The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours

Discovery of positive allosteric modulators and silent allosteric modulators of the  -opioid receptor

(2013) N. T. Burford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of cocaine and heroin seeking by μ-opioid receptor antagonism

(2013) Chiara Giuliano et al.   PSYCHOPHARMACOLOGY

Inhibition of Opioid Transmission at the μ-Opioid Receptor Prevents Both Food Seeking and Binge-Like Eating

(2012) Chiara Giuliano et al.   NEUROPSYCHOPHARMACOLOGY

Multiple-Dose Safety, Pharmacokinetics, and Pharmacodynamics of the μ-Opioid Receptor Inverse Agonist GSK1521498

(2011) Pradeep J. Nathan et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Opioid Receptor Modulation of Hedonic Taste Preference and Food Intake: A Single-Dose Safety, Pharmacokinetic, and Pharmacodynamic Investigation With GSK1521498, a Novel μ-Opioid Receptor Inverse Agonist

(2011) Pradeep J. Nathan et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Analgesic Tone Conferred by Constitutively Active Mu Opioid Receptors in Mice Lacking β-Arrestin 2

(2011) Hoa Lam et al.   Molecular Pain

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Neutral antagonist activity of naltrexone and 6β-naltrexol in naïve and opioid-dependent C6 cells expressing a µ-opioid receptor

(2009) MF Divin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

(2009) C. P. Bailey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Identification of a novel “almost neutral” μ-opioid receptor antagonist in CHO cells expressing the cloned human μ-opioid receptor

(2009) Elliott J. Sally et al.   SYNAPSE