Advancing the discovery of medications for autism spectrum disorder using new technologies to reveal social brain circuitry in rodents

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

Cortical Evolution: Judge the Brain by Its Cover

(2013) Daniel H. Geschwind et al.   NEURON

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

A Magnetic Resonance Imaging Study of Cerebellar Volume in Tuberous Sclerosis Complex

(2013) Neil I. Weisenfeld et al.   PEDIATRIC NEUROLOGY

Local Functional Overconnectivity in Posterior Brain Regions Is Associated with Symptom Severity in Autism Spectrum Disorders

(2013) Christopher Lee Keown et al.   Cell Reports

Optogenetic Insights into Social Behavior Function

(2012) Ofer Yizhar   BIOLOGICAL PSYCHIATRY

Molecular Tools and Approaches for Optogenetics

(2012) Yuan Mei et al.   BIOLOGICAL PSYCHIATRY

Genetic architecture in autism spectrum disorder

(2012) Bernie Devlin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mining and modeling human genetics for autism therapeutics

(2012) Daniel G Smith et al.   CURRENT OPINION IN NEUROBIOLOGY

Neural correlates of emotion processing: From emotional to social brain

(2012) P. Fossati   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex

(2012) Sharon W. Way et al.   HUMAN MOLECULAR GENETICS

Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex

(2012) Robert P. Carson et al.   HUMAN MOLECULAR GENETICS

Social ‘wanting’ dysfunction in autism: neurobiological underpinnings and treatment implications

(2012) Gregor Kohls et al.   Journal of Neurodevelopmental Disorders

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

(2012) Sarah R Gilman et al.   NATURE NEUROSCIENCE

Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex

(2012) R. Michelle Reith et al.   NEUROBIOLOGY OF DISEASE

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response

(2012) H. Sophie Knobloch et al.   NEURON

Six Developmental Trajectories Characterize Children With Autism

(2012) C. Fountain et al.   PEDIATRICS

High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism

(2012) Raymond J. Kelleher III et al.   PLoS One

Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53

(2012) Eleonora Napoli et al.   PLoS One

Oxytocin facilitates protective responses to aversive social stimuli in males

(2012) N. Striepens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction

(2012) James P. Burkett et al.   PSYCHOPHARMACOLOGY

Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism

(2012) S. J. Baudouin et al.   SCIENCE

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

(2012) J. L. Silverman et al.   Science Translational Medicine

Reward system dysfunction in autism spectrum disorders

(2012) Gregor Kohls et al.   Social Cognitive and Affective Neuroscience

The social motivation theory of autism

(2012) Coralie Chevallier et al.   TRENDS IN COGNITIVE SCIENCES

Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders

(2012) Will Spooren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

(2012) Atsushi Sato et al.   Nature Communications

Brain Surface Anatomy in Adults With Autism

(2012) Christine Ecker et al.   JAMA Psychiatry

Animal Models of Psychiatric Disorders That Reflect Human Copy Number Variation

(2012) Jun Nomura et al.   NEURAL PLASTICITY

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

(2011) Joachim Hallmayer   ARCHIVES OF GENERAL PSYCHIATRY

Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses

(2011) Corinne M. Spencer et al.   Autism Research

Single-Unit Responses Selective for Whole Faces in the Human Amygdala

(2011) Ueli Rutishauser et al.   CURRENT BIOLOGY

Vasopressin, oxytocin, and social odor recognition

(2011) Douglas W. Wacker et al.   HORMONES AND BEHAVIOR

The oxytocin system in drug discovery for autism: Animal models and novel therapeutic strategies

(2011) Meera E. Modi et al.   HORMONES AND BEHAVIOR

Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action

(2011) Oliver J. Bosch et al.   HORMONES AND BEHAVIOR

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

(2011) Chiara Verpelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factors Associated With Driving in Teens With Autism Spectrum Disorders

