Article
Multidisciplinary Sciences
Julija Gecaite-Stonciene, Brian M. Hughes, Nijole Kazukauskiene, Adomas Bunevicius, Julius Burkauskas, Julius Neverauskas, Marcella Bellani, Narseta Mickuviene
Summary: This study aimed to explore the relationship between cortisol response, mental distress, fatigue, and health-related quality of life in individuals with coronary artery disease. The results showed that mental distress was linked to a blunted cortisol response during anticipation of psychosocial stress, while fatigue and health-related quality of life were not.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Svetlana P. Chumakova, Olga I. Urazova, Vladimir M. Shipulin, Sergey L. Andreev, Olga A. Denisenko, Margarita V. Gladkovskaya, Larisa S. Litvinova, Mikhail A. Bubenchikov
Summary: This study aimed to investigate the angiopoietic endothelial dysfunction in ischemic cardiomyopathy (ICMP) patients. It was found that there was an imbalance in the number of endothelial progenitor cells (EPCs) and desquamated cells (EDCs) in ICMP patients. Additionally, alterations in the levels of HIF-1α, HIF-2α, ADMA, and endothelin-1 were observed in ICMP patients.
Article
Psychology, Multidisciplinary
Yan Zhou, Xue-Ping Zhu, Jing-Jing Shi, Guo-Zhen Yuan, Zi-Ang Yao, Yu-Guang Chu, Shuai Shi, Qiu-Lei Jia, Ting Chen, Yuan-Hui Hu
Summary: This study conducted a bibliometric analysis on the association between coronary heart disease (CHD) and depression or anxiety, identifying leading authors, institutions, and countries. The research hotspots were found to be the relationship between depression and CHD, depression and myocardial infarction, and characteristics of women suffering depression after MI. Potential future research directions include treating depression in CHD patients with multimorbidity, assessing psychometric properties of instruments for depression and anxiety in CHD patients, exploring depression or anxiety in post-PCI patients, and investigating other mental diseases in CHD patients.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mohammed A. Nayeem, Ahmad Hanif, Werner J. Geldenhuys, Stephanie Agba
Summary: Adenosine affects the cardiovascular system through the activation of receptors and interacts with enzymes such as CYP450-epoxygenases and soluble epoxide hydrolase to produce oxylipins, regulating cardiovascular functions. This interaction is associated with susceptibility to cardiovascular diseases, especially hypertension. Understanding the crosstalk between adenosine receptors and oxylipins is crucial for the development of diagnostic and therapeutic tools for cardiovascular diseases.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Nutrition & Dietetics
Xiao Zhang, Cole V. Veliky, Rahel L. Birru, Emma Barinas-Mitchell, Jared W. Magnani, Akira Sekikawa
Summary: Equol, derived from soy isoflavones through gut microbiome metabolism, may be the key cardioprotective component and have greater cardiovascular benefits than soy isoflavones. Studies show that equol possesses antioxidative, anti-inflammatory, and vasodilatory properties, improving arterial stiffness and atherosclerosis. Clinical studies on equol are warranted for further investigation as it is available as a dietary supplement.
Review
Cardiac & Cardiovascular Systems
Filippo Crea, Rocco A. Montone, Riccardo Rinaldi
Summary: Ischemic heart disease is commonly caused by coronary artery disease, but a significant number of patients may experience angina or myocardial infarction even without significant coronary artery stenosis. Coronary microvascular dysfunction has been identified as a relevant cause, involving functional and structural changes in the coronary microcirculation. Modifiable risk factors play a role in the pathogenesis, and further research is needed to develop precision medicine strategies.
