Article
Gastroenterology & Hepatology
Kaiyu Xu, Xuxuan Gao, Genghong Xia, Muxuan Chen, Nianyi Zeng, Shan Wang, Chao You, Xiaolin Tian, Huiling Di, Wenli Tang, Pan Li, Huidi Wang, Xiuli Zeng, Chuhong Tan, Fanguo Meng, Hailong Li, Yan He, Hongwei Zhou, Jia Yin
Summary: Stroke is a leading cause of death and disability worldwide, and neuroprotective approaches have been unsuccessful in clinical trials. This study reveals a reciprocal relationship between stroke and gut dysbiosis, with acute ischemic stroke triggering dysbiosis of the gut microbiome, exacerbating brain infarction. Administering certain treatments was able to alleviate post-stroke brain infarction, illustrating the translational value of the brain-gut axis in stroke treatment.
Article
Cell Biology
Hui Wu, Guihai Suo, Tianci Li, Yuqin Zheng, Haiying Li, Feifei Shen, Yongjun Wang, Haidong Ni, Youjia Wu
Summary: Congenital hypothyroidism (CH) can lead to cognitive impairment if not treated in a timely manner. This study found that CH inhibits the activity of CaMKIV, which in turn regulates the expression of early growth response factor 3 (EGR3) in hippocampal neurons. Reduced EGR3 expression then decreases the production of brain-derived neurotrophic factor (BDNF), impairing the growth of dendritic spines.
CELL DEATH DISCOVERY
(2022)
Article
Gastroenterology & Hepatology
Yi Yang, Peng Wang, Chaoyi Zhang, Fan Huang, Gaozong Pang, Chuansheng Wei, Changming Lv, Goma Chhetri, Tongcui Jiang, Jun Liu, Yujun Shen, Yuxian Shen
Summary: The study revealed that MANF expression and secretion are significantly upregulated during hepatic I/R. Hepatocyte-specific MANF knockout exacerbates I/R injury by over-activating ER stress. Administration of recombinant human MANF has the potential to alleviate I/R-induced UPR and liver injury.
LIVER INTERNATIONAL
(2021)
Article
Immunology
Yun Wang, Ce Gao, Tianyu Gao, Lu Zhao, Shiguang Zhu, Lin Guo
Summary: Exosomes from patients with depression showed antidepressant-like effects by ameliorating depressive-like behaviors, BDNF deficiency, and neuro-inflammation in LPS-challenged mice, which was found to be Sig-1R dependent. Additionally, these exosomes prevented LPS-induced inflammation responses in microglial BV2 cells.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Reai Shan, Hongyan Zhou, Xinfang Liu, Guangjun Su, Guangsen Liu, Xiaoli Zhang, Cong Sun, Zining Yu, Lifang Zhan, Zhihua Huang
Summary: This study evaluated the protective effects of different fluids on the blood-brain barrier in cerebral ischaemia/reperfusion injury, and the results showed that HSH and other fluids could alleviate neurological deficits, brain infarction, brain oedema, and increased BBB permeability.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Albert J. Yoo, Jazba Soomro, Tommy Andersson, Jeffrey L. Saver, Marc Ribo, Hormozd Bozorgchami, Guilherme Dabus, David S. Liebeskind, Ashutosh Jadhav, Heinrich Mattle, Osama O. Zaidat
Summary: This study aimed to identify a more optimal definition of angiographic success based on tissue reperfusion extent and speed of revascularization, finding that first-pass excellent reperfusion was the best predictor of functional independence.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Narges Marefati, Farimah Beheshti, Farzaneh Vafaee, Moslem Barabadi, Mahmoud Hosseini
Summary: The study showed that IA could improve LPS-induced learning and memory impairments by reducing neuro-inflammation and brain tissue oxidative damage while increasing BDNF levels.
