期刊
BMC ENDOCRINE DISORDERS
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12902-015-0026-1
关键词
Sleep quality; Arterial stiffness; Type 2 diabetes mellitus; Japanese
资金
- MSD
- Takeda
- Eli Lilly
- Manpei Suzuki Diabetes Foundation
- Boehringer Ingelheim
- Sanofi-Aventis
- Ono Pharmaceutical Co.
- Novo Nordisk Pharma
- Kissei Pharma
- Mitsubishi Tanabe Pharma
- Novartis Pharmaceuticals
- Sanwakagaku Kenkyusho
- Daiichi Sankyo Inc.
- Takeda Pharmaceutical Co.
- Dainippon Sumitomo Pharm.
- Kowa Co.
- Dainippon Sumitomo Pharma
- Asteras
- Astrazeneca
- Eli Lilly and Company
- Kissei Pharmaceutical Co.
- Kowa Pharmaceutical CO.
- Kyowa Hakko Kirin Co.
- Bristol-Myers Squibb
- Johnson and Johnson
- Mochida Pharmaceutical Co.
- Pfizer
Background: While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship. Methods: The study participants comprised 724 Japanese T2DM outpatients free of history of cardiovascular diseases. The relationships between sleep quality (assessed by the Pittsburgh Sleep Quality Index (PSQI)) and various clinical and laboratory parameters were investigated. Results: The mean PSQI was 5.1 +/- 3.0 (+/- SD). Patients were divided into three groups based on the total PSQI score; subjects with good sleep quality (n = 462), average sleep quality (n = 185), and poor sleep quality (n = 77). In the age/gender-adjusted model, patients with poor sleep quality tended to be obese, evening type and depressed. However, other lifestyles showed no significant trends. Alanine aminotransferase, fasting blood glucose, HbA1c, systolic blood pressure, urinary albumin excretion, and brachial-ankle pulse wave velocity (baPWV) tended to be higher in patients with poor sleep quality. High baPWV was the only parameter that correlated with poor sleep in a model adjusted for several other lifestyle factors. Conclusions: Our study indicates that poor sleep quality in T2DM patients correlates with increased arterial wall stiffness, a marker of atherosclerosis and a risk factor for cardiovascular diseases.
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