CIRCULATION JOURNAL
(2022)
Review
Nutrition & Dietetics
Fernando de la Guia-galipienso, Maria Martinez-Ferran, Nestor Vallecillo, Carl J. Lavie, Fabian Sanchis-Gomar, Helios Pareja-Galeano
Summary: The main source of vitamin D in humans is the skin's biosynthesis through sun exposure, with additional intake from foods like fatty fish. Deficiency can lead to global health issues due to inadequate sunlight exposure. Beyond maintaining calcium and phosphorus balance, vitamin D plays key roles in the immune and cardiovascular systems.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Raphael S. Peter, Andrea Jaensch, Ute Mons, Ben Schottker, Roman Schmucker, Wolfgang Koenig, Hermann Brenner, Dietrich Rothenbacher
Summary: In patients with stable coronary heart disease, a trajectory of high stable symptoms of depression was associated with an increased risk of incident diabetes mellitus (DM) and subsequent cardiovascular events (CVE). Identifying depressive symptoms and providing relevant treatment may be an important and promising approach to improve outcomes in patients with coronary heart disease, warranting further research and implementation.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jiawen Li, Deshan Yuan, Lin Jiang, Xiaofang Tang, Jingjing Xu, Ying Song, Jue Chen, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan, Xueyan Zhao
Summary: In PCI patients treated with clopidogrel, leukocyte count and hs-CRP were found to be independent predictors of platelet reactivity, with high leukocyte count associated with more LTPR and high hs-CRP associated with more HTPR. This study provides new insights for individualized antiplatelet therapy strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Oncology
Qingfei Song, Yanling Guo, Fei Pei, Xiaoyan Wang
Summary: This study aimed to explore the relationship between carotid atherosclerosis ultrasound parameters and the cardiac and endothelial functions of coronary heart disease patients. The results showed a positive correlation between the ultrasound parameters of carotid atherosclerosis, cardiac function, and endothelial function with the severity of coronary artery branch stenosis, suggesting their potential use for early diagnosis of coronary heart disease.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Engineering, Biomedical
Sadaf Iqbal, Sharad Agarwal, Ian Purcell, Alan Murray, Jaume Bacardit, John Allen
Summary: This study used a novel approach, DL-PPG, which uses deep learning analysis of bilateral-site photoplethysmography waveforms, to identify patients with coronary artery disease (CAD). The results showed that DL-PPG had higher sensitivity and specificity compared to conventional machine learning methods in classifying CAD. This approach could provide significant value in low-cost, portable, and easy-to-use diagnostics for CAD in various clinical settings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Medicine, Research & Experimental
Pawel Kleczynski, Artur Dziewierz, Lukasz Rzeszutko, Dariusz Dudek, Jacek Legutko
Summary: In the setting of severe AS, FFR shows good agreement with iFR. However, the optimal FFR/iFR threshold to identify iFR<0.89/FFR<0.80 may differ from the standard ischemia thresholds.
ADVANCES IN MEDICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Wen-Yi Zhang, Nan Nan, Yi He, Hui-Juan Zuo, Xian-Tao Song, Min Zhang, Yuan Zhou
Summary: This study aimed to assess the prevalence of depression and anxiety in CHD patients and explore the association between established cardiovascular risk factors and depression as well as anxiety. The study found that the prevalence rates of depression and anxiety in CHD patients were 8.2% and 5.4%, respectively. Female gender, smoking, and hyperlipidemia were associated with a higher occurrence of depression, while female gender was associated with a higher occurrence of anxiety.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Correction
Biochemistry & Molecular Biology
Golam M. Khandaker, Verena Zuber, Jessica M. B. Rees, Livia Carvalho, Amy M. Mason, Christopher N. Foley, Apostolos Gkatzionis, Peter B. Jones, Stephend Burgess
Summary: An amendment to this paper has been published and readers can access it through the link provided at the top of the paper.