NEUROCHEMICAL RESEARCH
(2021)
Article
Clinical Neurology
Derek A. Schreihofer, Dhwanil Dalwadi, Seongcheol Kim, Daniel Metzger, Anthony Oppong-Gyebi, Paromita Das-Earl, John A. Schetz
Summary: In this study, it was found that oxeladin, a selective sigma 1 receptor agonist, could stimulate the release of BDNF and improve neurological function after stroke in rats. However, oxeladin did not reduce inflammation or increase cell proliferation, suggesting that its mechanisms of action may be different.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Linying Feng, Yeli Li, Mu Lin, Dianyou Xie, Yunmei Luo, Yuandong Zhang, Zhixu He, Qihai Gong, Zhu Yi Zhun, Jianmei Gao
Summary: This study demonstrates that TLB can protect against blood-brain barrier disruption following cerebral I/R injury by targeting MMP9 and inhibiting the APOE4/CypA/NF-kappa B axis. TLB effectively maintained BBB integrity, inhibited neuronal loss, and reduced proinflammatory cytokines by increasing tight junction proteins and decreasing levels of APOE4, CypA, and phosphorylated NF-kappa B.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Muhammad Zahid Khan, Yong-Bo Zheng, Kai Yuan, Ying Han, Lin Lu
Summary: This study investigated the role of extracellular zinc in memory formation using a contextual fear conditioning model. The results suggest that extracellular zinc may regulate fear memory formation via the BDNF-TrKB pathway, and high doses of exogenous zinc may enhance fear memory formation.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Lou Rizzolo, Marianne Leger, Sophie Corvaisier, Mathilde Groussard, Herve Platel, Valentine Bouet, Pascale Schumann-Bard, Thomas Freret
Summary: Long-term exposure to music can rescue age-related spatial navigation deficits in aging rats, but does not affect spontaneous locomotor, circadian rhythmic activity, and anxiety-like behavior.
Review
Medicine, Research & Experimental
Yujiro Yamada, Emily M. Frith, Vickie Wong, Robert W. Spitz, Zachary W. Bell, Raksha N. Chatakondi, Takashi Abe, Jeremy P. Loenneke
Summary: The effects of blood flow restricted exercise on cognition are still unclear due to limited research in this area. The hypothesis suggests that blood flow restricted exercise could potentially enhance cognitive domains through increases in lactate production, catecholamine concentration, and PGC-1 alpha expression. Further investigations are needed to test this hypothesis.
MEDICAL HYPOTHESES
(2021)
Article
Pharmacology & Pharmacy
Ke Liu, Lulu Li, Zhijun Liu, Gang Li, Yanqing Wu, Xingjun Jiang, Mengdie Wang, Yanmin Chang, Tingting Jiang, Jianheng Luo, Jiahui Zhu, Hongge Li, Yong Wang
Summary: This research investigated the effect and mechanism of metformin in cerebral ischemia-reperfusion (I/R) injury. The results showed that metformin protected against cerebral I/R injury by upregulating BDNF expression and activating the AMPK/CREB pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Farimah Beheshti, Hamid Reza Akbari, Yousef Baghcheghi, Fatemeh Mansouritorghabeh, Sakineh Sadat Mortazavi Sani, Mahmoud Hosseini
Summary: The study showed that RAS inhibitor captopril could improve scopolamine-induced memory impairment in rats by increasing BDNF, thiol, SOD, and CAT levels, while decreasing IL-6, NO metabolites, and MDA levels. This suggests that the role of RAS in learning and memory impairment may involve its effects on BDNF, neuro-inflammation, and oxidative stress.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Endocrinology & Metabolism
Cheryl A. Frye, Vincent F. Lembo, Alicia A. Walf
Summary: The study found that progesterone can enhance cognitive performance in male mice by increasing allopregnanolone concentrations, BDNF levels, and GABA(A) activity. These effects may be independent of traditional progestin receptors' trophic actions.
FRONTIERS IN ENDOCRINOLOGY
(2021)