudes towards risk-stratified screening, as well as their preferences for continuing professional development. The results showed that 49% of GPs were not familiar with the concept of PRS. While 75% agreed with earlier and more frequent screening for high-risk women, there was hesitation and disagreement towards a low-risk screening pathway. The top priority for future implementation was identified as training healthcare professionals, preferably through online formats.
Article
Respiratory System
Pauline Balagny, Emmanuelle Vidal-Petiot, Adeline Renuy, Joane Matta, Justine Frija-Masson, Philippe Gabriel Steg, Marcel Goldberg, Marie Zins, Marie-Pia d'Ortho, Emmanuel Wiernik
Summary: This study found that one-fifth of the French population has a high likelihood of obstructive sleep apnoea (OSA), but only 3.5% are treated for the disorder, indicating significant underdiagnosis. Various factors, such as gender, age, and cardiovascular events, are associated with the prevalence of OSA.
Article
Environmental Sciences
Emeline Lequy, Sebastien Leblond, Jack Siemiatycki, Caroline Meyer, Danielle Vienneau, Kees de Hoogh, Marie Zins, Marcel Goldberg, Benedicte Jacquemin
Summary: This study analyzed the relationship between airborne metals and the risk of cancer in a large population. The findings suggested that most metals, except vanadium, were associated with an increased risk of cancer. These findings can help identify the sources and components of PM2.5 that contribute to its carcinogenicity.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Baptiste Pignon, Valentina Decio, Philippe Pirard, Olivier Bouaziz, Emmanuelle Corruble, Pierre A. Geoffroy, Viviane Kovess-Masfety, Marion Leboyer, Cedric Lemogne, Jonathan Messika, Vittorio Perduca, Franck Schurhoff, Nolwenn Regnault, Sarah Tebeka
Summary: COVID-19 may not increase the risk of hospitalization for psychotic disorders, as patients initially hospitalized for COVID-19 had a lower rate of subsequent hospitalization for psychotic disorders compared to those initially hospitalized for other reasons. This finding contradicts the hypothesis that there is an increased risk of psychotic disorders after a severe COVID-19 infection. Importantly, a history of psychotic disorder was found to be a major determinant of hospitalization for psychotic disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Marina Sanchez Rico, Marie Plessz, Guillaume Airagnes, Celine Ribet, Nicolas Hoertel, Marcel Goldberg, Marie Zins, Pierre Meneton
Summary: This study examined the specific effect of unemployment on cardiovascular health compared to social position and work environment. The results showed that both current and past unemployment were associated with increased risk of common cardiovascular risk factors. Past unemployment was additionally associated with obesity, diabetes, sleep disorders, and cardiovascular events. These effects were independent of social position and work environment and had a cumulative effect over time.
Article
Public, Environmental & Occupational Health
Svenja Hummel, Ina Michelsen, Ali Zafar, Steffen Moritz, Charles Benoy, Cedric Lemogne, Rosa Almeida, Raquel Losada, Oscar Ribeiro, Vincenza Frisardi, Ilaria Tarricone, Silvia Ferrari, Frieder Dechent, Christian G. Huber, Steffi Weidt, Gwendolyn Mayer, Jobst-Hendrik Schultz
Summary: The COVID-19 pandemic has had a severe impact on the lives and work conditions of Europeans, especially healthcare professionals. This study aimed to examine the job-related stressors and coping strategies of physicians, nurses, and nonmedical staff during the pandemic. The results revealed the most significant stressors and common coping strategies for healthcare professionals in two periods. Additionally, the study identified the psychosocial stressors and unmet needs of individuals.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Review
Oncology
Sophie Audet, Catherine Doyle, Christopher Lemieux, Marc-Antoine Tardif, Andrea Gauvreau, David Simonyan, Hermann Nabi, Julie Lemieux
Summary: The study aimed to determine the proportion of trials reporting the number of patients assessed for eligibility before randomization. A total of 456 phase II, III, and IV RCTs published between 2013 and 2015 were reviewed. It was found that 236 trials (51.8%) reported the number of patients assessed for eligibility, and 184 trials (78%) provided reasons for patient exclusion. However, there is a need to improve the reporting of external validity parameters in medical oncology RCTs.
Review
Oncology
Cynthia Mbuya-Bienge, Nora Pashayan, Cornelia D. Kazemali, Julie Lapointe, Jacques Simard, Hermann Nabi
Summary: This systematic review examines breast cancer (BC) risk prediction tools incorporating a polygenic risk score (PRS) and explores factors that may impact their ability to predict a woman's risk of developing BC.
Article
Allergy
Marine Savoure, Jean Bousquet, Benedicte Leynaert, Celine Ribet, Marcel Goldberg, Marie Zins, Benedicte Jacquemin, Rachel Nadif
Summary: This study provides insights into the impact of asthma status on the ARIA classification of allergic rhinitis, showing that individuals with rhinitis and asthma present more severe symptoms and require more intensive treatment. It highlights the importance of considering asthma status in the classification and guidelines for allergic rhinitis.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Medicine, Research & Experimental
Mathijs A. Langezaal, Egon L. van den Broek, Susan Peters, Marcel Goldberg, Gregoire Rey, Melissa C. Friesen, Sarah J. Locke, Nathaniel Rothman, Qing Lan, Roel C. H. Vermeulen
Summary: Work circumstances may impact health negatively. A decision support system was developed to improve occupational exposure assessment, outperforming expert coders and other current tools.
COMMUNICATIONS MEDICINE
(2023)