MOLECULAR PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Baofu Wang, Yu Teng, Yang Li, Sijia Lai, Yang Wu, Shiqi Chen, Tong Li, Xiaowan Han, Hufang Zhou, Yu Wang, Ziwen Lu, Haiyan Li, Yukun Ding, Liang Ma, Mingjing Zhao, Xian Wang
Summary: This study found that Chinese herbal medicine showed significant efficacy in treating coronary heart disease patients with anxiety or depression, especially in improving the symptom of angina pectoris. The active compounds of Chinese herbal medicine could simultaneously act on the pathological targets of CHD, anxiety, and depression, with advantages of multiple effective components and multiple targets compared with Western medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Psychiatry
Vincent Gosselin Boucher, Claudia Gemme, Anda I. Dragomir, Florent Larue, Simon L. Bacon, Kim L. Lavoie
PSYCHOSOMATIC MEDICINE
(2021)
Review
Endocrinology & Metabolism
Cassandre A. Julien, Kim L. Lavoie, Paula A. B. Ribeiro, Anda I. Dragomir, Li Anne Mercier, Pierre Y. Garneau, Radu Pescarus, Simon L. Bacon
Summary: The study found that behavioral weight management interventions conducted after metabolic and bariatric surgery can lead to greater decreases in weight and body mass index compared to interventions conducted before or both before and after surgery. However, there is high variability in study characteristics and risk of bias across trials.
Article
Medicine, General & Internal
Joanne Enticott, Jaskirath Singh Gill, Simon L. Bacon, Kim L. Lavoie, Daniel S. Epstein, Shrinkhala Dawadi, Helena J. Teede, Jacqueline Boyle
Summary: The majority of Australian adults are likely to receive a SARS-CoV-2 vaccine. Factors influencing vaccine uptake include age, gender, socioeconomic status, perceived risk of COVID-19 infection, trust in vaccine safety and efficacy, doctor's recommendation, and belief in the protecting effect of vaccination. These findings can inform public health messaging to improve vaccination rates.
Article
Cardiac & Cardiovascular Systems
Valery Legris, Bernard Thibault, Jocelyn Dupuis, Michel White, Anita W. Asgar, Annik Fortier, Celine Pitre, Nadia Bouabdallaoui, Christine Henri, Eileen O'Meara, Anique Ducharme
Summary: This study found that right ventricular function assessed by echocardiography is closely associated with exercise tolerance in patients with heart failure and reduced ejection fraction. When the TAPSE/PASP ratio is available, this marker of RV-PA coupling becomes the strongest echocardiographic predictor of exercise capacity in this population, highlighting its potential role as a screening tool.
Article
Medicine, General & Internal
Matea Belan, Myriam Gelinas, Belina Carranza-Mamane, Marie-France Langlois, Anne-Sophie Morisset, Stephanie-May Ruchat, Kim Lavoie, Kristi Adamo, Thomas Poder, Frances Gallagher, Marie-Helene Pesant, Farrah Jean-Denis, Jean-Patrice Baillargeon
Summary: This study aims to assess the clinical outcomes and cost-effectiveness of a lifestyle intervention targeting women with obesity and subfertility. It is a pragmatic multicentre randomised controlled trial that will include 616 women who will be evaluated for subfertility at a Canadian fertility clinic. The primary outcome is live birth rate at 24 months. The results of this study will provide valuable information for improving care and policies regarding fertility treatments for women with obesity and subfertility.
Article
Medicine, General & Internal
Kim Lavoie, Vincent Gosselin-Boucher, Jovana Stojanovic, Samir Gupta, Myriam Gagne, Keven Joyal-Desmarais, Katherine Seguin, Sherri Sheinfeld Gorin, Paula Ribeiro, Brigitte Voisard, Michael Vallis, Kimberly Corace, Justin Presseau, Simon Bacon
Summary: This study examined vaccine hesitancy rates and their correlates among Canadian adults between April 2020 and March 2021. The results showed that women, individuals aged 50 and younger, non-white individuals, those with lower education levels, and individuals with lower household incomes were more likely to report vaccine hesitancy. Additionally, endorsing prevention behaviors and having high COVID-19 health concerns were associated with a reduced likelihood of vaccine hesitancy.
Article
Peripheral Vascular Disease
Bingxun Liu, Yun-Peng Wei, Xiaohang Fan, Xiaoyi Hu, Zeshuai Chen, Xiaoyuan Liu, Yan Xu, Lu Wang, Tao Wang, Matthieu Ruiz, Jocelyn Dupuis, Ping Yuan, Jinming Liu, Songling Huang, Liping Zhu, Zhi-Cheng Jing, Qinghua Hu
Summary: The study revealed a significant association between CaSR gene variant and the formation of idiopathic pulmonary arterial hypertension (IPAH), suggesting a potential impact on the development and severity of IPAH. Patients with specific genotypes of CaSR gene may experience higher pulmonary artery pressure and reduced survival rates.