(2011) Patty Huang et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Functional identification of an aggression locus in the mouse hypothalamus

(2011) Dayu Lin et al.   NATURE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy

(2011) Robert P J Barretto et al.   NATURE MEDICINE

The conundrums of understanding genetic risks for autism spectrum disorders

(2011) Matthew W State et al.   NATURE NEUROSCIENCE

Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration

(2011) R. Michelle Reith et al.   NEUROBIOLOGY OF DISEASE

Gene expression studies in autism: Moving from the genome to the transcriptome and beyond

(2011) Irina Voineagu   NEUROBIOLOGY OF DISEASE

Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement

(2011) Ilana B. Witten et al.   NEURON

mGluR5-Antagonist Mediated Reversal of Elevated Stereotyped, Repetitive Behaviors in the VPA Model of Autism

(2011) Mili V. Mehta et al.   PLoS One

Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism

(2011) G. Horev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

(2011) Alexia M. Thomas et al.   PSYCHOPHARMACOLOGY

Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders

(2011) Y. Sakai et al.   Science Translational Medicine

Temporal dynamics reveal atypical brain response to social exclusion in autism

(2011) James C. McPartland et al.   Developmental Cognitive Neuroscience

What does the amygdala contribute to social cognition?

(2010) Ralph Adolphs   Annals of the New York Academy of Sciences

Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome

(2010) Dilja D. Krueger et al.   Annual Review of Medicine

The Neuroscience of Social Decision-Making

(2010) James K. Rilling et al.   Annual Review of Psychology

Flexible Accelerated STOP Tetracycline Operator-Knockin (FAST): A Versatile and Efficient New Gene Modulating System

(2010) Kenji F. Tanaka et al.   BIOLOGICAL PSYCHIATRY

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Neural circuitry of emotional face processing in autism spectrum disorders

(2010) Christopher Monk   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

(2010) Torfi Sigurdsson et al.   NATURE

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

The knockout rat pack

(2010) Elie Dolgin   NATURE MEDICINE

Retention of identity versus expression of emotional faces differs in the recruitment of limbic areas

(2010) Christian H. Röder et al.   NEUROPSYCHOLOGIA

Fast dopamine release events in the nucleus accumbens of early adolescent rats

(2010) D.L. Robinson et al.   NEUROSCIENCE

The neurobiology of repetitive behavior: Of mice…

(2010) Marieke Langen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The neurobiology of repetitive behavior: …and men

(2010) Marieke Langen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Neural Bases for Empathy

(2010) Simone G. Shamay-Tsoory   NEUROSCIENTIST

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

(2010) Feng Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in the Developmental Trajectories of Striatum in Autism

(2009) Marieke Langen et al.   BIOLOGICAL PSYCHIATRY

Oxytocin modulates unconditioned fear response in lactating dams: An fMRI study

(2009) Marcelo Febo et al.   BRAIN RESEARCH

Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13 Duplication Seen in Autism

(2009) Jin Nakatani et al.   CELL

NovelPTENmutations in neurodevelopmental disorders and macrocephaly

(2009) A Orrico et al.   CLINICAL GENETICS

Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition

(2009) A. H. Macbeth et al.   GENES BRAIN AND BEHAVIOR

Behavioral Triggers of Skin Conductance Responses and Their Neural Correlates in the Primate Amygdala

(2009) Christopher M. Laine et al.   JOURNAL OF NEUROPHYSIOLOGY

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

(2009) Jill L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Haploinsufficiency forPtenandSerotonin transportercooperatively influences brain size and social behavior

(2009) Damon T. Page et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Double Dissociation of the Effects of Medial and Orbital Prefrontal Cortical Lesions on Attentional and Affective Shifts in Mice

(2008) G. B. Bissonette et al.   JOURNAL OF NEUROSCIENCE

All My Circuits: Using Multiple Electrodes to Understand Functioning Neural Networks

(2008) Earl K. Miller et al.   NEURON

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES