Article
Orthopedics
Qiuru Wang, Wanli Zhang, Tingting Xiao, Liying Wang, Ting Ma, Pengde Kang
Summary: This study evaluated the efficacy of preemptive opioids for pain management in patients who underwent total knee arthroplasty (TKA). The results showed that preemptive opioid administration did not provide clinical benefits over placebo. Orthopaedic surgeons should consider not using pre-operative opioids in patients undergoing TKA.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Anesthesiology
Jonathan N. Davies, Louise Sharpe, Melissa A. Day, Ben Colagiuri
Summary: Recent studies suggest that placebo effects contribute to acute pain relief after mindfulness interventions. However, the specific effects of mindfulness processes and their interaction with placebo effects are still unclear. This study aimed to examine the role of mindfulness and placebo processes in mindfulness-based pain attenuation.
Article
Multidisciplinary Sciences
Dilan Sezer, Cosima Locher, Jens Gaab
Summary: This study examined the effects of placebos on guilt and found that both deceptive and open-label placebos were effective in reducing guilt. Additionally, the effects of placebos on guilt were specific and did not extend to shame, pride, or affect.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Joshua Baker, Matthias Gamer, Jonas Rauh, Stefanie Brassen
Summary: A perceptual bias towards negative emotions is common in mood disorders and is a target of therapeutic interventions. This study investigated how placebo-induced positive expectations can shape perception of emotional stimuli in healthy individuals. The results showed that positive expectations lowered the threshold for identifying happy emotions and decreased sensitivity to subtle emotional expressions. These findings suggest that expectations can induce a positive perceptual bias and improve mood state.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Dilan Sezer, Matthijs de Leeuw, Cordula Netzer, Markus Dieterle, Andrea Meyer, Sarah Buergler, Cosima Locher, Wilhelm Ruppen, Jens Gaab, Tobias Schneider
Summary: This study aims to investigate the efficacy of open-label placebos in acute pain and may be an important step towards their implementation in the clinical management of acute postoperative pain. This cost-efficient and patient-centered strategy could reduce opioid consumption and its related side effects without compromising pain management efficacy.
FRONTIERS IN MEDICINE
(2021)
Article
Plant Sciences
Amanda de Oliveira Marinho, Jessica de Santana Brito, Jainaldo Alves Da Costa, Abdenego Rodrigues Da Silva, Suellen Pedrosa Da Silva, Luciclaudio Cassimiro De Amorim, Maria Tereza dos Santos Correia, Patricia Maria Guedes Paiva, Alisson Macario De Oliveira, Leydianne Leite de Siqueira Patriota, Thiago Henrique Napolea
Summary: The study evaluated the antinociceptive activity of S. terebinthifolia leaf lectin (SteLL) and found that it has both peripheral and central analgesic effects, which are mediated through modulation of opioid receptors without affecting motor coordination in animals.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Lara Lakhsassi, Charmaine Borg, Sophie Martusewicz, Karen van der Ploeg, Peter J. de Jong
Summary: Sexual arousal alone does not modulate subjective pain in women, possibly due to the requirement of genital stimulation and/or orgasm for pain reduction, or the possibility of disgust induced by the pornographic stimulus interfering with sexual arousal in influencing pain.
Article
Medicine, General & Internal
Terence Ong, Chiann Ni Thiam
Summary: Pain is a common issue among older people, but it is often underestimated and not properly treated. A comprehensive assessment is necessary to identify the cause, severity, impact, and treatment response of pain. Managing pain in older individuals requires a different approach due to frailty, multimorbidity, polypharmacy, sensory deficits, and cognitive impairment. This review provides a summary of a comprehensive approach to pain management in older people.
Article
Psychology, Biological
Michael M. Morgan, Tammy N. Hilgendorf, Ram Kandasamy
Summary: This study investigated the effects of fentanyl on hindpaw inflammation, administration, and withdrawal in rats. The results showed that the effects of fentanyl on activity levels varied depending on the dose and pain condition, and withdrawal from fentanyl resulted in opioid withdrawal symptoms.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Veterinary Sciences
Daphna Emanuel, Sabine B. R. Kaestner, Julien Delarocque, Anne J. Grob, Astrid Bienert-Zeit
Summary: The aim of this study was to compare the effects of butorphanol, buprenorphine, and levomethadone on sedation quality and postoperative analgesia in horses undergoing cheek tooth extraction. The results showed that levomethadone and buprenorphine had better analgesic effects, with buprenorphine also increasing locomotor activity. However, it is important to note that serum cortisol levels may be influenced by other factors.
VETERINARY SCIENCES
(2022)
Article
Surgery
Hira Shafeeq, Jody C. DiGiacomo, Kelley A. Sookraj, Noam Gerber, Alaa Bahr, Om N. Talreja, Swapna Munnangi, Sarah Cardozo-Stolberg, L. D. George Angus
Summary: The study demonstrates that implementing a multimodal pain management approach with IV APAP as the first-line therapy in older polytrauma patients can significantly reduce opioid use and is associated with a shorter hospital stay.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Anesthesiology
Jonathan N. Davies, Ben Colagiuri, Louise Sharpe, Melissa A. Day
Summary: This study compared the effects of mindfulness and sham treatments on chronic pain, and found that improvements in pain unpleasantness may be driven by placebo effects rather than mindfulness-specific processes. These findings suggest that further research is needed to understand if mindfulness-specific effects emerge after longer durations of online training.
Article
Behavioral Sciences
Julian C. Motzkin, Jaryd Hiser, Ian Carroll, Richard Wolf, Mustafa K. Baskaya, Michael Koenigs, Lauren Y. Atlas
Summary: Pain is strongly influenced by expectations and beliefs. The ventromedial prefrontal cortex (VMPFC) plays a role in pain processing, predictions, and learning. Damage to the VMPFC enhances the effect of expectations on pain processing, specifically impairing the integration of new sensory feedback to update expectations about pain.
Review
Oncology
Morena Shkodra, Augusto Caraceni
Summary: This review discusses treatment approaches for neuropathic cancer pain caused by nerve damage due to the tumor. Diagnosing and treating neuropathic cancer pain remains difficult and evidence for the best treatments is limited. This review summarizes current management options and provides insights on new promising treatments for neuropathic cancer pain.
Article
Emergency Medicine
Ezra S. Hornik, Henry C. Thode Jr, Adam J. Singer
Summary: There were no significant sex, ethnic, or racial disparities in administration or prescription of analgesics or opioids in ED adult patients with long-bone fractures between 2016 and 2019.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Letter
Anesthesiology
Siri Leknes, Lauren Y. Atlas
BRITISH JOURNAL OF ANAESTHESIA
(2020)
Article
Neurosciences
In-Seon Lee, Elizabeth A. Necka, Lauren Y. Atlas
Article
Psychology, Biological
Dobromir Rahnev, Kobe Desender, Alan L. F. Lee, William T. Adler, David Aguilar-Lleyda, Basak Akdogan, Polina Arbuzova, Lauren Y. Atlas, Fuat Balci, Ji Won Bang, Indrit Begue, Damian P. Birney, Timothy F. Brady, Joshua Calder-Travis, Andrey Chetverikov, Torin K. Clark, Karen Davranche, Rachel N. Denison, Troy C. Dildine, Kit S. Double, Yalcin A. Duyan, Nathan Faivre, Kaitlyn Fallow, Elisa Filevich, Thibault Gajdos, Regan M. Gallagher, Vincent de Gardelle, Sabina Gherman, Nadia Haddara, Marine Hainguerlot, Tzu-Yu Hsu, Xiao Hu, Inaki Iturrate, Matt Jaquiery, Justin Kantner, Marcin Koculak, Mahiko Konishi, Christina Koss, Peter D. Kvam, Sze Chai Kwok, Mael Lebreton, Karolina M. Lempert, Chien Ming Lo, Liang Luo, Brian Maniscalco, Antonio Martin, Sebastien Massoni, Julian Matthews, Audrey Mazancieux, Daniel M. Merfeld, Denis O'Hora, Eleanor R. Palser, Boryslaw Paulewicz, Michael Pereira, Caroline Peters, Marios G. Philiastides, Gerit Pfuhl, Fernanda Prieto, Manuel Rausch, Samuel Recht, Gabriel Reyes, Marion Rouault, Jerome Sackur, Saeedeh Sadeghi, Jason Samaha, Tricia X. F. Seow, Medha Shekhar, Maxine T. Sherman, Marta Siedlecka, Zuzanna Skora, Chen Song, David Soto, Sai Sun, Jeroen J. A. van Boxtel, Shuo Wang, Christoph T. Weidemann, Gabriel Weindel, Michal Wierzchon, Xinming Xu, Qun Ye, Jiwon Yeon, Futing Zou, Ariel Zylberberg
NATURE HUMAN BEHAVIOUR
(2020)
Article
Neurosciences
Stephan Geuter, Elizabeth A. Reynolds Losin, Mathieu Roy, Lauren Y. Atlas, Liane Schmidt, Anjali Krishnan, Leonie Koban, Tor D. Wager, Martin A. Lindquist
Article
Psychiatry
Andrea W. M. Evers, Luana Colloca, Charlotte Blease, Jens Gaab, Karin B. Jensen, Lauren Y. Atlas, Chris J. Beedie, Fabrizio Benedetti, Ulrike Bingel, Christian Buechel, Jet Bussemaker, Ben Colagiuri, Alia J. Crum, Damien G. Finniss, Andrew L. Geers, Jeremy Howick, Regine Klinger, Stefanie H. Meeuwis, Karin Meissner, Vitaly Napadow, Keith J. Petrie, Winfried Rief, Ionica Smeets, Tor D. Wager, Vishvarani Wanigasekera, Lene Vase, John M. Kelley, Irving Kirsch
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2020)
Article
Multidisciplinary Sciences
Troy C. Dildine, Elizabeth A. Necka, Lauren Y. Atlas
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Rany Abend, Mira A. Bajaj, Anita Harrewijn, Chika Matsumoto, Kalina J. Michalska, Elizabeth Necka, Esther E. Palacios-Barrios, Ellen Leibenluft, Lauren Y. Atlas, Daniel S. Pine
Summary: The study investigates pain-anticipatory psychophysiological response in youth with anxiety and healthy youth using thermal stimulation. The results show that youth with anxiety exhibit enhanced psychophysiological response during the anticipation of painful stimulation, and this response is correlated with specific brain structures. Specifically, thinner dorsolateral prefrontal cortex thickness is associated with stronger anticipatory response, while thicker posterior insula thickness is associated with stronger response to thermal stimulation.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Lauren Y. Atlas
Summary: Pain is a fundamental experience that promotes survival, standing at the intersection of multiple health crises for humans. The study of placebo analgesia reveals how social, cognitive, and affective processes directly shape pain, offering potential paths for mitigating these crises. Collaborations between clinicians and social and affective scientists can address outstanding questions and leverage the placebo effect to reduce pain and improve human health.
TRENDS IN COGNITIVE SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Elizabeth A. Necka, Carolyn Amir, Troy C. Dildine, Lauren Y. Atlas
Summary: Results from five online studies suggest that participants tend to choose healthcare providers who appear more competent based on facial visual information alone. The perceived competence of providers also predicts participants' expectations about post-procedural pain and medication use. Additionally, participants' perception of similarity to providers influences expectations about pain and treatment outcomes.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Clinical Neurology
Carolyn Amir, Margaret Rose-McCandlish, Rachel Weger, Troy C. Dildine, Dominik Mischkowski, Elizabeth A. Necka, In-seon Lee, Tor D. Wager, Daniel S. Pine, Lauren Y. Atlas
Summary: This study found that pain threshold and tolerance are moderately reliable, while the correlation between pain rating and stimulus temperature has low reliability. Female participants showed higher reliability in pain sensitivity measures compared to male participants.
Article
Neurosciences
Xiaochun Han, Yoni K. Ashar, Philip Kragel, Bogdan Petre, Victoria Schelkun, Lauren Y. Atlas, Luke J. Chang, Marieke Jepma, Leonie Koban, Elizabeth A. Reynolds Losin, Mathieu Roy, Choong-Wan Woo, Tor D. Wager
Summary: The NPS has shown large effect sizes in predicting pain reports within individuals and medium effect sizes in predicting individual differences. It exhibits excellent short-term test-retest reliability, with reliability scaling with the number of trials. The NPS is not a substitute for individual differences in pain reports but can serve as a reliable measure of pain-related physiology.
Article
Psychology, Biological
Lauren Y. Atlas, Christina A. Sandman, Elizabeth A. Phelps
Summary: The study tested the impact of rating expectations on arousal during classical conditioning, finding that participants who provided online expectancy ratings showed slower learning speed, reduced reversal of SCR, and the effects of subjective expectancy on SCR could be fully explained within the rating group.
Article
Neurosciences
Rany Abend, Sonia G. Ruiz, Mira A. Bajaj, Anita Harrewijn, Julia O. Linke, Lauren Y. Atlas, Anderson M. Winkler, Daniel S. Pine
Summary: This study explores the pathological mechanisms of anxiety disorders and finds that patients with anxiety disorders exhibit excessive physiological responses to threats, which are related to intrinsic connectivity within specific brain circuits.
NEUROBIOLOGY OF STRESS
(2022)
Article
Psychiatry
Dominik Mischkowski, Caitlin M. Stavish, Esther E. Palacios-Barrios, Lauren A. Banker, Troy C. Dildine, Lauren Y. Atlas
Summary: The study found that dispositional mindfulness only mitigated acute thermal pain when assessed using the MPQ, and was not associated with experimental thermal pain assessments. These findings may reflect differences in evaluation methods or the type of pain assessed.
PSYCHOSOMATIC MEDICINE
(2021)
Letter
Psychiatry
Andrea W. M. Evers, Luana Colloca, Charlotte Blease, Jens Gaab, Karin B. Jensen, Lauren Y. Atlas, Chris J. Beedie, Fabrizio Benedetti, Ulrike Bingel, Christian Buchel, Jet Bussemaker, Ben Colagiuri, Alia J. Crum, Damien G. Finniss, Andrew L. Geers, Jeremy Howick, Regine Klinger, Stefanie Helena Meeuwis, Karin Meissner, Vitaly Napadow, Keith J. Petrie, Winfried Rief, Ionica Smeets, Tor D. Wager, Vishvarani Wanigasekera, Lene Vase, John M. Kelley, Irving Kirsch
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)