Article
Medicine, General & Internal
Rubee Dev, Valeria Raparelli, Simon L. Bacon, Kim L. Lavoie, Louise Pilote, Colleen M. Norris
Summary: This study aims to examine the association between sociocultural gender factors and the public's adherence to COVID-19-recommended protective health behaviors. The findings suggest that while females show greater adherence, factors such as employment status and high gender inequality at the country level are independently associated with non-adherence among females.
Letter
Medicine, General & Internal
Anda I. Dragomir, Brigitte Voisard, Vincent Gosselin Boucher, Genevieve Szczepanik, Simon L. Bacon, Kim L. Lavoie
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Yuan Su, Rubin Tan, Mengxiang Sun, Linbo Yuan, Matthieu Ruiz, Jocelyn Dupuis, Qinghua Hu, Liping Zhu
Summary: This study found that cigarette smoke-enriched microRNA-1249 can promote excessive proliferation and anti-apoptotic status of pulmonary artery smooth muscle cells, leading to the development of pulmonary hypertension. Inhibition of the histone deacetylase 10-NFκB-calcium-sensing receptor cascade can effectively suppress the proliferative capacity and anti-apoptotic ability of pulmonary artery smooth muscle cells, thereby slowing the progression of pulmonary hypertension.
Article
Oncology
Rui Xiao, Jie Liu, Shengquan Luo, Zhe Yu, Jiwei Zhang, Yankai Lv, Jiansha Li, Matthieu Ruiz, Jocelyn Dupuis, Qinghua Hu, Liping Zhu
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Keven Joyal-Desmarais, Jovana Stojanovic, Eric B. Kennedy, Joanne C. Enticott, Vincent Gosselin Boucher, Hung Vo, Urska Kosir, Kim L. Lavoie, Simon L. Bacon
Summary: Research on COVID-19 has heavily relied on convenience-based samples, which are susceptible to important sampling biases. This study found significant discrepancies between convenience samples and representative samples in COVID-19 prevention behaviors. Demographic covariates did not consistently reduce sampling differences or bias in adjusted results.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Jocelyn Dupuis, Pierre Laurin, Jean-Claude Tardif, Leslie Hausermann, Camille Rosa, Marie-Claude Guertin, Karen Thibaudeau, Lyne Gagnon, Frank Cesari, Martin Robitaille, John E. Moran
Summary: Hesperidin 1000 mg daily may help reduce certain COVID-19 symptoms, but most nonvaccinated patients remain symptomatic after 14 days, with anosmia being the most frequently persisting symptom.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Amine Nasri, Jocelyn Dupuis, Michel Carrier, Normand Racine, Marie-Claude Parent, Anique Ducharme, Annik Fortier, Leslie Hausermann, Michel White, Maxime Tremblay-Gravel
Summary: This study investigated the impact of new definitions of pulmonary hypertension (PH) and pulmonary vascular resistance (PVR) thresholds on the prevalence, clinical characteristics, and outcomes of patients undergoing cardiac transplantation (CTx). The results showed that the presence, severity, and type of PH were not significantly associated with short- or long-term mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Olivier Drouin, Tamara Perez, Tracie A. Barnett, Francine M. Ducharme, Eric Fleegler, Arvin Garg, Kim Lavoie, Patricia Li, Marie-Elaine Metras, Serge Sultan, Sze Man Tse, Jiaying Zhao
Summary: This project aims to investigate the relationship between unmet social needs, scarcity, and future discounting and their predictive power on medication adherence in children with asthma. The study will measure unmet social needs, scarcity, and future discounting using validated instruments, and compare adherence to medication between families with and without unmet social needs. This research will contribute to improving medication adherence in children with asthma and inform public policy.
JMIR RESEARCH PROTOCOLS
(2023)